Gene ERK2 (Mouse)

ERK2

Species: Mouse
Alias: ERK2, Mapk1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
Erk2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 289 Kinase domain by global Sugen HMM Fasta, JSON
Erk2.NA RNA Sugen 1932 None Fasta, JSON
Erk2.AA Protein Sugen 358 None Fasta, JSON

Protein domain

Protein domains of Erk2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Erk2.AA ERK1 23-311 92 7.79999999999e-248 829.62 In-house 1-289 (289) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-289/289
Sequence Identity: 92% (266 aa)

YTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSND
||||.|||||||||||||||...|.||||||||||||||||||||||||||.||.|||||.|.|||||.|||||.||||||.||||||||||||||||||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLSND

HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN
||||||||||||||||||||||||||||||||||||||||||||||||.|||.|||||||||||||||||||||||||||||||||||||||||||||||
HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN

RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL
||||||||||||||||||.||||||.||||||| |||||| |||||.||||.||||.|||||||||||||||||||||.||.|||||||
RPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase Erk2.AA MAPK 23-311 55 1.1e-203 682.91 In-house 1-328 (328) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-328/328
Sequence Identity: 55% (181 aa)

YTNLSYIGEGAYGMVCSAYDNL------NKVRVAIKKIS-PFEHQTYCQRTLREIKILLRF-RHENIIGINDIIRA------PTIEQMKDVYIVQDLMET
|..|..||.||||.||||.|..      .. .||||||| ||...|.|.||.||||.| .| .|||||...||...      ...|...|.|||..||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLYKLLKTQH-LSNDHICYFLYQILRG--LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADP-DHDHTG----------FLTEYVATRWYRAP
||....|.|  ||.|||.||.||||||  |||||||||.||||||||.|.|. ||||||||||||..|| .|.|..          ..||||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLN--SKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCII-NLKARNYLLSL---PHKNKVPWNRLFPN----ADSK
|||||  ...|||..|.||||||.||||. ..|.||||.|.||.|.|. .||.||.|...||  . .||||. ||   |...|.||  .|||    |...
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALDLLDKMLTFNPHKRIEVEQALAHPYL
|.|||.|||.|.|.||| ||.||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Erk2.AA ERK 23-311 55 2.4e-179 602.08 In-house 1-307 (307) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-307/307
Sequence Identity: 55% (169 aa)

YTNLSYIGEGAYGMVCSAYDNL-----NKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFR-HENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLK
|  .. ||.|||| |||| |..     .  .||||||  .|.|  || |||||||.|  |. |||||...||..   .||..|.|.|..|||||| .  .
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

TQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHT-----GFLTEYVATRWYRAPEIMLNSKGYTKSIDI
.|  || ||. ||.||||.||||||||||.||||||||.|.|  ||||||||||||. |....       .|.||||||||||||||||. . |||..||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP-SQEDLNCIINLKARNYLLSLPH--KNKVPWNRLFPNAD--SKALDLLDKMLTFNPHKRIEVEQ
||.|||.||||  .|.|||| |..|.|.|. |.|.| |.|||..| . .|..|. .||.  . ..||  .||||.  ..|.|||.|||.|.| ||| ||.
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALAHPYL
.|.|||.
CLEHPYF
Kinase Erk2.AA CMGC 23-311 28 1.7e-147 488.34 In-house 1-513 (513) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-513/513
Sequence Identity: 28% (149 aa)

YTNLSYIGEGAYGMVCSAYD--------------NLNKVRVAIKKIS-PFEHQTYCQ----------RTLREIKILLRFR-----------------HEN
|.....||||.||.|....|              . .. .||||||. || ... ..          |.||||||| ...                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIGINDIIRAP---TIEQ---------MKDVYIVQDLMETDLYKLLKTQH----------LSNDH------------ICYFL------YQILRGLK--YI
|... ||.. .   . |.         ....|.| ..|..|||...| ..          ||  |            |.||.      ||||||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--VLHRDLKPSNLLLNTTCDL--------------------KICDFGLARVADPDHDH------------------TGFLTEYVATRWYRAPEIML
||..  ..||||||.|.|.| .|.|                    |||||||||  .| .||                  . ..|.||.|||||||||.|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

NS---------KGYTKSIDIWSVGCILAEMLSN--------RPIFP-----------GKHYLDQLNHILGILGSP----------------SQEDLNCII
..         ..||..||.||||||.|||. .        .|.||           ||...|||..|  .||.|                ..|. |.| 
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------NLKARNYLLS---LPHKNKVPWNRLFPN-----------------------------------ADSKALDLLDKMLTFNP
                    . .||||. |   .| ... ||..|||.                                   .|..|.|||.|||...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

HKRIEVEQALAHPYL
.||| .||||.|||.
DKRITAEQALQHPYF
Kinase Erk2.AA p38 23-311 47 9.1e-139 467.3 In-house 1-289 (289) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-289/289
Sequence Identity: 47% (140 aa)

YTNLSYIGEGAYGMVCSAYDNLNKVR---VAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIRA--PTIEQMKDVYIVQDLMETDLYKLLKT
| ||...|.|||| ||.|.|   . .   |||||.. ||.   .  || ||.. |   ||||.|.. |.       .....|||.|  .|..||....|.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL
|.|| ||| . .|||||||||||||.. ||||||||. .|  |.|.| |||||| .| .      .|.|||||||||||||||   ||. .||||||||.
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDE------MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIM

AEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL
||... |. |||. ..|||. |. ..|.|..| .. | . .||||. |.|   .    ..|..|. .|.|||.|||   | ||| .|.|..|||.
AELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase Erk2.AA ERK5 23-311 51 6.9e-127 427.85 In-house 1-295 (295) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-295/295
Sequence Identity: 51% (152 aa)

YTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPT-IEQMKDVYIVQDLMETDLYKLLK-TQHL
|  .  ||.||||.||||   .|  .||||||   |.  |  .||.||.|||  |||.||| | ||..    .  |||||.| |||| || ...   | .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADP--DHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILA
. .|| ||||||||||||.|||.|.|||||||||| |  |.||| |||.||        .|  |.|||||||||||||.|. |. ||. ||.||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLS-LPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL
||.. | .|||| |..||. |. .|| |.   .  .   . .||. . .| .  ..|....| || .||||| .|| | | .|| | .|| ||.|
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase Erk2.AA ERK7 23-311 46 4.5e-119 401.88 In-house 1-292 (292) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-292/292
Sequence Identity: 46% (138 aa)

YTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFR-HENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLK-TQHL
|  .. .| ||||.|  |||   |  ||.|||   |  ||  ||| ||| .|  |. |.||| . ..|||   .  .|.|.| . |||||    .  . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRA---DNDRDIYLVFEFMETDLHAVIRKGNIL

SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPD--HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL
 . |  | .||.|| .||.||.||.||||||||.||.. | .|.||||||| .|. .  ..... |||||||||||||||.| |. ||| .| ||.||||
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL
.||| ..|.|||   ..|.. || ... |.|||.. |    | | | ....... . . ..|..   |.||| ..| |||.||...||||.||| 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase Erk2.AA ERK3 23-311 42 4.5e-107 345.64 In-house 1-300 (300) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-300/300
Sequence Identity: 42% (129 aa)

YTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKD-----------VYIVQDLMETDLY
.  |   | |  |.| || |.    .||||||.    .  |   ||||||. |  |.||. . ...     .   |           |.||| .||||| 
FCDLRPLGCGSNGLVFSAVDSECCKKVAIKKIVLTDKKS-CKHALREIKIIRRLDHDNIVKVYEVLFPKGSDNQDDEDIGILFELRTVCIVQEYMETDLA

KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIW
 ..  | ||..|.  | || ||||||||||||||||||| |.. ||    ||| |||.||. ||.  | |.|.| . |.||| |. .|    ||| ||.|
CVMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMARIVDPHYSHKGYLSEGLVTKWYRSPRLLLQPNNYTKAIDMW

SVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY
. ||||||||  .. |.| | | |.  ||        ||.| .       |.       . |  .| .| |. |||.| .||||.|  |.  | || |||
AAGCILAEMLTGKMLFAGAHELEQMMLILDSIPVVHEEDKNELLCVMPSKYIKNYMWYPHHPLKQLLCNIDCHALDFLEQMLTFDPMDRLTAEMALQHPY

L
.
M
Kinase Erk2.AA CDK 23-311 34 1.5e-102 328.96 In-house 1-284 (284) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-284/284
Sequence Identity: 34% (111 aa)

YTNLSYIGEGAYGMVCSAYDNLNK-----VRVAIKKIS-PFE----HQTYCQR-TLREIKILLRFRHENIIGINDIIRAPTIEQM------KDVYIVQDL
|  |  ||||.|| |  | | ...       ||.|||    |    . .     ..|||..|    |.||. . |..   . .        . .|.| . 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

METDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD-----LKICDFGLARVADP----DHDHTGFLTEYVATRWYRAPEI
|..||.|...        |  ...|.|||| |.|| ...||||||.|.|.| .       ||| ||||||        . . .  .|  | |.||||||.
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRAPEL

MLNSKGYT--KSIDIWSVGCILAEMLS---NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKM
 | || |.   .||.||||||.|||.    ..|.|||.  .||| .|  |.|.|. ..   .  |                             |||.||
LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNKM

LTFNPHKRIEVEQALAHPYL
|...|.|||  |||| |||.
LCYDPKKRISAEQALQHPYF
Kinase Erk2.AA S_TKc 23-311 28 6.4e-98 332.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-231/231
Sequence Identity: 28% (89 aa)

YTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMET---DLYKLLKTQH-
|. |  ||.||.| |. ....  . .||||.|.        ....|||.|| . .|.||. . |...       ...|.| .....   ||....| .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGR

------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTK-SIDIWS
      ..  |.....|||...|.|.|| ...||||||.|.||..   .|||||||||.           | .. |.||.|||..    ||.| ..|.||
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCDWWS

VGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALA----
.||||.|||. .| ||      |.. .. ..|                                     .. |.|...|.|...| ||. . .||.    
CGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPYL
   ||..
IKCHPWF
Kinase Erk2.AA Pkinase 23-311 30 5.5e-88 303.4 Pfam 1-293 (293) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-293/293
Sequence Identity: 30% (95 aa)

YTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLR---EIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMET-----DLYKLL
|. .. ||.|..| |. ...  .  .||.|.|.  .    ...|.|   ||.|..|..|.||. . |. .       ...|.|....|      ||. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

K---TQHL--SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL----KICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTK
.      .  | .... ..|||||||.|.|| ...||||||.|.|.. ....    ||||||||...|  . . . .| .. |.||.|||. . ...|..
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

SIDIWSVGCILAEMLSNRPIFPGK----HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIE
..|.||.||||.|||. ||.|||.    . .||.  |  |.| |  .|    ..   .. .   . .   . ...|.|... ..|.....|...|.||. 
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTFHNWSEECKDFIKWCLCKDPKKRPT

VEQALAHPYL
 ||.| ||..
AEQILQHPWF
Kinase Erk2.AA MAPK-Unclassified 23-173 50 1.8e-68 233.82 In-house 1-161 (575) Show / Hide 
Range on Protein: 23-173
Range on HMM: 1-161/575
Sequence Identity: 50% (81 aa)

YTNLSYIGEGAYGMVCSAYDNLN-KVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQ--MKDVYIVQDLMET---DLYKLLK
|.   .|| |||| || | |. | .  |||||.   |. .| | |.|||| ||    |.||| |.||...   .    .|.||| |.|.|   ||....|
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

-TQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VAD
  | |..  || ||.|||||||||.|||...||||||||||.|  | ..|||||..| . |
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIED
Kinase Erk2.AA MAPK-Unclassified 174-311 36 1.4e-58 200.98 In-house 397-575 (575) Show / Hide 
Range on Protein: 174-311
Range on HMM: 397-575/575
Sequence Identity: 36% (65 aa)

PDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN-----------RPIFPGKH--------------------YLDQLNHILGIL
.|  | . .|.||.||||||||||| .. |.. .||||.|||.|||...           ||.|||.                     . ||.. |.  |
NDCHHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYL

GSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADS----------KALDLLDKMLTFNPHKRIEVEQALAHPYL
|.| .||.| | . .|| |. |.  |. |..  |.. . .           ..|...||| ||| |||  .||| ||| 
GMPPEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase Erk2.AA TyrKc 23-306 20 3.1e-15 23.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-306
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

YTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRF--RHENIIGINDIIRAPTIEQM---KDVYIVQDLMET-DLYKLLKT
 | .  .||||.| |. .  .   . ||.|.. .       .  .||..|. ..  .|.||. .  ... .        . ..||  .|.  || . |. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRK

QH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPD------HDHTGF----LTEY-VATRWYRAPEIMLNSKGY
 .  |.... ..| .|| .|  |.|| |. ||||   | |..     ||.||||.|  . |      .|         . . .  ||. ||| .  .|  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECINYGKFT

TKSIDIWSVGCILAEMLSNRPIFPGK-----HYLDQLNHILGILGSPSQEDL----NCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTF
||| |.|| |  . |....    .          ... . .   . . | .                               |. . ..  ..  .   .
TKS-DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQIMKQCWHE

NPHKR---IEVEQAL
.|..|    |. . .
DPEDRPTFSEIHECF
Kinase Erk2.AA Pkinase_Tyr 23-175 29 2.7e-13 45.64 Pfam 1-164 (270) Show / Hide 
Range on Protein: 23-175
Range on HMM: 1-164/270
Sequence Identity: 29% (49 aa)

YTNLSYIGEGAYGMVCSAYDN----LNKVRVAIKKISPFEHQTY--CQRTLREIKILLRF-RHENIIGINDIIRAPTIEQMKD--VYIVQDLMET-DLYK
 | .  .||||.|.|. .. .     .|. ||.|.. .  ..     .  .||.||.  . .|.||.    ..     .| .   .|||  .|.  ||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT----DQGEPNQIYIVMEYMPHGDLLD

LLKTQ-----HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPD
 |...     .|.  ... . .|| .|. | .| |  ||||   | |.. .   |||||||||   .|
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYND