Gene eEF2K (Mouse)

eEF2K

Species: Mouse
Alias: eEF2K, Eef2k
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Atypical
Family: Alpha
Subfamily: eEF2K

Sequence

Name Sequence Type Origin Length Description Download
eEF2K.NA RNA Sugen 3079 None Fasta, JSON
eEF2K.AA Protein Sugen 724 None Fasta, JSON
eEF2K.kin_dom Protein Kinase Domain None 199 None Fasta, JSON

Protein domain

Protein domains of eEF2K.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase eEF2K.AA Alpha 126-317 35 1e-122 351.05 In-house 1-215 (215) Show / Hide 
Range on Protein: 126-317
Range on HMM: 1-215/215
Sequence Identity: 35% (77 aa)

DEVLIKMASQPFGRGAMR------ECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRSVYFEDVQLQMEAKLWGEDYNRHK------PPKQVDIMQMCI
....|.|.|.||..||||      .|....|.....|..|||.. .||....|..|.|....... ......||.. |..|.      |.||........
QCTKIQMSSYPFMEGAMRYAMHAWDCWLHQKMVKKQHKKQWKSF-KYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYE

IELKDRPGQPLFHLEHYIEGKYIKYNSNSGFVR----DDNIRLTPQAFSHFTFERSGHQLIVVDIQ-GVG-DLYTDPQIHT----EKGTDFGDGNLGVRG
........ .....|.|.||.|.|||.|.|.|.    |.......|||||.|...|..||.|||.| ||| ...||||||.    ..|..|||||.|..|
LIHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMKFGDGNCGYEG

MALFFYSH--ACNRIC
|. |||.|  .||..|
MFRFFYTHHVQCNHYC
Alpha_kinase eEF2K.AA Alpha_kinase 120-317 34 4.4e-113 382.89 SMART 1-255 (255) Show / Hide 
Range on Protein: 120-317
Range on HMM: 1-255/255
Sequence Identity: 34% (88 aa)

TGEWLKDEVLIKM-ASQPFGRGAMRECFRTKKLSNFLH--AQQWKGASNYVAKRYIEPVDRSVYFE--------DVQLQMEAKLWGEDYNR---HKP-PK
...|...|. .|. ...||..||||.|......|...|   ..|. ...|..|.|....|...||.        ||..||..|.|....|.   |.| ||
DNKWTCQETCVKIKEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQHNPCPK

QVDIMQMCIIELK-------DRPGQPL----------------FHLEHYIEGKYIKYNSNSGFVRDDNIRLT-----------PQAFSHFTFERSGHQLI
..|..........       ||.. ..                ||.|...||...|||.|.|.|.|.. ..|           .|||||.|.|.|.||..
KIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSNHQML

VVDIQGV----GD--LYTDPQIHTEK--GTDFGDGNLGVRGMALFFYSHACNRIC
|.|||||    ||  .|||||||||.  |. ||.||||..|.. || .| || ||
VCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC
Kinase eEF2K.AA Alpha_kinase 137-317 35 1.9e-81 281.66 Pfam 1-225 (225) Show / Hide 
Range on Protein: 137-317
Range on HMM: 1-225/225
Sequence Identity: 35% (81 aa)

FGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIE----PVD------RSVYFEDVQLQMEAKLWGEDYNRH-----KPPKQVDIMQMC-IIELKDRP
|..||||.|||.....     ..|.  .|.|||.|..     ..      .  ||.|.. || .. | |..|.      .||........| ..||.|..
FAQGAMRWCFRMFDTW----DPNWRNNQNCVAKWYKKIKNYNQKQSIYVEEDYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYELEDHN

G---------------QPLFHLEHYIEG-KYIKYNSNSGFVRDDNIRLTP-----QAFSHFTFERSGHQLIVVDIQGVG--D---LYTDPQIHTEKGTD-
.               ......|.|||| ...|||.|.|.|.| . | .|     |||||||..||..|..|.||||||  .   ..|||||||..|   
KPDCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKDGNYE

--F--GDGNLGVRGMALFFY-SHACNRIC
  |  |.|||| .|.  ||  .| ||.||
MDFDEGMGNLGQEGIEKFFQNQHKCNHIC
Kinase eEF2K.AA VWL 228-322 46 1.6e-41 121.61 In-house 108-206 (206) Show / Hide 
Range on Protein: 228-322
Range on HMM: 108-206/206
Sequence Identity: 46% (46 aa)

EHYIEGKYIKYNSNSGFV--RDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVG-DLYTDPQIHTEKG-TDFGDGNLGVRGMALFFYSHACNRICQSMGL
| |||| | ||| |.|..  .|.   .  |||||||.  |  .. .||.||..  . ||||||. .    ||.||||  ||  ||..| || .||.. |
ENYIEGDYQKYNNNAGWCNQTDMEYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGMLRFFMTHQCNKYCQKLQL
Kinase eEF2K.AA Alpha-Unclassified 227-317 30 5.1e-29 91.65 In-house 110-215 (215) Show / Hide 
Range on Protein: 227-317
Range on HMM: 110-215/215
Sequence Identity: 30% (33 aa)

LEHYIEGKYIKYNSNSG----FVR-DDNIRLTPQAFSHFTFERSGHQLIVVDIQG-VG------DLYTDPQIHTEKGTDFG--DGNLGVRGMALFFYSH-
.| |..| . ||..|.|    ||. ..      ....|.|.. ..|..||.| || |.         ||||||| .   ..  ..| | |..  .| .| 
VEPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHT-IRQRYQGFKTNCGMRFIDYWFNNHH

-ACNRIC
  || .|
VQCNHYC
Kinase eEF2K.AA ChaK 225-317 36 2e-10 37.46 In-house 120-219 (219) Show / Hide 
Range on Protein: 225-317
Range on HMM: 120-219/219
Sequence Identity: 36% (36 aa)

FHLEHYIEGKYIKYNSNSG--FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQ-IHTE----KGTDFGDGNLGVRGMALFFYSHACNRIC
| .|... | . ||| | |   .    .     ||||.|.|     |.|.|.||||.  |||  |  |    ..  ||  |||   .  |   | ||  |
FTIEKCMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEEKQSCDMVFGPANLGEDAIRNFRAKHHCNSCC