Gene ErbB2 (Mouse)

ErbB2

Species: Mouse
Alias: ErbB2, Erbb2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: EGFR

Sequence

Name Sequence Type Origin Length Description Download
ErbB2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
ErbB2.NA RNA Sugen 4998 None Fasta, JSON
ErbB2.AA Protein Sugen 1256 None Fasta, JSON

Protein domain

Protein domains of ErbB2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain ErbB2.AA Recep_L_domain 52-174 34 7.6e-40 135.68 Pfam 1-121 (121) Show / Hide 
Range on Protein: 52-174
Range on HMM: 1-121/121
Sequence Identity: 34% (46 aa)

GCQVVQGNLELTYLPAN----ASLSFLQDIQEVQGYMLIAHN--RVKHVPLQRLRIVRGTQLFED-KYALAVLDNRDPLDNVTTAAPGRTPEGLRELQLR
.|.|. ||||.|.   .      |||.. |.|. ||.||...   ..  ....|||.||.|||.| .|||...||..               ||.||...
NCTVIYGNLEITWRDEHNELEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNM--------------GLQELWMW

SLTEILK--GGVLIRGNP--QLCYQDM-VLWKDVL
.|..|.   ||| |  ||  .||| .  ..|.. .
NLKNITRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
Furin-like ErbB2.AA Furin-like 190-344 40 2.8e-75 247.43 Pfam 1-182 (182) Show / Hide 
Range on Protein: 190-344
Range on HMM: 1-182/182
Sequence Identity: 40% (74 aa)

SRACP--------PCAPTC------KDNH-CWGESPEDCQILTGTICTSGCA--RCKGRLPTDCCHEQCAAGCTGPK-HSDCLACLHFNHSGICELHCPA
.| ||        || | |      .... |||..|..||.|| ..|...|   ||.|. |..||||||..|||||. ..||.|| ||.|.|.|  .|| 
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPP

LITYNTDTFESMLNPEGRYTF-GASCV--TTCP-------YNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCAGVCY
...|| .||....||.|.|.| |. ||   .||       .||. ...|.|...||....|.. |..|. ||.|..||  |||
MMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKLSHNPDCNYYVIHNGECMRECPSGYTENE-ENNTMMCEPCEGPCPKVCY
FU ErbB2.AA FU 233-276 34 4.2e-09 37.47 SMART 1-48 (48) Show / Hide 
Range on Protein: 233-276
Range on HMM: 1-48/48
Sequence Identity: 34% (17 aa)

PTDC--CHEQCAAGCTGPKHSDCLACLHFNHS---GICELHCPALITYN
 . |  ||..|| ||.||.  .|..| |...    |.|   ||   .| 
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCP-PGYYP
FU ErbB2.AA FU 190-231 28 0.075298 4.34 SMART 1-48 (48) Show / Hide 
Range on Protein: 190-231
Range on HMM: 1-48/48
Sequence Identity: 28% (14 aa)

SRACPPCAPTCKDNHCWGESPEDCQ------ILTG-TICTSGCARCKGR
.. |.|| |.|.. .|||  |..|.       | .  .| | |     .
DGVCKPCHPECAT-GCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain ErbB2.AA Recep_L_domain 367-487 28 1.8e-31 107.57 Pfam 1-121 (121) Show / Hide 
Range on Protein: 367-487
Range on HMM: 1-121/121
Sequence Identity: 28% (37 aa)

GCKKIFGSLAFLPESFDGNPSSGVAPLKPEHLQVFETLEEITGYLYISAWPESFQDLSVFQNLRVIRGRILHDG-AYSLTLQGLG---IHSLGLRSLREL
.| .|.|.| ...... ..         .| | .|....||||||.|  .  ....||.|.|||.|||| |...  |.|         . .|....|...
NCTVIYGNLEITWRDEHNE--------LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNI

GS--GLALIHRNT--HLCFVNT-VPWDQLF
 .  |   ||.|    ||...| . |....
TRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
FU ErbB2.AA FU 502-551 30 1.2e-07 32.63 SMART 1-48 (48) Show / Hide 
Range on Protein: 502-551
Range on HMM: 1-48/48
Sequence Identity: 30% (16 aa)

EEACGLEGLVCNSLCARGHCWGPGPTQCVNCSQFLRGQE---CVEECRVWKGL
.  |      |.. ||  .||||||.||. |. .. ...   ||..|  .   
DGVC----KPCHPECAT-GCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Furin-like ErbB2.AA Furin-like 502-529 25 0.0692 6.8 Pfam 1-39 (182) Show / Hide 
Range on Protein: 502-529
Range on HMM: 1-39/182
Sequence Identity: 25% (10 aa)

EEACG----LEGLVCNSLC------ARGH-CWGPGPTQC
.. |.     .   |.. |       .|. ||||.| .|
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHC
FU ErbB2.AA FU 558-607 37 1.6e-10 42.2 SMART 1-48 (48) Show / Hide 
Range on Protein: 558-607
Range on HMM: 1-48/48
Sequence Identity: 37% (20 aa)

GKHCLPCHPECQPQNSSETCYGSEADQCEACAHYKDS---SSCVARCPSGVKP
...| ||||||       .|.|. .||| .|.|...    . ||. ||.|  |
DGVCKPCHPECAT-----GCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Furin-like ErbB2.AA Furin-like 577-602 37 1.916854 2.07 Pfam 73-99 (182) Show / Hide 
Range on Protein: 577-602
Range on HMM: 73-99/182
Sequence Identity: 37% (10 aa)

CYGSE-ADQCEACAHYKDSSSCVARCP
| |   .  | || |. ..  ||..||
CTGPNNDTDCVACRHFYHNGTCVDQCP
Kinase ErbB2.AA EGFR 721-978 80 3.4e-203 680.77 In-house 1-258 (258) Show / Hide 
Range on Protein: 721-978
Range on HMM: 1-258/258
Sequence Identity: 80% (207 aa)

LRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGS
|.|.||||||||||||||||||.|||||||||||||||.|.||||.|.||||||||.| .|...||||.|..|..|||||.||||||||.||.|....||
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIGS

QDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFG
|.||||||||||||.|||| |.||||||||||||||||||||||||||.||..||.||||.|||.||||||||.|..|..||||||||||||.|||||||
QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFG

AKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFS
.|||||||||||||||||||||||||||||||||.||||||||...||.|.||..||.
QKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase ErbB2.AA Pkinase_Tyr 721-977 43 3e-134 455.29 Pfam 1-270 (270) Show / Hide 
Range on Protein: 721-977
Range on HMM: 1-270/270
Sequence Identity: 43% (118 aa)

LRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKA--NKEILDEAYVMAGV-GSPYVSRLLGICL--TST--VQLVTQLMPYGCLLDHVRE
....|.||.||||.||||.| .|..| |||||.|.|.|......   .. . || .|      | . ||.|.|.       . .|. .||.|.|||. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---RGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETE-YHADGGKVPIKWMALESILRRRFTHQSDVWSY
|   ...|  .|||..|.||||||.|||. ...||||||||.||...|.|||.||||||..  |..  . ..|||.||||||.|.|  ..||..|||||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVTVWELMTFGAKP-YDGIPAREIPDLL-EKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEF
||. ||..|.|..| | |..  |. ... |.|.|.|.|. |. ..|..| .||. | | ||.|.|.....
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ErbB2.AA TyrKc 721-977 38 4.1e-129 436.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 721-977
Range on HMM: 1-280/280
Sequence Identity: 38% (113 aa)

LRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGV--GSPYVSRLLGICLT--------STVQLVTQLMPYGCLLDH
....|.||.||||.||||.|.       |.||.|.|.|..     .....|| .|  .    | . ||.|.|..          . .|. .||.|.|.|.
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

VREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDID------ETEYHAD---GGK--VPIKWMALESILRRR
 |.||..|  .|||..|.|||.||.||.. ...||||||||.||.....|||.||||.| .. |      .  |..    |||  .||.|||.|.|  ..
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FTHQSDVWSYGVTVWELMTFGAKPYDG-----IPAREIPDLLEKGERLPQPPI--------CTIDVYMIMVKCWMIDSECRPRFRELVSEF
||..|||||.||. ||..|.|..|| |     ....|.  ....|.|.||||         |. ..|.|| .||. | |.||.|.|....|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ErbB2.AA TK 721-977 22 6.2e-111 373.26 In-house 1-486 (486) Show / Hide 
Range on Protein: 721-977
Range on HMM: 1-486/486
Sequence Identity: 22% (112 aa)

LRKLKVLGSGAFG---TVYKGIWIPD---------------------GENVKIPVAIKVLRENTSPKANKEIL-------------DEAYVMAGVG----
.. .|.||.|.||   .||||.|...                     .|..|.|||.|.|.| ..  .. ...              || .|.       
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-SPYVSRLLGICLTST-------------VQLVTQLMPYGC----LLDHVREHRGR--------------------------------------------
  | . ||.|.|. .              . .|. .||.|.    |.|. |..|..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LGSQDLLNWCVQIAKGMSYLEEV------RLVHRDLAARNVLVKSPNH-----------VKITDFG---
                               |  ..|| .|.|||.||.||..       ..|||||||||.|| . |.           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLLDIDETEYHAD------------------------GGKVPIKWMALESIL---------RRRFTHQSDVWSYGVTVWELMTFGAKPYDG-I
     ||| .. |.  | ..                        |||.||.||| |...          ..||..|||||.||..||..|.|..|| | .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PA---------REIPDLLEKG--------------ERLPQPPICT--------------IDVYMIMVKCWMIDSECRPRFRELVSEF
.          .|. ..|..|               |.|||| |.               ..| .| .||  | | ||.|..|....
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ErbB2.AA Ack 721-977 37 4.5e-87 293.76 In-house 1-266 (266) Show / Hide 
Range on Protein: 721-977
Range on HMM: 1-266/266
Sequence Identity: 37% (101 aa)

LRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLREN--TSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTV-QLVTQLMPYGCLLDHVREHRG-
.. .. ||.| || | .| |     .  |.||.|.||    ..|..  . | |. .|     | . || |. |..   ..|| | | | |||  |.| . 
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRT

-RLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSP-NHVKITDFGLARLLDIDETEYHADGGK---VPIKWMALESILRRRFTHQSDVWSYGV
  .    |...|.|||.||.|||  |..||||||||.|. |. . ||| |||| | | . |  |   . .   ||. |.| |..  |.|.| ||||..||
AFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGV

TVWELMTFGAKPYDGIPAREIPDLLE-KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEF
| ||  ..| .|. | .. .|  ... .|||||.|. |  |.| .|..||  . . ||.| ...  .
TLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase ErbB2.AA UTK 721-977 31 7.1e-84 284.96 In-house 1-296 (296) Show / Hide 
Range on Protein: 721-977
Range on HMM: 1-296/296
Sequence Identity: 31% (93 aa)

LRKLKVLGSGAFGTVYKGIWIPDGENVKI-PVAIKVLR-ENTSPKANK---EILDEAY---VMAGVG-SPYVSRLLGICLTST-VQLVTQLMPYGCLLDH
.. .. ||.||||.|.|. . .. | ..   ||.||.. . .....     ... ||    .|. .   |.| ||.|.|. .    .|| .|. | |.. 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

VREHRGRLG-------SQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSP-------NHVKITDFG---LARLLD---------IDETEYHADGGK
.| ||  ..       . ..| ....|| ||.||.. ..|||||||||.|| .        . .|| |||   ..|..           .. ..... ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

VPIKWMALESILRR-RFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKG--ERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEF
.||.||| |..  . |||..|||||.||..||..|.|..|| |. ....   ...|   |.|.|. |  .||..|..||. | . ||.|..||...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ErbB2.AA TK-Unique 721-977 32 1.2e-83 284.18 In-house 1-294 (294) Show / Hide 
Range on Protein: 721-977
Range on HMM: 1-294/294
Sequence Identity: 32% (96 aa)

LRKLKVLGSGAFGTVYKGIWIPDG--ENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVG-SPYVSRLLGICLTST--VQLVTQLMPYGCLLDHVREHR
|. ..|.|.||||.|..|   ..   .. .. ||.| |..| ..   .. |.|. .|  .|  |.. ..||.| .|.  ....   .|.|.|... |. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GR-------------------------LGSQDLLNWCVQIAKGMSYLEE--VRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADG--GKVP
.                          . ..||.....|||.||.||..   . |||||.|||||. . . .||.|||.|| ..  ...|   .  |..|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRIP

IKWMALESIL--RRRF-THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPIC-TIDVYMIMVKCWMIDSECRPRFRELVSEF
|.|||.||..  .. . | .|||||.||. ||..|.|| || |.|...| .....| |.|||. | . ..| .|  ||  . | || ||......
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ErbB2.AA Syk 721-971 38 5.4e-83 282.04 In-house 1-257 (257) Show / Hide 
Range on Protein: 721-971
Range on HMM: 1-257/257
Sequence Identity: 38% (99 aa)

LRKLKVLGSGAFGTVYKGIWIPD---GENVKIPVAIKVLRENTSPKA-NKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRG
| . . .|.| ||.| ||        || . |.||||.|..  . .|  .|.. || ||..   |.. |..|||.     .|  . . | ...   .|| 
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

RLGS-QDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHAD-GGKVPIKWMALESILRRRFTHQSDVWSYGVTVW
      .|  |  |.| || ||||   |||||||||||       || |||. . |  |...| |  .|| |.|| | |.|  . | |.|||||.||| |
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMW

ELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFR
|    |.||| ..   |. ...|.|.|...|. |  ..| .| |||  . . || | 
EMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase ErbB2.AA Src 721-977 39 5.4e-83 281.81 In-house 1-255 (255) Show / Hide 
Range on Protein: 721-977
Range on HMM: 1-255/255
Sequence Identity: 39% (103 aa)

LRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTS-TVQLVTQLMPYGCLLDHVR-EHRGR-
.. .. ||.| || |..|.|     | ...||.|.|.. |   ...  | || .|  .  . . .|. .| .   .  || .|  |.|||  . . .|| 
IKLCRKLGQGQFGEVWMGYW-----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

LGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEY-HADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
|  ..|.    |.|.||.|||. ...|||||||||||   | .|. |||||||.. |. ||    | |.||||.| | |...|||  |||||.|.  .|.
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYM-IMVKCWMIDSECRPRFRELVSEF
.|.|  || |   .|  . .|.| |.|.|. |   .|. || .||  | | || |  | . .
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ErbB2.AA FAK 721-982 35 5.2e-80 267.77 In-house 1-285 (285) Show / Hide 
Range on Protein: 721-982
Range on HMM: 1-285/285
Sequence Identity: 35% (102 aa)

LRKLKVLGSGAFGTVYKGIWIPDGE-----------------------NVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQL
    ...| | || ||.|...                             || ||||  ......    . . |||.|     | . .|.|||    . .
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWI

VTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHAD-GGKVPIKWMALESIL
.  |..|| |    . .. .|    |. .| |... |.|||  . |||| ||||||| ||. ||  |||| |... |.. |.|   || |||||. ||| 
IMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMH-DHSYYKASPKGKLPIKWMSPESIN

RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMAR
 ||||  |||| .|| .|| . .| ||. ..   ..   .|.||||| || |    | .| .||  |   ||||.||. . . .  
FRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase ErbB2.AA Abl 721-977 41 5.4e-70 232.56 In-house 1-252 (252) Show / Hide 
Range on Protein: 721-977
Range on HMM: 1-252/252
Sequence Identity: 41% (107 aa)

LRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGIC-LTSTVQLVTQLMPYGCLLDHVRE-HRGRL
.   . || | .| ||.|.|       .  ||.| |.|.|   . .| | || .|  .  | . .|||.|   .   ..|  |.|| |||..||  |  |
IMMKHKLGGGQYGEVYEGVW----KRHDCTVAVKTLKEDT--MEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREEL

GSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMT
 .  ||    ||| ||||||.   .|||||||| ||   . ||. ||||||..  |    || | | |||| | ||.   .|  .|||| .|| .||. |
PAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHA-GAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIAT

FGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEF
.|  || ||   .. ..|||| |. .|. |  .|| .| .||  .   ||.|.|.  ..
YGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase ErbB2.AA RTKB 721-977 37 9.1e-70 234.37 In-house 1-264 (264) Show / Hide 
Range on Protein: 721-977
Range on HMM: 1-264/264
Sequence Identity: 37% (99 aa)

LRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS-PYVSRLLGICLTSTVQLV-TQLMPYGCLLDHVREHRGR-
..  . ||.|||| |...     . | .  .| |||.   |  .  ....|  ||  .|  | |  ..| ||  . ...   |  .| | |  |. |.  
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQ

-----LGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQS-DVWSYGV
     | .. |.  | |||.||..|.    .||||.|||||| .  | || |||.|| .| .. |  ..  . |||||| ||. .|..| .| ||||.||
HNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCT--RLPIKWMAPESWAHRIYTTKSGDVWSFGV

TVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEF
| ||  ..|. ||   . ..| ..||.| |||.|      .. || .||... . || | |||..|
TMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase ErbB2.AA S_TKc 721-978 21 9.1e-45 155.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 721-978
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)

LRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPY--GCLLDHVREHRGR-
 ..|...|.||||.|||....      .  ||||...        . |. |  ..   . |.. .|.... .. . .|. ...   | |.|. ...... 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH-QSDVWSYGVT
    .   .   .. ||.... |. . . .||||   |.|. .  |.||.||||||.|         .   .   .|| | .    ...  .|.|| |..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

VWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVS--------EFS
..|... |  |..     ..  ...|          . ..  .. ||.  | | ||   |.          .. 
LYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ErbB2.AA Pkinase 721-977 20 3.7e-39 139.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 721-977
Range on HMM: 1-293/293
Sequence Identity: 20% (62 aa)

LRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILD----EAYVMAGVGSPYVSRLLGICL-TSTVQLVTQLMPYG----CLLDHV
.......|||.||.|||.... .|.     ||.|...   . | .|.. .    |...|. ...|.. ||....   . . .|. ... |     | |..
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

R-EHRGRL--GSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHV----KITDFGLARLLDIDETEYHADGGKVPIKWMALESIL-RRRFTHQ
. . .|..    ... ... ||..|. |. . . .||||   |.|... .|.    ||.|||||...|       ...  . . .|| | |. ..  .. 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVWSYGVTVWELMTFGAKPYDGI----PAREIPDLLEKGER----LPQPPICT-------------------IDVYMIMVKCWMIDSECRPRFRELVSE
.|.||.|....|... |  |..|     . ..   ....  .     . |  |.                    .   .. .|.  | ..|| .....  
VDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--F
  |
PWF