Gene FLT1 (Mouse)

FLT1

Species: Mouse
Alias: Flt1, FLT1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: VEGFR

Sequence

Name Sequence Type Origin Length Description Download
FLT1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 327 Kinase domain by global Sugen HMM Fasta, JSON
FLT1.AA Protein Sugen 1333 None Fasta, JSON
FLT1.NA RNA Sugen 6280 None Fasta, JSON

Protein domain

Protein domains of FLT1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG FLT1.AA IG 38-130 13 5e-06 27.38 SMART 1-58 (58) Show / Hide 
Range on Protein: 38-130
Range on HMM: 1-58/58
Sequence Identity: 13% (13 aa)

GTQHVMQAGQTLFLKCRGEAAHSWSLPTTVSQEDKRLSITPPSACGRDNRQFCSTLTLDTAQANHT---GLYTCRYLPTSTSKKKKAES--SIYIFVS
   .. ..|.|. |.|  .   .|.                              ||.  .|....   | |.|.        .....|  .... |.
PP-VTVKEGETVTLTC-VS-QIWWY------------------------------LTI-NVQPEDSQQHGTYYCQAT------HGQYWSIQGTTLTVQ
IGc2 FLT1.AA IGc2 44-115 17 0.006495 2.84 SMART 1-56 (56) Show / Hide 
Range on Protein: 44-115
Range on HMM: 1-56/56
Sequence Identity: 17% (13 aa)

QAGQTLFLKCR----GEAAHSWSLPTTVSQEDKRLSITPPSACGRDNRQFCSTLTLDTAQANHTGLYTCRYLPTST
. ||.. |.|.     ..  .|         ...|.               .|||.  .. .. |.|||.      
HEGQSVTLTCPATGNPDPNIHWYK-------GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FLT1.AA IG 144-225 17 3.9e-05 24.31 SMART 1-58 (58) Show / Hide 
Range on Protein: 144-225
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

PKLVHMTEGRQLIIPCRVTSPNVTVTLKKFPFDTLTPDGQRITWDSRRGFIIANATYKEI---GLLNCEATVNGHLYQ--TNYLTHR
|. |   ||  . ..| |.    .....                     ..| |...      |   |.|| .|  ..  . .|| .
PP-VTVKEGETVTLTC-VS----QIWWY---------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
IGc2 FLT1.AA IGc2 150-215 17 0.00328 5.68 SMART 1-56 (56) Show / Hide 
Range on Protein: 150-215
Range on HMM: 1-56/56
Sequence Identity: 17% (12 aa)

TEGRQLIIPCR-VTSPNVTVTLKKFPFDTLTPDGQRITWDSRRGFIIANATYKEIGLLNCEATVNGH
 ||......|.   .|. ... .|     |          ..    | |.|.   |.  |.|. . .
HEGQSVTLTCPATGNPDPNIHWYK--GQPLP---------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FLT1.AA IG 238-330 18 5.8e-13 50.31 SMART 1-58 (58) Show / Hide 
Range on Protein: 238-330
Range on HMM: 1-58/58
Sequence Identity: 18% (18 aa)

PSPVRLLHGQTLVLNCTATTELNTRVQMSWNYPGKATKRASIRQRIDRSHSHNNVFHSVLKINNVESRDK---GLYTCRVKSGSSFQSF--NTSVHVY
|. |    |.|..|.| ..       |..|                             | | ||.  |    | |.|...  .  ..   .| ..|.
PP-VTVKEGETVTLTC-VS-------QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set FLT1.AA V-set 232-331 15 1.8e-09 34.48 Pfam 1-128 (128) Show / Hide 
Range on Protein: 232-331
Range on HMM: 1-128/128
Sequence Identity: 15% (20 aa)

DVQIRP--PS----PVRLLHGQTLVLNCTAT--TELNTRV-QMSWNY--PGKATKRASIRQRIDRSHS----------HNNVF--------HSVLKINNV
..|. .  |.    .|.   ||.. |.|. .  .. .... ...| .  |   . .  |.. .  ...           ..|.        .  |.|.|.
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

ESRDKGLYTCRVKSGSSFQSFNTSVHVYE
.. | | |.| |... ....| .....  
QPSDSGTYYCAVWNC-NEDYFGHGTRLTV
IGc2 FLT1.AA IGc2 244-319 21 1.1e-05 26.1 SMART 1-56 (56) Show / Hide 
Range on Protein: 244-319
Range on HMM: 1-56/56
Sequence Identity: 21% (16 aa)

LHGQTLVLNCTATTELNTRVQMSWNYPGKATKRASIRQRIDRSHSHNNVFHSVLKINNVESRDKGLYTCRVKSGSS
. ||...|.|    . |   . .| . |.                      . |.| ||.  | |.|||.. .  .
HEGQSVTLTCP--ATGNPDPNIHWYK-GQPLP-----------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IGv FLT1.AA IGv 248-314 20 0.003676 2.61 SMART 1-76 (76) Show / Hide 
Range on Protein: 248-314
Range on HMM: 1-76/76
Sequence Identity: 20% (17 aa)

TLVLNCTATTELNTRVQMSWNYP-------GKATK---RASIRQRIDRSH------SHNNVFHSVLKINNVESRDKGLYTCRV
.. | |....  .   .|.| .        ||. .   . |.. |.  |       | | ..   |...|... | | |.| .
SVTLSCKFSGFTF---YMHWYRQPPDSTPKGKGLEWMGY-SYKGRFTWSKDNITRWSKNQFY---LTMSNLRPEDTGTYYCAR
I-set FLT1.AA I-set 294-329 27 0.004095 13.08 Pfam 57-92 (92) Show / Hide 
Range on Protein: 294-329
Range on HMM: 57-92/92
Sequence Identity: 27% (10 aa)

HSVLKINNVESRDKGLYTCRVKSGSSFQSFNTSVHV
.. | | ||...| | |||...  .  ..   .. |
TYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
I-set FLT1.AA I-set 231-256 23 18.449531 0.68 Pfam 1-25 (92) Show / Hide 
Range on Protein: 231-256
Range on HMM: 1-25/92
Sequence Identity: 23% (6 aa)

LDVQIRPPSPVRLLHGQTLVLNCTAT
  ....| ..|    |.|. ..|..|
PKFTQKP-KDVEVQEGETARFECQVT
I-set FLT1.AA I-set 355-406 32 2.4e-07 27.44 Pfam 19-75 (92) Show / Hide 
Range on Protein: 355-406
Range on HMM: 19-75/92
Sequence Identity: 32% (19 aa)

RLSMKVKAFPSPEIVWLKDGSPATLKS----ARYLVHG---YSLIIKDVTTEDAGDYTI
|.. .|.  | |...|.|||.|  |..     ..   |   |.|.|..|. .|.| ||.
RFECQVTGDPPPQVSWFKDGQP--LRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTC
IG FLT1.AA IG 345-426 13 6.3e-05 23.61 SMART 1-58 (58) Show / Hide 
Range on Protein: 345-426
Range on HMM: 1-58/58
Sequence Identity: 13% (12 aa)

QETTAGRRSYRLSMKVKAFPSPEIVWLKDGSPATLKSARYLVHGYSLIIKDVTTEDA---GDYTILLGIKQSRLFKN-LTATLIVN
.. . ...  .....  .    .| |.                   |.| .|. ||.   |.|.       .   .   ..||.| 
PP-VTVKEGETVTLTC-VS---QIWWY-------------------LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ
V-set FLT1.AA V-set 389-425 21 7.881654 1.24 Pfam 93-128 (128) Show / Hide 
Range on Protein: 389-425
Range on HMM: 93-128/128
Sequence Identity: 21% (8 aa)

YSLIIKDVTTEDAGDYTILLGIKQSRLFKNLTATLIV
.|| |.... .| | |.       . .      .|.|
FSLTISNLQPSDSGTYYCAVWNC-NEDYFGHGTRLTV
IG FLT1.AA IG 440-554 13 6.6e-05 23.54 SMART 1-58 (58) Show / Hide 
Range on Protein: 440-554
Range on HMM: 1-58/58
Sequence Identity: 13% (16 aa)

PSPPLYPLGSRQVLTCTVYGIPRPTITWLWHPCHHNHSKERYDFCTENEESFILDPSSNLGNRIESISQRMTVIEGTNKTVSTLVVADSQTP-----GIY
|.  .  .|.. .||| |      .|.|.                                                      |.. . |       |.|
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------------------------------------LTI-NVQPEDSQQHGTY

SCRAFNKIGTVER--NIKFYVT
 |.|    |...   ... .|.
YCQAT--HGQYWSIQGTTLTVQ
I-set FLT1.AA I-set 448-468 33 0.057352 9.19 Pfam 15-35 (92) Show / Hide 
Range on Protein: 448-468
Range on HMM: 15-35/92
Sequence Identity: 33% (7 aa)

GSRQVLTCTVYGIPRPTITWL
|..  ..|.| | | |...|.
GETARFECQVTGDPPPQVSWF
I-set FLT1.AA I-set 532-553 36 0.591908 5.75 Pfam 71-92 (92) Show / Hide 
Range on Protein: 532-553
Range on HMM: 71-92/92
Sequence Identity: 36% (8 aa)

GIYSCRAFNKIGTVERNIKFYV
|.|.|.| |. |..|  ..  |
GKYTCVATNSFGEAECTAELTV
IG FLT1.AA IG 563-657 22 2.8e-11 44.7 SMART 1-58 (58) Show / Hide 
Range on Protein: 563-657
Range on HMM: 1-58/58
Sequence Identity: 22% (22 aa)

SLEKMPAEGEDLKLSCVVNKFLYRDITWILLRTVNNRTMHHSISKQKMATTQDYSITLNLVIKNVSLEDS---GTYACRARNIYTGEDILR--KTEVLVR
.      |||...|.| |.      |.|                               |.| ||..|||   ||| |.|.    . ..     |.. |.
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ
IGc2 FLT1.AA IGc2 569-644 26 9.1e-11 43.02 SMART 1-56 (56) Show / Hide 
Range on Protein: 569-644
Range on HMM: 1-56/56
Sequence Identity: 26% (20 aa)

AEGEDLKLSCVVNKFLYRDITWILLRTVNNRTMHHSISKQKMATTQDYSITLNLVIKNVSLEDSGTYACRARNIYT
 ||... | | .. .   .|.|.   .  .                       | ||||..||||.|.|.|||   
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set FLT1.AA I-set 622-647 46 0.000129 18.17 Pfam 60-84 (92) Show / Hide 
Range on Protein: 622-647
Range on HMM: 60-84/92
Sequence Identity: 46% (12 aa)

LVIKNVSLEDSGTYACRARNIYTGED
| |.||  .|.|.| |.|.|   ||.
LTISNVQPDDEGKYTCVATNS-FGEA
IGv FLT1.AA IGv 573-639 20 0.001356 6.95 SMART 1-76 (76) Show / Hide 
Range on Protein: 573-639
Range on HMM: 1-76/76
Sequence Identity: 20% (16 aa)

DLKLSCVVNKFLYRDITWILLR------TVNNRTMHHSISKQKMATTQD-----YSITLNLVIKNVSLEDSGTYACRA
...||| .  | .  ..|.  .       .    |.   .| .   . |      . .  |...|.  ||.||| |  
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY-SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
V-set FLT1.AA V-set 619-656 31 0.028913 9.64 Pfam 92-128 (128) Show / Hide 
Range on Protein: 619-656
Range on HMM: 92-128/128
Sequence Identity: 31% (12 aa)

TLNLVIKNVSLEDSGTYACRARNIYTGEDILRKTEVLV
...| |.|....||||| | . |          |.. |
DFSLTISNLQPSDSGTYYCAVWNC-NEDYFGHGTRLTV
I-set FLT1.AA I-set 662-749 34 9.4e-24 83.11 Pfam 1-92 (92) Show / Hide 
Range on Protein: 662-749
Range on HMM: 1-92/92
Sequence Identity: 34% (32 aa)

PHLLQNLSDYEVSISGSTTLDCQARGVPAPQITWFKNNHKIQQ-EPGIILGPGN---STLFIERVTEEDEGVYRCRATNQKGAVESAAYLTV
|. .| ..| ||..  . ...||..| | ||..|||.. .... .  .     .   .||.|..|. .|||.|.|.|||  | .|. | |||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 FLT1.AA IGc2 674-739 37 3.2e-21 77.76 SMART 1-56 (56) Show / Hide 
Range on Protein: 674-739
Range on HMM: 1-56/56
Sequence Identity: 37% (25 aa)

SISGSTTLDCQARGVPAPQITWFKNNHKIQQEPGIILGPGNSTLFIERVTEEDEGVYRCRATNQKG
 . .| || | |.| |.|.|.|.| . ...         .|.|| |..||.||.|.|.|.|.| .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP---------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FLT1.AA IG 668-750 26 2e-16 61.81 SMART 1-58 (58) Show / Hide 
Range on Protein: 668-750
Range on HMM: 1-58/58
Sequence Identity: 26% (23 aa)

LSDYEVSISGSTTLDCQARGVPAPQITWFKNNHKIQQEPGIILGPGNSTLFIERVTEEDE---GVYRCRATNQKGAVES--AAYLTVQ
 . ..|.  .. || | .      ||.|.                    | | .|..||.   |.|.|.||  .| ..|   ..||||
PP-VTVKEGETVTLTC-VS-----QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set FLT1.AA V-set 696-749 23 0.003109 12.98 Pfam 78-128 (128) Show / Hide 
Range on Protein: 696-749
Range on HMM: 78-128/128
Sequence Identity: 23% (13 aa)

FKNNHKIQQEPGIILGPGNSTLFIERVTEEDEGVYRCRATNQ-KGAVESAAYLTV
||..  ... |.     .. .| |  ....|.|.| | ..|  ..  ..   |||
FKGRVTFSGNPS----KNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
Kinase FLT1.AA VEGFR 828-1154 71 1.2e-271 908.68 In-house 1-332 (332) Show / Hide 
Range on Protein: 828-1154
Range on HMM: 1-332/332
Sequence Identity: 71% (239 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTK--QGGPLMVIVEYCKYGNLSNYLKSK
|||||.|||||||.|..||||||.|..||.|||||||||||||||..|||.|||.|.||||||||||.||.|||  |.||||||||||..|||||||..|
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RDLFCLNKDAALHMELKKESLEPGLEQGQKPRLDSVSSS-SVTSSSFPEDRSVSDVEGDEDYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIHRDLA
|..|....|...||...||...|...|..|.|.||..|. |...|.|....|..|||.||......|.||||||||.||||||||||||.||||||||||
RMYFVPYPDKSPHMRQRKECMGPQDHQDHKRRRDSGNSFQSSFGSFFRMKKSYDDVEPDEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLA

ARNILLSENNVVKICDFGLARD-IYKNPDYVRRGD-TRLPLKWMAPESIFDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTP
||||||.||||||||||||||. |||.|||||.|| .|||.|||||||||||||.|.||||||||.||||||||||||||||.||.||.|||.|.|||.|
ARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAP

EYATPEIYQIMLDCWHKDPKERPRFAELVEKL
.|.|||||.||||||||.|.|||.|.||||.|
DYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FLT1.AA Pkinase_Tyr 828-1154 41 1.1e-157 534.68 Pfam 1-270 (270) Show / Hide 
Range on Protein: 828-1154
Range on HMM: 1-270/270
Sequence Identity: 41% (139 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASE--YKALMTELKILTHIGHHLNVVNLLGACTKQGGP--LMVIVEYCKYGNLSNYLK
...|| ||.||||.|... ..| ... |. .||||||||||. ..   ...| |.||....||| |.|.|.|.||.||.|  .....||...|.| .||.
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SKRDLFCLNKDAALHMELKKESLEPGLEQGQKPRLDSVSSSSVTSSSFPEDRSVSDVEGDEDYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIHRDL
..|                                                               .||||||.||.....|.|.|||.|.|..||||||
KHR--------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL

AARNILLSENNVVKICDFGLARDIYKNPDY-VRRGDTRLPLKWMAPESIFDKVYSTKSDVWSYGVLLWEIFSLGGSP-YPGVQMDEDFCSRL-KEGMRMR
||||.|..|||||||||||||||||.   | . ||...|| ||||||.|......|||||||.|||.||||..|..| |||.  .|... .. ..| || 
AARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMP

TPEYATPEIYQIMLDCWHKDPKERPRFAELVEKL
 ||....|||..|..|||.||..||.|.|..|.|
CPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FLT1.AA TyrKc 828-1154 35 3.1e-146 493.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 828-1154
Range on HMM: 1-280/280
Sequence Identity: 35% (126 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIG-HHLNVVNLLGACTKQG------GPLMVIVEYCKYGNLSN
..||| ||.||||.|... .         ..||||||||.|     ...| |..|....| || |.|.|.|.||.||      .|||...||...|.| .
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLKSKRDLFCLNKDAALHMELKKESLEPGLEQGQKPRLDSVSSSSVTSSSFPEDRSVSDVEGDEDYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIH
||...|.                                                                  |.|.||.|...|.|.|||.|.|..|||
YLRKHRPK-----------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIH

RDLAARNILLSENNVVKICDFGLARDIYKN-------PDYVRRG--DTR--LPLKWMAPESIFDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGV----QM
|||||||.|..||..|||.||||.||||           |. ..  ...  ||..|||||.|......|||||||.||..||||..|..||||.      
RDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMS

DEDFCSRLKEGMRMRTPEY--------ATPEIYQIMLDCWHKDPKERPRFAELVEKL
...   ..|.|.||. |..        ...|.||||..||| ||..||.|.|..|..
NQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FLT1.AA TK 828-1154 26 1.8e-131 443.03 In-house 1-486 (486) Show / Hide 
Range on Protein: 828-1154
Range on HMM: 1-486/486
Sequence Identity: 26% (133 aa)

LKLGKSLGRGAFG---KVVQASAFGIK--------------------KSPTCRTVAVKMLKEG--ATASEYKA--------------LMTELKILTH-IG
..||| ||.|.||   .| .. ..|..                    |. .. .|||||||||  ... | ..              .. |.|.. | .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHLNVVNLLGACTKQG-----------GPLMVIVEYCKYGN----LSNYLKSKRDLFCLNKDAALHMELKKESLEPGLEQGQKPRLDSVSSSSVTSSSFP
|| |.|.|.|.||...           .|.|...||...|.    | .||...|. |  . |   ... |... . ..          ..        . 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LH----------HC--------M-

E-----------DRSVSDVEGDEDYSEISKQPLTMEDLIS-------------------YSFQVARGMEFLSSRKC------IHRDLAARNILLSENNV-
.           .. ... . |.| .. . .|||. ||..                   ...|.|.|||.|.|..|      .||||||||.|..|||| 
KGDITYSHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVC

----------VKICDFG--------LARDIYKNPDYVRRG------------------------DTRLPLKWMAPESIFDKV---------YSTKSDVWS
          .||.|||        ||||||.. ||.|..                        ...||..|||||...|.|         ..|||||||
KWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWS

YGVLLWEIFSLG-GSPYPGVQM--------DEDFCSRLKEG--------------MRMRTPEYAT--------------PEIYQIMLDCWHKDPKERPRF
.|||.||||..| . .|.|.          ..... .|..|              |||  |....              .|.|..|..|||.||..||.|
FGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTF

AELVEKL
..|.|.|
SQLHEQL
Kinase FLT1.AA TK-Unique 828-1154 35 8.60000000001e-116 390.98 In-house 1-294 (294) Show / Hide 
Range on Protein: 828-1154
Range on HMM: 1-294/294
Sequence Identity: 35% (121 aa)

LKLGKSLGRGAFGKVVQASAFGIK-KSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKR
|..|...|.|||| |  . ..||. ..   . |||||||..||  . .... |.... ..| | |.|..||.||| ..| | | ||| .||| .||...|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

DL-FCLNKDAALHMELKKESLEPGLEQGQKPRLDSVSSSSVTSSSFPEDRSVSDVEGDEDYS------EISKQPLTMEDLISYSFQVARGMEFLSS--RK
.  .  .. . |                                                ..      . .. |....||... .|.|.|||.|.|  .|
PAMRQHQTYGNLK-----------------------------------------------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKK

CIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRR-GDTRLPLKWMAPESIF--DKVY-STKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRL
..||||.|||.||.|..|.||||||.|||.|.| .|..  .  |.|..||||||.   ...| .|||||||.|||.||||.||. ||||.  .. .  ..
IVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECI

KEGMRMRTPEYA-TPEIYQIMLDCWHKDPKERPRFAELVEKL
..|.||  ||.  ..|.|..|  ||...|.||| |.... .|
RDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FLT1.AA PDGFR 992-1154 61 4.6e-107 344.83 In-house 196-358 (358) Show / Hide 
Range on Protein: 992-1154
Range on HMM: 196-358/358
Sequence Identity: 61% (101 aa)

QPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKSDVWSYGVLLWE
..|| .||...|.|||.||||| |  |.||||||||.|| .  ||||||||||||| .   || .| .|||.|||||||||| || |.|||||||.||||
NVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWE

IFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKL
||||||.||||. .|. |    ||| ||  |..|. |||.||  ||  ||. || | .|.. |
IFSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FLT1.AA FGFR 989-1154 54 1.8e-95 323.45 In-house 120-293 (293) Show / Hide 
Range on Protein: 989-1154
Range on HMM: 120-293/293
Sequence Identity: 54% (95 aa)

ISKQP--------LTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKS
.. |.        ||  ||.|  .|||||||.| |||||||||||||.| ....| ||||||||||| ..  |  ... ||| ||||||. ||.|| ..|
KPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQS

DVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKL
||||||||||||. .||.|||..   |.  . |||| ||  |.  . ||| .| .|||  |..|| |..||| |
DVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FLT1.AA UTK 828-1154 27 4e-88 299.08 In-house 1-296 (296) Show / Hide 
Range on Protein: 828-1154
Range on HMM: 1-296/296
Sequence Identity: 27% (99 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKA----LMTELK---ILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSN
..||. ||.|||| |  |..  ..   .   |||| ....|.|   ..    .| | .   .. .  .| ||..|.| ||.... .|...||.. |.|..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

YLKSKRD-LFCLNKDAALHMELKKESLEPGLEQGQKPRLDSVSSSSVTSSSFPEDRSVSDVEGDEDYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCI
|| . |. ..                                                           .    ||........ ..||||..|.|....
YLRRHRPTPP-----------------------------------------------------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFV

HRDLAARNILLSEN-------NVVKICDFG---LARDIY---------KNPDYVRRGDTRLPLKWMAPESIFDK-VYSTKSDVWSYGVLLWEIFSLGGSP
||||||||.|. ..       .|.||.|||   ..|...           . | .....|.|..|||||.. .   ..|||||||.||..|||.. |  |
HRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLP

YPGVQMDEDFCSRLKEG-MRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKL
|||   .. . . .. |  ||. |.    ..|..|..|||.|| |||.| .||...
YPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase FLT1.AA Src 828-1154 33 4.5e-84 285.53 In-house 1-255 (255) Show / Hide 
Range on Protein: 828-1154
Range on HMM: 1-255/255
Sequence Identity: 33% (110 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRD
.|| . ||.| || | ..   |  |      |||| ||.|    . .|.  | .|..    | ..|.|.  |..   |   . || . |.|  |||    
IKLCRKLGQGQFGEVWMGYWNGNTK------VAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEE-PIYIVTEYMSHGSLLDYLKK---

LFCLNKDAALHMELKKESLEPGLEQGQKPRLDSVSSSSVTSSSFPEDRSVSDVEGDEDYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAARN
                                                            .   . | ...||. . |||.||..|.|.. |||||||||
------------------------------------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARN

ILLSENNVVKICDFGLARDIYK--NPDYVRRGDTRLPLKWMAPESIFDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYA
.| .||||.|..|||||| . |     |. | . ..| ||.||| |   ....||||||.|.||.||.. |  |||| .  | .  ... | ||  |.  
VLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVL-QQVERGYRMPCPHNC

TPEIYQ-IMLDCWHKDPKERPRFAELVEKL
 .|.|. ||| ||||||..|| |. | ..|
PDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FLT1.AA Ret 991-1156 46 4.2e-71 242.1 In-house 124-293 (293) Show / Hide 
Range on Protein: 991-1156
Range on HMM: 124-293/293
Sequence Identity: 46% (79 aa)

KQPLT-----MEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKSDVWSY
| ...     | ..||.  |. .|| .||. | .||||||||.|. |  . || |||| ||.|    ||.|   |.| ||||.|| .| || |||||||.
KDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSF

GVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKLGD
|||.|||  .|..||||.   |  .. || | ||  ||    |.| ||. ||   |  || |. .   .  
GVLCWEIVTMGANPYPGIPP-ERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase FLT1.AA RTKB 992-1154 44 1.8e-66 223.13 In-house 104-264 (264) Show / Hide 
Range on Protein: 992-1154
Range on HMM: 104-264/264
Sequence Identity: 44% (73 aa)

QPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKS-DVWSYGVLLW
|.|  . |.... |.|.|| ||.... |||||.|||.|.. .   ||||||.|| |    . .. . |||| |||||||. .. |.||| ||||.||  |
QSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDH--ECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTMW

EIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKL
||||||| ||.  .   |  . |  |.|. .|. . .... || .||  .. .|| |.|||. .
EIFSLGGTPYQQYRN-GDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase FLT1.AA Tie 994-1154 50 8.7e-64 192.76 In-house 111-267 (267) Show / Hide 
Range on Protein: 994-1154
Range on HMM: 111-267/267
Sequence Identity: 50% (82 aa)

LTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKSDVWSYGVLLWEIF
|. . .. .   |||||..|| ..||||||||||||  || | || ||||.|    .  ||..   ||| .||| ||.   || ||||||||||||||| 
LSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRG---DEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWEIV

SLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKL
|||| || |.   | .  .| .| ||  |     |.|..|  || . | ||| ||... .|
SLGGTPYCGMTCAE-LYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase FLT1.AA PDGFR 828-929 60 2e-58 186.03 In-house 1-101 (358) Show / Hide 
Range on Protein: 828-929
Range on HMM: 1-101/358
Sequence Identity: 60% (62 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRD
|..|| || ||||||| | |.|. ||    .|||||||. | .||  ||| ||||..| |.|.|.||||||||. |||  .| ||| || | |||..||.
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTH-GGPIYIITEYCCYGDLLNYLHRKRH

LF
 |
SF
Kinase FLT1.AA Pkinase 828-1154 20 6.5e-47 166.96 Pfam 1-293 (293) Show / Hide 
Range on Protein: 828-1154
Range on HMM: 1-293/293
Sequence Identity: 20% (75 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATAS--EYKALM-TELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG----NLSN
...|. .|.|.||.|     .  ..  |...|||| .|   . |  .. ..  .|..|. .. .| |.| |.....  .. . .. |||  |     |. 
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFD

YLKSKRDLFCLNKDAALHMELKKESLEPGLEQGQKPRLDSVSSSSVTSSSFPEDRSVSDVEGDEDYSEISKQPL--TMEDLISYSFQVARGMEFLSSRKC
|..                                                                  .. ..  .......|  |..||.|.. |...
YIST----------------------------------------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGI

IHRDLAARNILLSENNVV----KICDFGLARDIYKNPDYVRRGDTRLPLKWMAPESIF-DKVYSTKSDVWSYGVLLWEIFSLGGSPYPGV----QMDEDF
|||||   |||...|...    ||||||||. .. .  ..   .    . .|||| |  .. |..|.|.||.|..|.| .. |  |.||      .|...
IHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQ

CSRLKEGMRMRTPEYAT---------------------PEIYQIMLDCWHKDPKERPRFAELVEK--L
. ... | . . ... .                     .|  ... .|..||||.|| ......   .
MICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase FLT1.AA FGFR 828-926 49 3.3e-40 134.69 In-house 1-100 (293) Show / Hide 
Range on Protein: 828-926
Range on HMM: 1-100/293
Sequence Identity: 49% (50 aa)

LKLGKSLGRGAFGKVVQASAFGIKKS--PTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSK
| ||| || |.||.|. | |.||...      ||||||||...|  .   |  |. ..  || | |..||||.|| |.||| ||||||. |||  .|...
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCT-QEGPLYVIVEYCHHGNLRDFLRAR

R
|
R
Kinase FLT1.AA Ret 828-926 46 1.7e-37 125.59 In-house 1-100 (293) Show / Hide 
Range on Protein: 828-926
Range on HMM: 1-100/293
Sequence Identity: 46% (47 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEG-ATASEYKALMTELKILTHIGHHLNVVNLLGACTKQG-GPLMVIVEYCKYGNLSNYLKSK
| |.. || | ||.|| | || |.  |   ||||||||.. |. |||..| .|. .|  .  | .|. |.|||. ..  |...|||||||| |  .|   
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS

R
|
R
Kinase FLT1.AA S_TKc 828-1158 24 8e-34 119.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 828-1158
Range on HMM: 1-231/231
Sequence Identity: 24% (82 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKY--GNLSNYLKSK
 .... .|.|||||| ..   .     | | ||.|..|        . .. |..|| .  || |.|.|....    . | .. |||    |.|  |.|..
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR

RD--LFCLNKDAALHMELKKESLEPGLEQGQKPRLDSVSSSSVTSSSFPEDRSVSDVEGDEDYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIHRDL
.   |                                                              ..|..  .  .|  |.....|.. |.. |||||
GRHGL--------------------------------------------------------------RFPFPE-HARFYMYQICCALEYCHSHGIIHRDL

AARNILLSENNVVKICDFGLARDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYST-KSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTP
   ||||.|  ..||||||||| .               . .|||| .    |.. |.|.|| |..|.| .. |  |.|  ||.. |   .         
KPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG---------

EYATPEIYQIMLDCWHKDPKERPRFAELVE-----KLGDLL
   .||  ...  |..|||..||   |. .     |.   .
---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FLT1.AA Tie 837-928 41 3.1e-28 82.48 In-house 2-89 (267) Show / Hide 
Range on Protein: 837-928
Range on HMM: 2-89/267
Sequence Identity: 41% (38 aa)

GAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDL
| ||.|..|    |||      ||.||.||.|   . .  | || ..  .||| |..||.||| ..|  | | .|| .|||| ..|.. | .
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGY-LYVAIEYAPYGNLLDFLRKSRVI
Kinase FLT1.AA RTKB 828-926 37 3.4e-20 64.79 In-house 1-97 (264) Show / Hide 
Range on Protein: 828-926
Range on HMM: 1-97/264
Sequence Identity: 37% (37 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKR
..||. || |||| | ||  .  . . | . .|.| || ||   |  .  .|. ..  .| | ||. ..| |  |  |... ||.| .|||  ||.  |
VWLGEKLGNGAFGEVFQA-WVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCL-QDEPYILLVELCELGNLRDYLRMCR