Gene EphB3 (Mouse)

EphB3

Species: Mouse
Alias: EphB3, Ephb3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphB3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
EphB3.NA RNA Sugen 4145 None Fasta, JSON
EphB3.AA Protein Sugen 993 None Fasta, JSON

Protein domain

Protein domains of EphB3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphB3.AA Ephrin_lbd 31-204 62 6.5e-137 426.84 Pfam 1-190 (190) Show / Hide 
Range on Protein: 31-204
Range on HMM: 1-190/190
Sequence Identity: 62% (119 aa)

EETLMDTKWVTSELAWTSHPESG---------WEEVSGYDEAMNPIRTYQVC-NVRESSQNNWLRTGFIWRREVQRVYVELKFTVRDCNSIPNIPGSCKE
|..|||||..||.| ||..| .|         ||||||.|| ..|||||||| ||.|..|||||||..|.||. ||.|||||||.|||||.|. .|.|||
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCKE

TFNLFYYEADS-DVASASSPFWMENPYVKVDTIAPDES-FSRLDAG----RVNTKVRSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKC
||||.|||.|. | |....|.||||.|.|.||||.||| |...| |    ..||.|||.|||||.|||||||||||||.|.||| .||||
TFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphB3.AA EPH_lbd 31-204 68 2.7e-128 433.44 SMART 1-184 (184) Show / Hide 
Range on Protein: 31-204
Range on HMM: 1-184/184
Sequence Identity: 68% (126 aa)

EETLMDTKWVTSELAWTSHPESG--WEEVSGYDEAMNPIRTYQVCNVRE---SSQNNWLRTGFIWRREVQRVYVELKFTVRDCNSIPNIPG-SCKETFNL
|..|||||..|.|| ||..|..|  ||||||.|| .|||||||||||.|   ..|||||||..|.||..||.|||||||.|||||.|. .| ||||||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

FYYEADSDVASASSPFWMENPYVKVDTIAPDESFSRLDAG----RVNTKVRSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKC
.|||.|.|.|.|..||||||||.|.||||.||||.. | |    ..||.|||||||||.|||||||||||||.|.||| |||||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 EphB3.AA GCC2_GCC3 266-308 31 3e-06 23.42 Pfam 1-44 (49) Show / Hide 
Range on Protein: 266-308
Range on HMM: 1-44/49
Sequence Identity: 31% (14 aa)

GHEPAAKESQCRACPPGSYKAKQGEGPCLPCPPN-SRTTSPAAS
|.   .  . | .|| |.|. . | . |.||||. . | .|...
GTYYNKGQNPCEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGST
FN3 EphB3.AA FN3 332-430 17 4.5e-11 44.02 SMART 1-69 (69) Show / Hide 
Range on Protein: 332-430
Range on HMM: 1-69/69
Sequence Identity: 17% (20 aa)

PSPPRG----VISNVNET------SLILEWSEPRDLGGRDDLLYNVICKKCRGSSGAGGPATCSRCDDNVEFVPRQLGLTERRVHISHLLAH----TRYT
|.||..    ....|..|      |. |.|..|                                    |...          . ...| ..    |.|.
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----------------------------------IVGYR----------YTVTGLKPGQYPWTEYE

FEVQAVNG-VSGKS
| |.||||   | .
FRVRAVNGNDAGEG
FN3 EphB3.AA FN3 448-527 23 1.4e-14 55.65 SMART 1-69 (69) Show / Hide 
Range on Protein: 448-527
Range on HMM: 1-69/69
Sequence Identity: 23% (22 aa)

PSEVPT---LHLHSSSGS------SLTLSWAPPERPNGVILDYEMKYFEKSKGIASTVTSQKNSVQLDGLQPD----ARYVVQVRARTV--AGYG
|. .|    |.... . .      |.|||| ||      |. |.                    . ..||.|.     .|...|||..   ||.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphB3.AA Eph 628-887 85 8.10000000001e-224 749.84 In-house 1-264 (264) Show / Hide 
Range on Protein: 628-887
Range on HMM: 1-264/264
Sequence Identity: 85% (227 aa)

VKIEEVIGAGEFGEVCRGRLKLP-GRREV---FVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDG
.|||.|||||||||||.|||||| |.|||   .|||||||.||||.||.||||||||||||||||||||||||||||||||.||.|||..|||||| .||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPS-DPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIV
|||||||||||||||.||||||.||||||||||||||||||||||||||||||.|||||| ..|||.. |||||||||||||||||||||||||||||||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGIV

MWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTL
|||||||||||||||||||||.|.||.||||||||||.|||||||||| .||| ||.|.|||..|
MWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphB3.AA Pkinase_Tyr 628-887 43 2.3e-144 489.58 Pfam 1-270 (270) Show / Hide 
Range on Protein: 628-887
Range on HMM: 1-270/270
Sequence Identity: 43% (120 aa)

VKIEEVIGAGEFGEVCRGRLK-LPGRREVFVAIKTLKVGYTERQ--RRDFLSEASIMGQF-DHPNIIRLEGVVT-KSRP--VMILTEFMENCALDSFLRL
... ...|.|.||||..|..| .|.  .. ||.|.|| |....|  |.||..||.|| |. .||||.|| ||.| ...|  ..| .|.|..  |...|| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---DGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTY-TSSLGGKIPIRWTAPEAIAYRKFTSASDV
.   ....|. .|..| . ||.|| ||...|..||||||||.||..|.|.|..||||.| .    .| .| ... |||.||.|.|||.|.|.|||..|||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSYGIVMWEVMSYGERP-YWDMSNQDVINAV-EQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTL
||.|..|||...||| | |..|||..|.... |. ||.|.|..||  ...||..||  | . || ||.|.. |
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphB3.AA TyrKc 628-887 41 4.1e-137 462.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 628-887
Range on HMM: 1-280/280
Sequence Identity: 41% (120 aa)

VKIEEVIGAGEFGEVCRGRLKLPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQF--DHPNIIRLEGVVTKS-------RPVMILTEFMENCALDSFL
.. ....| |.||||..|..|      . ||.|.|| .     |.||..||.|| ..  .||||.|| ||.|..        |.||..|.|.. .|...|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDD----PSDPTYTSSL--GGK--IPIRWTAPEAIAYRKF
| . ..... .|. .   ||.|| ||...|..||||||||.||..|...|.|||||||...||     |. .|...   |||  .||||.|||.| |.||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TSASDVWSYGIVMWEVMSYGERPYWD-----MSNQDVINAVEQDYRLPPPMD--------CPTALHQLMLDCWVRDRNLRPKFSQIVNTL
|..|||||.|..|||...||. ||..     ||||.||. |.| ||.|.| .        ||....|.|..|| .| . || ||.|.  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphB3.AA TK 628-887 25 1.2e-123 416.64 In-house 1-486 (486) Show / Hide 
Range on Protein: 628-887
Range on HMM: 1-486/486
Sequence Identity: 25% (124 aa)

VKIEEVIGAGEFG---EVCRGRLKL--PGRREVF--------------------VAIKTLKVGYTERQRR-------------DFLSEASIMGQFD----
.......|.|.||   ||..|...   |.. ..|                    ||.|.|| | .. |..             |||.||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIIRLEGVVTKS------------RPVMILTEFMENCA----LDSFLRLNDG---------------------------------------------
 ||||.|| ||.|..            .|.||..|.|..      |...|| ...                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QFTVIQLVGMLRGIAAGMKYLSEM------NYVHRDLAARNILVNSNLV-----------CKVSDFGLSR
                              |.|. ||. | . ||.|| ||...      |.|||||||||.||..|.|           ||..||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----FLEDDPSDPTYTSSL------------------------GGKIPIRWTAPEAIA---------YRKFTSASDVWSYGIVMWEVMSYG-ERPYWDM
        |..||  |...                         |||.||||.|||...         |.|||..|||||.|..|||...|| | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------QDVINAVEQD--------------YRLPPPMDCP--------------TALHQLMLDCWVRDRNLRPKFSQIVNTL
||         |.|.. ...               .|.|.|..||              .....||..|| .| . || |||... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphB3.AA UTK 628-887 37 4.8e-110 371.88 In-house 1-296 (296) Show / Hide 
Range on Protein: 628-887
Range on HMM: 1-296/296
Sequence Identity: 37% (111 aa)

VKIEEVIGAGEFGEVCRGRLKLPG--RREVFVAIKTLKVGYT-ERQRR---DFLSEAS---IMGQFD-HPNIIRLEGVVTKSRPVMILTEFMENCALDSF
|.. . .|.|.||||...|.. .   . |. ||.|..... . .....   ||. ||    .|.||. |||..|| ||.|.. | ||.||.|||  |.|.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR---L----NDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSN-------LVCKVSDFG---LSRFLED------DPSDPTYTSSLGGK
||        .. ..|  |...| . ||.|| ||.....|||||||||.||...       .|||..|||   .|| . .      . ... |...  ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTAPEAIAYR-KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQD--YRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTL
.||||.||||.... .||..|||||.|.|.||....| .|| .|||..|. .|.    ||.|.| ||| .. .||..||  |   || | ..| ..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphB3.AA Src 628-887 42 5.8e-105 355.0 In-house 1-255 (255) Show / Hide 
Range on Protein: 628-887
Range on HMM: 1-255/255
Sequence Identity: 42% (113 aa)

VKIEEVIGAGEFGEVCRGRLKLPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLR-LNDGQ-F
.| .. .|.| ||||  |  .     .. ||.|||| |    .  .|| || || ...|.....|  |...  |. | ||.|..  |  .|.   .|.  
IKLCRKLGQGQFGEVWMGYWN----GNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

TVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWE
 . ||. |   .|.||.||..|||.||||||||.||. |.|||| |||| | ...|  |  |... | |.||.||||||| |..||  |||||.|| ..|
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED--DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

VMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQ-LMLDCWVRDRNLRPKFSQIVNTL
...||  ||  |.|..|. .||. ||.| |. ||  |.. .|| || .|   || |  . . |
IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphB3.AA SFK-Src 628-891 41 5.6e-99 293.98 In-house 1-259 (259) Show / Hide 
Range on Protein: 628-891
Range on HMM: 1-259/259
Sequence Identity: 41% (111 aa)

VKIEEVIGAGEFGEVCRGRLKLPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRL-NDGQFT
.. |.  |.| ||.| .||          ||.|||| | .  .   ||.|| .| .  ||| |.|  | |   |. | || | .  |  .|.  .    .
IRLEKKLGSGQFGDVWKGRWN----NTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

VIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEV
. ||| |   .|.|| || . |.|||||||||.||  | |||| |||.|| |..|  |  ||   | | ||.||||||  . .|   |||||.|| | |.
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQD--DEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEI

MSYGERPYWDMSNQDVINAVEQ--DYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLI
  ||  ||  |.|. |.  |..   ||.| |  || .....|.|||      || |      ..   
VTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphB3.AA Fer 628-888 33 1.4e-98 333.85 In-house 1-283 (283) Show / Hide 
Range on Protein: 628-888
Range on HMM: 1-283/283
Sequence Identity: 33% (95 aa)

VKIEEVIGAGEFGEVCRGR--LKLPGRREVFV---AIKTLKV---GYTERQRRDFLSEASIMGQ-FDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFL
|......| | ||||..||  ||.   . ..|   |.|. |.   . |. |...|. || || . .||||.... || .   |.||. ||. . .|||.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RLNDGQ-FTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNS-NLVCK--VSDFGLSRFLEDDPSDPTYTSSLG---GKIPIRWTAPEAIAYRKFT
. |...  .. ... |. ..|.||.|| ..| .|||.||||.|.   ....|  .||||.|| ..|.    .|.....    |.||||.|||.. .. ..
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDY----GYDYKMKEKACKVPIRWLAPETWQTGIYS

SASDVWSYGIVMWEVMSYGERPYWD----MSNQDV----INAVEQ-DYRLPPPMDCPTALHQLML-DCWVRDRNLRPKFSQIVNTLD
...||||.|...||... |. || .    | .  |    . .... .|..|.|  .|... |.|. .||..| . ||....|...| 
PKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphB3.AA TK-Unique 628-887 33 1.2e-87 297.52 In-house 1-294 (294) Show / Hide 
Range on Protein: 628-887
Range on HMM: 1-294/294
Sequence Identity: 33% (99 aa)

VKIEEVIGAGEFGEVCRGRLKLPG---RREVFVAIKTLKVGYTERQRRDFLSEASIMGQFD-HPNIIRLEGVVTKSR-PVMILTEFMENCALDSFLRLND
.....||| |.||.|.|| .. .     . . ||.|.|| . |. ...|||.|...| . . ||||....|. |||  |.||. |....  |...|| . 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-GQFTV---------------------IQ---LVGMLRGIAAGMKYLSE--MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLG-GK
 .....                     |.   |.  . .|| ||.||..  .. |||||.|||.|.....|||..|||..| ...   .  | .. . |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT---NGVYSMMCSQGR

IPIRWTAPEAIA--YRKF-TSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDC-PTALHQLMLDCWVRDRNLRPKFSQIVNTL
||||| |||..   .. . |. |||||.|..|||....|..|| .|.. |....... ||.| |  | . ....||  || ...  || |.||.. |
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphB3.AA Frk 628-891 42 1.5e-86 293.81 In-house 1-260 (260) Show / Hide 
Range on Protein: 628-891
Range on HMM: 1-260/260
Sequence Identity: 42% (114 aa)

VKIEEVIGAGEFGEVCRGRLKLPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLR---LNDGQ
...   .|.| ||||  |.       .. ||.|||| |  . .  ||| || || .  || .|.|  | |   |..|.|| |.. .|  .|.    .  |
IQLIRRLGSGQFGEVWEGLWNN----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

FTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMW
  . ||| |   .|||| || ..||.||||||||.||. ...||. |||| | |  |  |  | |  | ..||.||||||. | |||  |||||.||.. 
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNED-IYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT

EVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLI
|.. ||  ||  | |..|.. |...||.| | .||  | ..||.||  | . || |  .   |.. .
EIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphB3.AA Tec 628-889 39 3.2e-84 286.13 In-house 1-254 (254) Show / Hide 
Range on Protein: 628-889
Range on HMM: 1-254/254
Sequence Identity: 39% (104 aa)

VKIEEVIGAGEFGEVCRGRLKLPGRREVFVAIKTLKVG-YTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFT
 .. . .| | || | .|..    | . .||||..| |   |    ||. || .|    ||. ..| || .. ||. | ||.||.  | ..|| . ..| 
LTFMKELGSGQFGVVHLGKW----RHQYDVAIKMIKEGSMSE---EDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQ

VIQ--LVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMW
  .  | .|   .  || || . ...|||||||| ||... | ||||||..|.  ||     |||| | | |..| .||   | .. | ||||..|. ||
KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDD----QYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMW

EVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDK
|| | |  ||  ||| .|. .| | .||  |  |.. . | | .||      || |.|   .. .
EVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase EphB3.AA SrcB 628-888 42 9.9e-82 276.25 In-house 1-251 (251) Show / Hide 
Range on Protein: 628-888
Range on HMM: 1-251/251
Sequence Identity: 42% (112 aa)

VKIEEVIGAGEFGEVCRGRLKLPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDG-QFT
.|... .||| ||||  |  .    ... ||.||.| |    .   || || .| .  |  ..||  ||||  |. |.||.|.. .|  ||. ..| . .
LKLVKKLGAGQFGEVWMGYYN----NHMKVAVKTMKQGTMSPEA--FLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLS

VIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEV
. .|. |   || || |. .|||.|||| | ||||   |.||. |||| | .||.     ||   | | ||.||||||| .  ||  |||||.||.. |.
LPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDN----EYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEI

MSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLD
. ||  ||  |.| .||...|. ||.| |  ||  | ..|  ||      || |  .   ||
VTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase EphB3.AA S_TKc 628-891 20 2.2e-45 157.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 628-891
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)

VKIEEVIGAGEFGEVCRGRLKLPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMEN--CALDSFLRLNDGQ-
 .| ..|| | ||.|...| |        |||| .|        .....| .|. . .||||..| .|      . . .|....    | .... . .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTS-ASDVWSY
    |.  .   ... |. ...|. ... .||||   |||...  . |..||||.|.|                    . ||| .   ...  ..|.|| 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVN-----TLDKLI
|....| .. |. |..    | ... .            .  . ...  |...| . ||   .. .      ..  .
GCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphB3.AA Pkinase 628-887 21 1.7e-42 151.31 Pfam 1-293 (293) Show / Hide 
Range on Protein: 628-887
Range on HMM: 1-293/293
Sequence Identity: 21% (66 aa)

VKIEEVIGAGEFGEVCRGRLKLPGRREVFVAIKTLKVGYTER--QRRDFL-SEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENC----ALDSFLR-
 .|...||.| ||.|.... |  |.    ||.|..|.  ..   ...... ||..||  ..||||.|| .... .. . . .|..|.      | .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

LNDGQF--TVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVC----KVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIA-YRKFTS
 ..| |  .  ..  ... |. |..|. .|. .||||   |||...| ..    |..||||.....       ..   .    ... ||| |  ... ..
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

ASDVWSYGIVMWEVMSYGERPYWDM----SNQDVINAVEQDYRLPPPMDCP-----------------------TALHQLMLDCWVRDRNLRPKFSQIVN
..|.||.|....|... |. |...     .  | .  .... . |.. |.|                        .. ... .|. .| . || . ||..
KVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

T--L
   .
HPWF
SAM_1 EphB3.AA SAM_1 918-982 46 4.3e-32 116.62 Pfam 1-66 (66) Show / Hide 
Range on Protein: 918-982
Range on HMM: 1-66/66
Sequence Identity: 46% (31 aa)

DYTTFTTVGDWLDAIKMGRYKESFVGAGFASFDLVAQMTAEDLLR-IGVTLAGHQKKILCSIQDMR
||..| .|..||..|.|..|...|. ||. ..|...|||.|||.. .||||.||.|||..|||...
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
SAM_2 EphB3.AA SAM_2 917-982 40 1.6e-27 97.3 Pfam 1-71 (71) Show / Hide 
Range on Protein: 917-982
Range on HMM: 1-71/71
Sequence Identity: 40% (29 aa)

PDYTTFTTVGDWLDAIKM-GRYKESFVGAGFASFDLV-AQMTAEDL--L-RIGVTLAGHQKKILCSIQDMR
..|.|| .|..||..|.| ..||..| ..|. .|... |.||..||    |.|.|..||.|||...||.|.
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
SAM EphB3.AA SAM 917-984 41 1.5e-26 95.49 SMART 1-67 (67) Show / Hide 
Range on Protein: 917-984
Range on HMM: 1-67/67
Sequence Identity: 41% (28 aa)

PDYTTFTTVGDWLDAIKMGRYKESFVGAGFASFDLVAQMTAEDLLRIGVTLAGHQKKILCSIQDMRLQ
.|  |. .|.|||..|.|..||. |  .|. ...|..... |||...|.|..||.||||..||.|. |
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
Sam7 EphB3.AA sam7 920-982 38 6.5e-25 86.36 In-house 1-70 (70) Show / Hide 
Range on Protein: 920-982
Range on HMM: 1-70/70
Sequence Identity: 38% (27 aa)

TTFTTVGDWLDAIKM---GRYKESFVGAGF----ASFDLVAQMTAEDLLRIGVTLAGHQKKILCSIQDMR
.|| .|..||..|.|   ..|...|  .|.     ..|....|| |||...|.|. ||.|||...||.||
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR