Gene DAPK1 (Mouse)

DAPK1

Species: Mouse
Alias: Dapk1, DAPK1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: DAPK
Subfamily: DAPK

Sequence

Name Sequence Type Origin Length Description Download
DAPK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON
DAPK1.NA RNA Sugen 5886 None Fasta, JSON
DAPK1.AA Protein Sugen 1430 None Fasta, JSON

Protein domain

Protein domains of DAPK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DAPK1.AA DAPK 13-275 84 4.7e-272 794.17 In-house 1-264 (264) Show / Hide 
Range on Protein: 13-275
Range on HMM: 1-264/264
Sequence Identity: 84% (224 aa)

YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIR-HPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESL
||.|||.|||||||||||||||||..||||||||||...|||||||||||||||||.||| |||.||||.||||||||.||||||.||||||||.|||.|
YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKECL

TEEEATEFLKQILSGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILL
.|||||.|.||||.||...||..|.|||||||||||||||||.||||||||||||.|..|||||||||||||||||||||||||||.|||||||||||||
NEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYILL

SGASPFLGDTKQETLANVSAVNYDFEEEFFRNTSTLAKDFIRRLLVKDPKKRMTIQDSLQHPWI
|||||||||||||||||..||||.|.||.|.|||..||||||||||||||||||||..||||||
SGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI
Kinase DAPK1.AA DAPK 15-275 71 5.1e-257 716.92 In-house 1-264 (264) Show / Hide 
Range on Protein: 15-275
Range on HMM: 1-264/264
Sequence Identity: 71% (190 aa)

TGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIR-HPNVITLHEVYENKTDVILILELVAGGELFDFLAE--KESL
.|||||.||||||.|||.||||..||||||||||...|||||.||.||.|..||.|.| |||||.||||||..||||||||.|.||||||...|  .|.|
MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREECL

TEEEATEFLKQILSGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILL
.||.||.|.|||| ||.||||..|.|.||||.||||.|||.|...||||||||..||..|.||..|.||||.|||||||||||.|..|||||||||||.|
CEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIML

SGASPFLGDTKQETLANVSAVNYDFEEEFFRNTSTLAKDFIRRLLVKDPKKRMTIQDSLQHPWI
||.|||||||||||..|.|.|||||.||.|..||..|||||||||||||.||||....||||||
SGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI
Kinase DAPK1.AA MLCK 13-275 49 7.4e-172 457.34 In-house 1-257 (257) Show / Hide 
Range on Protein: 13-275
Range on HMM: 1-257/257
Sequence Identity: 49% (131 aa)

YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIRHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKE-SL
|. .|||| | | .| .|.|||||...||||||       |... .|....|..|... .|||.| .|. .|.|.....|.|.. |||||.   . .  |
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKC------RKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHL

TEEEATEFLKQILSGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNE-FKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYIL
||.|  ....||. || ..|. .|.|.||||||||. .|.    .||||||||| |.| ... .|  ||||||||||.|||.|.|.  ||||.|||.|.|
TEREVIHYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTS--HQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYML

LSGASPFLGDTKQETLANVSAVNYDFEEEFFRNTSTLAKDFIRRLLVKDPKKRMTIQDSLQHPWI
||| |||.||. .||..||.....||..|.|.. |  |||||.||||||..||||... |||||.
LSGLSPFMGDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL
Kinase DAPK1.AA Trio 13-275 40 1.4e-134 347.49 In-house 1-258 (258) Show / Hide 
Range on Protein: 13-275
Range on HMM: 1-258/258
Sequence Identity: 40% (108 aa)

YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIRHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLT
|.  ||.| | |.||..|..|.||.  ||||| .|  .       .|   .| ..|.  .|| |..||. ||  .  ||||||  .||| . |....|..
YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFIPYRMMD-------KEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWGSYC

EEEATEFLKQILSGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFG--NEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYIL
|.|   .. |.|..| |||.  |.| |.||||.|. ..|  .|.|||.||| | ... .      .  |.|||.||||.. .| .. .| |||||.||..
ESEVKTYMWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVM

LSGASPFLGDTKQETLANVSAVNYDFEEEFFRNTSTLAKDFIRRLLVKDPKKRMTIQDSLQHPWI
||| |||... ..||..|.  ....|.|. | ..|  ||.||. .|. || || . .. ||||| 
LSGISPFYDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
Kinase DAPK1.AA CAMK 18-275 28 3.8e-130 421.85 In-house 1-425 (425) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-425/425
Sequence Identity: 28% (119 aa)

ELGSGQFAVVKKCREKSTG------------LQYAAKFIKKRRTKSS----------------------RRGVSREDIEREVSILKE-------IRHPNV
.||.|.|..||.|..|.|.             ..|.|.|.|.. |..                      ||...|. ..||..|.|        ..|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITLHEVYEN-------------------KTDVILIL---ELVAGGEL----FDFLAEKES---------------LTEEEATEFLKQILSGVYYLHSLQI
| |.||||.                   ........   |.. ||||    ||.. |...               .||.||  . .||.|.| |.||. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHFDLKPENIMLLDRNVPKP-------------RIKIIDFGLAHKIDF------------------------GNEFKNIFGTPEFVA-PEIVNY------
.| |||||||.| |.|  ..              |||||||.| |.|                         |  .|  .||||..| ||..|.      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------EPLGLEADMWSIGVITYILLSGASPFLGD-------------TKQETLANVSAVNYDFEEEFFRNTS--------------------TLAKD
        .. | ..||||.|||.||.|.| .|| ||             . .|.. .. . .|||....| ..|                    . .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FIRRLLVKDPKKRMTIQDSLQHPWI
.||..|..||.|||||.. |.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase DAPK1.AA DRAK 15-275 47 4.90000000001e-130 406.55 In-house 1-259 (259) Show / Hide 
Range on Protein: 15-275
Range on HMM: 1-259/259
Sequence Identity: 47% (125 aa)

TGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIRH-PNVITLHEVYENKTDVILILELVAGGELFD--FLAEKESL
|. |.| |.|||| || .|.||  .||||.||||   .    .|..| .|. .|   .  |.|| ||||||.....||.||. ||||.|.   . . | .
TAKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQD----CRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECF

TEEEATEFLKQILSGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILL
.|...   ..||| ||.|||. .|.| |||| ||.|     |   |||.|||.. .|  | |  .| |||..||||| ||.|. .  |||||||.||..|
CEKDVQRCMRQILEGVHYLHQRNIVHLDLKPQNILLTS-EYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVML

SGASPFLGDTKQETLANVSAVNYDFEEEFFRNTSTLAKDFIRRLLVKDPKKRMTIQDSLQHPWI
.. |||.||.||||  |.| .| |. || |   | .| |||..|.|..| .||| .  |.|||.
THISPFVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase DAPK1.AA CAMK1 13-275 42 1.1e-118 346.7 In-house 1-276 (276) Show / Hide 
Range on Protein: 13-275
Range on HMM: 1-276/276
Sequence Identity: 42% (119 aa)

YDTGEELGSGQFAVVKKCREKST---GLQYAAKFIK-KRRTKSSRRGVSREDIEREVSILK---EIRHPNVITLHEVYENKTDVILILELVAGGELFDFL
|  |.|.|.| |..|..| .|.|   | ||| | |. |. .| ...   .| .|.|..|.|   .| |||.| ..|.|| .... |..||| ||||||  
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQK-QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

AEKESLTEEEATEFLKQILSGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIK--IIDFGLAHKIDFGN-EFKNIFGTPEFVAPEIVNY---EPLGLEAD
 ||.. ||..| .  ||||| |.|.||. |.| ||||||. . | . .   ||  |.||||. ..| ..   |  .|||..||||....   .| . . |
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYD-KDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACD

MWSIGVITYILLSGASPFLGDT-KQETLANVSAVNYDFEEEFFRNTSTL-AKDFIRRLLVKDPKKRMTIQDSLQHPWI
|||||||||||| | .|| ... ..| .. ..   |.| . .. | |   |||||. .|..||||| |....|.||||
MWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase DAPK1.AA Ciliate-E2a 13-275 37 5.6e-103 303.96 In-house 1-275 (275) Show / Hide 
Range on Protein: 13-275
Range on HMM: 1-275/275
Sequence Identity: 37% (105 aa)

YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIRHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLT
|..  ..|.|.|..|.. . | || |.|.| ..|   | .  .  .| ...|..|.....|||.| |.||||...   |..|.. ||||.| . .. ...
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK---KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFF

EE--EATEFLKQILS-GVYYLHSLQIAHFDLKPENIMLL--DRNV-PKPRIKIIDFGLAHKI--DFGNEFKNIFGTPEFVAPEIVNYEP------LGLEA
||  |. ....|.|. |. |.|.. | | |||||||..   . |  ..  ||||||||| .|  | ..  . . ||| .||||. |..        .   
EEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKC

DMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYDFEEEF-FRNTSTLAKDFIRRLLVKDPKKRMTIQDSLQHPWI
||||.||| ||||.| .|| | | .|.| .. . ..||.    . . |  .||.....|.|||||| |.|. |.||| 
DMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase DAPK1.AA S_TKc 13-275 34 3.9e-101 343.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-275
Range on HMM: 1-231/231
Sequence Identity: 34% (95 aa)

YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIRHPNVITLHEVYENKTDVILILELVAG--GELFDFLAEKES
|. ....|.| |..|.|||.|.|| ..| | ||             |.|.||..|||. .|||...|..|... ... ...|.. |  |.|||.. .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------LTEEEATEFLKQILSGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGL-EADMWSI
      ..| .|  ...||.... |.||..| | |||||||.| .      .|||.||||| ..      . . |||...|||..   . |  ..|.||.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVITYILLSGASPFLGDTKQETLANVSAVNYDFEEEFFRNTSTLAKDFIRRLLVKDPKKRMTIQDSLQ-------HPWI
|.| |..|.|  ||   . |... ..               |  ||||||..|.|||.||.|. . ||       |||.
GCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DAPK1.AA Pkinase 13-275 32 5.1e-91 313.49 Pfam 1-293 (293) Show / Hide 
Range on Protein: 13-275
Range on HMM: 1-293/293
Sequence Identity: 32% (98 aa)

YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSR------RGVSREDIEREVSILKEIRHPNVITLHEVYENKTDVILILELVAGG----ELF
| .|. .||| |..|.||..|.|| ..| | ||||..||.       .        .|..|.|...|||...|....|.|... ...|.. ||    .||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

DFLA--EKESL--TEEEATEFLKQILSGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK--IDFGNEFKNIFGTPEFVAPEIVN-YEPLG
|..   .. ..  .|.|.  ...|||.|..|.||  | | |||||||.. .........||.||||| .  .  .  .. . |||...|||... ... |
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

LEADMWSIGVITYILLSGASPFLGD------TKQETLANVSAVNYDFEEEFFRNTS-----------------TLAKDFIRRLLVKDPKKRMTIQDSLQH
 ..||||.|.| |..|.|  || |.      .... ....    ..|...  .. |                   .||||...| |||||| |... |||
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PWI
||.
PWF
Kinase DAPK1.AA CAMKL 13-275 31 1.9e-87 279.11 In-house 1-297 (297) Show / Hide 
Range on Protein: 13-275
Range on HMM: 1-297/297
Sequence Identity: 31% (96 aa)

YDTGEELGSGQFAVVKKCRE-KSTGLQYAAKFIKKRRTKS-----------SRRGVSRED-IEREVSILKEIR---HPNVITLHEVY-------ENKTDV
|. |..|| | |..|| ..  . || ..| |.|.|....             .   .. . |.||..|.| ..   |||.| |.||.       |. ...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKH---ESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKI

ILILELVAGGE--LFDFLAEK----ESLTEEEATEFLKQILSGVYYLHSLQIAHFDLKPENIMLLDRN-VPKPRIKIIDFGLAHKID-F----GNEFKNI
 |..|.. |||  |||.. ..    ....|.||  . .||.|.|.|.||. |.| |.|||||.| ...      |||||||.. ...      |. .|  
YLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDFGFSNMYRPCIFGPGQKLKTF

FGTPEFVAPEIVNY--E-PLGLEADMWSIGVITYILLSGASPFLGDT--------KQETLANVSAVNYDFEEEFFRNTSTLAKDFIRRLLVKDPKKRMTI
 |.|.. ||||..   .   | ..|.||.||| | .. |. || .||        . . .  .    | .   ..   |  ..|.||..|...|.||.||
CGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHV--S-DCRDLIRKMLQVNPEKRPTI

QDSLQHPWI
.. ..||| 
HQIMNHPWM
Kinase DAPK1.AA Ciliate-E2 13-275 25 1.7e-86 293.66 In-house 1-365 (365) Show / Hide 
Range on Protein: 13-275
Range on HMM: 1-365/365
Sequence Identity: 25% (97 aa)

YDTGEELGSGQFAVVKKCREKSTGLQYAAK--------------FIKKRRTKSSRRGVSREDIEREVSILKEIR----------------HPNVITLHEV
|.  . .|.|.|..|.||. .... |.| |              . .|   . . .    | |..| .|..||.                |||.| ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--NKTDVILILELVAGGELFDFLAEK-----------ESLTEEEATEFLKQILS---------------GVYYLHSLQ-IAHFDLKPENIMLLDRNVP
..  ... . |..|.. ||.|||.. ..           ...||.|. .. ||||.               .. ||||   | | |.|||||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

KPRIKIIDFGLAHKIDFGNE--------------------------------FKNIFGTPEFVAPEIVNYEP---------LGLEADMWSIGVITYILLS
   ||||||||. |.|  |.                                |..| |||...||||.|...          . ..|.||.||| |..|.
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GASPFLGDTKQETLANVSAVNYDFEEEF--------------FRNTSTLAKDFIRR----LLVKDPKKRMT-IQDSLQHPWI
|  ||        . .    ..|| ...              . . |  .||.|..    .|.|||.||.| ... |.|||.
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase DAPK1.AA Pkinase_Tyr 13-132 28 1.6e-13 46.45 Pfam 1-129 (270) Show / Hide 
Range on Protein: 13-132
Range on HMM: 1-129/270
Sequence Identity: 28% (38 aa)

YDTGEELGSGQFAVVKKCREK----STGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEI-RHPNVITLHEVYENKTD---VILILELVAGGELFDF
   |..||.|.| .|.|.. |    .|... | | .|   ...      |||  ||..|.|.. .|||.. |. |   . .   .....|....| | |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LAE----KESLTEEEATEFLKQILSGVYYLHS
| .    |..|| ..  ..  || .|  ||.|
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase DAPK1.AA TyrKc 13-275 23 1.7e-13 -4.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-275
Range on HMM: 1-280/280
Sequence Identity: 23% (72 aa)

YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEI--RHPNVITLHEVYENK-------TDVILILELVAGGELFD
   |..||.|.| .| |.. |   .| | | .|.           |||. || .|....  .|||.. |. |   .         . ...|....| | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLAEKES-LTEEEATEFLKQILSGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFG-------NEFKNIF--GTPEFV-----APEI
.| ...  |. ..  .|  || .|  |||| .. | ||   |... ...    ..|| ||||. .|. .          .     |.   .     ||| 
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

VNYEPLGLEADMWSIGVITY-ILLSGASPFLG-----DTKQETLANVSAVNYDFEEEFFRN---------TSTLAKDFIRRLLVKDPKKRMTIQDSLQHP
 ||     . | || ||  . |.  |..|  |      . || ...| . ..    .   |         .. . .  ...    ||..| | ..   | 
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR---MPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HE

WI
 .
CF
Ank DAPK1.AA Ank 444-476 42 1.1e-10 42.79 Pfam 1-33 (33) Show / Hide 
Range on Protein: 444-476
Range on HMM: 1-33/33
Sequence Identity: 42% (14 aa)

SGETALHVAARYGHADVVQLLCSFGSNPDFQDK
 |.|.||.|.|.||..||..| . | ... ||.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank DAPK1.AA Ank 510-542 45 1.5e-09 38.75 Pfam 1-33 (33) Show / Hide 
Range on Protein: 510-542
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

EGETPLLTASARGYHDIVECLAEHGADLNASDK
.|.|||  |. .|....|..| .||||.|| |.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank DAPK1.AA Ank 609-641 45 3.3e-08 33.87 Pfam 1-33 (33) Show / Hide 
Range on Protein: 609-641
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

YGRTPLHLAANNGILDVVRYLCLMGANVEALTS
.|.||||||. .| ..||..|   ||.| | . 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank DAPK1.AA Ank 477-509 36 4e-08 33.55 Pfam 1-33 (33) Show / Hide 
Range on Protein: 477-509
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

EEETPLHCAAWHGYYSVAKALCEVGCNVNIKNR
. .||||.|. .|...|.| | . |..||....
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank DAPK1.AA Ank 543-575 51 1.7e-07 31.31 Pfam 1-33 (33) Show / Hide 
Range on Protein: 543-575
Range on HMM: 1-33/33
Sequence Identity: 51% (17 aa)

DGHIALHLAVRRCQMEVIKTLLGHGSFVDFQDR
||  .||||.|. ..||.| ||.||  |. ||.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank DAPK1.AA Ank 576-608 30 2.6e-07 30.61 Pfam 1-33 (33) Show / Hide 
Range on Protein: 576-608
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

HGNTPLHVACKDGSAPIVVALCEASCNLDISNK
.|.||||.||. |.. .|  | .. ..... ..
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank DAPK1.AA Ank 378-410 30 2e-06 27.2 Pfam 1-33 (33) Show / Hide 
Range on Protein: 378-410
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

HGTPPLLIAAGCGNIQMLQLLIKRGSRIDVQDK
.|  || .|. ||.......|...|  ...||.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank DAPK1.AA Ank 411-443 24 0.002938 16.01 Pfam 1-33 (33) Show / Hide 
Range on Protein: 411-443
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

GGSNAIYWASRHGHVDTLKFLNENKCPLDVKDK
 |  .  .|.|.||.. .|.| .. . ....|.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
ROC DAPK1.AA ROC 687-710 37 0.006323 6.36 In-house 3-26 (215) Show / Hide 
Range on Protein: 687-710
Range on HMM: 3-26/215
Sequence Identity: 37% (9 aa)

RIKLKLFGHSGSGKSTLVESLKCG
..|| | |. |.||..|...|...
EMKLMLCGQGGVGKTSLCKQLMHD
COR DAPK1.AA COR 948-1304 20 5.4e-101 328.36 In-house 1-434 (434) Show / Hide 
Range on Protein: 948-1304
Range on HMM: 1-434/434
Sequence Identity: 20% (91 aa)

LQEIRSQIVS-------GCSPMTHLCEKIISTLPSWRKLNG---PNQLMSLQQFVYDVQDQLNP--------LASEDDLRRIAQQLHSTGEINIMQ----
.......| .        | |. . ..|....| ..||...    ...||...|....|.. .|        . .|| |...|..||..|.| ...    
IRKTAKKIKHKQMFEDYMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIWDH

SETVQDVLLLDPRWLCTNVLGKLLSVETPRALH--HYRGR-YTMEDIQRLVP---------------DSDVEELLQILDAMDICARDLSS--------GT
 . ..|.. |||.|.|. .......... |..|  |..|. .| .|.... .               |.|.| |.... ....| .  ..        .|
DPMLKDFVVLDPQWFCQ-MMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQETT

MVDIPALIKTDSLQRS-----------WADEEDEVMVYGGVRIVPVEHLTPFPCGIFHKVQVNLCRWIHQQS--------AEGDADIRLWVSGCRIANRG
.. ||.|...|  | .           ..|...  ..|     ....|....|.|.... ||.|...||..          |..     | .|.   ..|
TYLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHY---CMDHHHMFLPAGFWPRFQVRLHHFIHDMFKCFYERSCCEWM----YWRNGMVLKWEG

A---ELLVLLVNHGQGIEVQVRGLETEKIK-CCLLLDSVCSTIETVMATTL--PGLL-------TVKHYLSPQQLREHHE-PVM--VYQPRDFFRAQTLK
.   | ||...||...| ..||| ....|. || |.......|. .... .  |||        .......|.....|.. . .   || ....||.. .
HNKNEALVKCDNHDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHWVCREWIPCPHCIQDHWDTCCDICYYQYDWCIRAEEMG

ESSLTNTMG-GYKESFSSITCFGCHDVYSQASLGMDI-HASD
. |.....  .|...|... |...|..||....|..| . ||
MDSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWIQRISD
ROC DAPK1.AA ROC 755-947 19 1e-51 171.32 In-house 1-215 (215) Show / Hide 
Range on Protein: 755-947
Range on HMM: 1-215/215
Sequence Identity: 19% (43 aa)

NVSVRSRSMMFEPGLTKGMLEVFVAPSHHLHCS------TDDQSTKAID-IQNAYLNGV----------GDFSVWEFSGNPVYFCCYDYFAANDPTSIHI
. ...   .....|  | .|  .   ... .||       ....|..|. ||. .|...          ..|.||.| |...|......|  |.  |...
CNEMK-LMLCGQGGVGKTSLCKQLMHDKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMFRKKEDEIKFNVWDFGGQEIYHATHQFFLTNH-RSVYL

IVFSLEE---PYEIQ----LNQ--VIFWLSFLKSLVPVEEPIAFGGKLKNPLRVVLVATHADIMNIPRPAGGEFGYDKDTSL--LKEIRNRFGNDLH---
.|.....   ... .    ...  ...||.|.||..| .|. .....     .|..|.||.| ..  ....    |......   ...||.|.| .|   
LVWDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEH-HCMQP----SPVIIVGTHWDKVPRQDNKV----YQHKQCCRMWQKLRNKFPNICHSWM

-VSNKLFVLDAGASGS-KDIKVLRNH
 .... ..... . .. |.|. ||.|
QIEHYQGFFHVDCETGCKGIDKLRHH
Death DAPK1.AA Death 1311-1396 35 1.1e-21 75.06 Pfam 1-87 (87) Show / Hide 
Range on Protein: 1311-1396
Range on HMM: 1-87/87
Sequence Identity: 35% (31 aa)

RKLSRLLDPPDPMGKDWCLLAMNLGLPDMVAKHNVNNRASRDFLPSPVHALLQEWTSY--PESTVGILISKLRELGRRDAADFLLKAS
.||.|||||....||||. ||  ||..|   ..  ..  ... | |.....|. |     .. ||. ||. ||..||||.|. .  ..
QKLCRLLDPDHHPGKDWRRLARKLGMSDNEIDQIEHD-QNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEALRKMGRRDCAEKIQSWL