Gene FGFR3 (Mouse)

FGFR3

Species: Mouse
Alias: FGFR3, Fgfr3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: FGFR

Sequence

Name Sequence Type Origin Length Description Download
FGFR3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 277 Kinase domain by global Sugen HMM Fasta, JSON
FGFR3.NA RNA Sugen 4222 None Fasta, JSON
FGFR3.AA Protein Sugen 800 None Fasta, JSON

Protein domain

Protein domains of FGFR3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG FGFR3.AA IG 44-124 18 1e-07 32.89 SMART 1-58 (58) Show / Hide 
Range on Protein: 44-124
Range on HMM: 1-58/58
Sequence Identity: 18% (16 aa)

QEQVAFGSGDTVELSCHPPGGAPTGPTVWAKDGTGLVASHRILVGPQRLQVLNASHEDA---GVYSCQHRLTRRVLC--HFSVRVT
.. |    |.||.|.|  .       ..| .                 |.. |.. ||.   |.| || .    . .   . ..|.
PP-VTVKEGETVTLTC-VS-------QIWWY-----------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
IGc2 FGFR3.AA IGc2 50-114 27 3e-06 28.26 SMART 1-56 (56) Show / Hide 
Range on Protein: 50-114
Range on HMM: 1-56/56
Sequence Identity: 27% (18 aa)

GSGDTVELSCHPPGGAPTGPTVWAKDGTGLVASHRILVGPQRLQVLNASHEDAGVYSCQHRLTRR
 .|..|.| |.   |.|.    | | |. |        . ..|.. |.. ||.|.|.|. |    
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP-------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set FGFR3.AA I-set 71-108 27 1.838048 4.08 Pfam 33-76 (92) Show / Hide 
Range on Protein: 71-108
Range on HMM: 33-76/92
Sequence Identity: 27% (12 aa)

VWAKDGTGLVA---SHRILVGP---QRLQVLNASHEDAGVYSCQ
.| |||  |      |..       ..| ..|.  .|.|.|.|.
SWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCV
V-set FGFR3.AA V-set 38-108 13 4.745753 2.0 Pfam 1-111 (128) Show / Hide 
Range on Protein: 38-108
Range on HMM: 1-111/128
Sequence Identity: 13% (15 aa)

GPEPSQ--QE----QVAFGSGDTVELSCHPPGGA----PTGPTVWAK-DGT------------GLVAS------------HRILVGPQR-----LQVLNA
  . .|  ..     |    |..|.|.||.  .     ...   | .   .            .....             . . |  .     |.  |.
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

SHEDAGVYSCQ
. .| |.| |.
QPSDSGTYYCA
IGc2 FGFR3.AA IGc2 161-229 33 6e-18 66.86 SMART 1-56 (56) Show / Hide 
Range on Protein: 161-229
Range on HMM: 1-56/56
Sequence Identity: 33% (23 aa)

PAANTVRFRCPAAGNPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFG
   ..|...|||.|||.|.|.|.| |..                |.|  ..| |.|.|.|||...|. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set FGFR3.AA I-set 165-239 36 2.9e-16 57.69 Pfam 17-92 (92) Show / Hide 
Range on Protein: 165-239
Range on HMM: 17-92/92
Sequence Identity: 36% (28 aa)

TVRFRCPAAGNPTPSISWLKNGKEFRG-EHRIGGIKLRH-QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDV
|.|| | . |.|.|..||.|.|.. |  ..|.  .. .. .  .| .. | |.| | ||||..|.||.   | .| |
TARFECQVTGDPPPQVSWFKDGQPLRPDSDRH-QMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG FGFR3.AA IG 155-240 18 2.8e-12 48.02 SMART 1-58 (58) Show / Hide 
Range on Protein: 155-240
Range on HMM: 1-58/58
Sequence Identity: 18% (17 aa)

KKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDR---GNYTCVVENKFGSIRQ--TYTLDVL
 . . | .  ||...| ..     .|.|.                       |.. .| |.|    |.|.|...   |.. .  . || |.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGv FGFR3.AA IGv 165-224 19 0.000922 8.63 SMART 1-76 (76) Show / Hide 
Range on Protein: 165-224
Range on HMM: 1-76/76
Sequence Identity: 19% (15 aa)

TVRFRCPAAGNPTPSISWLKN-------GK-------EFRGEHRIGGIKL---RHQQWSLVMESVVPSDRGNYTCVV
.|.  | . |. .  ..|..        ||       ...|   . .  .      |..|.| .. |.| |.|.| .
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
V-set FGFR3.AA V-set 205-239 33 0.025299 9.84 Pfam 93-128 (128) Show / Hide 
Range on Protein: 205-239
Range on HMM: 93-128/128
Sequence Identity: 33% (12 aa)

WSLVMESVVPSDRGNYTCVVENK-FGSIRQTYTLDV
.|| . .. ||| | |.|.| |  ...  . ..| |
FSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IG FGFR3.AA IG 254-351 18 8.3e-16 59.76 SMART 1-58 (58) Show / Hide 
Range on Protein: 254-351
Range on HMM: 1-58/58
Sequence Identity: 18% (19 aa)

PANQTAILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDA---GEYTCLAGNSIGFSH-HSAWLV
|  .|. .|..|...| |      .|.|.                                   | . ||..||.   |.|.| |  .   .  ....| 
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLT

VL
|.
VQ
IGc2 FGFR3.AA IGc2 260-340 25 1.7e-10 42.13 SMART 1-56 (56) Show / Hide 
Range on Protein: 260-340
Range on HMM: 1-56/56
Sequence Identity: 25% (21 aa)

ILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIG
. | .|.. |..  .  | |.|.|     |...                         |.. |||.||.|.|||.| |..|
HEGQSVTLTCPATGNPDPNIHWYK-----GQPLP--------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set FGFR3.AA V-set 247-350 13 2.5e-05 20.19 Pfam 1-128 (128) Show / Hide 
Range on Protein: 247-350
Range on HMM: 1-128/128
Sequence Identity: 13% (19 aa)

PI-LQAGLPA----NQTAILGSDVEFHCKVYSDA----QP-HIQWLK-HVEVNGSKVGPDGTPYVTV-----LKTAGANTTDKELEV-------------
.. ...  |.      |. .| .|...|.. .|     .. .|.| . .          ...|   .     ... . ... ..                
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPP--------GQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKND

--LSLHNVTFEDAGEYTCLAGNS-IGFSHHSAWLVV
  |...|.. .| | |.| . |. ..  .|. .|.|
FSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set FGFR3.AA I-set 318-350 45 0.000135 18.11 Pfam 60-92 (92) Show / Hide 
Range on Protein: 318-350
Range on HMM: 60-92/92
Sequence Identity: 45% (15 aa)

LSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVV
|   ||. .|.|.||| | || | .  .| | |
LTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGv FGFR3.AA IGv 264-335 17 0.000692 9.88 SMART 1-76 (76) Show / Hide 
Range on Protein: 264-335
Range on HMM: 1-76/76
Sequence Identity: 17% (14 aa)

DVEFHCKVYSDAQPHIQWLKHV------EVNGSKVGPDGTPYVTVLKTAGANT---TDKELEVLSLHNVTFEDAGEYTCLA
.|.  ||.  .   .. |...        .  . .|      .    |   ..   ..|    |...|.. || | |.|  
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY----SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
I-set FGFR3.AA I-set 254-283 30 0.082732 8.65 Pfam 7-36 (92) Show / Hide 
Range on Protein: 254-283
Range on HMM: 7-36/92
Sequence Identity: 30% (9 aa)

PANQTAILGSDVEFHCKVYSDAQPHIQWLK
| ....  |....| |.|  | .| ..|.|
PKDVEVQEGETARFECQVTGDPPPQVSWFK
Kinase FGFR3.AA FGFR 466-742 75 1.6e-240 805.3 In-house 1-293 (293) Show / Hide 
Range on Protein: 466-742
Range on HMM: 1-293/293
Sequence Identity: 75% (221 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR
|||||.|||||||||.||||.|||.||..| .||||||||...|||||||||||||||||||||||||||||.|||.|||||.|||...||||.||||||
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PPGMDYSFDAC-------RLPEEQ--------LTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRL
||||||..|..       | ||.|        ||.|||||||||||||||||||.|||||||||||||||.|.||||.|||||||.|..|||.|||||||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDL
|.|||||||||||||||||||||.|||||||.|.||.|||.|| ||||.|.|||||||.||. |....|..|..|||..|.||||||||||.|
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FGFR3.AA Pkinase_Tyr 466-742 47 2.3e-158 536.99 Pfam 1-270 (270) Show / Hide 
Range on Protein: 466-742
Range on HMM: 1-270/270
Sequence Identity: 47% (134 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKD--LSDLVSEMEMMKMIGKHKNIINLLGACT-QGGP--LYVLVEYAAKGNLREF
.|.|| ||||.||.|..... |   |   . ..|||||||..|....  . |. .|...|| .|.|.||..|.|.|| ||.|  .|. .||...|.|...
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYY-KKTTNGRLPVKWMAPEA
||..|             ....|| |||.. ..|.|.|||||.|..||||||||||.||||.||.||.|||||||..| ||| .|...|.||.||||||.
LRKHR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC

LFDRVYTHQSDVWSFGVLLWEIFTLGGSP-YPGIPVEELFKLL-KEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDL
......|..|||||||||.|||||.|..| |||.. ||..... ..|.||..|  |. ..|..|..|||. |..||||....|.|
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FGFR3.AA TyrKc 466-742 40 9.60000000001e-156 524.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 466-742
Range on HMM: 1-280/280
Sequence Identity: 40% (126 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIG-KHKNIINLLGACTQG-------GPLYVLVEYAAKGNL
.|||| ||||.||.|. ....          ..|||||||.||    . |. .|...|...| .|.||..|.|.|||.       .||....||...|.|
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

REFLRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNL-------DYYKKTT--NG
...||..||                |. |||.| ..|.|.|||||.|..||||||||||.||.|....||.||||.||...        |||.|..  .|
KDYLRKHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

R--LPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPG-----IPVEELFKLLKEGHRMDKPAS--------CTHDLYMIMRECWHAVPSQRP
.  ||..|||||.......|..||||||||..|||||.|..||||     .. .|.....|.|.||..|..        |. ..|.||..|||. |..||
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

TFKQLVEDL
||....|..
TFSEIHECF
Kinase FGFR3.AA TK 466-742 27 8.9e-137 460.69 In-house 1-486 (486) Show / Hide 
Range on Protein: 466-742
Range on HMM: 1-486/486
Sequence Identity: 27% (136 aa)

LTLGKPLGEGCFG---QVVMAEAIGIDKDR------------------TAKPVTVAVKMLK--DDATDKDLSD--------------LVSEMEMMKM-IG
.|||| |||| ||   .| ..|..|.....                  . ....|||||||  |......  |              ...||.||.. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHKNIINLLGACTQG------------GPLYVLVEYAAKGN----LREFLRARRPPGMDYSFDAC-----------------------------------
.|.||..|.|.||||            .|.....||...|.    ||..||..||......                                       
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----RLPEEQLTCKDLVS-------------------CAYQVARGMEYLASQKC------IHRDLAARNVLVTEDNV-----------MKIADFG----
     .. ...|| |||..                   ...|.|.|||||.|..|      .||||||||.||.|.||            ||||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LARDVHNLDYYKKTT------------------------NGRLPVKWMAPEALFDRV---------YTHQSDVWSFGVLLWEIFTLG-GSPYPGIP
    ||||... |.| ...                        .|.||..|||||.|.|||         .|..|||||||||.|||||.| . .|.|..
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

V---------EELFKLLKEG--------------HRMDKPASCT--------------HDLYMIMRECWHAVPSQRPTFKQLVEDL
          .|....|..|              .|| .|. |.               ..| .|..|||. |..||||.||.| |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FGFR3.AA Ret 466-744 46 1.6e-124 420.02 In-house 1-293 (293) Show / Hide 
Range on Protein: 466-744
Range on HMM: 1-293/293
Sequence Identity: 46% (139 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDD-ATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGG--PLYVLVEYAAKGNLREFLR
| |.. |||| ||||| | |. | . ..    |||||||| . |.   . || ||... | .  | ..| |.|||.| .  |. . |||.  | ||||||
LQLDDTLGEGHFGQVVKAQAFHI-RGHPGY-TTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLR

ARRPPGMDY-------SFDACRLPE--EQLT-----CKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNG
  |  |  |       .     .|   . ..      |...| | |. .|| ||.. | .||||||||||| |  ..|| |||| |||   | | |   .
LSRKIGPYYEYSIGNRNCSIVDHPDGKDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKD

RLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDR
|.||||||.|.|.| ||| .|||||||||.||| |.|..|||||| | |. ||| |.||| |  |   .| ||| ||   |  || || .  |. .
RIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase FGFR3.AA TK-Unique 466-742 46 2.6e-123 415.99 In-house 1-294 (294) Show / Hide 
Range on Protein: 466-742
Range on HMM: 1-294/294
Sequence Identity: 46% (137 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGG-PLYVLVEYAAKGNLREFLRAR
|..|. .||| ||||  .|. ||.|..  |.. ||||||||.||| | .|. .| .||| .|.|.||...||.||  . | . . ||...|||. .|| .
LEVGDVIGEGAFGQVWRGEVWGIWKHW-DKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

RPPGMDYS------FDACRLPEEQ----LTCKDLVSCAYQVARGMEYLAS--QKCIHRDLAARNVLVTEDNVMKIADFGLARDVHN-LDYYKKTTNGRLP
||.  .        ||. . |...    .. |||.. |.|.|.|||||||  .|..||||.|||||.|||.| ||.|||.||||..  .| .... ||.|
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

VKWMAPEALF--DRVY-THQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPASC-THDLYMIMRECWHAVPSQRPTFKQLVEDL
..|||||.|   ...| | .|||||||||.|||||||. ||||.| ... .....|.||..|..| .|..| .|..||. .|..||.| |..  |
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FGFR3.AA UTK 466-742 35 1.8e-106 360.04 In-house 1-296 (296) Show / Hide 
Range on Protein: 466-742
Range on HMM: 1-296/296
Sequence Identity: 35% (110 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSD----LVSEME---MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLR
. ||..||.| ||.| .|..  ..  ..   . |||| .. .|.. . ..    .  |     |||.   | |...|.| |||..|.....||...|.||
VQLGRQLGQGAFGEVHKARFTQCSEHMYE--MDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

EFLRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTED-------NVMKIADFG---LARDVH---------NL
 .||  ||  .         ....||  .....|...||||.||.|....||||||||.||...       .| ||||||   ..|.|.         . 
SYLRRHRPTPP--------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWES

DYYKKTTNGRLPVKWMAPEALFDR-VYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEG--HRMDKPASCTHDLYMIMRECWHAVPSQRPTFK
.||... ..|.|..||||||| ..  .|..||||||||..|||.| |  ||||.  ..... . .|  .|| .|..| |..|..|..|||. |. ||.|.
YYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFE

QLVEDL
.||. .
DLVQQM
Kinase FGFR3.AA Tie 474-742 47 2.2e-105 321.81 In-house 1-267 (267) Show / Hide 
Range on Protein: 474-742
Range on HMM: 1-267/267
Sequence Identity: 47% (131 aa)

EGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSF
|| ||||. |    | ||     . ||.||.|. | ..|  | . |.|.|  .|.| |||||.||| . | ||| .|||  ||| .|||  |    | .|
EGNFGQVMKAM---IKKDGLK--MEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAF

DACRLP------EEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTH
   .           |. . ..  |  |||||.||. ..||||||||||.|| |  | |||||||.|     . | |.| |||||.||| |.|   ||| 
AREHTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGD---EVYVKKTMGRLPVRWMAIESLNYSVYTT

QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDL
.|||||.||||||| .||| || |.   ||.. | .|.||..|  |  ..| .||.||   | .||.| |.. .|
KSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase FGFR3.AA VEGFR 578-742 57 3.8e-102 345.64 In-house 165-332 (332) Show / Hide 
Range on Protein: 578-742
Range on HMM: 165-332/332
Sequence Identity: 57% (97 aa)

LPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD-VHNLDYYKKTTN-GRLPVKWMAPEALFDRVYTHQSDVWSFG
. .. || .||.. ..|||||||.|||.|||||||||||.|..|.|| || ||||||.     . |.. .. |||| ||||||..||.||| .|||||.|
MWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYG

VLLWEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDL
|.|||||.||||||||.   ||... ||.| || .|  ||  .| || .|||  | .||.|  ||| |
VFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FGFR3.AA Src 466-742 39 2.2e-97 329.85 In-house 1-255 (255) Show / Hide 
Range on Protein: 466-742
Range on HMM: 1-255/255
Sequence Identity: 39% (111 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR
..| . ||.|.|| | |.   |         . |||| || .    .  ..  | . ||   .|.....|.  |.|. | |   || ..|.| ..|..  
IKLCRKLGQGQFGEVWMGYWNGN--------TKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK--

PPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHN--LDYYKKTTNGRLPVKWMAPEALFDR
           .  . .|  ..|.. | |||.||.|| |.. |||||||||||| |.|| |.||||||| .     | |   .  ..|.||.||||.  .
-----------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYG

VYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYM-IMRECWHAVPSQRPTFKQLVEDL
..|  |||||||.||.||.| |  ||||   .| .. .. | || .|. |   ||. ||..|||. | |||||. | . |
RFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FGFR3.AA PDGFR 580-742 58 5.6e-95 305.36 In-house 195-358 (358) Show / Hide 
Range on Protein: 580-742
Range on HMM: 195-358/358
Sequence Identity: 58% (96 aa)

EEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLW
.. || .||.. .||||.|||.|||  |.||||||||||...  | || |||||||. |   |    | |||||||||| .|| ||| ||||||.|.|||
SNVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLW

EIFTLGGSPYPGIPVEELF-KLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDL
|||.|||.||||.||.. | |. ||| ||..|.  . . | ||..|| . | .||||.||.. |
EIFSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FGFR3.AA InsR 466-744 36 6.6e-94 315.8 In-house 1-278 (278) Show / Hide 
Range on Protein: 466-744
Range on HMM: 1-278/278
Sequence Identity: 36% (103 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR
..|....|.| || |    | || .|       .|.| ....|....  .  .| . || . .......||| |..| | ||  |  ..|.|. .||.||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEF-NCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRR

PPGMDYSFDACRLP--EEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDR
|   .       ..   .. .  .... | ... || |||. | .|||||.|| .| .|   ||.|||..||.   |||.| . | ||| ||||| | | 
PEEEF---NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDG

VYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL-KEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDR
|.| .||||||||.|||. |||  || |   |.  |   ..|  ...|  |   .. .|. ||.  |. ||||..... |  
VFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase FGFR3.AA S_TKc 466-746 23 4.7e-52 180.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 466-746
Range on HMM: 1-231/231
Sequence Identity: 23% (68 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK--GNLREFLRA
 ......|.| ||.|  .  ..           ||.|..|         .. .|....|.  .|.||..|....   . ||.  ||.    |.|..... 
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

RRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDR
|...| .           ...  .  . .||.....||. |.. |||||   |.|..|  . ||.|||||| .         |       .|||| |   
RGRHGLR----------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---

VYTH-QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVE-----DLDRIL
 |..  .|.||.|..|.| .. |  |.|   ....||...           ....  ..| |..  |..|||  .. .      ..  .
GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FGFR3.AA Pkinase 466-742 21 6e-46 163.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 466-742
Range on HMM: 1-293/293
Sequence Identity: 21% (69 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLV---SEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKG----NLR
...|...|.| ||.|  .  .|  |       .|||| .| . ....        || ..||.. .|.||. |..... .. .|.  ||. .|     | 
YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

EFLRARRPPGMDYSFDACRLPEEQL--TCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVM----KIADFGLARDVHNLDYYKKTTNGRLPV
.....                .  .  . ... ...||..||.||. |...|||||   |.|. ....     ||.|||||. .  .  .  .|      
DYIST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTP

KWMAPEALF-DRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI----PVEELFKLLKEGHRMDKPASCT-----------------------HDLYMIMREC
 .|||| .  .. |.. .|.||.|..|.| .. |  |.||     .  .  .....  . . . ..                         ..  ... |
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

WHAVPSQRPTFKQLVED--L
..  |..|||..|....  .
LCKDPKKRPTAEQILQHPWF
Kinase FGFR3.AA VEGFR 466-565 52 2.5e-43 150.24 In-house 1-101 (332) Show / Hide 
Range on Protein: 466-565
Range on HMM: 1-101/332
Sequence Identity: 52% (54 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACT---QGGPLYVLVEYAAKGNLREFLR
| |||.||.| ||||. |.|.||.| .| .  ||||||||  ||      |.||..|.. ||.| |  |.||.||   |.||| | |||  .|||  .||
LKLGKMLGRGAFGQVHEASAFGIRKMETCT--TVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLR

ARR
. |
TKR
Kinase FGFR3.AA PDGFR 466-565 47 1.3e-34 108.27 In-house 1-98 (358) Show / Hide 
Range on Protein: 466-565
Range on HMM: 1-98/358
Sequence Identity: 47% (47 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR
| .|| || | ||.|| | | |. |   .   .|||||||  |       | ||  .|   |.| ||.||||||| ||| |.  ||   | | ..|. .|
LQFGKTLGSGAFGKVVEATAYGLSKSQAV--MKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR