Gene EphB2 (Mouse)
EphB2
Sequence
Protein domains of EphB2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Ephrin_lbd | EphB2.AA | Ephrin_lbd | 20-197 | 63 | 1.7e-144 | 450.44 | Pfam | 1-190 (190) | Show / Hide |
Range on Protein: 20-197 Range on HMM: 1-190/190 Sequence Identity: 63% (120 aa) EETLMDSTTATAELGWMVHPPSG---------WEEVSGYDENMNTIRTYQVC-NVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKE |..|||..|||..|||. .|..| ||||||.|||...||||||| ||.|..|||||||..|.||||.||.||.||..|||.|.| |.|.||| EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCKE TFNLYYYEADF-DLATKTFPNWMENPWVKVDTIAADES-FSQVDLGGRVMKINTEVRSFGPVSRNGFYLAFQDYGGCMSLIAVRVFYRKC ||||||||.| | |.|..||||||...|.|||||||| |.|.|.|.|.||.||||||.||.|. ||||||||.|.||.|..|||.|.|| TFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC |
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EPH_lbd | EphB2.AA | EPH_lbd | 20-197 | 67 | 3.1e-132 | 446.51 | SMART | 1-184 (184) | Show / Hide |
Range on Protein: 20-197 Range on HMM: 1-184/184 Sequence Identity: 67% (125 aa) EETLMDSTTATAELGWMVHPPSG--WEEVSGYDENMNTIRTYQVCNVFE---SSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPG-SCKETFNL |..|||..|.|.||||. .||.| ||||||.||..|.|||||||||.| ..|||||||..|.||||.||.||.||..|||.|.| |.| |||||||| EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL YYYEADFDLATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRNGFYLAFQDYGGCMSLIAVRVFYRKC ||||.| | ||...| |||||..|.|||||||||.|.|.|.||||.|||||||||.|..||||||||.| ||.|..|||||.|| YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC |
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GCC2_GCC3 | EphB2.AA | GCC2_GCC3 | 259-302 | 28 | 2e-08 | 30.37 | Pfam | 1-45 (49) | Show / Hide |
Range on Protein: 259-302 Range on HMM: 1-45/49 Sequence Identity: 28% (13 aa) GFEAVENGTVCRGCPSGTFKANQGDEACTHCPIN-SRTTSEGATN | .. | || ||.. . | .| .|| . . | ..|.|. GTYYNKGQNPCEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGSTS |
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FN3 | EphB2.AA | FN3 | 325-417 | 17 | 9.4e-09 | 36.33 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 325-417 Range on HMM: 1-69/69 Sequence Identity: 17% (19 aa) PSAPQA----VISSVNET------SLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAH----TQYTFEIQA |..|. ....|..| |. |.|.|| |.| ...| .. |.|.| ..| PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------------------------------IVGYR----------YTVTGLKPGQYPWTEYEFRVRA VNG--VTDQ ||| . VNGNDAGEG |
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FN3 | EphB2.AA | FN3 | 436-517 | 24 | 7.4e-13 | 49.96 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 436-517 Range on HMM: 1-69/69 Sequence Identity: 24% (24 aa) PSAVSI---MHQVSRTVD------SITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAG----AIYVFQVRARTV--AGYG |.... . .. | . |.||||. | |. |. .|| |||.| |.|.|||.. ||.| PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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Kinase | EphB2.AA | Eph | 622-881 | 86 | 8.60000000001e-226 | 756.4 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 622-881 Range on HMM: 1-264/264 Sequence Identity: 86% (228 aa) VKIEQVIGAGEFGEVCSGHLKLP-GKREI---FVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDG .|||.|||||||||||.|.|||| ||||. .|||||||.|||||||.||||||||||||||||.|.|||||||| ||||.||.||||||||||||.|| IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG QFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTS-DPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIV |||||||||||||||.|||||.|||||||||||||||||||||||||||||||.||||.| ..|||.. ||||||||||||||.|||||||||||||||| QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGIV MWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTL |||||||||||||||.|||||.||||.||||||||||.||||||||||||||||||.| |||..| MWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL |
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Kinase | EphB2.AA | Pkinase_Tyr | 622-881 | 43 | 4.4e-150 | 508.91 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 622-881 Range on HMM: 1-270/270 Sequence Identity: 43% (119 aa) VKIEQVIGAGEFGEVCSGHLK-LPGKREIFVAIKTLKSGYTEKQ--RRDFLSEASIMGQF-DHPNVIHLEGVVT-KSTP--VMIITEFMENGSLDSFLRQ ... ...|.|.||||. |..| .|.. .| ||.|.|| |....| |.||..||.|| |. .|||.. | ||.| .. | ..|..|.|..|.|...||. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK N---DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTY-TSALGGKIPIRWTAPEAIQYRKFTSASDV . ....|. .|..| . ||.|| ||...|..||||||||.||..|.|.|..||||.| . ..| .| ... |||.||.|.|||.|.|.|||..||| HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV WSYGIVMWEVMSYGERP-YWDMTNQDVINAI-EQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTL ||.|..|||...||| | |..|.|..|...| |. ||.|.|..|| ...||..||..| ..|| | .|.. | WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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Kinase | EphB2.AA | TyrKc | 622-881 | 40 | 4.2e-141 | 475.99 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 622-881 Range on HMM: 1-280/280 Sequence Identity: 40% (117 aa) VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQF--DHPNVIHLEGVVTKS-------TPVMIITEFMENGSLDSFL .. ....| |.||||. |..| | ||.|.||.. |.||..||.|| .. .|||.. | ||.|.. |.||..|.|..|.|...| ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDD----TSDPTYTSAL--GGK--IPIRWTAPEAIQYRKF | . ..... .|. . ||.|| ||...|..||||||||.||..|...|.|||||||...|| |. .|... ||| .||||.|||.|.|.|| RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF TSASDVWSYGIVMWEVMSYGERPYWD-----MTNQDVINAIEQDYRLPPPMD--------CPSALHQLMLDCWQKDRNHRPKFGQIVNTL |..|||||.|..|||...||. ||.. |.||.||. ..| ||.|.| . ||....|.|..||. | . || | .|. . TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | EphB2.AA | TK | 622-881 | 24 | 1.5e-126 | 426.54 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 622-881 Range on HMM: 1-486/486 Sequence Identity: 24% (119 aa) VKIEQVIGAGEFG---EVCSGHLKLPG----------------------KREIFVAIKTLKSGYTEKQRR-------------DFLSEASIMGQFD---- .......|.|.|| ||. | .. .. . .. ||.|.||.| .. |.. |||.||..| ... ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG -HPNVIHLEGVVTKS------------TPVMIITEFMENGS----LDSFLRQNDG--------------------------------------------- |||...| ||.|.. |.||..|.|..|. |...||.... HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY ------------------------------QFTVIQLVGMLRGIAAGMKYLADM------NYVHRDLAARNILVNSNLV-----------CKVSDFGLSR |.|. ||. | . ||.|| ||... |.|||||||||.||..|.| ||..|||||| DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR -----FLEDDTSDPTYTSAL------------------------GGKIPIRWTAPEAIQ---------YRKFTSASDVWSYGIVMWEVMSYG-ERPYWDM |. || |... |||.||||.|||... |.|||..|||||.|..|||...|| | .|..| QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM TN---------QDVINAIEQD--------------YRLPPPMDCP--------------SALHQLMLDCWQKDRNHRPKFGQIVNTL .| |.|.. ... .|.|.|..|| ....||..||..| ..|| | |... | SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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Kinase | EphB2.AA | UTK | 622-881 | 36 | 8.60000000001e-110 | 371.05 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 622-881 Range on HMM: 1-296/296 Sequence Identity: 36% (109 aa) VKIEQVIGAGEFGEVCSGHLKLPG--KREIFVAIKTLK-SGYTEKQRR---DFLSEAS---IMGQFD-HPNVIHLEGVVTKSTPVMIITEFMENGSLDSF |.. . .|.|.||||. .... . | ||.|... .. ...... ||. || .|.||. ||||. | ||.|.. | ||.||.||||.|.|. VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY LR-------QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSN-------LVCKVSDFG---LSRFLED------DTSDPTYTSALGGK || ... ..| |...| . ||.|| ||. ...|||||||||.||... .|||..||| .|| . . . ... |... .. LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR IPIRWTAPEAIQYR-KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQD--YRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTL .||||.||||. .. .||..|||||.|.|.||....| .|| .|.|..|. ... ||.|.| ||| .. .||..||..| || | ..| .. WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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Kinase | EphB2.AA | Src | 622-881 | 44 | 7.2e-109 | 367.99 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 622-881 Range on HMM: 1-255/255 Sequence Identity: 44% (116 aa) VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR-QNDGQ-F .| .. .|.| |||| | . .. ||.||||.| . .|| || || ...|.....| |... |. |.||.|..||| .|. . .|. IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL TVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWE . ||. | .|.||.|| |||.||||||||.||. |.|||| |||| | ...| | |.. | |.||.|||||||.|..|| |||||.|| ..| HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED--DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE VMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQ-LMLDCWQKDRNHRPKFGQIVNTL ...|| || |||..|. ..|. ||.| |. || |.. .|| ||.|| || | . . | IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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Kinase | EphB2.AA | SFK-Src | 622-885 | 42 | 1.8e-105 | 313.57 | In-house | 1-259 (259) | Show / Hide |
Range on Protein: 622-885 Range on HMM: 1-259/259 Sequence Identity: 42% (114 aa) VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQ-NDGQFT .. |. |.| ||.| | ||.||||.| . . ||.|| .| . ||| | | | | |. |||| | .||| .|.. . . IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR VIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEV . ||| | .|.|| || . |.|||||||||.|| | |||| |||.|| |..| | || | | ||.|||||| .. .| |||||.|| | |. MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQD--DEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEI MSYGERPYWDMTNQDVINAIEQ--DYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMI || || |||. |. ... ||.| | || .....|.||||. || |. .. VTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF |
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Kinase | EphB2.AA | Fer | 622-882 | 35 | 1.5e-99 | 337.06 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 622-882 Range on HMM: 1-283/283 Sequence Identity: 35% (102 aa) VKIEQVIGAGEFGEVCSG--HLKLPGKREIFV---AIKTLKS---GYTEKQRRDFLSEASIMGQ-FDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL |... ..| | ||||..| ||. .. ..| |.|. | . |..|...|. || || . .|||||. . || . |.||. ||. .|||||.| VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL RQNDGQ-FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNS-NLVCK--VSDFGLSRFLEDDTSDPTYTSA-LGGKIPIRWTAPEAIQYRKFTSA . |... .. ... |. ..|.||.|| .| .|||.||||.|. ....| .||||.|| ..|...| |. . |.||||.|||..|.. .... KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYD--YKMKEKACKVPIRWLAPETWQTGIYSPK SDVWSYGIVMWEVMSYGERPYWD----MTNQDV----INAIEQ-DYRLPPPMDCPSALHQLML-DCWQKDRNHRPKFGQIVNTLD .||||.|...||... |. || . |.. | . .|.. .|..|.| .|... |.|. .||||| . ||.. .|...| TDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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Kinase | EphB2.AA | TK-Unique | 622-881 | 34 | 9.7e-94 | 317.73 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 622-881 Range on HMM: 1-294/294 Sequence Identity: 34% (102 aa) VKIEQVIGAGEFGEVCSGHLKLPG---KREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFD-HPNVIHLEGVVTKST-PVMIITEFMENGSLDSFLRQND .....||| |.||.|. | .. . . . ||.|.|| . |. ...|||.|...| . . |||.....|. |||. |.||| |....|.|...||.. LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR -GQFTV---------------------IQ---LVGMLRGIAAGMKYLAD--MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALG-GK ..... |. |. . .|| ||.||| .. |||||.|||.|.....|||..|||..| ... . | . . |. PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT---NGVYSMMCSQGR IPIRWTAPEAIQ--YRKF-TSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDC-PSALHQLMLDCWQKDRNHRPKFGQIVNTL ||||| |||... .. . |. |||||.|..|||....|..|| .| . |....|.. ||.| | | . ....|| |||... .|| | ||.. | IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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Kinase | EphB2.AA | Frk | 622-885 | 43 | 2.6e-91 | 309.65 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 622-885 Range on HMM: 1-260/260 Sequence Identity: 43% (117 aa) VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR---QNDGQ ... . .|.| |||| | .. ||.||||.| . . ||| || || . || .|.| | | |..|||| |..||| .|. .. | IQLIRRLGSGQFGEVWEGLWNN----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMW . ||| | .|||| || ..||.||||||||.||. ...||. |||| | | | | | | | ..||.||||||..| ||| |||||.||.. CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNED-IYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT EVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMI |.. || || |||..|.. ....||.| | .|| | ..||.||..| ..|| | . |.. . EIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF |
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Kinase | EphB2.AA | Tec | 622-883 | 37 | 2e-86 | 293.45 | In-house | 1-254 (254) | Show / Hide |
Range on Protein: 622-883 Range on HMM: 1-254/254 Sequence Identity: 37% (100 aa) VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSG-YTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFT .. . .| | || | | .. ...||||..| | | ||. || .| ||. . | || .. |. |.||.||.|.| ..||.. ..| LTFMKELGSGQFGVVHLGKWRH----QYDVAIKMIKEGSMSEE---DFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQ VIQ--LVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMW . | .| . || || ...|||||||| ||... | ||||||..|. || ||| | | |..| .|| .| .. | ||||..|. || KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDD----QYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMW EVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDK || | | || |.| .|. .. | .|| | |. . | | .||. || | | .. . EVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE |
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Kinase | EphB2.AA | SrcB | 622-882 | 43 | 2.7e-85 | 288.51 | In-house | 1-251 (251) | Show / Hide |
Range on Protein: 622-882 Range on HMM: 1-251/251 Sequence Identity: 43% (114 aa) VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDG-QFT .|... .||| |||| | .... ||.||.| | . || || .| . | ...| |||| |. ||||.|..|.| ||. ..| . . LKLVKKLGAGQFGEVWMGYY----NNHMKVAVKTMKQGTMSPEA--FLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLS VIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEV . .|. | || || |. |||.|||| | |||| |.||. |||| | .||. || | | ||.|||||||.. || |||||.||.. |. LPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDN----EYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEI MSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLD . || || ||| .||...|. ||.| | || | ..| ||.. || | . || VTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD |
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Kinase | EphB2.AA | S_TKc | 622-885 | 20 | 2.6e-51 | 177.69 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 622-885 Range on HMM: 1-231/231 Sequence Identity: 20% (58 aa) VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMEN--GSLDSFLRQNDGQ- .| ..|| | ||.|. .. | |||| .| .....| .|. . .|||...| .| . . ...|.... |.| ...... .. YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG ----FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTS-ASDVWSY |. . ... |. ...|. ... .|||| |||... . |..||||.|.| . ||| . ... ..|.|| LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC GIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVN-----TLDKMI |....| .. |. |.. . | ... | .. . ... |.||| ..|| .. . .. . GCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | EphB2.AA | Pkinase | 622-881 | 22 | 1.5e-47 | 169.12 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 622-881 Range on HMM: 1-293/293 Sequence Identity: 22% (69 aa) VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEK--QRRDFL-SEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENG----SLDSFLR- .|...||.| ||.|. .| | || ||.|..| ... ...... ||..|| ..|||.. | .... .. . ...|..|.| .| .... YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST QNDGQF--TVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVC----KVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQ-YRKFTS ...| | . .. ... |. |..|. .|. .|||| |||...| .. |..||||..... .. . . ... ||| |. ... .. WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP ASDVWSYGIVMWEVMSYGERPYWDM----TNQDVINAIEQDYRLPPPMDCP-----------------------SALHQLMLDCWQKDRNHRPKFGQIVN ..|.||.|....|... |. |... . | . |... . |.. |.| ... ... .|..|| . || . ||.. KVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ T--L . HPWF |
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SAM_1 | EphB2.AA | SAM_1 | 912-976 | 48 | 7.8e-31 | 112.16 | Pfam | 1-66 (66) | Show / Hide |
Range on Protein: 912-976 Range on HMM: 1-66/66 Sequence Identity: 48% (32 aa) DYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILR-VGVTLAGHQKKILNSIQVMR ||..|..|.||||.|.|.||...|. ||....| ..|| .||... .||||.||.|||..||| .. DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK |
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SAM | EphB2.AA | SAM | 911-978 | 38 | 4.5e-26 | 93.87 | SMART | 1-67 (67) | Show / Hide |
Range on Protein: 911-978 Range on HMM: 1-67/67 Sequence Identity: 38% (26 aa) PDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQ .| ....| .|||.|.|.|||. |. .|..... .... .||....|.|..||.||||..|| |..| VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ |
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SAM_2 | EphB2.AA | SAM_2 | 911-976 | 40 | 6.8e-25 | 88.27 | Pfam | 1-71 (71) | Show / Hide |
Range on Protein: 911-976 Range on HMM: 1-71/71 Sequence Identity: 40% (29 aa) PDYTSFNTVDEWLEAIKM-GQYKESFANAGFTSFDVV-SQMMMEDI--L-RVGVTLAGHQKKILNSIQVMR ..|..|..| |||..|.| .|||..| .|.|.|... .| ..| | |.|..||.|||.|.|| |. VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK |
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Sam7 | EphB2.AA | sam7 | 914-976 | 41 | 4.2e-24 | 83.49 | In-house | 1-70 (70) | Show / Hide |
Range on Protein: 914-976 Range on HMM: 1-70/70 Sequence Identity: 41% (29 aa) TSFNTVDEWLEAIKM---GQYKESFANAGF----TSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMR ..|..| ||||.|.| .||...| ..|. |..|.. .| .||... |.|. ||.|||.|.|| || WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR |