Gene EphA1 (Mouse)

EphA1

Species: Mouse
Alias: Epha1, EphA1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphA1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
EphA1.AA Protein Sugen 977 None Fasta, JSON
EphA1.NA RNA Sugen 3273 None Fasta, JSON

Protein domain

Protein domains of EphA1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphA1.AA Ephrin_lbd 28-205 49 1e-114 357.7 Pfam 1-190 (190) Show / Hide 
Range on Protein: 28-205
Range on HMM: 1-190/190
Sequence Identity: 49% (96 aa)

EVTLMDTSTAQGELGWLLDPPETG---------WSEVQQM-LNGTPLYMYQDC-PIQEGGDTDHWLRSNWIYRGEEASRIYVELQFTVRDCKSFPGGAGP
||.||||.||...|||. .|.. |         |.||..|  ||.|...|| |  .   .....|||.|||.| ..|.||||||.||.|||.||||.|| 
EVVLMDTKTATSDLGWTTYPYN-GRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNV-MEPNQNNWLRTNWIER-RGAQRIYVELKFTMRDCNSFPGVAG-

LGCKETFNLFYMESDQ--DVG---IQLRRPLFQKVTTVAADQS-FTIRDLASGSVKLNVERCSLGHLTRRGLYLAFHNPGSCVALVSVRVFYQRC
  |||||||.|.|||.  |.|   ...... . |. |.|||.| || ||. |...|||.| .|.| |..||.||||.. | |.|||||||.|..|
-TCKETFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphA1.AA EPH_lbd 28-205 50 1.4e-105 358.01 SMART 1-184 (184) Show / Hide 
Range on Protein: 28-205
Range on HMM: 1-184/184
Sequence Identity: 50% (93 aa)

EVTLMDTSTAQGELGWLLDPPETG-WSEVQQMLNG-TPLYMYQDCPIQE--GGDTDHWLRSNWIYRGEEASRIYVELQFTVRDCKSFPGGAGPLGCKETF
||.||||.|..|||||. .||..| |.||..| .. .| ..||.|...|  ......|||..|||| ..|.||||||.||.|||.|.||.|| . |||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYR-RGAQRIYVELKFTMRDCNSMPGVAG-VSCKETF

NLFYMESDQDVG---IQLR-RPLFQKVTTVAADQSFTIRDLASGSVKLNVERCSLGHLTRRGLYLAFHNPGSCVALVSVRVFYQRC
||.|.|||.|..   .. . .. ..|. |.|||.||| ||... ..|.|.| .|.|.|...|.||||.. | |.|||||||||..|
NLYYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 EphA1.AA GCC2_GCC3 268-310 29 0.000116 18.13 Pfam 1-44 (49) Show / Hide 
Range on Protein: 268-310
Range on HMM: 1-44/49
Sequence Identity: 29% (13 aa)

GYEESSGNVGCTACPTGFYRVDMNTLRCLKCPQH-SIAESEGST
|.  ..|.  |..|| |.|.   . . |..|| . .. ...|||
GTYYNKGQNPCEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGST
FN3 EphA1.AA FN3 334-428 16 4.6e-11 44.0 SMART 1-69 (69) Show / Hide 
Range on Protein: 334-428
Range on HMM: 1-69/69
Sequence Identity: 16% (19 aa)

PSAPQN---LSFS-TSGT------QLSLRWEPPRDTGGRHDIRYSVECLQCRGIAQDGGPCQPCGKGVHFSPAASGLTTSTVQVQGLEPY----ANYTFT
|..|.|   |... .. |      ...|.|.||        ..|.                                    . | ||.|.     .|.|.
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR------------------------------------YTVTGLKPGQYPWTEYEFR

VKSQN---RVSG
|.  |   . .|
VRAVNGNDAGEG
FN3 EphA1.AA FN3 448-526 15 8.5e-07 29.83 SMART 1-69 (69) Show / Hide 
Range on Protein: 448-526
Range on HMM: 1-69/69
Sequence Identity: 15% (15 aa)

SLSGLS---LKLVKKEPR------QLELTWAGSRPRNPGGNLSYELHVLNQDEEWHQMVLEPRVLLTKLQPD----TTYIVRVRTLTP--LGPG
  .      |...   ..      ...|.|   .|      ..|.                  . .| |.|.    |.| .|||  .    |.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK--PP-----IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphA1.AA Eph 625-881 62 8.9e-193 646.72 In-house 1-264 (264) Show / Hide 
Range on Protein: 625-881
Range on HMM: 1-264/264
Sequence Identity: 62% (165 aa)

LIVDTVIGEGEFGEVYRGALRLPSQDCKT----VAIKTLKDTSPDGYWWNFLREATIMGQFNHPHILRLEGVITKRKPIMIITEFMENGALDAFLKERED
. ...|||.||||||..| |.|||.....    |||||||.....  .|.||.||.|||||.||.|.|||||.||..|.||.||.||||.||.||.....
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QLAPGQLVAMLLGIASGMNCLSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDG---TYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVM
|. ..|||.|| ||||||..|| .|||||||||||||||.||.||||||||.|.|.|...   ||.|.|||||||||||||||.|.||.||||||.||||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFLQLQAHL
|||.|.|..||..||||.|.|.||.|||||||.|||..|..||..||..||..|||| |....|
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphA1.AA Pkinase_Tyr 625-881 43 7.89999999999e-140 474.19 Pfam 1-270 (270) Show / Hide 
Range on Protein: 625-881
Range on HMM: 1-270/270
Sequence Identity: 43% (119 aa)

LIVDTVIGEGEFGEVYRGALR-LPSQDCKTVAIKTLKDTSPDGY--WWNFLREATIMGQF-NHPHILRLEGVIT-KRKP--IMIITEFMENGALDAFLKE
.. . ..|||.|||||.| .. .|.... .||.|.||... .    .  |.||| || |. .||.|.|| ||.| ...|  |.|..|.|..| |. .|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---EDQLAPGQLVAMLLGIASGMNCLSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLL--DDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWS
.   ...| . .|. | . ||.||. |. .|..||||||||.||. |...|..||||.|..  ||   .. ..|||.||.|.|||.|....|||.|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGIVMWEVLSFGDKP-YGEMSNQEVMKSI-EDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFLQLQAHL
||..|||....|..| | .|||.||.. | |||||.|.| .||...|.||| ||.|| ..|| | ... .|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphA1.AA TyrKc 625-881 38 7.79999999999e-129 435.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 625-881
Range on HMM: 1-280/280
Sequence Identity: 38% (113 aa)

LIVDTVIGEGEFGEVYRGALRLPSQDCKTVAIKTLKDTSPDGYWWNFLREATIMGQF--NHPHILRLEGVITKR-------KPIMIITEFMENGALDAFL
.  . ..|||.|||||.| ..       .||.|.||. .       |.||| || ..  .||.|.|| ||.|.        .|.||..|.|..|.|. .|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KEREDQLAPGQLVAMLLGIASGMNCLSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDF------DGTYETQ---GGK--IPIRWTAPEAIAHRIF
......| . .|. . . ||.||. |. .|..||||||||.||. |...|.|||||.| ..|       . .| ..   |||  .||||.|||.| ...|
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TTASDVWSFGIVMWEVLSFGDKPYGE-----MSNQEVMKSIEDGYRLPPPVD--------CPAPLYELMKNCWAYDRARRPHFLQLQAHL
||.|||||||..|||....|..|| .     ||||||.. ...|||.|.| .        ||. .|..|| ||..| . || | ..   .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphA1.AA TK 625-881 25 4.2e-116 390.91 In-house 1-486 (486) Show / Hide 
Range on Protein: 625-881
Range on HMM: 1-486/486
Sequence Identity: 25% (122 aa)

LIVDTVIGEGEFG---EVYRGALRL----------------------PSQDCKTVAIKTLKDTSPDGYWW-------------NFLREATIMGQFN----
...  ..|||.||   |||.| .|                       ... . .||.|.||.....                 .||.|| .| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPHILRLEGVITKR------------KPIMIITEFMENGA----LDAFLKERED---------------------------------------------
 ||.|.|| ||.|.             .|.||..|.|..|     |. .|... .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QLAPGQLVAMLLGIASGMNCLSGH------NYVHRDLAARNILVNQNLC-----------CKVSDFGLTR
                              || . ||. | . ||.||  |. .      |.|||||||||.||..|.            ||..||||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LLDDFD---GTYETQ------------------------GGKIPIRWTAPEAIAHRI---------FTTASDVWSFGIVMWEVLSFGDKPYGE-M
     |  | .     | ..                        |||.||||.|||....|.         |||.|||||||..|||....|..||.. |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------QEVMKSIEDG--------------YRLPPPVDCP--------------APLYELMKNCWAYDRARRPHFLQLQAHL
||         ||||. ...|              .|.|.|..||              . .|.||. ||.|| ..|| | ||.  |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphA1.AA UTK 625-881 38 1.1e-103 350.71 In-house 1-296 (296) Show / Hide 
Range on Protein: 625-881
Range on HMM: 1-296/296
Sequence Identity: 38% (113 aa)

LIVDTVIGEGEFGEVYRGALRLPSQDCKT--VAIKTLK-----DTSPDGYWWNFLREAT---IMGQFN-HPHILRLEGVITKRKPIMIITEFMENGALDA
..    .|.|.||||... .. .|   ..  ||.|...      ..|..|   |..||.   .|.||. ||..||| || |. .|.||.||.|||| |..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPY-PDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRS

FLK-------EREDQLAPGQLVAMLLGIASGMNCLSGHNYVHRDLAARNILVNQN-------LCCKVSDFG---LTRLLDD--------FDGTYETQG-G
.|        .....|   |.. | . ||.||. |.....|||||||||.||...       . ||..|||   ..|.. .        ..  |  |. .
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

KIPIRWTAPEAIAHR-IFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDG--YRLPPPVDCPAPLYELMKNCWAYDRARRPHFLQLQAHL
..||||.||||..|.  |||.|||||||.|.||....| .||..|||..| .....|  ||.|.| |||.|.|.||. ||.|| ..|| | .| . .
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphA1.AA Src 625-881 43 3.7e-101 342.39 In-house 1-255 (255) Show / Hide 
Range on Protein: 625-881
Range on HMM: 1-255/255
Sequence Identity: 43% (114 aa)

LIVDTVIGEGEFGEVYRGALRLPSQDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFNHPHILRLEGVITKRKPIMIITEFMENGALDAFLK--EREDQL
.     .|.| ||||. |  .    .   ||.||||  .       ||.|| || .. |.....|  | .. .|| |.||.|..| | ..||  ... .|
IKLCRKLGQGQFGEVWMGYWN----GNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

APGQLVAMLLGIASGMNCLSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTY-ETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVL
   ||. |   .|.||. |.  ||.||||||||.||..|..||| |||| ||... |  |   .| |.||.||||||| .. ||. |||||||| ..|. 
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIV

SFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYE-LMKNCWAYDRARRPHFLQLQAHL
..|  ||  |.|.||.. .| |||.| |  ||. ||| .|. ||  |  .|| |  ||  |
TYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphA1.AA SFK-Src 625-885 41 1.8e-97 289.4 In-house 1-259 (259) Show / Hide 
Range on Protein: 625-885
Range on HMM: 1-259/259
Sequence Identity: 41% (109 aa)

LIVDTVIGEGEFGEVYRGALRLPSQDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFNHPHILRLEGVITKRKPIMIITEFMENGALDAFLKE-REDQLA
       |.| ||.|..|       .   ||.||||  .       ||.|| .| .  ||   .|  | |   || |||| | .| |  .|.| .   | 
IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

PGQLVAMLLGIASGMNCLSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYET-QGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLS
  ||| |   .|.||  | . |.|||||||||.|| .|  ||| |||. | | . |  |.  .| | ||.||||||     | . |||||||| | |.  
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVT

FGDKPYGEMSNQEVMKSIED--GYRLPPPVDCPAPLYELMKNCWAYDRARRPHFLQLQAHLEQLL
.| .||  |.|.||.. ..   |||.| |  ||  .|..| .||      || |  |.  .|   
YGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphA1.AA Fer 625-882 31 8.3e-92 311.31 In-house 1-283 (283) Show / Hide 
Range on Protein: 625-882
Range on HMM: 1-283/283
Sequence Identity: 31% (90 aa)

LIVDTVIGEGEFGEVYRG--ALRL--PSQDCK---TVAIKTLKDTSPDGY-WWNFLREATIMGQ-FNHPHILRLEGVITKRKPIMIITEFMENGALDAFL
 . . ..||| |||||.|  .|..  . .  .    |. |..| ....      |..|| || . ..||.. .. ||.. . ||||. ||. .|.|| .|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

KEREDQ-LAPGQLVAMLLGIASGMNCLSGHNYVHRDLAARNILVNQ-NLCCK--VSDFGLTRLLDDFDGTYETQ--GGKIPIRWTAPEAIAHRIFTTASD
|. ... .   ... |....|.||. | ..| .|||.||||.|. . .. .|  .||||. | ..|   .|.      |.||||.|||..  .|.....|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSFGIVMWEVLSFGDKPYGE----MSNQEV-----MKSIEDGYRLPPPVDCPAPLYELMK-NCWAYDRARRPHFLQLQAHLE
|||||...||. . |..||..    | . .|     .. |..||..|.|  .| .....|. .||..|   ||.. ...  |.
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphA1.AA FAK 625-886 39 5.5e-89 298.31 In-house 1-285 (285) Show / Hide 
Range on Protein: 625-886
Range on HMM: 1-285/285
Sequence Identity: 39% (112 aa)

LIVDTVIGEGEFGEVYRGALRLPSQ------------------------DCKTVAIKTLKDTSPDGYWWNFLREATIMGQFNHPHILRLEGVITKRKPIM
     .|||| ||.|| |   .. .                        |   ||||| |    |    .|. || || || |||| .| |...  .|| 
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEE-MPIW

IITEFMENGALDAFLKEREDQLAPGQLVAMLLGIASGMNCLSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQ-GGKIPIRWTAPEAI
|| | .. | | ..|. . ..|  . |.   . ..  |  |   ..|||| ||||.||  . | |  |||| |...| .  |     || ||.| .|| |
IIMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMHDHS-YYKASPKGKLPIKWMSPESI

AHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFLQLQAHLEQLLT
  | |||||||| ||. |||.|..| ||.  . |..|   || | ||| |  ||  || ||  |||||  .|| | .| ..|...  
NFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase EphA1.AA TK-Unique 625-881 36 5.8e-87 295.22 In-house 1-294 (294) Show / Hide 
Range on Protein: 625-881
Range on HMM: 1-294/294
Sequence Identity: 36% (108 aa)

LIVDTVIGEGEFGEVYRGALRLPS-QDCKT--VAIKTLKDTSPDGYWWNFLREATIMGQFN-HPHILRLEGVITKRK-PIMIITEFMENGALDAFLKERE
| |. |||||.||.|.|| .. ..  ..|.  ||.|.||| . |    .||.|. .| .   ||.|....|. ||   | ||| |....| |. .|... 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

DQ-------------------------LAPGQLVAMLLGIASGMNCLSG--HNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQG--GKIP
..                         . |..|.  . .||.||. |..  .. |||||.|||.|.. .. ||..|||..| ... .| |....  |.||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRIP

IRWTAPEAIA--HRIF-TTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDC-PAPLYELMKNCWAYDRARRPHFLQLQAHL
||| |||..   |... || |||||||..|||....|  ||..|.. ..|. |.||||.| |  | .  .|.|||.|| ...  || | |.   |
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphA1.AA Csk 625-881 39 3.4e-84 286.04 In-house 1-251 (251) Show / Hide 
Range on Protein: 625-881
Range on HMM: 1-251/251
Sequence Identity: 39% (104 aa)

LIVDTVIGEGEFGEVYRGALRLPSQDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFNHPHILRLEGVITKRK-PIMIITEFMENGALDAFLKEREDQLA
| .   ||.|||| |  | ..      . ||.| .|. .  |    || || .| |  ||   .| ||| . |  . |..|.| .| |  .|  |. .. 
LHLGECIGHGEFGDVMQGEYQ-----NRKVAVKCIKCDG-NGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVI

PGQLVAML-LGIASGMNCLSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQ---GGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWE
 ..   .  . ...||  | . . ||||||||||||   .  |||||||..     . ...     .||.|| ||||||  |  |.| |||||||| .||
TRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAK-----EECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWE

VLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFLQLQAHL
. |||  ||  .. ..| | .| |||  .|  || . |..||.||. . |.|| |.|..  |
IYSFGRVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase EphA1.AA Frk 625-885 43 3.9e-84 285.84 In-house 1-260 (260) Show / Hide 
Range on Protein: 625-885
Range on HMM: 1-260/260
Sequence Identity: 43% (116 aa)

LIVDTVIGEGEFGEVYRGALRLPSQDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFNHPHILRLEGVITKRKPIMIITEFMENGALDAFLK---EREDQ
. .   .| | ||||. |           ||.||||  . |    .||||| || .  || ...|  | |  .||.|||| |..|.|  .|.   ..  |
IQLIRRLGSGQFGEVWEGLW----NNTTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

LAPGQLVAMLLGIASGMNCLSGHNYVHRDLAARNILVNQNLCCKVSDFGLTR-LLDDFDGTYETQGG-KIPIRWTAPEAIAHRIFTTASDVWSFGIVMWE
.   ||| |   .|.||  |  .||.||||||||.||.... ||. |||| | |. |    ||.. | ..||.||||||.    ||. ||||||||.. |
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE

VLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFLQLQAHLEQLL
.. .|  ||  | |.||.. .. |||.| | .||  |||.| .||  |  .|| |  ||  ||. .
IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphA1.AA S_TKc 625-885 21 9.1e-42 145.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 625-885
Range on HMM: 1-231/231
Sequence Identity: 21% (59 aa)

LIVDTVIGEGEFGEVYRGALRLPSQDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFNHPHILRLEGVITKRKPIMIITEFMEN--GALDAFLKEREDQ-
  .  .||.| ||.||..  .    . . |||| .|         ...||  |. . .||.| .| .|.   . . ...|....  | |  ..|.|  . 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LAPGQLVAMLLGIASGMNCLSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTT-ASDVWSFGIV
    . . .   ..  |..... .  |. .||||   |||...  . |..|||| |.|                 . ||| .    ... ..|.||.|..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

MWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFLQLQA-----HLEQLL
..| |. |  |.     |...| |            . .. .....|. .| ..||   .. .      . . .
LYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphA1.AA Pkinase 625-881 21 5.1e-38 135.51 Pfam 1-293 (293) Show / Hide 
Range on Protein: 625-881
Range on HMM: 1-293/293
Sequence Identity: 21% (65 aa)

LIVDTVIGEGEFGEVYRGALRLPSQDCKTVAIKTLKDTSPDG-YWWNFLR--EATIMGQFNHPHILRLEGVITKRKPIMIITEFMENG----ALDAFLK-
. .  .||.| ||.||..  .  ..   .||.|..|  . .   . . .|  |. ||  .|||.|.|| .. . .. | ...|..|.|     | .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

EREDQL--APGQLVAMLLGIASGMNCLSGHNYVHRDLAARNILVNQNLCC----KVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIA-HRIFTTASD
.|.  .   . ..  ... |..|.. .  .. .||||   |||...|  .    |..|||| ...|       ...    ... ||| |  ..  ....|
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VWSFGIVMWEVLSFGDKPYGEM------SNQEVMKSIED-GYRLPPPVDCP-------------------APLYELMKNCWAYDRARRPHFLQLQAH--L
.||.|....|.|. |  |. .       . ..... | .  .. . | .|.                    .. ...|.|...| ..|| . |.  |  .
MWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
SAM_1 EphA1.AA SAM_1 912-976 53 4.7e-31 112.93 Pfam 1-66 (66) Show / Hide 
Range on Protein: 912-976
Range on HMM: 1-66/66
Sequence Identity: 53% (35 aa)

DGIPYRSVSEWLESIRMKRYILHFRSAGLDTMECVLELTAEDLTQ-MGITLPGHQKRILCSIQGFK
|. ....|.||||||.|..|| || .||...|.|.|..|.||| . ||.|||||.|.|..|||..|
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
Sam7 EphA1.AA sam7 914-976 37 6.9e-24 82.72 In-house 1-70 (70) Show / Hide 
Range on Protein: 914-976
Range on HMM: 1-70/70
Sequence Identity: 37% (26 aa)

IPYRSVSEWLESIRM---KRYILHFRSAGL----DTMECVLELTAEDLTQMGITLPGHQKRILCSIQGFK
 . ..|.||||.|.|   ..|. .||..|     .........| ||| .||||.|||.|.|...|| ..
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM EphA1.AA SAM 911-977 46 1.6e-21 78.76 SMART 1-66 (67) Show / Hide 
Range on Protein: 911-977
Range on HMM: 1-66/67
Sequence Identity: 46% (31 aa)

SDGIPYRSVSEWLESIRMKRYILHFRSAGLDTMECVLELTAEDLTQMGITLPGHQKRILCSIQGFKD
 |  . ..|..|||||.| .|. .||..|.|.|. ..... |||..||||.|||.|.||..||..||
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKD
SAM_2 EphA1.AA SAM_2 911-976 36 1.3e-19 70.16 Pfam 1-71 (71) Show / Hide 
Range on Protein: 911-976
Range on HMM: 1-71/71
Sequence Identity: 36% (26 aa)

SDGIPYRSVSEWLESIRM-KRYILHFRSAGLDTMECV-LELTAEDL--T-QMGITLPGHQKRILCSIQGFK
 .     .|.|||.||.| ..|   ||..|....| . . .|..||  . .||||..||.|.|...|| .|
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK