Gene DYRK2 (Mouse)

DYRK2

Species: Mouse
Alias: 4932442E05Rik, DYRK2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
DYRK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 314 Kinase domain by global Sugen HMM Fasta, JSON
DYRK2.AA Protein Sugen 599 None Fasta, JSON
DYRK2.NA RNA Sugen 2137 None Fasta, JSON

Protein domain

Protein domains of DYRK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DYRK2.AA DYRK2 220-533 67 1.9e-243 800.15 In-house 1-318 (318) Show / Hide 
Range on Protein: 220-533
Range on HMM: 1-318/318
Sequence Identity: 67% (217 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFS
||.|.||||||||||||.|||| .||||.||.||.||||.||.||||||.|.|.||||||||..|||. |.||||.|.|||||||||||.||||.|||||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQ-RVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYP
| |||.|||||||||..||||.|||||||||||||||..||.||||||||||.||| |.||||||||||||||||| .|||.|||||.|||.|||.||||
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LLPGEDEGDQLACMIELLGMPSQKLLDAS-----KRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQC
|.|||.|.||.|||.|.||||..|..| .     .|.|.|. |.....||  |...|.|.........|.. |.||.|..|...||||.|..|.||.|.|
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYC--TFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRC

LEWDPAVRMTPGQALRHPWL
.||||. |||| |||.|||.
FEWDPSERMTPSQALKHPWI
Kinase DYRK2.AA DYRK 220-533 57 5.4e-209 700.59 In-house 1-320 (320) Show / Hide 
Range on Protein: 220-533
Range on HMM: 1-320/320
Sequence Identity: 57% (187 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGF-
||.|..|||||||||||..||| ...||.|..||.||||||| .||.|||.|..||.|......||.. |..||| |..||||||||||..|.|.|||| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLPLVRKFAHSILQCLDALHKN-RIIHCDLKPENILLKQQ-GRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTG
|| ||||||..||.||. |||| .|||||||||||.|||. ..| ||||||||||.||||.||||||||||||||||| .|...|||||||||||||.||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

YPLLPGEDEGDQLACMIELLGMPSQKLLDAS--KRAKNFVSSKGYPRYCTVTTLSDGSV------VLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLD
.||.|||.| |||||..|.||||.....|..  .|...|  .   ..||.... .....      .... ...| . |.||..| |..... ||| .|.|
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKD

FLKQCLEWDPAVRMTPGQALRHPWL
|.|.||.|||. |.|| |||.|||.
FIKKCLQWDPHKRITPSQALQHPWF
Kinase DYRK2.AA CMGC 220-533 22 5.5e-129 426.36 In-house 1-513 (513) Show / Hide 
Range on Protein: 220-533
Range on HMM: 1-513/513
Sequence Identity: 22% (114 aa)

YEVLKVIGKGSFGQVVKAYD--------------HKVHQHVALKMVRNEKRFHRQAA-------------EEIRILEHLR-KQDKDN-----------TM
||..|.||.|..|.|.|..|              |.  ..||.| ..|.. ...||               ||.||.||. ..|. |             
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

NVIHMLENFTFRN-----------------HICMTFELLSMNLYELIKKNK--------------------------FQGFSLPLVRKFAHSILQCLD--
|...... |...|                 |... ||.. ..||..||.|.                           . |.. ..| ... ||..|.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

ALHKNR--IIHCDLKPENILLKQQGRS------------------SIKVIDFGSSCYEHQR------------------------VYTYIQSRFYRAPEV
 .|...  |||.||||||||. .....                   .|..|||.....|..                         ..|...|.|||||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGAR----------YGMPIDMWSLGCILAELLTG--------YPLLPGEDE-----------GDQLACMIELLGMPSQKLLDASK-------RAKNFVS
.||..          |. ||||||.|||.||..||        .|| ||..|            |||......||.|. ......|       . ... .
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

SKGYPRYCT---------VTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKG-------------------------------CDDPLFLDFLKQCLE
 ...|.| .         .|.  . .. .   . .| . . |.  ...   ..                                |.||...|.||..|.
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

WDPAVRMTPGQALRHPWL
.||. |.|. |||.||..
YDPDKRITAEQALQHPYF
Kinase DYRK2.AA DYRK1 220-533 46 2.8e-113 382.66 In-house 1-321 (321) Show / Hide 
Range on Protein: 220-533
Range on HMM: 1-321/321
Sequence Identity: 46% (149 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFS
||.   |||||||||||||||. ...||.|...| | |  ||  |||.|| . |.||..  ...|. . | ||||.|. ||||| |||.|..  .|.| |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LPLVRKFAHSILQCLDALHKN--RIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGY
| |.||||. ... |  .      |||||||||||||    || ||.|||||||   ||.| ||||||||.|||.|| .| | |||||||||| |. || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRR-----GKLRGPPESREWGNALKGCDDPL-FLDFLK
||  | .| ||.  ..| |||| ....| . .|. .   |   .  ..    |.    .  . |.     |   | |..|  | .     |.| | | .|
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYF-EKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLIK

QCLEWDPAVRMTPGQALRHPWL
. |..||. |.|| .||.|...
RMLQYDPKQRITPYYALQHSFF
Kinase DYRK2.AA YAK 220-445 46 4e-95 322.32 In-house 1-230 (347) Show / Hide 
Range on Protein: 220-445
Range on HMM: 1-230/347
Sequence Identity: 46% (107 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMN----VIHMLENFTFRNHICMTFELLSMNLYELIKKNKF
| || . |.| ||||||         .| | . |   .  ||  ||.||. | .|   |  |    .. |.  | ..|| |. ||.||.||||..| |||
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

QGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLT
 |||  |.| .  .||  .  |   .|||||||||||.|..  .  ||.|||||||.| . ||||||.|.||.||.|..  |   |||||||||.|||  
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GYPLLPGEDEGDQLACMIELLGMPSQKLLD
| |. ||  | .|.   |. || |   ..|
GLPIFPGNSEYNQIKRIIDMLGYPPSWMID
Kinase DYRK2.AA S_TKc 220-533 26 7.2e-95 322.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 220-533
Range on HMM: 1-231/231
Sequence Identity: 26% (88 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSM---NLYELIKKNKFQ
||.|..||||.||.| |....| ...||.|...      ...  ||.||..    . .|  . . . ..    .|..| .|...    .|...|||.. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK----HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----FSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGM-PIDMWSLGCILA
|    |.   .|.... |.. |. .|...|||.||||||||| .     ||..|||...      .|.. ...|.||||.    ||  ..|.||.||||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLK
|.|.|||. |      |.. |....|                                                                 .| ..||..
EMLCGYPPFP------QMQMMFKKIG-----------------------------------------------------------------SPEAKDFIR

QCLEWDPAVRMTPGQALR-------HPWL
.||..||. |.|  .||.       |||.
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DYRK2.AA HIPK 220-453 41 9e-74 231.59 In-house 1-236 (329) Show / Hide 
Range on Protein: 220-453
Range on HMM: 1-236/329
Sequence Identity: 41% (99 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFS
|||| ..|.| ||||||.  .  .  ||.|. .|.  . ||   |..||. |.... |. .... ..| |  .||.|. ||.|  |||.  |.|||    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSS--IKVIDFGSSCYEHQRVY-TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTG
|  .|     .|  |  | .  .|| |||||||.|  . |    .|||||||  .  . |  ||.|||.|||||.||| ..   .|||||||..|||  |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

YPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNF
 || || || ||   ...  . | . || |  ... |
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRF
Kinase DYRK2.AA CDK 220-533 25 2.8e-67 214.23 In-house 1-284 (284) Show / Hide 
Range on Protein: 220-533
Range on HMM: 1-284/284
Sequence Identity: 25% (92 aa)

YEVLKVIGKGSFGQVVKAYDHKVH-----QHVALKMVRNEK--------RFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFR-----------NHI
|| |. || |..|.| || |.. .     | ||||..| |.         |   |  || .| .|         |..  .. ..             | .
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-------HPNIVKLHDVCHTKNMDRNNKDKHENKL

CMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG---RSSIKVIDFGSSCYEH--------QRVYT-YIQS
 | || . . |.....           .. . . .|. |. .|.|.|.| |||| |||.  .|   . ..|. ||| ..  .        .|.||  .  
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVT

RFYRAPEVILGAR-YG--MPIDMWSLGCILAELLT---GYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG
. |||||. ||.. |.   ||||||.|||.||..|   . ||.||. | ||| . ....| |. .     .   ..                        
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------

GRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL
                              |.| ..|  ||. |..  ||| ||..
------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase DYRK2.AA Pkinase 220-439 31 2.4e-61 214.91 Pfam 1-234 (293) Show / Hide 
Range on Protein: 220-439
Range on HMM: 1-234/293
Sequence Identity: 31% (76 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAE-----EIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSM-----NLYEL
|.....||.||||.| |.....  . ||.| .. ... . .  .     ||.|. .|.        |.. ... |. ..||.| .|.. .      |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IK---KNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRS--SIKVIDFGSSC---YEHQRVYTYIQSRFYRAPEVIL-GARYGMP
|.   ...|  ||   .....  ||. |. .|...|||.||||||||....|    ..|..|||...   | ... .|.  ...|.|||||. |  || .
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPK

IDMWSLGCILAELLTGYPLLPGE----DEGDQLACMIELLGMP
.||||.||||.|.|.|.|. ||.    .  ||.... . .| |
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPP
Kinase DYRK2.AA DyrkP 220-416 40 4.7e-58 189.49 In-house 1-201 (323) Show / Hide 
Range on Protein: 220-416
Range on HMM: 1-201/323
Sequence Identity: 40% (82 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNK----F
| ..  .|   | . ..  | .  | . .|.. | | .  |. .||..|  .         ||... . |  . |. .  |||  ||||  | |.     
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

QGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLT
. | .  . |    ||  || .|  |.|||||||||||.| . .  .|.|||||||. |  .  |.||| |||||||.| .|   ||||||||||||| |
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

G
|
G
Kinase DYRK2.AA PRP4 220-422 39 9e-55 188.28 In-house 1-207 (320) Show / Hide 
Range on Protein: 220-422
Range on HMM: 1-207/320
Sequence Identity: 39% (82 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQ-HVALKMVRNEKRFHRQAAEEIRILEHLRKQ--DKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKN-KF
|.|   .|.| |. |... |    .  || | .||    |.    |. ||  |  .  ||.    .. | . | .|.|.|. || .|||| |..||  | 
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

QGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGS-SCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELL
 |..|  || .|  ..  |  | |. |.| |.|| |||     .. .| .|||| |  . . .  | .||||||||.|.| .|   ||||| || |.|| 
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNES-KNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

TGYPLLPG
||  . ||
TGKIMFPG
Kinase DYRK2.AA CLK 220-354 31 8.2e-52 153.24 In-house 1-147 (350) Show / Hide 
Range on Protein: 220-354
Range on HMM: 1-147/350
Sequence Identity: 31% (46 aa)

YEVLKVIGKGSFGQVVKAYDHKV-HQHVALKMVRNEKRFHRQAAEEIR-ILEHLRKQ-DKDNTMN--VIHMLENFTF-RNHICMTFELLSMNLYELIKKN
||.... | | || ||.  |||   ..|||| .|| ...  .|  ||. |.... .  |..|.    ...|.. | .  .|||. |||.  ..|...|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

K------FQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILL
.      .... .  .|..|. ... .  ||.....| |||||||..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase DYRK2.AA CLK 362-439 48 3.5e-27 77.93 In-house 186-266 (350) Show / Hide 
Range on Protein: 362-439
Range on HMM: 186-266/350
Sequence Identity: 48% (39 aa)

IKVIDFGSSC---YEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMP
|.||||||     ..|   .| ...| |||||||||  .  | | || |||| || ||. | .. |. . || | ...|||
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMP
Kinase DYRK2.AA TyrKc 220-537 16 4.9e-11 -44.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 220-537
Range on HMM: 1-280/280
Sequence Identity: 16% (59 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHL-RKQDKDNTMNVIHMLENFTFR-------NHICMTFELLSM-NLYELI
 . .|..| | ||.|.|.      . || ||.....  ..   .|.||. .|       .  |.. ..   |           ... .|. .  .| . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGG-----HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQR-------VYTYI----QSR-----FYRAPEVILG
.|.. . ....   .|.. | .  . ||....|| ||   |.|.. ..   .|. ||| | . .          |       ...        |||.|  
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

ARYGMPIDMWSLGCILAELLT-GYPLLPGE----DEGDQLACMIELLGMPSQKLL----DASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKL
 ..    | || |  . |..| | .  ||.     . ...   ..  ... |                                                
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------------

RGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRL
              .| | ..    ||| . ||. | |  .       ....
-----------F-VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI------HECF
Kinase DYRK2.AA DyrkP 502-533 50 9.7e-10 27.55 In-house 292-323 (323) Show / Hide 
Range on Protein: 502-533
Range on HMM: 292-323/323
Sequence Identity: 50% (16 aa)

DDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL
|| .|.|| .|||  |   | |   ||.|||.
DDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase DYRK2.AA CLK 506-533 39 7.6e-09 21.9 In-house 323-350 (350) Show / Hide 
Range on Protein: 506-533
Range on HMM: 323-350/350
Sequence Identity: 39% (11 aa)

FLDFLKQCLEWDPAVRMTPGQALRHPWL
. | ....|| ||. |.| ..|| ||. 
LFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase DYRK2.AA YAK 505-533 41 4.7e-08 23.05 In-house 319-347 (347) Show / Hide 
Range on Protein: 505-533
Range on HMM: 319-347/347
Sequence Identity: 41% (12 aa)

LFLDFLKQCLEWDPAVRMTPGQALRHPWL
.|.||. | |. .|  | .| ||  || .
CFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase DYRK2.AA PRP4 506-533 46 1.1e-07 24.25 In-house 293-320 (320) Show / Hide 
Range on Protein: 506-533
Range on HMM: 293-320/320
Sequence Identity: 46% (13 aa)

FLDFLKQCLEWDPAVRMTPGQALRHPWL
| |.| .||  ||. | |. .||.|| .
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase DYRK2.AA Pkinase 506-533 50 1e-06 24.67 Pfam 266-293 (293) Show / Hide 
Range on Protein: 506-533
Range on HMM: 266-293/293
Sequence Identity: 50% (14 aa)

FLDFLKQCLEWDPAVRMTPGQALRHPWL
..||.| ||..||. | |. |.| |||.
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DYRK2.AA HIPK 506-533 42 9e-06 13.62 In-house 302-329 (329) Show / Hide 
Range on Protein: 506-533
Range on HMM: 302-329/329
Sequence Identity: 42% (12 aa)

FLDFLKQCLEWDPAVRMTPGQALRHPWL
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FVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase DYRK2.AA Pkinase_Tyr 220-253 28 4.9e-05 17.68 Pfam 1-38 (270) Show / Hide 
Range on Protein: 220-253
Range on HMM: 1-38/270
Sequence Identity: 28% (11 aa)

YEVLKVIGKGSFGQVVKAYDH----KVHQHVALKMVRN
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ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE