Gene EphB4 (Mouse)

EphB4

Species: Mouse
Alias: Ephb4, EphB4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphB4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON
EphB4.NA RNA Sugen 3741 None Fasta, JSON
EphB4.AA Protein Sugen 987 None Fasta, JSON

Protein domain

Protein domains of EphB4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphB4.AA Ephrin_lbd 17-197 47 2.6e-116 362.7 Pfam 1-190 (190) Show / Hide 
Range on Protein: 17-197
Range on HMM: 1-190/190
Sequence Identity: 47% (92 aa)

EETLLNTKLETADLKWVTYPQAEG--------QWEELSGLDEEQHSVRTYEVC-DMKRPGGQAHWLRTGWVPRRGAVHVYATIRFTMMECLSLPRASRSC
|..|..|| .|.||.| |||.  |        ||||.||.||.....|||.|| .. . ..| .||||.|..|||| ..| ...|||..| |.|.....|
EVVLMDTKTATSDLGWTTYPYN-GRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNV-MEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTC

KETFTVFYYESEA-DTATAHTPAWMENPYIKVDTVAAEHL-TRKRPGAEATGKVNIKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKC
||||...||||.. |.|....|.||||.|.|.||.||... ...|.  ... |.| .....|||||.|||||||||||||||.|.. .||||
KETFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphB4.AA EPH_lbd 17-197 54 2.7e-108 366.99 SMART 1-184 (184) Show / Hide 
Range on Protein: 17-197
Range on HMM: 1-184/184
Sequence Identity: 54% (101 aa)

EETLLNTKLETADLKWVTYPQAEGQWEELSGLDEEQHSVRTYEVCDMKR---PGGQAHWLRTGWVPRRGAVHVYATIRFTMMECLSLPRASR-SCKETFT
|..|..|| ||..|.|.|||. .|.|||.||.||.....|||.||.. .   |. | .||||.|..|||| ..|  ..|||..| |.|.. . ||||||.
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPN-QNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFN

VFYYESEADTATAHTPAWMENPYIKVDTVAAEHLTRKRP-GAEATGKVNIKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKC
..||||..|.||||||.||||||||.||.||......|  |...  |.| .....|||||.|||||||||||||||.|...|||||
LYYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRV-MKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 EphB4.AA GCC2_GCC3 258-293 29 1.7e-09 33.88 Pfam 1-37 (49) Show / Hide 
Range on Protein: 258-293
Range on HMM: 1-37/49
Sequence Identity: 29% (11 aa)

GYEAAESNKVCRACGQGTFKPQIGDESCLPCPAN-SH
|.    ... | .|. ||.....|  ||.|||.. ..
GTYYNKGQNPCEPCPRGTYQNEEGQDSCIPCPPGKTT
FN3 EphB4.AA FN3 324-413 14 9.2e-09 36.36 SMART 1-69 (69) Show / Hide 
Range on Protein: 324-413
Range on HMM: 1-69/69
Sequence Identity: 14% (16 aa)

PSAPRS----VVHHLNGS------TLRLEWSAPLESGGREDLTYAVRCRECRPGGSCLPCGGDMTFDPGPRDLVEPWVAIRGLRPD----VTYTFEVAAL
|..|.     .|.. . .      ...|.|..|            |..|                            . ..||.|.     .|.| |.| 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----------IVGYR----------------------------YTVTGLKPGQYPWTEYEFRVRAV

----NGVS
    .| .
NGNDAGEG
FN3 EphB4.AA FN3 434-516 22 5.8e-13 50.32 SMART 1-69 (69) Show / Hide 
Range on Protein: 434-516
Range on HMM: 1-69/69
Sequence Identity: 22% (22 aa)

PPAVSD---IRVTRSSPS------SLILSWAIPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRG----ASYLVQVRARSE--AGYG
|.....   .|||  ...      |. |||  |          .| |.                   . ..||| |      | ..|||...  ||.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------IVGYR-------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphB4.AA Eph 615-874 81 1.1e-216 726.1 In-house 1-264 (264) Show / Hide 
Range on Protein: 615-874
Range on HMM: 1-264/264
Sequence Identity: 81% (215 aa)

VKIEEVIGAGEFGEVCRGRLKAP-GKKES---CVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDG
.|||.|||||||||||.||||.| ||.|    .||||||| ||||.||..|||||||||||.|||||||||||| | ||||.||.||||.|||||| .||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSS-DPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIV
||||||||||||||||||.||..|.||||||||||||||||||||||||||||.||...| ..|||.. |||||||||||||||.||||||||.||||||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGIV

MWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSAL
||||||.||||||||||||||.||||.||||||.|||..|||||||||||||| ||.| |.||.|
MWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphB4.AA Pkinase_Tyr 615-874 42 3e-142 482.4 Pfam 1-270 (270) Show / Hide 
Range on Protein: 615-874
Range on HMM: 1-270/270
Sequence Identity: 42% (115 aa)

VKIEEVIGAGEFGEVCRGRLK-APGKKESCVAIKTLKGGYTERQ--RREFLSEASIMGQF-EHPNIIRLEGVVT-NSVP--VMILTEFMENGALDSFLRL
... ...|.|.||||..|..|  |....  ||.|.|| |....|  |..|..||.|| |.  ||||.|| ||.|  . |  ..| .|.|..| |...|| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTY-TSSLGGKIPIRWTAPEAIAFRKFTSASDA
.   ....|. .|..| . ||.|| ||... ..||||||||.||..|.|.|..||||.| .    .| .| ... |||.||.|.|||.|...|||..|| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSYGIVMWEVMSFGERP-YWDMSNQDVINAI-EQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSAL
||.|..|||....|| | |..|||..|...| |. ||.|.|..||  ...||..||..| . ||.| .... |
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphB4.AA TyrKc 615-874 38 1.6e-132 447.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 615-874
Range on HMM: 1-280/280
Sequence Identity: 38% (112 aa)

VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQF--EHPNIIRLEGVVTNS-------VPVMILTEFMENGALDSFL
.. ....| |.||||..|..|        ||.|.|| .     |..|..||.|| ..  .||||.|| ||.| .        |.||..|.|..|.|...|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEEN----SSDPTYTSSL--GGK--IPIRWTAPEAIAFRKF
| . ..... .|. .   ||.||.||... ..||||||||.||..|...|.|||||||....      |. .|...   |||  .||||.|||.| ..||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TSASDAWSYGIVMWEVMSFGERPYWD-----MSNQDVINAIEQDYRLPPPPD--------CPTSLHQLMLDCWQKDRNARPRFPQVVSAL
|..|| ||.|..|||....|. ||..     ||||.||. ..| ||.|.||.        ||. ..|.|..||. | . ||.| .... .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphB4.AA TK 615-874 24 1.6e-122 412.78 In-house 1-486 (486) Show / Hide 
Range on Protein: 615-874
Range on HMM: 1-486/486
Sequence Identity: 24% (117 aa)

VKIEEVIGAGEFG---EVCRGRLKAPG----------------------KKESCVAIKTLKGGYTERQRR-------------EFLSEASIMGQFE----
.......|.|.||   ||..|... ..                      ...  ||.|.|| | .. |..             .||.||..| ..     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIIRLEGVVTNSVP------------VMILTEFMENGA----LDSFLRLNDG---------------------------------------------
 ||||.|| ||.| ..|            .||..|.|..|     |...|| ...                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QFTVIQLVGMLRGIASGMRYLAEM------SYVHRDLAARNILVNSNLV-----------CKVSDFGLSR
                              |.|. ||. | . ||.||.||...       .|||||||||.||..|.|           ||..||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----FLEENSSDPTYTSSL------------------------GGKIPIRWTAPEAIA---------FRKFTSASDAWSYGIVMWEVMSFG-ERPYWDM
        .  ||  |...                         |||.||||.|||...         ..|||..|| ||.|..|||....| | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------QDVINAIEQD--------------YRLPPPPDCP--------------TSLHQLMLDCWQKDRNARPRFPQVVSAL
||         |.|.. ...               .|.|.||.||              . ...||..||..| . ||.| |....|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphB4.AA UTK 615-874 36 3.8e-112 378.86 In-house 1-296 (296) Show / Hide 
Range on Protein: 615-874
Range on HMM: 1-296/296
Sequence Identity: 36% (109 aa)

VKIEEVIGAGEFGEVCRGRLKAPG--KKESCVAIKTLK-GGYTERQRR---EFLSEAS---IMGQFE-HPNIIRLEGVVTNSVPVMILTEFMENGALDSF
|.. . .|.|.||||...|.. .    .|. ||.|... .. ......   .|. ||    .|.||. |||..|| ||.|.. | ||.||.|||| |.|.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR---L----NDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSN-------LVCKVSDFG---LSRFLEE------NSSDPTYTSSLGGK
||        .. ..|  |...| . ||.|| ||... .|||||||||.||...       .|||..|||   .|| .         .... |...  ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTAPEAIAFR-KFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQD--YRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSAL
.||||.||||.. . .||..|| ||.|.|.||....| .|| .|||..|. ...    ||.|.|.||| .. .||..||..|   ||.|...|...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphB4.AA Src 615-874 41 3.3e-100 339.22 In-house 1-255 (255) Show / Hide 
Range on Protein: 615-874
Range on HMM: 1-255/255
Sequence Identity: 41% (110 aa)

VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLR-LNDGQ-F
.| .. .|.| ||||  |      ...  ||.|||| |    .   || || || .. |.....|  |..   |. | ||.|..| |  .|.   .|.  
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

TVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWE
 . ||. |   .|.|| || .| |.||||||||.||. |.|||| |||| | ..|.  |  |... | |.||.||||||| ...||  || ||.|| ..|
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED--DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

VMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQ-LMLDCWQKDRNARPRFPQVVSAL
....|  ||  |.|..|. ..|. ||.| |. || .|.. .|| ||.||   || |    . |
IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphB4.AA SFK-Src 615-878 40 2.8e-99 294.88 In-house 1-259 (259) Show / Hide 
Range on Protein: 615-878
Range on HMM: 1-259/259
Sequence Identity: 40% (109 aa)

VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLRL-NDGQFT
.. |.  |.| ||.| .||      .   ||.|||| | .  .  |||.|| .| .  ||| |.|  | |   |. | || | .| |  .|.  .    .
IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

VIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEV
. ||| |   .|.|| || .  .|||||||||.||  | |||| |||.|| |....    ||   | | ||.||||||    .|   || ||.|| | |.
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDE--GYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEI

MSFGERPYWDMSNQDVINAIEQ--DYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMI
  .|  ||  |.|. |.  ...   ||.| || ||  ....|.||||.    || |      ..   
VTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphB4.AA Fer 615-875 32 2e-95 323.32 In-house 1-283 (283) Show / Hide 
Range on Protein: 615-875
Range on HMM: 1-283/283
Sequence Identity: 32% (94 aa)

VKIEEVIGAGEFGEVCRGR-----LKAPGKKESCVAIKTLKG---GYTERQRREFLSEASIMGQ-FEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFL
|......| | ||||..||     .|. .     ||.|. |    . |. |..||. || || . . |||.... || .   |.||. ||. .|.|||.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RLNDGQ-FTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS-NLVCK--VSDFGLSRFLEENSSDPTYTSSLG---GKIPIRWTAPEAIAFRKFT
. |...  .. ... |. ..|.||.|| ..  .|||.||||.|.   ....|  .||||.|| ....    .|.....    |.||||.|||.. .. ..
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDY----GYDYKMKEKACKVPIRWLAPETWQTGIYS

SASDAWSYGIVMWEVMSFGERPYWD----MSNQDV----INAIEQ-DYRLPPPPDCPTSLHQLML-DCWQKDRNARPRFPQVVSALD
...| ||.|...||... |. || .    | .  |    . .|.. .|..|.|. .|. . |.|. .||||| . || . ...  | 
PKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphB4.AA TK-Unique 615-874 34 2.5e-88 299.74 In-house 1-294 (294) Show / Hide 
Range on Protein: 615-874
Range on HMM: 1-294/294
Sequence Identity: 34% (101 aa)

VKIEEVIGAGEFGEVCRGRLKAPG---KKESCVAIKTLKGGYTERQRREFLSEASIMGQFE-HPNIIRLEGVVTNSV-PVMILTEFMENGALDSFLRLND
.....||| |.||.|.|| .. .     | .|||.|.|| . |. ....||.|...| .   ||||....|. | |  |.||. |....| |...|| . 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-GQFTV---------------------IQ---LVGMLRGIASGMRYLAE--MSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLG-GK
 .....                     |.   |.  . .||.|| |||.  .  |||||.|||.|.....|||..|||..| ..    .  | .. . |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT---NGVYSMMCSQGR

IPIRWTAPEAIA--FRKF-TSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDC-PTSLHQLMLDCWQKDRNARPRFPQVVSAL
||||| |||..    . . |. || ||.|..|||....|..|| .|.. |....|.. ||.| |. | .  ...||  |||...  || | |... |
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphB4.AA Frk 615-878 40 1.5e-83 283.84 In-house 1-260 (260) Show / Hide 
Range on Protein: 615-878
Range on HMM: 1-260/260
Sequence Identity: 40% (108 aa)

VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLR---LNDGQ
...   .|.| ||||  |.       .  ||.|||| |  . .  .|| || || .  || .|.|  | |   |..|.|| |..|.|  .|.    .  |
IQLIRRLGSGQFGEVWEGLWNN----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

FTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMW
  . ||| |   .|.|| || .. |.||||||||.||. ...||. |||| | |  .  |  | |  | ..||.||||||.   |||  || ||.||.. 
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNED-IYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT

EVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMI
|.. .|  ||  | |..|.. ....||.| ||.||  | ..||.||..| . || |  .   |.. .
EIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphB4.AA SrcB 615-875 42 3.6e-82 277.76 In-house 1-251 (251) Show / Hide 
Range on Protein: 615-875
Range on HMM: 1-251/251
Sequence Identity: 42% (111 aa)

VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDG-QFT
.|... .||| ||||  |      ...  ||.||.| |    .   || || .| .  |  ..||  |||   |. |.||.|..|.|  ||. ..| . .
LKLVKKLGAGQFGEVWMGYY----NNHMKVAVKTMKQGTMSPE--AFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLS

VIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEV
. .|. |   || || |. .| |.|||| | ||||   |.||. |||| | .|.|     ||   | | ||.||||||| |  ||  || ||.||.. |.
LPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDN----EYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEI

MSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALD
. .|  ||  |.| .||...|. ||.| |  ||  | ..|  ||..    || |  . | ||
VTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase EphB4.AA Tec 615-876 36 3.4e-81 276.04 In-house 1-254 (254) Show / Hide 
Range on Protein: 615-876
Range on HMM: 1-254/254
Sequence Identity: 36% (98 aa)

VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK-GGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFT
 .. . .| | || | .|....    .  ||||..| |   |    .|. || .|    ||. ..| || .   |. | ||.||.| | ..|| . ..| 
LTFMKELGSGQFGVVHLGKWRH----QYDVAIKMIKEGSMSE---EDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQ

VIQ--LVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMW
  .  | .|   .  || || . ...|||||||| ||... | ||||||..|.      |  |||| | | |..| .||   . .. | || |..|. ||
KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYV----LDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMW

EVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDK
|| | |  ||  ||| .|. .. | .||  |  |.... | | .||.     || | |  ... .
EVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase EphB4.AA S_TKc 615-878 21 1.2e-46 162.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 615-878
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMEN--GALDSFLRLNDGQ-
 .| ..|| | ||.|...| |        |||| .|        . ...| .|. .  ||||..| .|  .   . . .|....  | | .... . .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTS-ASDAWSY
    |.  .   ... |.... |. ..  .||||   |||...  . |..||||.|.|                    . ||| .   ...  ..| || 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVS-----ALDKMI
|....| .. |. |..    | ... |            . .. ...  |.||| . ||   ..       ...  .
GCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphB4.AA Pkinase 615-874 23 5.8e-42 149.46 Pfam 1-293 (293) Show / Hide 
Range on Protein: 615-874
Range on HMM: 1-293/293
Sequence Identity: 23% (70 aa)

VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTER-QRREFLS--EASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENG----ALDSFLR-
 .|...||.| ||.|.... |  ||    ||.|..|   ..  .... .   |..||  . ||||.|| ......  . . .|..|.|     | .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

LNDGQF--TVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVC----KVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIA-FRKFTS
 ..| |  .  ..  ... |..|. |. .|. .||||   |||...| ..    |..||||..... . ... .|.  |    ... ||| |   .. ..
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGT---PWYMAPEVIRGGQYYGP

ASDAWSYGIVMWEVMSFGERPYWDM----SNQDVINAIEQDYRLPPPPDCP-----------------------TSLHQLMLDCWQKDRNARPRFPQVVS
..| ||.|....|... |. |...     .  | .  |... . |.. |.|                        .. ... .|..|| . || ..|.. 
KVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

A--L
   .
HPWF
SAM_1 EphB4.AA SAM_1 905-969 42 4.1e-29 106.05 Pfam 1-66 (66) Show / Hide 
Range on Protein: 905-969
Range on HMM: 1-66/66
Sequence Identity: 42% (28 aa)

HYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFEVVSQISAEDLLR-IGVTLAGHQKKILASVQHMK
.| .| .|.|||..|.|..|...|..||. ... ..|...|||.. .||||.||.|||. |.|..|
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
SAM_2 EphB4.AA SAM_2 904-969 39 3e-25 89.47 Pfam 1-71 (71) Show / Hide 
Range on Protein: 904-969
Range on HMM: 1-71/71
Sequence Identity: 39% (28 aa)

PHYSAFGSVGEWLRAIKM-GRYEESFAAAGFGSFEVV-SQISAEDL--L-RIGVTLAGHQKKILASVQHMK
.||..| .|.||||.|.| ..|...| ..|. .||..  .....||    |.|.|..||.|||. ..| ||
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
SAM EphB4.AA SAM 904-971 35 9.1e-24 86.2 SMART 1-67 (67) Show / Hide 
Range on Protein: 904-971
Range on HMM: 1-67/67
Sequence Identity: 35% (24 aa)

PHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFEVVSQISAEDLLRIGVTLAGHQKKILASVQHMKSQ
..   . .|..||..|.|..|.. |...|. ... ....| |||...|.|..||.|||| ..| ||.|
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
Sam7 EphB4.AA sam7 907-969 31 4.8e-23 79.73 In-house 1-70 (70) Show / Hide 
Range on Protein: 907-969
Range on HMM: 1-70/70
Sequence Identity: 31% (22 aa)

SAFGSVGEWLRAIKM---GRYEESFAAAGF----GSFEVVSQISAEDLLRIGVTLAGHQKKILASVQHMK
  | .|.|||..|.|   ..|...| ..|.     ..... ... |||...|.|. ||.|||. ..|.|.
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR