Gene FLT3 (Mouse)
FLT3
Sequence
Protein domains of FLT3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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IG | FLT3.AA | IG | 79-162 | 15 | 0.004891 | 17.31 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 79-162 Range on HMM: 1-58/58 Sequence Identity: 15% (14 aa) AATVEVAESGSITLQVQLATPGDLSCLWVFKHSSLGCQPHFDLQNRGIVSMAILNVTETQA---GEYLLHIQSEAANYTV--LFTVNVR |.| | ...||. . . | . | ||.. . |.| . . .|. .|. |. PP-VTVKEGETVTLTC-VS-----QIWWY---------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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IGc2 | FLT3.AA | IGc2 | 264-338 | 16 | 0.000142 | 18.72 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 264-338 Range on HMM: 1-56/56 Sequence Identity: 16% (12 aa) KVGEPLWIRCKAIHVNHGFGLTWELEDKALEEGSYFEMSTYSTNRTMIRILLAFVSSVGRNDTGYYTCSSSKHPS . |......|. |.. .| .. |. . | . . ..| |||||. . . . HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP----------------WNWTLTIKNVT-PEDSGYYTCYARNPWG |
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IG | FLT3.AA | IG | 258-346 | 14 | 0.00669 | 16.13 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 258-346 Range on HMM: 1-58/58 Sequence Identity: 14% (14 aa) LPQLFLKVGEPLWIRCKAIHVNHGFGLTWELEDKALEEGSYFEMSTYSTNRTMIRILLAFVSSVGRNDT---GYYTCSSS--KHPS-QSALVTIL | . |.||.. ..| . ..| . .| ..|. | |.| . .. | |.. .|.. PP-VTVKEGETVTLTC-VS------QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ |
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Kinase | FLT3.AA | PDGFR | 611-946 | 60 | 6.8e-272 | 883.01 | In-house | 1-358 (358) | Show / Hide |
Range on Protein: 611-946 Range on HMM: 1-358/358 Sequence Identity: 60% (218 aa) LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKREK |.|||.|||||||.|..|||||.||......|||||||..|.|.||||||||||.|.|||.|.||||||||||..||.|.|.||||||||||||..||.. LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKRHS FHR---------TWTEIFKEHNFSFYPTFQAHSN--------SSMPGSREVQ--LHPPLDQLSGFNGN---LIHSEDEIEYENQKRLAEEEEEDLNVLTF ||. ||......||||||.....|.. ||...|..|. |...|.......| .||..|..|..|....|..|.|.||||. FHQHHPEKPKKETWSNQQDPHNFSFYKNVHHHKENDGDYMDMSSCEDSQYVPMLMHKGVDKYVDMQRNNYMSPHSNYEDSYIEQDVKNELMEDDSNVLTY EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLG .|||||.||||||||||..|.||||||||||||..||||||||||||||||..||.|||.||||||||||||||.|...||..||||||||||||||||| WDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLG VNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL .|||||.|||..|||.|..|..|.|||.|.|.||..||.||.||..|||.|..|..|| GNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL |
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Kinase | FLT3.AA | Pkinase_Tyr | 611-946 | 39 | 3e-150 | 509.48 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 611-946 Range on HMM: 1-270/270 Sequence Identity: 39% (137 aa) LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCE--KEALMSELKMMTHLGHHDNIVNLLGACT-LSGP--VYLIFEYCCYGDLLNYLR ..|||.||.||||.|. .|..| .. . |.||||||||.|.. . .|..|.|.|.|..||||.|||.|.|.|| ..| .|...||...||||.||| ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR SKREKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGMEFL ..| || . || .|||....|.|||||.| KHR------------------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYL EFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSY-VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNP-YPGIPVDANFYK | | |.||||||||.|||...||||||||||||| .|. | ..||...||.||||||....|..|.||||||.|.|.||||..| | |||. .. .|. ESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYE LI-QSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL .| ..| |..| .... || .|..||..| .||.| . ..| YIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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Kinase | FLT3.AA | TyrKc | 611-946 | 32 | 5.2e-143 | 482.32 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 611-946 Range on HMM: 1-280/280 Sequence Identity: 32% (119 aa) LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLG-HHDNIVNLLGACTLS-------GPVYLIFEYCCYGDLLN ...||.||.||||.|. .|.. |||||||||| | .|..|.|...|..|| ||.|||.|.|.|| . .|.....||...|||.. ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD YLRSKREKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGM |||..|.| |. .||| |..|.|.|| YLRKHRPK---------------------------------------------------------------------------LCMKDLLSFCWQIACGM EFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSD-------SSYVVRG--NAR--LPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNP |.|. | |.||||||||.||.....|||.||||.||| .| . |.... ... ||..|||||....|..|.||||||.|...||||..| | EYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQP YPGI----PVDANFYKLIQSGFKMEQPFY--------ATEGIYFVMQSCWAFDSRKRPSFPNLTSFL |||. .. ......|. |.|| . ... .| .|..||..| .||.| .. ... YPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | FLT3.AA | TK | 611-946 | 24 | 1.9e-127 | 429.6 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 611-946 Range on HMM: 1-486/486 Sequence Identity: 24% (129 aa) LEFGKVLGSGAFG---RVMNATAYGIS--------------------KTGVSIQVAVKMLKEKADSCEKEALM----------------SELKMMTH-LG ...||.||.|.|| .|. ....|.. |.|. ..||||||||.... ..| .. .|.||| | || ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG HHDNIVNLLGACTLS------------GPVYLIFEYCCYGD----LLNYLRSKREKF--------------------HRTWTEIFKEHNFSFYPTFQAHS ||.|||.|.|.|| . .|.... ||...|| |..|||..|.|| |. HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHC--------------------- NSSMPGSREVQLHPPLDQLSGFNGN-----LIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLC-------------------FAYQVAKGMEFLEFK-- . . ..|... .|.|. . .. ..... ||. |||. ...|.|.|||.|. | ---------------------M--KGDITYSHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNC ----SCVHRDLAARNVLVTHGKV-----------VKICDFG--------LARDILSDSSYVVRG------------------------NARLPVKWMAPE .|||||||||.||....| .||.||| ||||| ||. |.... ...||..||||| EFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPE SLFEGI---------YTIKSDVWSYGILLWEIFSLG-VNPYPGIPV--------DANFYKLIQSG--------------FKMEQPFYAT----------- .|.... .|.||||||.|.|.||||..| . .|.|.. .. .......| . |.|| ... CLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPH ---EGIYFVMQSCWAFDSRKRPSFPNLTSFL | .| .||.||..| ..||.| | ..| CPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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Kinase | FLT3.AA | TK-Unique | 611-946 | 36 | 1.5e-107 | 363.61 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 611-946 Range on HMM: 1-294/294 Sequence Identity: 36% (127 aa) LEFGKVLGSGAFGRVMNATAYGIS-KTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSG-PVYLIFEYCCYGDLLNYLRSKR ||.|.|.|.|||| | ... ||. . . ..|||||||..|. .| ....|..|| .|| | |||..||.|| |. |...|.||| .|.|..|||..| LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR -EKFHR-TWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNV-LTFEDLLCFAYQVAKGMEFL ... | . .. ....... .. .||. ||.|.|.|||.| PAMRQHQTYGNLK-----------------------------------------------------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYL EF--KSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVR-GNARLPVKWMAPESLF--EGIY-TIKSDVWSYGILLWEIFSLGVNPYPGIPVDA . | .|||||.|||||.|..||.||||||.|||. . |. . |.|..||||||| .|.| |.||||||.|.|.||||.|| ||||.| . ASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD NFYKLIQSGFKMEQPFYA-TEGIYFVMQSCWAFDSRKRPSFPNLTSFL . ..|. |. |.|| . .. .| .|.||| . .|||| ... | -IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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Kinase | FLT3.AA | VEGFR | 777-946 | 52 | 2.1e-94 | 319.97 | In-house | 159-332 (332) | Show / Hide |
Range on Protein: 777-946 Range on HMM: 159-332/332 Sequence Identity: 52% (92 aa) EEEEEDLN--VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARD-ILSDSSYVVRGN-ARLPVKWMAPESLFEGIYTIKS .|. ||. || |||.|...|||.|||||. . |.||||||||.|.. .|||||||||||. | .| || .|. .||| |||||||.|. .||..| DEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYS DVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL ||||||..|||||||| ||||. .| |.. . .| |. | |.| .|| .|..|| . ||.| | | DVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL |
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Kinase | FLT3.AA | UTK | 611-946 | 27 | 8.7e-85 | 287.99 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 611-946 Range on HMM: 1-296/296 Sequence Identity: 27% (101 aa) LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEA----LMSELK---MMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNY ...|. ||.|||| | .|.. .| . .|||| ....||. ... .| | . || .. .| |...|.| || ..| ... ||.. |||..| VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY LRSKREKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGME ||. |... .. || ...||.|...| ||. LRRHRPTPP--------------------------------------------------------------------ACPHWLTLHQRLCMAWDIARGMQ FLEFKSCVHRDLAARNVLVTHG-------KVVKICDFG---LARDIL-------SDSSYVVRGNA--RLPVKWMAPESLFEG-IYTIKSDVWSYGILLWE .|. . .|||||||||.||.. |.||.||| ..|.. ...|| .. . |.|..|||||.| .. .|.||||||.|...|| YLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWE IFSLGVNPYPGIPVDANFYKLIQSG-FKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL |.. | ||||. .. . . | |..| . .| .|..||. | ..||.|. |.... IWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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Kinase | FLT3.AA | Src | 611-946 | 30 | 1.5e-84 | 287.15 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 611-946 Range on HMM: 1-255/255 Sequence Identity: 30% (104 aa) LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKREK . . . ||.| || | .. | ...|||| ||.. . ||. | . |. | |...|.|. |. |.| . || . | || ||. IKLCRKLGQGQFGEVWMGYWNG------NTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK---- FHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSC ... | ...|. .| |||.||..|| . ---------------------------------------------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNY VHRDLAARNVLVTHGKVVKICDFGLARDILS--DSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSG .||||||||||| .. |.|..|||||| .. | |. | |..|.||.||| . .| .||||||||.||||.||.. | |||| . . .. | IHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGM-TNHEVLQQVERG FKMEQPFYATEGIYF-VMQSCWAFDSRKRPSFPNLTSFL ..| .| . .| .|. || | ..|| | | .|| YRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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Kinase | FLT3.AA | FGFR | 763-946 | 50 | 2.6e-84 | 286.41 | In-house | 107-293 (293) | Show / Hide |
Range on Protein: 763-946 Range on HMM: 107-293/293 Sequence Identity: 50% (94 aa) SEDEIEYENQKRLAEEEE---EDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMA ..| || ..| . |.. | . ||. || .|||||.|||.|. . |.|||||||||||| . | ||||||||||| . | ..| |||.|||| KKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMA PESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL ||.||. .|| .|||||||.|||||. .| |||.|| ||. ..| || | .. || .| .|| | . ||.| | | PEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL |
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Kinase | FLT3.AA | Ret | 785-948 | 47 | 1.4e-66 | 226.4 | In-house | 126-293 (293) | Show / Hide |
Range on Protein: 785-948 Range on HMM: 126-293/293 Sequence Identity: 47% (80 aa) VLT-----FEDLLCFAYQVAKGMEFL-EFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYG |.. . ... || |. ||| .| | | |||||||||||| |.. || |||| ||. | ||| | |.||||||.|||. .|| ||||||.| VINRFDIGMKMIISFAWQICKGMHYLSEMK-LVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFG ILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFLGC .|.||| .| ||||||| . . . | |. |. | | .| .| ||. |||.| . . . VLCWEIVTMGANPYPGIPPE-RLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK |
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Kinase | FLT3.AA | KIN6 | 785-946 | 43 | 2e-66 | 218.48 | In-house | 140-305 (305) | Show / Hide |
Range on Protein: 785-946 Range on HMM: 140-305/305 Sequence Identity: 43% (72 aa) VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK---VVKICDFGLARDILSDSSYVVRGNAR-LPVKWMAPESLFEGIYTIKSDVWSYGIL .... ||. ||.|.. |||.| | |.|||||||||||| | || ||||.| .. |.. . . | ||.||||||.| . .||||||.|.| CIRHKDLYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRYLPIKWMAPECLKHYEFSYKSDVWSFGVL LWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL ..|.|||| |||... . || ...| ...| || .|||||. .. || | . . MFEMFSLGDVPYPEMQRPTEMIEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF |
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Kinase | FLT3.AA | Tie | 786-946 | 48 | 7.5e-60 | 180.55 | In-house | 111-267 (267) | Show / Hide |
Range on Protein: 786-946 Range on HMM: 111-267/267 Sequence Identity: 48% (78 aa) LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF |. . .| || ||.||..| | |.||||||||.|| | || ||||.| .| || . ||||.||| ||| .|| ||||||||.||||| LSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWEIV SLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL ||| || |. |..|. . |..|||| . .| .|. || .||.| . | SLGGTPYCGMTC-AELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL |
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Kinase | FLT3.AA | VEGFR | 611-711 | 57 | 5.2e-52 | 179.12 | In-house | 1-104 (332) | Show / Hide |
Range on Protein: 611-711 Range on HMM: 1-104/332 Sequence Identity: 57% (60 aa) LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTL---SGPVYLIFEYCCYGDLLNYLRSK | ||.|| |||| |. |.| || |. . |||||||| |.. |. ||||||||..|.||| | ||.||.|| ||. | ||||.| |.||||.| LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK REKF |. | RMYF |
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Kinase | FLT3.AA | Pkinase | 611-946 | 19 | 2.7e-41 | 147.08 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 611-946 Range on HMM: 1-293/293 Sequence Identity: 19% (74 aa) LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKE--ALM-SELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYG----DLLNY ...|...|||.||.| | . | ...|||| .| . ....|. .. ||...| .| .|.||| |..... .. .|...||| | || | YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY LRSKREKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVL--TFEDLLCFAYQVAKG .. .. ... . ... ...||...| IST--------------------------------------------------------------------------WRHGCFYFSEWECKFYMYQILRG MEFLEFKSCVHRDLAARNVLVTHGKVV----KICDFGLAR---DILSDSSYVVRGNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYP .|.. ....|||| |.|. . .. ||||||||. . ... | . .|||| . |. |.|.||.|..|.| .. | |.| LEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW----YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFP GI------PVDANFYKLIQSGFKMEQPFYAT-------------------EGIYFVMQSCWAFDSRKRPSFPNLTSF--L | .. ... . .. . | . | .. .|...| |||... . . GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | FLT3.AA | FGFR | 611-708 | 48 | 2.9e-34 | 114.17 | In-house | 1-100 (293) | Show / Hide |
Range on Protein: 611-708 Range on HMM: 1-100/293 Sequence Identity: 48% (48 aa) LEFGKVLGSGAFGRVMNATAYGISKT--GVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKR | ||.|| |.||.| |.| || . | |||||||. . . | ||. || | | ||.||||.|| || | | ||| | | .||..| LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR |
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Kinase | FLT3.AA | Tie | 620-708 | 46 | 8.6e-32 | 93.52 | In-house | 2-87 (267) | Show / Hide |
Range on Protein: 620-708 Range on HMM: 2-87/267 Sequence Identity: 46% (41 aa) GAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKR | || || |. | | | ..||.||.|| | .. | || .| .||| ||.||.||| | .|. || || ||..||. | GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSR |
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Kinase | FLT3.AA | Ret | 611-708 | 40 | 9.6e-27 | 88.34 | In-house | 1-100 (293) | Show / Hide |
Range on Protein: 611-708 Range on HMM: 1-100/293 Sequence Identity: 40% (41 aa) LEFGKVLGSGAFGRVMNATAYGIS-KTGVSIQVAVKMLKEK-ADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSG--PVYLIFEYCCYGDLLNYLRS | ....|| | ||.|. |.| | ..| |||||||. | | | .| ||. . . | ... |.|||. .. | || ||| || | .|| LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTT-VAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRL KR | SR |
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Kinase | FLT3.AA | S_TKc | 611-946 | 19 | 1.5e-25 | 92.09 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 611-946 Range on HMM: 1-231/231 Sequence Identity: 19% (69 aa) LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCY--GDLLNYLRSKR |.....|.||||.|. .. . .||.|..| | ...|.... . ||.|||.|.... . .|...||| |||. |..... YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG EKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFK . | ... . ...||.....|.. . RHGLR----------------------------------------------------------------------FPFPE-HARFYMYQICCALEYCHSH SCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTI-KSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQS .|||| |.|... ..||||||||| . .|||| | |. |.|.|| |..|.| .. | |.| .. .|.| GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG- GFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTS---------FL .. .. |. .| .|||. . .. ----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | FLT3.AA | KIN6 | 641-709 | 46 | 1.1e-19 | 61.56 | In-house | 46-114 (305) | Show / Hide |
Range on Protein: 641-709 Range on HMM: 46-114/305 Sequence Identity: 46% (32 aa) QVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKRE |.||||| . || .. .| | | ||||. .||.|| | | ...|. |||| .||| ||| ... QCAVKMLPSHADEMAHHDFMHEIAFMKQLGHHPHLVNMLGCVTNSYKPCLVVEYCCHMDLLKYLRNRCQ |