Gene EPHA6 (Mouse)

EPHA6

Species: Mouse
Alias: EPHA6, Epha6
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphA6.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 300 Kinase domain by global Sugen HMM Fasta, JSON
EphA6.AA Protein Sugen 1130 None Fasta, JSON
EphA6.NA RNA Sugen 4213 None Fasta, JSON

Protein domain

Protein domains of EphA6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphA6.AA Ephrin_lbd 128-301 64 1.9e-140 437.87 Pfam 1-190 (190) Show / Hide 
Range on Protein: 128-301
Range on HMM: 1-190/190
Sequence Identity: 64% (122 aa)

QVVLLDTTTVMGELGWKTYPLNG---------WDAITEMDEHNRPIHTYQVC-NVMEPNQNNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKE
.|||.||.|....||| ||| ||         |. ...|||..|||.||||| ||||||||||||||||.|..||.||||.|||.|||||.|.|.|||||
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCKE

TFNLYYIESDE--SHG---TKFKPSQYIKIDTIAADES-FTQMDLGDRILKLNTEIREVGPIERKGFYLAFQDIGACIALVSVRVFYKKC
|||||| |||.   .|   ......||.|||||||||| |||.|.|.|..|||||.|..||. ..||||||||.|||.|||||||.||||
TFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphA6.AA EPH_lbd 128-301 67 2.5e-127 430.25 SMART 1-184 (184) Show / Hide 
Range on Protein: 128-301
Range on HMM: 1-184/184
Sequence Identity: 67% (125 aa)

QVVLLDTTTVMGELGWKTYPLNG--WDAITEMDEHNRPIHTYQVCNVME---PNQNNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLG-TCKETFNL
.|||.||.|..|||||.||| .|  |. . .||||..||.|||||||||   |||||||||.||.|..||.||||.|||.|||||.|.|.| .|||||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

YYIESDESHG---TKFK-PSQYIKIDTIAADESFTQMDLGDRILKLNTEIREVGPIERKGFYLAFQDIGACIALVSVRVFYKKC
|| |||..|.   |.|.  ..|||||||||||||||.|.|||..|.|||.|..||...|||||||||.|||.||||||||||||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 EphA6.AA GCC2_GCC3 370-406 35 6e-06 22.4 Pfam 11-49 (49) Show / Hide 
Range on Protein: 370-406
Range on HMM: 11-49/49
Sequence Identity: 35% (14 aa)

CHACRPGFYKAFAGNTKCSKCPPH-SST-YVEATSVCHC
|..|  |.|.  .|...| .|||. ..| |  .||. .|
CEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGSTSESDC
FN3 EphA6.AA FN3 426-518 14 3.1e-05 24.65 SMART 1-69 (69) Show / Hide 
Range on Protein: 426-518
Range on HMM: 1-69/69
Sequence Identity: 14% (16 aa)

PSAPRN---VAFN-INET------ALILEWSPPSDTGGRKDLTYSVICKKCGLDTTQCEDCGGGLRFIPRHTGLINNSVVVLDFVSH----VNYTFEIEA
|..|.|   . .  ...|       . |.|.||        ..|.                                 ..| . . .     .|.| . |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR---------------------------------YTVTGLKPGQYPWTEYEFRVRA

MNG--VSEL
 ||  . | 
VNGNDAGEG
FN3 EphA6.AA FN3 537-618 20 1.2e-09 39.34 SMART 1-69 (69) Show / Hide 
Range on Protein: 537-618
Range on HMM: 1-69/69
Sequence Identity: 20% (20 aa)

PSLIGM---MRKDWASQN------SLALSWQAPAFSNGAILDYEIKYYEKEHEQLTYSSTRSKAPSVIVTGLKPA----TTYIFHIRVRTA--TGYS
|.  .     |    . .      |. |||..|      |. |.                      ..||||||     |.| | .|....   |..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphA6.AA Eph 725-1024 72 3e-218 731.34 In-house 1-264 (264) Show / Hide 
Range on Protein: 725-1024
Range on HMM: 1-264/264
Sequence Identity: 72% (223 aa)

IRIERVIGAGEFGEVCSGRLKTP-GKREI---PVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNGIQ
|.||.|||||||||||.||||.| ||||.   |||||||| |....||.|||.||||||||||||||||||||||                         
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTK-------------------------

APHPVTAGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD
                 .||||||.|||||||||||||.|||.|||||||||||||||||||||||.|||||||||||||||||||||||||||||||||
-----------------SRPVMIVTEYMENGSLDSFLRQHDGQFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD

P--EAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPPSLHQLMLHCWQKERNHRPKFT
|  ||.|||.|||||||||||||||||||.||||.|||||||||||||||||||.||||||| .||.|||||.||.||..||||||.||||.|||||.|.
PSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQ

DIVSFL
.|||.|
QIVSIL
Kinase EphA6.AA Pkinase_Tyr 725-1024 41 1.7e-145 493.38 Pfam 1-270 (270) Show / Hide 
Range on Protein: 725-1024
Range on HMM: 1-270/270
Sequence Identity: 41% (128 aa)

IRIERVIGAGEFGEVCSGRLK-TPGKREIPVAIKTLKGGHMDRQ--RRDFLREASIMGQF-DHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNGIQ
|.. ...|.|.||||. |..|  |.. .||||.|.|| |.|..|  |.||.|||.|| |. .||||.|| ||.|                          
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT--------------------------

APHPVTAGGSLPPRIPAGRP--VMIVVEYMENGSLDSFLRKH---DGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSR
               . |.|  ..||.|||..|.|...||||   ....|. .|..| . ||.|| ||......||||||||.||..|.|.|..||||.|
---------------DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR

VL-EDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERP-YWEMSNQDVILSI-EEGYRLPAPMGCPPSLHQLMLHCWQKERN
 . .||    ....|||.||.|.|||.|.|.||...|| ||.|..|||...||| | |..|||..|.  | |.|||.|.|..||. ...||..||... .
DIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPE

HRPKFTDIVSFL
.|| |..|...|
DRPTFSEIHEQL
Kinase EphA6.AA TyrKc 725-1024 37 1.2e-124 421.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 725-1024
Range on HMM: 1-280/280
Sequence Identity: 37% (122 aa)

IRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQF--DHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNGIQAP
|. ....| |.||||. |..|      |.||.|.|| ..    |.||.|||.|| ..  .||||.|| ||.|. .            |. .         
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----------FMYI---------

HPVTAGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD--
                 |.|||.|||..|.|...|||| ..... .|. .   ||.|| ||......||||||||.||..|...|.||||||| ..||  
----------------EPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQ

--PEAAYTTT----GGK--IPIRWTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWE-----MSNQDVILSIEEGYRLPAPMG--------CPPSL
   .  | ..    |||  .||||.|||.| |.||...|| ||.|..|||...||. ||..     ||||.||  ...|||.| |          ||. .
QGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEM

HQLMLHCWQKERNHRPKFTDIVSFL
.|.|. ||. . . || |..|....
YQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphA6.AA TK 725-1024 22 3.6e-121 408.17 In-house 1-486 (486) Show / Hide 
Range on Protein: 725-1024
Range on HMM: 1-486/486
Sequence Identity: 22% (118 aa)

IRIERVIGAGEFG---EVCSGRLKTPG----------------------KREIPVAIKTLKGGH-MDRQ-RRD-----------FLREASIMGQFD----
|......|.|.||   ||. |......                      . ..|||.|.|| |. |. . ..|           ||.||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIIRLEGVVTKRS----FPAIGVEAFCPSFLRAGFLNGIQAPHPVTAGGSLPPRIPAG-RPVMIVVEYMENGS----LDSFLRKHDGH---------
 ||||.|| ||.|.      |                                    .  . .|.|||.|||..|.    |...|||....         
HHPNIVRLYGVCTQGEPKPCFE---------------------------------V-V-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPD

------------------------------------------------------------------FTVIQLVGMLRGIASGMKYLSDM------GYVHR
                                                                  .|. ||. | . ||.|| ||...      ..|||
NQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHR

DLAARNILVNSNLV-----------CKVSDFGLS------RVLEDDPEAAYTTTG-------------------------GKIPIRWTAPEAIA------
||||||.||..|.|           ||..|||||      .  .....  |....                         ||.||||.|||...      
DLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSE

---YRKFSSASDAWSYGIVMWEVMSYG-ERPYWEMSNQDVIL-----------------------SIEEGYRLPAPMGCP--------------PSLHQL
   |.||...|| ||.|..|||...|| | .|..||||||.                        ......|.|.|..||              . ...|
AEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDL

MLHCWQKERNHRPKFTDIVSFL
|. ||... ..|| |......|
MQQCWHYDPEDRPTFSQLHEQL
Kinase EphA6.AA UTK 837-1024 39 4.8e-87 295.49 In-house 81-296 (296) Show / Hide 
Range on Protein: 837-1024
Range on HMM: 81-296/296
Sequence Identity: 39% (85 aa)

AGRPVMIVVEYMENGSLDSFLRKHDG-------HFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSN-------LVCKVSDFG---LSRVLE-
.. | |||.||||||.|.|.||.|         ..|  |...| . ||.|| ||. .|.|||||||||.||...       .|||..|||   .|| .  
QEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNT

------DDPEAAYTTTG-GKIPIRWTAPEAIAYR-KFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEG--YRLPAPMGCPPSLHQLMLHCWQ
      ..    |. .. ...||||.||||.... .|...|| ||.|.|.||....| .|| .|||..|......|  ||.|.| .|| .. .||. ||.
FHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWH

KERNHRPKFTDIVSFL
..   || | |.|...
YDPQERPDFEDLVQQM
Kinase EphA6.AA Src 840-1024 47 7e-87 294.95 In-house 68-255 (255) Show / Hide 
Range on Protein: 840-1024
Range on HMM: 68-255/255
Sequence Identity: 47% (89 aa)

PVMIVVEYMENGSLDSFLR-KHDGH-FTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAY-TTTGGKIPIRW
|. || |||..|||  .|. . .|.   . ||. |   .|.||.||. | |.||||||||.||. |.|||| |||| |....| .  |   .| |.||.|
PIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED-DDEYCARHGAKFPIKW

TAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPPSLHQ-LMLHCWQKERNHRPKFTDIVSFL
|||||| |..|.  || ||.|| ..|...||  ||  |.|..|.  .| |||.| |..||..|.. .||.||.|.   || |  . .||
TAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphA6.AA SFK-Src 838-1028 44 7.2e-85 251.36 In-house 66-259 (259) Show / Hide 
Range on Protein: 838-1028
Range on HMM: 66-259/259
Sequence Identity: 44% (86 aa)

GRPVMIVVEYMENGSLDSFLRKHDGH-FTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRW
| |. |. | | .|||  .|.   |.  .. ||| |   .|.|| || .  .|||||||||.||  | |||| |||.||||..| |     .| | ||.|
GEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKW

TAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEE--GYRLPAPMGCPPSLHQLMLHCWQKERNHRPKFTDIVSFLDKLI
|||||  . .||  || ||.|| | |.  ||  ||  |.|. |.  ..   |||.|.| .||. ....|. |||.|   || |      ..   
TAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphA6.AA Fer 840-1025 35 3.7e-70 238.11 In-house 83-283 (283) Show / Hide 
Range on Protein: 840-1025
Range on HMM: 83-283/283
Sequence Identity: 35% (71 aa)

PVMIVVEYMENGSLDSFLRKHDGH-FTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNS-NLVCK--VSDFGLSRVLEDDPEAAYTT-TGGKIPI
|.||| |.. .|||||.|.| ..   .. ... |. ..|.||.||  .. .|||.||||.|.   ....|  .||||.|| ..|. .. .   .  |.||
PIMIVMEFCNGGSLDSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPI

RWTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWE----MSNQDV----ILSIEE-GYRLPAPMGCPPSLHQLML-HCWQKERNHRPKFTDIVSFL
||.|||.. .. .|...| ||.|...||... |. || .    | .  |    .  |.. ||..| | ..|| . |.|. .||||. . ||....|.  |
RWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKL

D
 
K
Kinase EphA6.AA TK-Unique 840-1024 33 4.5e-69 235.78 In-house 79-294 (294) Show / Hide 
Range on Protein: 840-1024
Range on HMM: 79-294/294
Sequence Identity: 33% (74 aa)

PVMIVVEYMENGSLDSFLRKHD-GHFTV---------------------IQ---LVGMLRGIASGMKYLSD--MGYVHRDLAARNILVNSNLVCKVSDFG
|.||. ||...|.|...||.   .....                     |.   |.  . .||.||.||.   .. |||||.|||.|.....|||..|||
PWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFG

LSRVLEDDPEAAYTTTG--GKIPIRWTAPEAIA--YRKF-SSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGC-PPSLHQLMLHC
..| ...  . .| ...  |.||||| |||..   .. . .. || ||.|..|||....|..|| .|.. |..  |..|||.| | .| .. ...||  |
MARDVYT--NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSC

WQKERNHRPKFTDIVSFL
||.|. .|| |..|.. |
WQWEPEERPSFRQIKHRL
Kinase EphA6.AA Frk 840-1028 42 3.4e-67 229.55 In-house 68-260 (260) Show / Hide 
Range on Protein: 840-1028
Range on HMM: 68-260/260
Sequence Identity: 42% (82 aa)

PVMIVVEYMENGSLDSFLR---KHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAY-TTTGGKIPIR
|..|. | |..|||  .|.   ..  .  . ||| |   .|.|| || .. |.||||||||.||. ...||. |||| |||  | |  | . .| ..||.
PIYIITELMRHGSLQEYLQAINDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIK

WTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPPSLHQLMLHCWQKERNHRPKFTDIVSFLDKLI
||||||. | ||.  || ||.||.. |.. ||  ||  | |..|.  ...|||.| | .||. | ..||.||... ..|| |  .   |.. .
WTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphA6.AA Syk 838-1018 42 5.8e-67 228.78 In-house 76-257 (257) Show / Hide 
Range on Protein: 838-1018
Range on HMM: 76-257/257
Sequence Identity: 42% (78 aa)

GRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLR-GIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRW
. . | | |  | |..  .| .|  . |.   . ..   .|.||.||     |||||||||.|       |.||||.|. |  | .    ||.|| |..|
AEMMMMVMEMAELGPMHKYLQQHRHEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKW

TAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPPSLHQLMLHCWQKERNHRPKFT
 ||| | |.|||..|| ||.|. |||  ||| .|| ||..|.|.  || | |.. | |||. . |||  ||  .   || | 
YAPECIYYYKFSHKSDVWSFGVTMWEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase EphA6.AA Ack 840-1024 40 1.2e-61 206.75 In-house 75-266 (266) Show / Hide 
Range on Protein: 840-1024
Range on HMM: 75-266/266
Sequence Identity: 40% (78 aa)

PV-MIVVEYMENGSLDSFLRKHDG--HFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSN-LVCKVSDFGLSRVLEDDPEAAYTTTGGK---I
|  | | |  . |||   |||| .  .|..  |   .. ||.|| ||   . .||||||||||. |     |..||||.| |    |  |.. . .   .
PMLMMVTELAPCGSLLDCLRKHCRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQN-EDYYRMEFHRNLKV

PIRWTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIE-EGYRLPAPMGCPPSLHQLMLHCWQKERNHRPKFTDIVSFL
|. | |||.. .|.||.||| |..|  .||. |||| |.  ..  ...  |. || ||| |  ||. . |.|. |||..   ||.| .|. .|
PFAWCAPECLRHRQFSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase EphA6.AA S_TKc 725-1028 20 1e-39 139.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 725-1028
Range on HMM: 1-231/231
Sequence Identity: 20% (66 aa)

IRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNGIQAPHP
 .| |.|| | ||.|. .| |        |||| .|        ....|| .|. . .||||..| .|                                
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-----------------------------

VTAGGSLPPRIPAGRPVMIVVEYMEN--GSLDSFLRKHDGH-----FTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVL
                . .| ||...  |.| ....|. .|     |.  .   ... |.....|. ..| .||||   |||...  . |..||||.|.|
--------------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL

EDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSS-ASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPPSLHQLMLHCWQKERNHRPK
          |       . ||| .   ...  ..| || |....| .. |. |..   ...... .            .|.. ... .|.||. ..|| 
----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPT

FTDIVS-----FLDKLI
  ..        ..  .
A-EALQDEWDIKCHPWF
Kinase EphA6.AA Pkinase 725-1024 20 1.9e-37 133.47 Pfam 1-293 (293) Show / Hide 
Range on Protein: 725-1024
Range on HMM: 1-293/293
Sequence Identity: 20% (72 aa)

IRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDR--QRRDFL-REASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNGIQA
..|.|.||.| ||.|. .. |  ||    ||.|..|  | .   ...... .|..||  ..||||.|| ....                           
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--------------------------

PHPVTAGGSLPPRIPAGRPVMIVVEYMENG----SLDSFLR-KHDGHF--TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVC----KVSD
                .. . .| ||.|.|    .| .... . .| |  .  ..  ... |..|..|. .|| .||||   |||...| ..    |..|
----------------KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICD

FGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIA-YRKFSSASDAWSYGIVMWEVMSYGERPYWEM----SNQDVILSIEEGYRLPAPMGCP---------
|||.....        .|.    ... ||| |  ... ....| ||.|....|... |. |...     .  | .  |..  . | .  .|         
FGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF

--------------PSLHQLMLHCWQKERNHRPKFTDIVSF--L
              ... ...  |..|  . || ...|.    .
FRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase EphA6.AA Fer 725-792 29 2.2e-20 66.2 In-house 1-77 (283) Show / Hide 
Range on Protein: 725-792
Range on HMM: 1-77/283
Sequence Identity: 29% (23 aa)

IRIERVIGAGEFGEVCSGR-----LKTPGKRE--IPVAIKTLKGGHMDRQ-RRDFLREASIMGQ-FDHPNIIRLEGV
. .. ..| | ||||..||     .|  .     ..|. |..|. ....  ...|..|| || . .||||.... ||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGV
Kinase EphA6.AA UTK 725-795 33 3e-20 66.0 In-house 1-81 (296) Show / Hide 
Range on Protein: 725-795
Range on HMM: 1-81/296
Sequence Identity: 33% (27 aa)

IRIERVIGAGEFGEVCSGRLKTPG--KREIPVAIKTLKGGHMDRQRRD----FLREAS---IMGQFD-HPNIIRLEGVVTK
... | .|.|.||||. .|....     |  ||.|... .....| ..    |..||    .|.||. |||..|| ||.|.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQ
Kinase EphA6.AA Ack 725-793 42 2.6e-19 61.81 In-house 1-71 (266) Show / Hide 
Range on Protein: 725-793
Range on HMM: 1-71/266
Sequence Identity: 42% (30 aa)

IRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQ--RRDFLREASIMGQFDHPNIIRLEGVV
|.    .| |.|| |  |  ..||   |.||.| |. . |       |||||..|| . |||...|| |||
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVV
Kinase EphA6.AA Src 725-795 36 1.6e-18 59.51 In-house 1-65 (255) Show / Hide 
Range on Protein: 725-795
Range on HMM: 1-65/255
Sequence Identity: 36% (26 aa)

IRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTK
|. .| .|.| ||||  |      . ...||.|||| |.|. .  .||.|| || ...|.....|  |...
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGTMSPE--AFLQEAQIMKKLRHEKLVQLYAVCSQ
Kinase EphA6.AA Syk 725-792 38 3.6e-18 59.14 In-house 1-73 (257) Show / Hide 
Range on Protein: 725-792
Range on HMM: 1-73/257
Sequence Identity: 38% (28 aa)

IRIERVIGAGEFGEVCSGRLKTP----GKREIPVAIKTLKGGHMDRQ-RRDFLREASIMGQFDHPNIIRLEGV
.   . || |.|| | .| ..       |. |.||||.||  | .      |.|||..| | ||| |.|. |.
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGI
Kinase EphA6.AA TK-Unique 725-799 34 6.7e-17 54.92 In-house 1-79 (294) Show / Hide 
Range on Protein: 725-799
Range on HMM: 1-79/294
Sequence Identity: 34% (27 aa)

IRIERVIGAGEFGEVCSGRLKTPG---KREIPVAIKTLKGGHMDRQRRDFLREASIMGQFD-HPNIIRLEGVVTKRSFP
.....||| |.||.|. | ....     . . ||.|.|| .. | ...|||.|...| . . ||||....|. || ..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEP
Kinase EphA6.AA Frk 725-794 47 8.8e-16 50.86 In-house 1-64 (260) Show / Hide 
Range on Protein: 725-794
Range on HMM: 1-64/260
Sequence Identity: 47% (33 aa)

IRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVT
|.. | .|.| ||||  |.       ..|||.|||| | || .  |||||| || .  || .|.|  | |
IQLIRRLGSGQFGEVWEGLWNN----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCT
Kinase EphA6.AA SFK-Src 725-794 42 4.6e-15 40.51 In-house 1-64 (259) Show / Hide 
Range on Protein: 725-794
Range on HMM: 1-64/259
Sequence Identity: 42% (30 aa)

IRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVT
|| |.  |.| ||.|  ||          ||.|||| | |  .   ||.|| .| .  ||| |.|  | |
IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCT
SAM_1 EphA6.AA SAM_1 1053-1117 40 8.8e-29 104.89 Pfam 1-66 (66) Show / Hide 
Range on Protein: 1053-1117
Range on HMM: 1-66/66
Sequence Identity: 40% (27 aa)

EYPLFVTVGDWLDSIKMGQYKSNFMAAGFTTFDLISRMSIDDIRR-IGVILIGHQRRIVSSIQTLR
.|  | .|..||.||.|.||...||.||....|....|. .|... .||.|.||. .|..|||.|.
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
SAM EphA6.AA SAM 1052-1119 32 4.5e-25 90.53 SMART 1-67 (67) Show / Hide 
Range on Protein: 1052-1119
Range on HMM: 1-67/67
Sequence Identity: 32% (22 aa)

PEYPLFVTVGDWLDSIKMGQYKSNFMAAGFTTFDLISRMSIDDIRRIGVILIGHQRRIVSSIQTLRLH
.. . . .|.|||.||.|.|||.||...|.....|....| .|. ..|. ..||...| ..||... .
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
SAM_2 EphA6.AA SAM_2 1052-1117 36 4.4e-23 82.05 Pfam 1-71 (71) Show / Hide 
Range on Protein: 1052-1117
Range on HMM: 1-71/71
Sequence Identity: 36% (26 aa)

PEYPLFVTVGDWLDSIKM-GQYKSNFMAAGFTTFDLI-SRMSIDDI--R-RIGVILIGHQRRIVSSIQTLR
..|. | .|..||.||.| .||| ||...|.|.|...  .|. ||     |.|. . ||...| ..|| ..
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
Sam7 EphA6.AA sam7 1055-1117 31 4.7e-23 79.74 In-house 1-70 (70) Show / Hide 
Range on Protein: 1055-1117
Range on HMM: 1-70/70
Sequence Identity: 31% (22 aa)

PLFVTVGDWLDSIKM---GQYKSNFMAAGF----TTFDLISRMSIDDIRRIGVILIGHQRRIVSSIQTLR
. | .|..||..|.|   .||..||...|.    |..|.. .|. .|....|. ..||...| ..|| .|
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR