Gene FMS (Mouse)

FMS

Species: Mouse
Alias: Csf1r, FMS
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: PDGFR

Sequence

Name Sequence Type Origin Length Description Download
FMS.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 329 Kinase domain by global Sugen HMM Fasta, JSON
FMS.AA Protein Sugen 977 None Fasta, JSON
FMS.NA RNA Sugen 3875 None Fasta, JSON

Protein domain

Protein domains of FMS.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG FMS.AA IG 27-102 25 1.2e-10 42.56 SMART 1-58 (58) Show / Hide 
Range on Protein: 27-102
Range on HMM: 1-58/58
Sequence Identity: 25% (20 aa)

GPELVVEPGETVTLRCVSNGSVEWDGPISPYWTLDPESPGSTLTTRNATFKNT---GTYRCTELEDPMAGS-TTIHLYVK
 | ..| .||||||.|  . .. |                  ||  |... ..   |||.|.     .. |  ...|.|.
PP-VTVKEGETVTLTC-VS-QIWWY-----------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
V-set FMS.AA V-set 20-83 15 4.1e-05 19.45 Pfam 1-71 (128) Show / Hide 
Range on Protein: 20-83
Range on HMM: 1-71/128
Sequence Identity: 15% (11 aa)

APVIEP-SGP----ELVVEPGETVTLRCVSN-GSVEWDGPISPYWTL-DPESPGSTLTTRNATFKNTGTYR
. .... . .    ...|..|..|||.|    .. .|... . ||    |  .....  .  |...... .
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGH
IGc2 FMS.AA IGc2 33-91 23 0.006014 3.16 SMART 1-56 (56) Show / Hide 
Range on Protein: 33-91
Range on HMM: 1-56/56
Sequence Identity: 23% (15 aa)

EPGETVTLRCV----SNGSVEW--DGPISPYWTLDPESPGSTLTTRNATFKNTGTYRCTELEDPM
..|..|||.|      . .. |  . |..          ..||| .|.|.   |.|.|.      
HEGQSVTLTCPATGNPDPNIHWYKGQPLP---------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FMS.AA IG 112-196 19 2.1e-08 35.17 SMART 1-58 (58) Show / Hide 
Range on Protein: 112-196
Range on HMM: 1-58/58
Sequence Identity: 19% (17 aa)

AQEVTVVEGQEAVLPCLITDPALKDSVSLMREGGRQVLRKTVYFFSPWRGFIIRKAKVLDS---NTYVCKTMVNGRESTS-TGIWLKVN
 . |||.||. ..|.| ..      .....                    ..| .... ||    ||.|     . . .|  |..|.| 
PP-VTVKEGETVTLTC-VS------QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set FMS.AA V-set 107-127 32 6.323523 1.57 Pfam 1-28 (128) Show / Hide 
Range on Protein: 107-127
Range on HMM: 1-28/128
Sequence Identity: 32% (9 aa)

SWNLLA-Q------EVTVVEGQEAVLPC
.  . . .      .|||.||| . |||
QSQVTQHPPRGCPWWVTVQEGQSVTLPC
V-set FMS.AA V-set 154-195 23 10.431673 0.82 Pfam 82-128 (128) Show / Hide 
Range on Protein: 154-195
Range on HMM: 82-128/128
Sequence Identity: 23% (11 aa)

YFFSPWRG-----FIIRKAKVLDSNTYVCKTMVNGRESTSTGIWLKV
..||. ..       |..... || || |  .  .  .  .|..| |
VTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IG FMS.AA IG 209-296 13 7.9e-09 36.58 SMART 1-58 (58) Show / Hide 
Range on Protein: 209-296
Range on HMM: 1-58/58
Sequence Identity: 13% (13 aa)

PSKLVRIRGEAAQIVCSATNAEVGFNVILKRGDTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDA---GIYSCVASNDVGTRTA--TMNFQVV
|. ..  .|| ... | ..      .. ..                        | .  | ..|.   |.| |.|.   |. ..  . . .| 
PP-VTVKEGETVTLTC-VS------QIWWY------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 FMS.AA IGc2 215-285 18 6.9e-08 33.45 SMART 1-56 (56) Show / Hide 
Range on Protein: 215-285
Range on HMM: 1-56/56
Sequence Identity: 18% (13 aa)

IRGEAAQIVCSATNAEVGFNVILKRGDTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDAGIYSCVASNDVG
. |..... |   ..  . |.  .. ...|.             .   |..  | . |.|.|.|.|.| .|
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set FMS.AA I-set 268-295 39 7.7e-07 25.73 Pfam 65-92 (92) Show / Hide 
Range on Protein: 268-295
Range on HMM: 65-92/92
Sequence Identity: 39% (11 aa)

VDFQDAGIYSCVASNDVGTRTATMNFQV
|.  |.|.|.|||.| .|. ..| . .|
VQPDDEGKYTCVATNSFGEAECTAELTV
V-set FMS.AA V-set 263-295 20 0.243258 6.45 Pfam 95-128 (128) Show / Hide 
Range on Protein: 263-295
Range on HMM: 95-128/128
Sequence Identity: 20% (7 aa)

LSLNAVDFQDAGIYSCVASN-DVGTRTATMNFQV
|... .   | |.| |...| . ..  . .. .|
LTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IG FMS.AA IG 308-397 13 8.6e-05 23.16 SMART 1-58 (58) Show / Hide 
Range on Protein: 308-397
Range on HMM: 1-58/58
Sequence Identity: 13% (13 aa)

SLLQEVSVGDSLILTVHADAYPSIQHYNWTYLGPFFEDQRKLEFITQRAIYRYTFKLFLNRVKASEA---GQYFLMAQNKAGWNNL--TFELTLR
.  ..|..|... ||  .       .. |.                          | . .|... .   | |. .|.  .|      ...|| .
PP-VTVKEGETVTLTC-VS------QIWWY--------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set FMS.AA I-set 359-396 31 0.263988 6.94 Pfam 55-92 (92) Show / Hide 
Range on Protein: 359-396
Range on HMM: 55-92/92
Sequence Identity: 31% (12 aa)

RYTFKLFLNRVKASEAGQYFLMAQNKAGWNNLTFELTL
..| .|.  .|... .|.|   |.|..|    |.||| 
DGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
I-set FMS.AA I-set 311-329 21 25.030744 0.23 Pfam 10-28 (92) Show / Hide 
Range on Protein: 311-329
Range on HMM: 10-28/92
Sequence Identity: 21% (4 aa)

QEVSVGDSLILTVHADAYP
.||..|... ...... .|
VEVQEGETARFECQVTGDP
I-set FMS.AA I-set 415-429 46 0.016681 11.01 Pfam 20-34 (92) Show / Hide 
Range on Protein: 415-429
Range on HMM: 20-34/92
Sequence Identity: 46% (7 aa)

LFCDVSGYPQPSVTW
. |.|.|.|.|.|.|
FECQVTGDPPPQVSW
IG FMS.AA IG 402-504 11 0.467066 0.14 SMART 1-58 (58) Show / Hide 
Range on Protein: 402-504
Range on HMM: 1-58/58
Sequence Identity: 11% (13 aa)

VSVTWMPVNGSDVLFCDVSGYPQPSVTWMECRGHTDRCDEAQALQVWNDTHPEVLSQKPFDKVIIQSQLPIGTLKHN-----MTYFCKTHNSVGNSSQYF
 . ..  . .. .| | ||     ...|.                                       | |  .. .      ||.|  .     . ||.
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------------------------LTI-NVQPEDSQQHGTYYCQAT-----HGQYW

R--AVSLGQS
    . |  .
SIQGTTLTVQ
Kinase FMS.AA PDGFR 580-908 64 2.8e-270 877.74 In-house 1-358 (358) Show / Hide 
Range on Protein: 580-908
Range on HMM: 1-358/358
Sequence Identity: 64% (231 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEA
||||||||.|||||||||||.||.|..||.||||||||.|||..||||||||||||||||||.||||||||||||||...||||||||||||.|.||...
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKRHS

MLGP--------SLSPGQDSEGDSSYKNIHLEKK--------YVRRDSGFS----SQGVDTYVEMRPV---STSSS--DSFFKQDLD----KEASRPLEL
....        ..|..||....|.|||.|..|.        ....||...    ..|||.||.|...   |..|.  ||...||..    .. |..|..
FHQHHPEKPKKETWSNQQDPHNFSFYKNVHHHKENDGDYMDMSSCEDSQYVPMLMHKGVDKYVDMQRNNYMSPHSNYEDSYIEQDVKNELMEDDSNVLTY

WDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLG
||||.||.|||.||.|||||||.|||.|||||||..|.|.||.||||||||||||||||||||||||||||||||||||||.||||||||||||||||||
WDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLG

LNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQQICFLL
.|||||..|..||||..|.||.||||..||..||.|||.|||..|..||||||.|..|
GNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FMS.AA Pkinase_Tyr 580-908 39 5e-157 532.43 Pfam 1-270 (270) Show / Hide 
Range on Protein: 580-908
Range on HMM: 1-270/270
Sequence Identity: 39% (132 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADE--KEALMSELKIMSHLGQHENIVNLLGACT-HGGP--VLVITEYCCYGDLLNFLR
..|||.||.||||.|...|..|  ...  ..||||||| .|. ..  .|..|.|.|||..||.|.|||.|.|.|| .|.|  .....||...||||..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIH
..                                                                  |  .|| . |||... |.|.||..|.||||||
KHR-----------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH

RDVAARNVLLTSGHVAKIGDFGLARDIMNDSNY-VVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNP-YPGILVNNKFYKLV-KDGY
||.||||.|.|...|.||.||||||||.||..| ...|...||.||||||.|.....|..|||||.|.|.||||..|  | |||.  |. .|... .|||
RDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGY

QMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQQICFLL
.|..|  .|. ||..|..||. .| .||||..|   |
RMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FMS.AA VEGFR 580-908 49 2.3e-154 519.1 In-house 1-332 (332) Show / Hide 
Range on Protein: 580-908
Range on HMM: 1-332/332
Sequence Identity: 49% (165 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH---GGPVLVITEYCCYGDLLNFLRRK
|. || ||.||||.|.||.|||. |.     |||||||..| |.|. |||||||.. |.|.| | ||.||.||    .||..|| ||||.| |.|.|| |
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

AEA-MLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHR
... .. |..|| .    ..    .|  .|  ||||| |.|.. .    ..   | .|    .. .     || . ||. .| ||| || ||||..||||
RMYFVPYPDKSPHMRQRKECMGPQDHQDHK-RRRDSGNSFQSSFG--SFFRMKKSYDDVEPDEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHR

DVAARNVLLTSGHVAKIGDFGLARD-IMNDSNYVVKGN-ARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQM
| ||||.||..  | || ||||||. |  | .|| ||. .||| |||||||||| ||| .|||||||..||||||||  ||||. .. .|..  |||| |
DLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRM

AQPVFAPKNIYSIMQSCWDLEPTRRPTFQQICFLL
  | ...  || ||..||  ||  ||.|      |
RAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FMS.AA TyrKc 580-908 33 4.6e-137 462.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 580-908
Range on HMM: 1-280/280
Sequence Identity: 33% (121 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG-QHENIVNLLGACTHG-------GPVLVITEYCCYGDLLN
...||.|| ||||.|...|.         ..|||||||. |    .|..|.|..||..|| .|.|||.|.|.||..       .|.....||...|||..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKN
.||.. .                                                                     | . |||.|. |.|.||..|.|||
YLRKHRPK--------------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKN

CIHRDVAARNVLLTSGHVAKIGDFGLARDIMND-------SNYVVKG--NAR--LPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGI---
||||| ||||.|....|..||.||||.||| .|       . |..|.  ...  ||..|||||.|.....| .|||||.|...||||..|  ||||.   
CIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ

-LVNNKFYKLVKDGYQMAQPVF--------APKNIYSIMQSCWDLEPTRRPTFQQICFLL
 . |   ...||.|| | ||          .|. .|.||..||. .|  ||||..|. ..
MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FMS.AA TK 580-908 24 2.4e-128 432.65 In-house 1-486 (486) Show / Hide 
Range on Protein: 580-908
Range on HMM: 1-486/486
Sequence Identity: 24% (126 aa)

LQFGKTLGAGAFG---KVVEATAFGLG--------------------KEDAVLKVAVKMLKSTAHADEKEALM----------------SELKIMSH-LG
...||.||.|.||   .| .....|..                    ||... .|||||||........| ..                .|.|.|.| ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHENIVNLLGACTHG------------GPVLVITEYCCYGD----LLNFLRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVE
.|.|||.|.|.||.|            .|.....||...||    |...||.. . .  .. .|.  .... ..| .|..                    
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LHHC--------------------

MRPVSTSSSDSFFK--------------------QDLDKEASRPLELWDLLH-------------------FSSQVAQGMAFLASK------NCIHRDVA
           . |                    .|| |... || ..|||.                   .. |.|.||..|.||      |..|||.|
-----------M-KGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLA

ARNVLLTSGHV-----------AKIGDFG--------LARDIMNDSNYVVKG------------------------NARLPVKWMAPESIFDCV------
|||.|.....|           .||.|||        ||||| .|..|..|.                        ...||..|||||...| |      
ARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEK

---YTVQSDVWSYGILLWEIFSLG-LNPYPGILV--------NNKFYKLVKDG--------------YQMAQPVFAP--------------KNIYSIMQS
   .| .|||||.|.|.||||..|   .|.|.          |  .......|              ..|.||. .|              . .| .||.
YGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQ

CWDLEPTRRPTFQQICFLL
||...| .||||.|.   |
CWHYDPEDRPTFSQLHEQL
Kinase FMS.AA TK-Unique 580-908 36 9.20000000001e-110 370.96 In-house 1-294 (294) Show / Hide 
Range on Protein: 580-908
Range on HMM: 1-294/294
Sequence Identity: 36% (124 aa)

LQFGKTLGAGAFGKVVEATAFGLG-KEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGG-PVLVITEYCCYGDLLNFLRRKA
| .|...| |||| |  ....|.  ..|.  .|||||||  |.  .| ....|...|..||.|.|||..||.||  . |.. | ||| .|.|...||...
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

EAMLGP----SLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEASR--PLELWDLLHFSSQVAQGMAFLAS--
 || ..     |                                                  |. . ...  |  |. . ||.||  |.|.||..|||  
PAMRQHQTYGNLK-------------------------------------------------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQR

KNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVK-GNARLPVKWMAPESIF--DCVY-TVQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYK
|...|||..|||||||...|.||.|||.|||....  |. . .  |.|..||||||.   . .| | .|||||.|.|.||||.||  ||||.   . . .
KKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IME

LVKDGYQMAQPVFA-PKNIYSIMQSCWDLEPTRRPTFQQICFLL
...||| | ||    .. .|..|.||| .||. ||.| || . |
CIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FMS.AA Src 580-908 32 3.6e-88 299.23 In-house 1-255 (255) Show / Hide 
Range on Protein: 580-908
Range on HMM: 1-255/255
Sequence Identity: 32% (109 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEA
... . ||.| || | .      |. .   ||||| ||.     . ||.  | .||  | .||..|.|.  |. . |.. .||| . | || .|..    
IKLCRKLGQGQFGEVWM------GYWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----

MLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAA
                                                              ..  | |.| .|. .. |||.|||.| |.| |||| ||
--------------------------------------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAA

RNVLLTSGHVAKIGDFGLARDIMN--DSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPV
||||   . |.|..|||||| ..   | .|. .  |..|.||.||| |   ..|. |||||.||||.||.. |  ||||   |    . |. || | .| 
RNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPG-MTNHEVLQQVERGYRMPCPH

FAPKNIYS-IMQSCWDLEPTRRPTFQQICFLL
  |...|  ||. ||. .| .||||  ..  |
NCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FMS.AA UTK 580-908 27 2.5e-85 289.81 In-house 1-296 (296) Show / Hide 
Range on Protein: 580-908
Range on HMM: 1-296/296
Sequence Identity: 27% (98 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAH-ADEKE---ALMSELK---IMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNF
.|.|..||.|||| | .|..        ...|||| ....|   .|.|    .| | .   .|...  |.|...|.| || ..| ...|||.. |||...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNC
||| ...                                                               ..   | | ..|......| ||..|.|...
LRRHRPTPP-------------------------------------------------------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGF

IHRDVAARNVLLTSGH-------VAKIGDFG---LARDIMN--------DSNYVVK-GNARLPVKWMAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLN
.|||.||||.|... .       |.||.|||   ..|.. .        .|.|. . .. |.|..|||||.. .   .| .|||||.|...|||.. |  
VHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRL

PYPGILVNNKFYKLVKDG--YQMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQQICFLL
|||| . | .  . | .|  |.|..|   | ..| .|..||  .| .||.|...   .
PYPG-MSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase FMS.AA FGFR 725-908 46 3e-81 276.22 In-house 100-293 (293) Show / Hide 
Range on Protein: 725-908
Range on HMM: 100-293/293
Sequence Identity: 46% (90 aa)

RPVS-TSSSDSF-FKQDLDKEASRP--------LELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNAR
||     ..||  . ... . .. .        |   ||  .  |||.|| .|||. ||||| |||||| | ..| || |||||||| .   |  ..| |
RPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGR

LPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQQICFLL
||.||||||. || |||.||||||||.|||||. .|  |||.|.     ||. | |. |  |   ...|| .| .||  .|  |||| |.   |
LPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FMS.AA KIN6 752-908 43 2.4e-67 221.59 In-house 145-305 (305) Show / Hide 
Range on Protein: 752-908
Range on HMM: 145-305/305
Sequence Identity: 43% (70 aa)

DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGH---VAKIGDFGLARDIMNDSNYVVKGNAR-LPVKWMAPESIFDCVYTVQSDVWSYGILLWEIF
||. |. |...|| .|.||||||||.||||||.|.|     .||.||||.| .  |..  . .  | ||.||||||..    . . |||||.|.|..|.|
DLYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRYLPIKWMAPECLKHYEFSYKSDVWSFGVLMFEMF

SLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQQICFLL
|||  |||..          . |  ...|  .|..|| ||||||   | .|| | ..  ..
SLGDVPYPEMQRPTEMIEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase FMS.AA Ret 752-910 45 4.3e-62 210.85 In-house 136-293 (293) Show / Hide 
Range on Protein: 752-910
Range on HMM: 136-293/293
Sequence Identity: 45% (73 aa)

DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGL
... |  |. .||..|..   .||| ||||||.  | . || |||| ||.  |  || .   |.||||||.|| .| |||..|||||.|.|.|||  .| 
MIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGA

NPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQQICFLLQE
||||||   .  . | |.|| |  |      .|.||  ||  ||  || |  |   .  
NPYPGIPPER-LWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase FMS.AA Tie 753-908 50 1.7e-61 185.63 In-house 116-267 (267) Show / Hide 
Range on Protein: 753-908
Range on HMM: 116-267/267
Sequence Identity: 50% (79 aa)

LLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLN
.||| . ||.|| .|. |.|||||.||||.|     |.|| ||||.|    |  || |   ||||.||| ||.   ||| .|||||||.||||| |||  
ILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWEIVSLGGT

PYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQQICFLL
|| |.   . . || . ||.| ||     ..| .|. ||   |  ||.| ||   |
PYCGMTCAELYEKLPQ-GYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase FMS.AA Pkinase 580-908 19 7.5e-45 159.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 580-908
Range on HMM: 1-293/293
Sequence Identity: 19% (72 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKE---ALM-SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYG----DLLN
...|...|.|.||.| ...  | ||     .|||| .|   |.....   ..  ||..|| .| .|.||| |..... .. . ...|||  |    ||  
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

FLRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEASRPL--ELWDLLHFSSQVAQGMAFLAS
....                                                                   ......  . |.. ..  |...|.... |
YIST-------------------------------------------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHS

KNCIHRDVAARNVLLTSGHVA----KIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIF-DCVYTVQSDVWSYGILLWEIFSLGLNPYPGI----LVN
...||||.   |.|. .  .     ||.|||||. .    |..          .|||| |  .  |.  .|.||.|..|.| .. |  |.||       .
MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-H

NKFYKLVKDGY-QMAQPVFAP---------------------KNIYSIMQSCWDLEPTRRPTFQQICFL--L
.. ........ .   . . .                     ..  ... .|... |..|||..||.    .
DQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase FMS.AA FGFR 580-676 45 3.7e-36 120.7 In-house 1-99 (293) Show / Hide 
Range on Protein: 580-676
Range on HMM: 1-99/293
Sequence Identity: 45% (45 aa)

LQFGKTLGAGAFGKVVEATAFGLGKE--DAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRK
|  ||.|| |.||.|. |.|.|. ..  ..  .|||||||. .. ..   | ||. .|   |.|.||.||||.|| .||  || |||  | |  ||| .
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRAR
Kinase FMS.AA Tie 589-675 43 4.2e-29 85.19 In-house 2-85 (267) Show / Hide 
Range on Protein: 589-675
Range on HMM: 2-85/267
Sequence Identity: 43% (38 aa)

GAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRR
| ||.|. |.   . |.  ...||.||.|  |  |..   | || .|  .|.| ||.||.||| | | . | .||  || ||.|||.
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRK
Kinase FMS.AA S_TKc 580-907 18 2.5e-26 94.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 580-907
Range on HMM: 1-231/231
Sequence Identity: 18% (64 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCY--GDLLNFLRRKA
 ......| ||||||  ..  .        .||.|..|        | ...|..|...  .|.|||.|.... . . . ...|||    |||. ..... 
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

EAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDV
   |.                                                               .|.   .  ..  |........ |.. ||||.
RHGLR---------------------------------------------------------------FPFPE-HARFYMYQICCALEYCHSHGIIHRDL

AARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTV-QSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQP
   |.||..  . ||.|||||| .                 .|||| .    |.   .|.|| |..|.| .. |  |.|     .. .|...        
KPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG--------

VFAPKNIYSIMQSCWDLEPTRRPTFQQIC----------FL
   ..   .... |.. .|..|||  ..           ..
---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FMS.AA Ret 580-674 41 4.8e-26 85.92 In-house 1-97 (293) Show / Hide 
Range on Protein: 580-674
Range on HMM: 1-97/293
Sequence Identity: 41% (41 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKST-AHADEKEALMSELKIMSHLGQHENIVNLLGACTHGG--PVLVITEYCCYGDLLNFLR
||...||| | ||.|| |.|| .        |||||||   |   |  .| ||. .   .  | ... |.|||.  .  | ..| ||| || |  |||
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLR
Kinase FMS.AA KIN6 611-682 40 6.1e-14 42.25 In-house 47-123 (305) Show / Hide 
Range on Protein: 611-682
Range on HMM: 47-123/305
Sequence Identity: 40% (31 aa)

VAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLR-RKAEAM----LG
.||||| | |   ..  .| |   |  || |. .||.||  |   ... . |||| .||| .|| |. ..|    ||
CAVKMLPSHADEMAHHDFMHEIAFMKQLGHHPHLVNMLGCVTNSYKPCLVVEYCCHMDLLKYLRNRCQYMMNLDDLG