Gene EphA5 (Mouse)

EphA5

Species: Mouse
Alias: EphA5, Epha5
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphA5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON
EphA5.NA RNA Sugen 4810 None Fasta, JSON
EphA5.AA Protein Sugen 1040 None Fasta, JSON

Protein domain

Protein domains of EphA5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphA5.AA Ephrin_lbd 62-235 64 2.5e-139 434.35 Pfam 1-190 (190) Show / Hide 
Range on Protein: 62-235
Range on HMM: 1-190/190
Sequence Identity: 64% (122 aa)

EVNLLDSRTVMGDLGWIAFPKNG---------WEEIGEVDENYAPIHTYQVC-KVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKE
||.|.|..|...||||...|.||         |||....|||..||.|||||  |||.|||||| | ||. .||.||..|||||.|||||.||..|||||
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCKE

TFNMYYFESDD--ENG---RSIKENQYIKIDTIAADES-FTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKC
|||.|| |||   ..|   ....||||.|||||||||| ||..|.|.|.||||||||..|||||.||||||||.|||.||||||||||||
TFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphA5.AA EPH_lbd 62-235 64 3e-124 419.98 SMART 1-184 (184) Show / Hide 
Range on Protein: 62-235
Range on HMM: 1-184/184
Sequence Identity: 64% (119 aa)

EVNLLDSRTVMGDLGWIAFPKNG--WEEIGEVDENYAPIHTYQVCKVME---QNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLG-TCKETFNM
||.|.|..|..|.|||...|..|  |||....||...||.||||| |||   .||||||.| ||. .||.||..|||||.|||||.||..| .||||||.
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

YYFESDDENG---RSIK-ENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKC
|| |||. ..   . .. ||.||||||||||||||. |.||||||.|||||..||||||||||||||.|||.|||||||.||||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 EphA5.AA GCC2_GCC3 297-337 28 0.00033 16.65 Pfam 4-45 (49) Show / Hide 
Range on Protein: 297-337
Range on HMM: 4-45/49
Sequence Identity: 28% (12 aa)

YEEKNGTCQVCRPGFFKASPHSQTCSKCPPH-SYTHEEASTS
|   ...|. |  |... .  ...| .|||. ..| ...|||
YNKGQNPCEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGSTS
FN3 EphA5.AA FN3 360-450 17 8.1e-09 36.54 SMART 1-69 (69) Show / Hide 
Range on Protein: 360-450
Range on HMM: 1-69/69
Sequence Identity: 17% (19 aa)

PSAPRN----AISNVNET------SVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPQQIGLKNTSVMMVDLLAH----TNYTFEIEA
|..|.|     ...|..|      || |.| ||        . .|.                                .   .| ..    |.|.| . |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR--------------------------------YTVTGLKPGQYPWTEYEFRVRA

V----NGVS
|    .| .
VNGNDAGEG
FN3 EphA5.AA FN3 471-551 22 1e-14 56.1 SMART 1-69 (69) Show / Hide 
Range on Protein: 471-551
Range on HMM: 1-69/69
Sequence Identity: 22% (22 aa)

PSPVTN---VKKGKIAKN------SISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETSITAEGLKPA----SVYVFQIRARTA--AGYG
|.|..|   ..   . ..      |..|||..|      |..|.                      | .||||     . |.|..||...  ||.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR---------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphA5.AA Eph 678-935 85 1.5e-225 755.61 In-house 1-264 (264) Show / Hide 
Range on Protein: 678-935
Range on HMM: 1-264/264
Sequence Identity: 85% (225 aa)

ITIERVIGAGEFGEVCSGRLKLP-GKREL---PVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDG
|.||.|||||||||||.|||||| ||||.   ||||||||.|||||||.|||.||||||||||||||.||||||||.|||||||||||||||.||...||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDP--EAAYTTRGGKIPIRWTAPEAIAFRKFTSSSDVWSYGIVM
|||||||||||||||.||||||||.||||||||||||.|||||||||||||||||||||  ||.|||||||||||||||||||.|||||.||||||||||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDEIVNML
|||.||||||||.|.|||||||.|.|||||.|||||.||.||||||||||||.||.|..||..|
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphA5.AA Pkinase_Tyr 678-935 45 6.00000000001e-149 505.08 Pfam 1-270 (270) Show / Hide 
Range on Protein: 678-935
Range on HMM: 1-270/270
Sequence Identity: 45% (123 aa)

ITIERVIGAGEFGEVCSGRLK-LPGKRELPVAIKTLKVGYTEKQ--RRDFLGEASIMGQF-DHPNIIHLEGVVT-KSKP--VMIVTEYMENGSLDTFLKK
||. ...|.|.||||. |..| .|.. ..|||.|.|| |....|  |.||. ||.|| |. .||||. | ||.| ...|  ..||.|||..|.|...|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---DGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL-EDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSSSDVWS
.   ....|. .|..| . ||.|| ||......||||||||.|...|.|.|..||||.| . .||    ... |||.||.|.|||.|...|||. |||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGIVMWEVVSYGERP-YWEMTNQDVIKAV-EEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDEIVNML
.|..|||...||| | |..|.|..|.... |.|||.| |..||. .|.||..||..| . || | ||...|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphA5.AA TyrKc 678-935 41 2.9e-140 473.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 678-935
Range on HMM: 1-280/280
Sequence Identity: 41% (120 aa)

ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQF--DHPNIIHLEGVVTKS-------KPVMIVTEYMENGSLDTFL
|| ....| |.||||. |..|      ..||.|.|| .     |.||. ||.|| ..  .||||. | ||.|..       .|.|||.|||..|.|. .|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKNDGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDD-----PEAAYTTR---GGK--IPIRWTAPEAIAFRKF
.|. ..... .|. .   ||.|| ||......||||||||.|...|...|.||||||| ..||      .  |...   |||  .||||.|||.| ..||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TSSSDVWSYGIVMWEVVSYGERPYWE-----MTNQDVIKAVEEGYRLPSPMD--------CPAALYQLMLDCWQKDRNSRPKFDEIVNML
|. |||||.|..|||. .||. ||..     |.||.||. |..|||.| | .        ||...||.|..||. | ..|| | ||.  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphA5.AA TK 678-935 24 2.8e-125 422.18 In-house 1-486 (486) Show / Hide 
Range on Protein: 678-935
Range on HMM: 1-486/486
Sequence Identity: 24% (118 aa)

ITIERVIGAGEFG---EVCSGRLKLPG----------------------KRELPVAIKTLKVGYTEKQRR-------------DFLGEASIMGQFD----
||.....|.|.||   ||. |... ..                      . . |||.|.|| | .. |..             ||| ||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIIHLEGVVTKS------------KPVMIVTEYMENGS----LDTFLKKNDG---------------------------------------------
 ||||..| ||.|..            .|.|||.|||..|.    |...|.|...                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QFTVIQLVGMLRGIAAGMKYLSDM------GYVHRDLAARNILINSNLV-----------CKVSDFGLS-
                              |.|. ||. | . ||.|| ||...      ..|||||||||.|...|.|           ||..||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----RVLEDDPEAAYTTRG-------------------------GKIPIRWTAPEAIA---------FRKFTSSSDVWSYGIVMWEVVSYG-ERPYWEM
     .  .....  |....                         ||.||||.|||...         ..|||. |||||.|..|||...|| | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------QDVIKAVEEG--------------YRLPSPMDCP--------------AALYQLMLDCWQKDRNSRPKFDEIVNML
.|         |.|.. ...|              .|.| |..||              ...|.||..||..| . || |......|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphA5.AA Src 678-935 45 1.8e-113 383.26 In-house 1-255 (255) Show / Hide 
Range on Protein: 678-935
Range on HMM: 1-255/255
Sequence Identity: 45% (120 aa)

ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLK-KNDGQ-F
|. .| .|.| ||||  |      . . .||.|||| |    .  .|| || || ...|.....|  |... .|. ||||||..||| ..|| . .|.  
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

TVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY-TTRGGKIPIRWTAPEAIAFRKFTSSSDVWSYGIVMWEV
 . ||. |   .|.||.||. | |.||||||||.|.. |.|||| |||| |....| .  |    | |.||.||||||| ...||  |||||.|| ..|.
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED-DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

VSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQ-LMLDCWQKDRNSRPKFDEIVNML
|.||  ||  |||..|...|| |||.| |. ||. ||. .|| ||.||   || |. . . |
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphA5.AA UTK 678-935 37 1.6e-109 370.15 In-house 1-296 (296) Show / Hide 
Range on Protein: 678-935
Range on HMM: 1-296/296
Sequence Identity: 37% (112 aa)

ITIERVIGAGEFGEVCSGRLKLPG--KRELPVAIKTLKVGYT-EKQRR---DFLGEAS---IMGQFD-HPNIIHLEGVVTKSKPVMIVTEYMENGSLDTF
. . | .|.|.||||. .|.. .     |. ||.|..... . .....   ||. ||    .|.||. |||.. | ||.|...| ||||||||||.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LK-------KNDGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSN-------LVCKVSDFG---LSRVLE-------DDPEAAYTTRG-GK
|         .. ..|  |...| . ||.|| ||. .|.|||||||||.|....       .|||..|||   .|| .        ..    |. .. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTAPEAIAFR-KFTSSSDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEG--YRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDEIVNML
.||||.||||.. . .||..|||||.|.|.||....| .|| .|.|..|...|..|  ||.|.| |||...|.||..||..|   || |...|  .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphA5.AA SFK-Src 678-939 43 2e-105 313.48 In-house 1-259 (259) Show / Hide 
Range on Protein: 678-939
Range on HMM: 1-259/259
Sequence Identity: 43% (116 aa)

ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKK-NDGQFT
|  |.  |.| ||.|  ||          ||.|||| | .  .   || || .| .  ||| | |  | |   |. |.|| | .|||  .|.  .    .
IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

VIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSSSDVWSYGIVMWEVVS
. ||| |   .|.|| || .  .|||||||||.|.  | |||| |||.||||..| |      | | ||.||||||    .|   |||||.|| | |.| 
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVT

YGERPYWEMTNQDVIKAVEE--GYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDEIVNMLDKLI
||  ||  |||. |.. |.   |||.| |  || ..|..|.||||.    || |.     ..   
YGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphA5.AA Fer 678-936 35 5e-102 345.25 In-house 1-283 (283) Show / Hide 
Range on Protein: 678-936
Range on HMM: 1-283/283
Sequence Identity: 35% (102 aa)

ITIERVIGAGEFGEVCSGR--LKLPGKRELPV---AIKTLKV---GYTEKQRRDFLGEASIMGQ-FDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFL
.|.. ..| | ||||..||  ||.  .. . |   |.|. |.   . |..|...|. || || . .||||.. . || .   |.||| |.. .||||..|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

KKNDGQ-FTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINS-NLVCK--VSDFGLSRVLEDDPEAAYTTR--GGKIPIRWTAPEAIAFRKFTSSS
|||...  .. ... |. ..|.||.||  .. .|||.||||.|.   ....|  .||||.|| ..|. . .|. .    |.||||.|||.. .. ... .
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDY-GYDYKMKEKACKVPIRWLAPETWQTGIYSPKT

DVWSYGIVMWEVVSYGERPYWE----MTNQDV----IKA-VEEGYRLPSPMDCPAALYQLML-DCWQKDRNSRPKFDEIVNMLD
||||.|...||. . |. || .    |..  |    .|. ...||..| |  .| ...|.|. .||||| . ||...||...| 
DVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphA5.AA TK-Unique 678-935 34 3e-97 329.41 In-house 1-294 (294) Show / Hide 
Range on Protein: 678-935
Range on HMM: 1-294/294
Sequence Identity: 34% (101 aa)

ITIERVIGAGEFGEVCSGRLKLPG---KRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFD-HPNIIHLEGVVTKSK-PVMIVTEYMENGSLDTFLKKND
.....||| |.||.|. | .. .     .   ||.|.|| . |. ...||| |...| . . ||||....|. |||  |.||. ||...|.|...|... 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-GQFTV---------------------IQ---LVGMLRGIAAGMKYLSD--MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG--GKI
 .....                     |.   |.  . .|| ||.||.   .. |||||.|||.|.....|||..|||..| ...  . .| . .  |.|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRI

PIRWTAPEAIA--FRKF-TSSSDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDC-PAALYQLMLDCWQKDRNSRPKFDEIVNML
|||| |||..    . . |. |||||.|..|||....|..|| .| . |.......|||.| |  | . ..|.||  |||... .|| |..|...|
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphA5.AA Frk 678-939 45 2.7e-93 316.26 In-house 1-260 (260) Show / Hide 
Range on Protein: 678-939
Range on HMM: 1-260/260
Sequence Identity: 45% (120 aa)

ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLK---KNDGQ
| . | .|.| ||||  |.       . |||.|||| |  . .  ||| || || .  || .|.|  | |  .|..|.|| |..||| ..|.   ..  |
IQLIRRLGSGQFGEVWEGLWNN----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

FTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG-KIPIRWTAPEAIAFRKFTSSSDVWSYGIVMWE
  . ||| |   .|||| || .. |.||||||||.|.. ...||. |||| |||  | |  | .| | ..||.||||||.   |||  |||||.||.. |
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE

VVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDEIVNMLDKLI
.. ||  ||  |||..|.. |..|||.| | .||  ||..||.||..| . || |. .   |.. .
IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphA5.AA SrcB 678-936 45 5e-88 297.86 In-house 1-251 (251) Show / Hide 
Range on Protein: 678-936
Range on HMM: 1-251/251
Sequence Identity: 45% (118 aa)

ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDG-QFT
. ... .||| ||||  |      ...  ||.||.| |    .   ||.|| .| .  |  ...|  ||||  |. |.||||..|.|  ||| ..| . .
LKLVKKLGAGQFGEVWMGYY----NNHMKVAVKTMKQGTMSPEA--FLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLS

VIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR-GGKIPIRWTAPEAIAFRKFTSSSDVWSYGIVMWEVV
. .|. |   || || |.  | |.|||| | |||.   |.||. |||| |..||.    || | | | ||.||||||| |  ||  |||||.||.. |.|
LPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDN---EYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIV

SYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDEIVNMLD
 ||  ||  ||| .||...|.|||.| |  ||  ||..|  ||..    || || .  .||
TYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase EphA5.AA Syk 678-929 38 2.1e-85 290.07 In-house 1-257 (257) Show / Hide 
Range on Protein: 678-929
Range on HMM: 1-257/257
Sequence Identity: 38% (99 aa)

ITIERVIGAGEFGEVCSGRLKLP----GKRELPVAIKTLKVGYTEKQ-RRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKND
.   . || |.|| | .| ..       |. ..||||.||   ...     |. ||..| | ||| |. . | . .  . | | |  | |..  .|... 
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIG-ICHAEMMMMVMEMAELGPMHKYLQQHR

GQFTVIQLVGMLR-GIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSSSDVWSYGIVM
   |.   . ..   .| ||.||     |||||||||.|       |.||||.|. |  | .    | .|| |..| ||| | ..|| ..|||||.|. |
HEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTM

WEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFD
||  ||| .|| ||..|.|.| .| | |.. |  ||. .|||| .||  .   || | 
WEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase EphA5.AA S_TKc 678-939 24 4.1e-52 180.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 678-939
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMEN--GSLDTFLKKNDGQ-
 .| |.|| | ||.|. .| |        |||| .|        .... | .|. . .||||..| .|    . . .|.||...  |.| ...||. .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTS-SSDVWSYGI
    |.  .   ... |. ...|. ..| .||||   |||...  . |..||||.|.|          .       . ||| .   ...  ..|.|| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDEIVN-----MLDKLI
...| .. |. |..  . | ..| .            .  . ...  |.||| . ||   |. .     ...  .
ILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphA5.AA Pkinase 678-935 23 6.1e-49 173.71 Pfam 1-293 (293) Show / Hide 
Range on Protein: 678-935
Range on HMM: 1-293/293
Sequence Identity: 23% (71 aa)

ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEK--QRRDFL-GEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENG----SLDTFLK-
..|.|.||.| ||.|. .. |  ||    ||.|..|.  ...  ......  |..||  ..||||. | .... .. . .|.||.|.|    .| .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

KNDGQF--TVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVC----KVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA-FRKFTSSS
...| |  .  ..  ... |. |..|. .|| .||||   ||||..| ..    |..||||.....        . .    ... ||| |   .. ....
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSYGIVMWEVVSYGERPYWEM----TNQDVIKAVEEGYRLPSPMDCP-----------------------AALYQLMLDCWQKDRNSRPKFDEIVNM-
|.||.|....|... |. |...     .  | .. ...  . | . |.|                        .. ... .|..|| ..|| ...|..  
DMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-L
 .
WF
SAM_1 EphA5.AA SAM_1 966-1030 48 1.5e-30 111.14 Pfam 1-66 (66) Show / Hide 
Range on Protein: 966-1030
Range on HMM: 1-66/66
Sequence Identity: 48% (32 aa)

GSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRR-LGVTLVGHQKKIMSSLQEMK
.  ....|.||||.|.|..|.. ||..||..||...| | |||.. .||||.||.||||.|.| .|
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
Sam7 EphA5.AA sam7 968-1030 34 6.6e-26 89.87 In-house 1-70 (70) Show / Hide 
Range on Protein: 968-1030
Range on HMM: 1-70/70
Sequence Identity: 34% (24 aa)

GAYRSVGEWLEAIKM---GRYTEIFMENGY----SSMDAVAQVTLEDLRRLGVTLVGHQKKIMSSLQEMK
   ..|.||||.|.|   ..|.. |...|.    ...|.....|.|||...|.|..||.|||....| |.
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM EphA5.AA SAM 965-1032 36 2.6e-25 91.35 SMART 1-67 (67) Show / Hide 
Range on Protein: 965-1032
Range on HMM: 1-67/67
Sequence Identity: 36% (25 aa)

LGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMSSLQEMKVQ
      ..|..|||.|.|..|...|..||...|. ... ..||| ..|.|..||.|||....|.|| |
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
SAM_2 EphA5.AA SAM_2 965-1030 35 4.9e-25 88.77 Pfam 1-71 (71) Show / Hide 
Range on Protein: 965-1030
Range on HMM: 1-71/71
Sequence Identity: 35% (25 aa)

LGSGAYRSVGEWLEAIKM-GRYTEIFMENGYSSMDAV-AQVTLEDL--R-RLGVTLVGHQKKIMSSLQEMK
  . .  .|.|||..|.| ..|...|...|....... |..|..||    |.|.|.|||.|||....|.||
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK