Gene FGR (Mouse)

FGR

Species: Mouse
Alias: Fgr, FGR
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Src
Subfamily: SrcA

Sequence

Name Sequence Type Origin Length Description Download
FGR.NA RNA Sugen 3353 None Fasta, JSON
FGR.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 250 Kinase domain by global Sugen HMM Fasta, JSON
FGR.AA Protein Sugen 517 None Fasta, JSON

Protein domain

Protein domains of FGR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 FGR.AA SH3 68-125 39 2.2e-24 88.25 SMART 1-58 (58) Show / Hide 
Range on Protein: 68-125
Range on HMM: 1-58/58
Sequence Identity: 39% (23 aa)

TIFVALYDYEARTGDDLTFTKGEKFHILNNTEYDWWEARSLSSGHRGYVPSNYVAPVD
  ..|||||.|.. |.|.|.||.....|. .. .||..|  ..| .|..|||||...|
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 FGR.AA SH3_1 71-118 42 2.2e-23 81.73 Pfam 1-49 (49) Show / Hide 
Range on Protein: 71-118
Range on HMM: 1-49/49
Sequence Identity: 42% (21 aa)

VALYDYEARTGDDLTFTKGEKFHILNNTEY-DWWEARSLSSGHRGYVPS
||||||.|...|.|.|.||...|... ..  |||..|....|..|..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 FGR.AA SH3_2 69-124 19 5.1e-13 48.49 Pfam 1-68 (68) Show / Hide 
Range on Protein: 69-124
Range on HMM: 1-68/68
Sequence Identity: 19% (14 aa)

IFVALYDYEA-RTGDD-----LTFTKGEKFHIL------NNTEYDWWEA-RSLSSGHR--GYVPSNYVAPV
 .... ||.. .  ..     |.|.||......      ..   .||.. .... |.|  |..||..|...
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWD---NWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 FGR.AA SH2 132-214 59 6.2e-54 160.17 Pfam 1-81 (81) Show / Hide 
Range on Protein: 132-214
Range on HMM: 1-81/81
Sequence Identity: 59% (49 aa)

WYFGKISRKDAERQLLSSGNPQGAFLIRESETTKGAYSLSIRDWDQNRGDHIKHYKIRKLDTGGYYITTRAQFDSIQDLVRHY
||.|||||..|||.|...||| |.||.||||.|.| |.|| ||...  ||..|||.|...|.||||||.| .|.|.|.|| ||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 FGR.AA SH2 130-220 43 2.1e-38 134.83 SMART 1-87 (87) Show / Hide 
Range on Protein: 130-220
Range on HMM: 1-87/87
Sequence Identity: 43% (40 aa)

EEWYFGKISRKDAERQLLSSGNPQGAFLIRESETTKGAYSLSIRDWDQNRGDHIKHYKIRKLDTGGYYITT--RAQFDSIQDLVRHYMEVNDG
..||.|.|||..||. |.. |.| |.||.|.||...|.|.||.|.      ...|||.||..|.|.|||..  | .|.|. .||.||.   .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase FGR.AA SrcA 251-500 86 2.4e-225 719.77 In-house 1-250 (250) Show / Hide 
Range on Protein: 251-500
Range on HMM: 1-250/250
Sequence Identity: 86% (217 aa)

IALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVSEEPIYIVTEFMCYGSLLDFLKDREGQNLMLPHLVDM
|.||||||.||||.||.||||..||||.||||||||||.||||||||||.|||||||||||||||||||||||.||.|||||||||.||..|.||.||||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVDM

AAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVPYPGM
||||||||||||||||||||||||||||||.|||||||||||||||||||...||.|||||||||||||.||||.||||||||||||||.||||||||||
AAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM

NNREVLEQVEHGYHMPCPPGCPASLYEVMEQAWRLDPEERPTFEYLQSFL
||||||||||.|||||||..||.||.|.|.|.||.|||||||||||||||
NNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase FGR.AA Src 251-500 72 5.8e-197 660.63 In-house 1-255 (255) Show / Hide 
Range on Protein: 251-500
Range on HMM: 1-255/255
Sequence Identity: 72% (185 aa)

IALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVSEE-PIYIVTEFMCYGSLLDFLK-DREGQNLMLPHLV
| |.|.||.|.||.|| |.|| .|||||||||||||||.|||.|||||| |||.||||||||.|.| |||||||.|. |||||.|| |.||..| ||.|.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMAAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLARLIE--DNEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVP
||||||||||||.|.||||||||.|.|.|||| ..||.|||||||||.  |.||....| |||||||||||...||||.|||||||||||||..|.||||
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGMNNREVLEQVEHGYHMPCPPGCPASLYE-VMEQAWRLDPEERPTFEYLQSFL
||||.|.|||.|||.||.||||..||..||| .| | |. |||.||||||||.||
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FGR.AA SFK-Src 251-504 59 5.8e-179 535.58 In-house 1-259 (259) Show / Hide 
Range on Protein: 251-504
Range on HMM: 1-259/259
Sequence Identity: 59% (154 aa)

IALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAV-VSEEPIYIVTEFMCYGSLLDFLKDREGQNLMLPHLVD
|.||..|| | ||||| |.|| .| |||||||||.|| . ||.|||.|| |||..|.|||||    |||||.|| | ||||||.|.. .|. | .| |||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MAAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLARLIE-DNE-YNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVPY
|||||| ||||.|  |..|||| | |.|||.  .||..|||..| .. |.| | ...| |||||||||||..  || .||||||||||..|..| ||.||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMNNREVLEQVEH--GYHMPCPPGCPASLYEVMEQAWRLDPEERPTFEYLQSFLEDYF
||| | ||| ||.   || |||||.||  .|..| . |.  |..||||| |.  .||.|
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase FGR.AA SrcB 251-501 66 1.3e-158 533.21 In-house 1-251 (251) Show / Hide 
Range on Protein: 251-501
Range on HMM: 1-251/251
Sequence Identity: 66% (168 aa)

IALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVSEEPIYIVTEFMCYGSLLDFLKDREGQNLMLPHLVDM
. |...||.| ||.||.|..| ..||||||.|.|||||.|||.|| .|| | ||.||.|||||. |||||.||.|  |.||||||  ||  | ||.|.||
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDM

AAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVPYPGM
.||.||||||.||||||||||||||||| | |.||||||||||.||||||  . | |||||||||||  || ||.|||||||||||.|..| ||.|||||
SAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGM

NNREVLEQVEHGYHMPCPPGCPASLYEVMEQAWRLDPEERPTFEYLQSFLE
 | ||....|.|| ||.|  ||  ||..|.. |.  |||||||.|||| |.
TNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase FGR.AA Pkinase_Tyr 251-500 47 3.5e-146 495.71 Pfam 1-270 (270) Show / Hide 
Range on Protein: 251-500
Range on HMM: 1-270/270
Sequence Identity: 47% (129 aa)

IALERRLGTGCFGDVWLGTWN-----CSTKVAVKTLKPGTMSP----KAFLEEAQIMKLL-RHDKLVQLYAVVS--EEP--IYIVTEFMCYGSLLDFLKD
| . . || |.||.|..|||.       ..||||.||.|.|..    ..|..||.||| | .|...|.||.|..  .||  ||||.|.|..|.|||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R--EGQNLMLPHLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLARLI-EDNEY-NPQQGTKFPIKWTAPEAALFGRFTVKSDVWSF
.  ..|.| ...|..|..|.|.||.| |..|.|||||.| |.||.| ...||.||||||.| .| .|   ..|.|.||||.|||.  .|.||.|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLTELITKGRVP-YPGMNNREVLEQV-EHGYHMPCPPGCPASLYEVMEQAWRLDPEERPTFEYLQSFL
|.|. |..| |. | |||| | ||.|.. |.|| ||||..||. .|..| | |. |||.||||......|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FGR.AA Src-Unclassified 251-500 49 1.8e-142 479.63 In-house 1-284 (284) Show / Hide 
Range on Protein: 251-500
Range on HMM: 1-284/284
Sequence Identity: 49% (140 aa)

IALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPG---TMSPKAFL--------EEAQIMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCYGSLLDFLKDRE
. | | || | || ||.| |  .  |||||..||   |||| |||        .|||||| .|| .||.|||| | |||.||.||.|  ||||..|.   
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GQNLMLPHL------------VDMAAQVAEGMAYMERMNYIHRDLRAANILVGEYL-----ICKIADFGLA--RLIEDNEYNPQQGTKFPIKWTAPEAAL
|| | .. .            ||.||||| || | |   |.|||| | |.|.|.       . |..|||||  .|..| .| . .| .||.||.|||...
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

FGRFTVKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVEHGYHMPCP--PGCPASLYE-VMEQAWRLDPEERPTFEYLQSFL
 | |..||||||.|||| |. |||..||||| ||||||.|| || || |   .|| ..|| .| . | .||. ||||. |  ..
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase FGR.AA Frk 251-504 65 2.6e-141 475.74 In-house 1-260 (260) Show / Hide 
Range on Protein: 251-504
Range on HMM: 1-260/260
Sequence Identity: 65% (171 aa)

IALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCYGSLLDFLK--DREGQNLMLPHL
| | ||||.| ||.|| | || .| ||||||||||| |. || |||||| ||| ||.|||||   ||||||.|| |  |||...|.  ...|... .. |
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VDMAAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLAR-LIEDNE--YNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGR
|||||||| ||||.| .||||||| | |.|||| .||||||||||| |. |||  |  ..| .|||||||||||   .||.|||||||||||||.|| ||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

VPYPGMNNREVLEQVEHGYHMPCPPGCPASLYEVMEQAWRLDPEERPTFEYLQSFLEDYF
.||||| |.|||..|.||| ||.||.||  |||.| . |. ||..||||| ||  |||||
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase FGR.AA Src-Echino1 251-500 55 1.3e-128 433.55 In-house 1-252 (252) Show / Hide 
Range on Protein: 251-500
Range on HMM: 1-252/252
Sequence Identity: 55% (141 aa)

IALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVSEE-PIYIVTEFMCYGSLLDFLKDREGQNLMLPHLVD
  .....| | .|.|| | ||  |.|||||||..|||| .|| || .|| .||. .||.||| |.. ||||||| |  |.|.|.||. ..... .. |.|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MAAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVPYPG
| |..| || |... |..|||| | |.|||.  .||||||||||......|  .|| |.|||||||||||.||||.||||||||||.||..| ||.||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MNNREVLEQVEHGYHMPCPPGCPASLYEV-MEQAWRLDPEERPTFEYLQSFL
| |||||.||..|| || .  || |||.. | . |  ||  |||||.| .|.
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase FGR.AA TyrKc 251-500 41 1.7e-128 434.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 251-500
Range on HMM: 1-280/280
Sequence Identity: 41% (118 aa)

IALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLL--RHDKLVQLYAVVSE--------EPIYIVTEFMCYGSLLDFLKDREGQ
| |.. || |.|| |..|||.  ..||||.||...   ..|..||.||. |  .|. .|.||.|...        ||..||.|.|..|.|.|.|......
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

NLMLPHLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLARLIEDN--------EYNPQQ--GTK--FPIKWTAPEAALFGRFTVKSD
 | ...|.... |.|.||.| ...|.||||| | |.|||| ...||.||||.| |.|          | ...  |.|  .||.|.|||.  .|.|| |||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILLTELITKGRVPYPG-----MNNREVLEQVEHGYHMPCPPG--------CPASLYEVMEQAWRLDPEERPTFEYLQSFL
|||||... |. | |  ||||     |.|.||.|.|..|| ||.||         ||. .|..|.| |. |||.||||. . ...
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FGR.AA TK 251-500 25 2.5e-118 398.51 In-house 1-486 (486) Show / Hide 
Range on Protein: 251-500
Range on HMM: 1-486/486
Sequence Identity: 25% (124 aa)

IALERRLGTGCFG---DVWLGTWNCS--------------------------TKVAVKTLKPG-TMSPKA--------------FLEEAQIMKLLR----
| |.. || | ||   .|..|.|.                            |.||||.||.| .||...              |||||..||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDKLVQLYAVVSEE-------------PIYIVTEFMCYGS----LLDFLKDREGQ--------------------------------------------
 |. .|.||.|....             |..||.|.|..|.    |.|.|... .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------NLMLPHLVDMAAQVAEGMAYMERM------NYIHRDLRAANILVGEYLI-----------CKIADFG---
                              .| ...|. |..|.|.||.|....      |..|||| | |.|||| ..           |||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLIE-------------------------DNEYNPQQGTKFPIKWTAPEAAL---------FGRFTVKSDVWSFGILLTELITKGRVPYPG-M
     ||| |.                         ...|  |.|.|.||.|.|||. .         .|.|| ||||||||.|. |. | |..||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NN---------REVLEQVEHG--------------YHMPCPPGCP--------------ASLYEVMEQAWRLDPEERPTFEYLQSFL
.|         .||.|... |              . ||.||.||              . .|..| | |..|||.||||. |...|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FGR.AA SRM 252-501 49 2.8e-118 397.29 In-house 2-253 (253) Show / Hide 
Range on Protein: 252-501
Range on HMM: 2-253/253
Sequence Identity: 49% (125 aa)

ALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGT-MSPKAFLEEAQIMKLLRHDKLVQLYAVVSE-EPIYIVTEFMCYGSLLDFLKDREGQNLMLPHLVD
.| |.|| | || || | |  . .||.|  |    |  . .  | | || ||| ... |.||.|  .|.||.|| |  |.|. .|.| ... | .|||.|
TLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLLD

MAAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVPYPG
.| ||||||.|.|  ||||||| | |.|||. ..||..|||||||| |  | |  . . |.||||||||  . .  ||||||||||| |. |.| .||||
FACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYPG

MNNREVLEQVEHGYHMPCPPGCPASLYEVMEQAWRLDPEERPTFEYLQSFLE
| | | . |.. || ||||  ||.. .  | . |. |||.||.|  |   | 
MTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase FGR.AA Tec 251-502 43 7.2e-104 351.38 In-house 1-254 (254) Show / Hide 
Range on Protein: 251-502
Range on HMM: 1-254/254
Sequence Identity: 43% (112 aa)

IALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVSEE-PIYIVTEFMCYGSLLDFLKDREGQNLMLPH--L
... . ||.| || | || |  . .||.|..| |.||   |.|||..|. | | |||||| | |.. |||||||.|  |.||..|. .... .      |
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHH-FQKNMAIL

VDMAAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVPY
 .|  .| ||||| || ..||||| | | |||.  . |..|||..| . | .|    |||||.|| .||   . |.  |||||.||.|  |  . |..||
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPY

PGMNNREVLEQVEHGYHMPCPPGCPASLYEVMEQAWRLDPEERPTFEYLQSFLED
. | | || |.|  |. .  |  |. ..|..| . |.  |||||||. | . ...
ENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase FGR.AA S_TKc 251-504 25 8.5e-53 182.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 251-504
Range on HMM: 1-231/231
Sequence Identity: 25% (67 aa)

IALERRLGTGCFGDVWLGTW-NCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVSEEPIYIVTEFMCY--GSLLDFLKDREGQN----LM
  . | .| | || |..... .   .||.| .|      . .. | ||.|  .|. .|.|| |  .. .|.|.|..    |.|.|..|.| ..     . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LPHLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQQGTKFPIKWTAPEAALFGRFTV-KSDVWSFGILLTELITK
  |   ...|......|. ... |||||  .|||. |    ||.||||||..                . |||      ..  |.|.||.|..| |... 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-

GRVPYPGMNNREVLEQVEHGYHMPCPPGCPASLYEVMEQAWRLDPEERPTFEYLQS-----FLEDYF
|. |.|  .  ......            . .. . ... .. |||.|||   .        .  .|
GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FGR.AA Pkinase 251-500 25 1.2e-44 158.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 251-500
Range on HMM: 1-293/293
Sequence Identity: 25% (75 aa)

IALERRLGTGCFGDVWLGTWNCSTK-VAVKTLKPGTMSPKAFLE-----EAQIMKLLRHDKLVQLYAVV-SEEPIYIVTEFMCYG----SLLDFLKDREG
. ..|..| | || |.....  . | ||||..|  . ...   .     |.|||| |.|.  |.|| .. ..  ||.|.|..  |    .| |... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QNL--MLPHLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGEYLIC----KIADFGLARL--IEDNEYNPQQGTKFPIKWTAPEAAL-FGRFTVKSDVW
 ..     .. ... |...|..|. .|. |||||  .|||. .   .    ||.|||||..  .  |...   || .   . |||  .     . |.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPW---YMAPEVIRGGQYYGPKVDMW

SFGILLTELITKGRVPYPGM------NNREVLEQVEH-GYHMPCPPGCP-------------------ASLYEVMEQAWRLDPEERPTFEYLQSF--L
|.|..| |... || |.||       . ....... .  .| ..|  |.                    .. ....  ...||..|||.| .     .
SCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF