CLIK1

Species: Mouse
Alias: 1700054C12Rik, CLIK1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: NKF4

Sequence

Name Sequence Type Origin Length Description Download
CLIK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 329 Kinase domain by global Sugen HMM Fasta, JSON
CLIK1.NA RNA Sugen 1871 None Fasta, JSON
CLIK1.AA Protein Sugen 539 None Fasta, JSON

Protein domain

Protein domains of CLIK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CLIK1.AA NKF4 207-535 80 8.9e-293 968.82 In-house 1-336 (336) Show / Hide
Range on Protein: 207-535
Range on HMM: 1-336/336
Sequence Identity: 80% (271 aa)

YSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNIVQFEECVLQRNGLAQRMSHGNKNSQLYLRLVETSLKGERI
|.|..||||||||||||||..|..||||||||||.|||||||||.|||||||.||.|||...||||.|||.|..|||||||..|||||.|||||||||||
YDLIREIGRGSYGVVYEAVIRRTSARVAVKKIRCHAPENVELALREFWALTSIKRQHQNVIHFEECILQRDGMVQRMSHGNNSSQLYLQLVETSLKGERI

LGYAEEPCYLWFVMEYCEGGDLNQYVLSRRP--DPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITE-RSGT----PILKVADFGLSKVCAGLAPR
..|..|||||||||..|.|||.|||.|||.|  ...|.||||.||..|.|.||||||.||||||.||.|.| |.|.    |..|||||||||||||||||
FDYPREPCYLWFVMDFCDGGDMNQYLLSRHPRLNDDTYKSFMMQLAQAMAHLHKNHIIHRDLKPYNIIIVEGRKGQSDLEPVVKVADFGLSKVCAGLAPR

GKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKR
||||.||||||||||.|||.|||.|||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||
GKEGQQDNKNVNVNKCWLSTACGTDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDTETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKR

RTSMSEGVKQLLKDMLAANPQDRPDAFELETRMDQV
||||.|..|||.|||||||||||||||||||||||.
RTSMNERMKQLIKDMLAANPQDRPDAFELETRMDQI

Kinase CLIK1.AA S_TKc 207-536 22 5.7e-58 199.81 SMART 1-231 (231) Show / Hide
Range on Protein: 207-536
Range on HMM: 1-231/231
Sequence Identity: 22% (76 aa)

YSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNIVQFEECVLQRNGLAQRMSHGNKNSQLYLRLVETSLKGERI
| .| .||.|..|.|| ..  ..| .||.|.|.       | .. |   | .   .| |||.. ..                                  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK---HHPNIVKLYDVFQD-------------------------------

LGYAEEPCYLWFVMEYCEG--GDLNQYVLSRRP-------DPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLA
        .|..|||||.|  ||| .|  .|..       .. . ...| |. .|....|...|.||||||.|||..|      .|..||||...     
-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----

PRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTA-KADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIP
                    .. ||. .||||||   .|.  |.|. ..|.|.. |. . .  .     ..  .. | |                     
--------------------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------

QKRRTSMSEGVKQLLKDMLAANPQDRPDAFELET-----RMDQVT
       |. .|.... .|  .|..|| | |. .     ....  
-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase CLIK1.AA Pkinase 207-528 22 6.8e-52 183.51 Pfam 1-287 (293) Show / Hide
Range on Protein: 207-528
Range on HMM: 1-287/293
Sequence Identity: 22% (77 aa)

YSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALA----EFWALTSLKRRHQNIVQFEECVLQRNGLAQRMSHGNKNSQLYLRLVETSLK
| ..  ||.||.|.||...   .| .||||.|. .  .  ..  .    |   . .|.  | |||.. ...                             
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--HPNIVRLYDWFED---------------------------

GERILGYAEEPCYLWFVMEYCEGG----DLNQYVL---SRRP--DPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGT-PILKVADFGLSKV
          . ....||||||||    ||  |.    ...   .. . |..|.|. ......|.. |.||||||.|||| ..  . ...|..||||.|.
----------KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQ

CAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWE--GHYTAKADIFALGIIIWAMIERITFIDSE----TKKELLGTYIKQGTEIVPVGEALL
                  . |.  ... ||. .||||||     .|. |.|....|.|.. |. . .  ...    .  . .  . . .  ...  .  .
FD----------------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWW

EN------PKMELHIPQKRRTSMSEGVKQLLKDMLAANPQDRPDAFEL
 .      .  . |..... . .||  |...|..|. .|..|| | ..
CSISYFFFRH-W-HFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQI

Kinase CLIK1.AA CAMK 212-448 17 4e-48 152.75 In-house 1-323 (425) Show / Hide
Range on Protein: 212-448
Range on HMM: 1-323/425
Sequence Identity: 17% (62 aa)

EIGRGSYGVVYEAVAGRSG------------ARVAVKKIRCD----------------------------APENVELALAEFWALTSLKR-----RHQNI
..||||.|.|....  ...             .||.| |  .                             |.. .  . |   . .|.      .| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQFEECVLQRNGLAQRMSHGNKNSQLYLRLVETSLKGERILGYAEEPCY------------LWFVM---EYCEGG----DLNQYVLSRRP----------
... |    ..  .  .                             . |            ...||   |||.||    || .|. ....          
IKLYEVYEDPHYFK-NT----------------------------ND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDI

------DPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTP--------------ILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYW-
      . .  . .. |. ||....|...||||||||.|||......                 .|..|||..... .     ..  .....   .. | 
VERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWT

-------LSSACGSDFYMA-PEVWEGH---------------YTAKADIFALGII
       ..  ||.  ||| ||| .|                |. |.|. ..|.|
TPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI

Kinase CLIK1.AA CAMKL 207-448 24 9.9e-39 121.12 In-house 1-225 (297) Show / Hide
Range on Protein: 207-448
Range on HMM: 1-225/297
Sequence Identity: 24% (67 aa)

YSLLAEIGRGSYGVVYEAVAGRS-GARVAVKKIR----CDAPENVELALA-----------EFWALTSLKRR-HQNIVQFEECV-----LQRNGLAQRMS
| .. ..|.||.|.|  |.  |  | .||.| |     .. | .    .            |   . .|. . |.||... |..                
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHD----------

HGNKNSQLYLRLVETSLKGERILGYAEEPCYLWFVMEYCEGGD--LNQYVLSR-----RPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERS
                          |   ... |||||.||.  | .|. ..     | ..   . .  |. ||....|...|||||.||.|||..|. 
-------------------------IET-KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENG

GTPILKVADFGLSKVCA-GLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEG---HYT-AKADIFALGII
    .|..|||.|  .  .              .. .   |.  |||  |||||. .|   .|   |.|| ..|.|
NN-NIKIIDFGFSNMYRPC--------------IFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVI

Kinase CLIK1.AA Ciliate-E2 318-528 21 1.8e-38 129.68 In-house 111-359 (365) Show / Hide
Range on Protein: 318-528
Range on HMM: 111-359/365
Sequence Identity: 21% (61 aa)

FVMEYCEGGDLNQYVLSR------------RPDPATNKSFMLQLTS---------------AIAFLHKNH-IVHRDLKPDNILITERSGTPILKVADFGL
.|||||.|||| .|  ..            ...    | .| |...               |. .||... |.|||.||.|||.        .|..||||
LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGL

SKVCAGLAPRGKEGNQDNKNVNVNK----------------YWLSSACGSDFYMAPEVWEG----------HYTAKADIFALGIIIWAMIERIT-FIDSE
|| .     .. . .| .|.    |                 .  . ||.  |||||. .|          .|. |.||..||.|.  |.   . |    
SKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----

TKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRT--------------SMSEGVKQLLKD----MLAANPQDRPD-AFEL
                      . .. . .. .|..  .              . |. .|.|.|     ||  .|. |.. . ..
----------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI

Kinase CLIK1.AA TKL 305-532 18 2.5e-36 127.0 In-house 89-364 (364) Show / Hide
Range on Protein: 305-532
Range on HMM: 89-364/364
Sequence Identity: 18% (58 aa)

RILGYAEEPCY-------------LWFVMEYCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNH--------IVHRDLKPDNILITERSG-----
...||. .| .             |..|||||.||.|  |..     .    ...|.  .....|| ..        |.|||||..|||. |        
QFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNY

-----TPI-LKVADFGLSKVC----------------AGLAPRGKEGNQDNKNVNVNKYW------LSSACGSDFYMAPEVWEGH---------------
      .. .|..|||||..                 |                  .         ... ||.  .||||| .|.               
MYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESA------------------E--HQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKG

--YTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGE-------ALLENPKMELHIPQKRR--------TSMSEGVKQLLKDMLAAN
  |. |.|... ||..| .. | .               ..  .. ...        ..  . .. . ||   .        ... ...|.|..|  ...
FEYSEKCDVYSFGIVLWEILTRCR-------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHD

PQDRPDAFELETRM
|..|| . |.  |.
PEKRPSFQEILKRL

Kinase CLIK1.AA STE 207-454 19 6.4e-36 124.34 In-house 1-263 (359) Show / Hide
Range on Protein: 207-454
Range on HMM: 1-263/359
Sequence Identity: 19% (60 aa)

YSLLAEIGRGSYGVVYEAVAG------RSGAR---------VAVKKIRCDAP-----------------ENVELALAEFWALTSLK-RRHQNIVQFEECV
. .. .||.|..|.|| |.        ..|           .|.|... .                   |...  | |   .  ..   |.|||..  | 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHM-HPNIVKYYGCY

LQR--NGLAQRMSHGNKNSQLYLRLVETSLKGERILGYAEEPCYLWFVMEYCEGGDLNQYVLSR----RPDP-----------ATNKSFMLQLTSA-IAF
..   |                                 ..  .|| .|||..|| | . . ..    .|..              . .  |.  .  ..
FKEGHN--------------------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYY

LHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVN----VNKYWLSSACGSDFYMAPEVWEG-------HYTAKADIFA
||..||.|||.||.|||.         | .|||...  .   ... . . .| . .     ..    . .|.  .||||| ..       .|..|.||  
LHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANI-Q-S-NN-I-IDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWS

LGIIIWAMIE
||. |. |..
LGCTIIEMAT

Kinase CLIK1.AA CMGC 207-453 19 1.9e-34 109.89 In-house 1-329 (513) Show / Hide
Range on Protein: 207-453
Range on HMM: 1-329/513
Sequence Identity: 19% (72 aa)

YSLLAEIGRGSYGVVYEAVAGRSGAR--------------VAVKKIRCDAPENVE------------LALAEFWALTSLK---------------RRHQN
|  .  ||.|.|||||...  |.. .              ||.|||. .  .  .             || |   |  |.               . | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVQFEECVLQRN---------GLAQRMSHGNKNSQLYLRLVETSLKGERILGYAEEPC---YLWFVMEYCEGGDLNQYVLSRR----------PDPAT--
||.  ...  .|         ..                          |  .        .| .|.||..  || ||  . .           ..    
IVKLYDIFYHKNSDGNEYEDKHI--------------------------I--S----QHFNHLYLVFEYMDH-DLYQYIKNNQFDYQGKRPMPLSE-HEN

----------NKSFM------LQLTSAIA--FLHKNH--IVHRDLKPDNILITERSGT-----------------PILKVADFGLSK-VCAGLAPRGKEG
           |.||       |.  ...  ..|..   |.|||||| ||||...                     .||..||||.. .     ..... 
KHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQ

NQDNKNVNVNKYW----LSSACGSDFYMAPEVWEGH-----------YTAKADIFALGIIIWAMI
 |  |||| ..      ...   . .| |||.  |            || . |. ..| |.  |.
PQSFKNVNKDD-KPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMY

Kinase CLIK1.AA TK 207-450 13 1e-31 103.04 In-house 1-385 (486) Show / Hide
Range on Protein: 207-450
Range on HMM: 1-385/486
Sequence Identity: 13% (58 aa)

YSLLAEIGRGSYG---VVYEAVAGRSG-------------------------ARVAVKKIRCDAPENVELALA-------------EFWALTSLKRR---
  |. ..|.| .|   .||.. . . .                          .|||| .. ..... |  ..             |...  .. ..   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HQNIVQFEECVLQR------NGLAQRMSHGNKNSQLYLRLVETSLKGERILGYAEEPCYLWFVMEYCEGGD----LNQYVLSRRPDPATNKS-------
 |.|||..  ...|       .                             . .  .   .. ||||...||    | .|  ..||.  .. .       
HHPNIVRLYGVCTQGEPKPCFE-----------------------------V-V-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHN

---------------------------------------------------------------------FMLQLTSAIAFLHKN------HIVHRDLKPD
                                                                     ...|. .. ..||..      ..|||||   
KYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAAR

NILITERSG--------TPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFY-----------------------------------
|.|..|.          .|. |.||||||...  .                           | |                                   
NCLVGENNVCKWHFDGCGPVCKIADFGLSRQGS-G-----------------------VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGG

------MAPEVWE----------GHYTAKADIFALGIIIW
      ||||...          |..| | |....|. .|
KLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMW

Kinase CLIK1.AA ULK 311-392 32 2.4e-27 92.58 In-house 88-191 (329) Show / Hide
Range on Protein: 311-392
Range on HMM: 88-191/329
Sequence Identity: 32% (34 aa)

EEP--CYLWFVMEYCEGGDLNQYVLSRRPDPATN-----------KSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGT---------PILKVADFG
|..  ......||||.|||| ||   ... | .            ..|. |. ..  .|||. |.|||.||.||||..  .          ..||.||||
ETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG

LSKV
..|.
FAKH

Kinase CLIK1.AA ULK 315-392 33 2.1e-26 90.7 In-house 91-187 (324) Show / Hide
Range on Protein: 315-392
Range on HMM: 91-187/324
Sequence Identity: 33% (33 aa)

YLWFVMEYCEGGDLNQYVLSRRPDPATN-----------KSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGT---------PILKVADFGLSKV
.....||||.|||| ||   ... |              ..|. |. ..  .|||. |.|||.||.||||..  .          ..||.||||..|.
NIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH

Kinase CLIK1.AA TyrKc 207-532 20 3.1e-15 23.62 SMART 1-280 (280) Show / Hide
Range on Protein: 207-532
Range on HMM: 1-280/280
Sequence Identity: 20% (72 aa)

YSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSL-KRRHQNIVQFEECVLQRNGLAQRMSHGNKNSQLYLRLVETSLKGER
 .|. ..|.| .|.||....      ||||... ||   .|  . |   ...| . .|.|||                                     |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGG-HHPNIV-------------------------------------R

ILGYAEEP-------CYLWFVMEYCEGGDLNQYVLSRR--PDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGL
..|.. ..         |. ||||...|||..|  ..|    ...  ||..|  .  ..||.....||||   |.|..|.    . |..|||||.     
LYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDD

------APRGKEGNQDNKN--VNVNKYWLSSACGSDFYMAPEVW-EGHYTAKADIFALGIIIWAMIERITFIDSE-----TKKELLGTYIKQGTEIVPVG
          .    ....  . .              ||||.. .| .| | |... |. .| .  .     ..      . . .  |.|||    .  
DQQGESKDYYRKKEHKGGKTMLPI------------RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPP

EALLENPKMELHIPQKRRTSMSEGVKQLLKDMLAANPQDRPDAFELETRM
...   | |           ... . |. |.  ...| |||   |.  ..
NDY---P-MSF-------VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase CLIK1.AA Pkinase_Tyr 315-391 28 5.9e-15 51.28 Pfam 81-159 (270) Show / Hide
Range on Protein: 315-391
Range on HMM: 81-159/270
Sequence Identity: 28% (23 aa)

YLWFVMEYCEGGDLNQYVLSR-----RPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSK
... ||||...|||  |  ..     .... .  .. .|  .. ..|. ....||||   |.|.||   . . |..||||..
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLAR

Kinase CLIK1.AA ULK 421-453 38 5.7e-09 27.53 In-house 212-250 (329) Show / Hide
Range on Protein: 421-453
Range on HMM: 212-250/329
Sequence Identity: 38% (15 aa)

CGSDFYMAPEVWEGH-----YT-AKADIFALGIIIWAMI
||.  ||||....|.     |. .|.||. ||.|.  |.
CGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEML

Kinase CLIK1.AA ULK 419-453 29 2e-08 26.07 In-house 200-246 (324) Show / Hide
Range on Protein: 419-453
Range on HMM: 200-246/324
Sequence Identity: 29% (14 aa)

SAC------GSDFYMAPEVWEGH-----YT-AKADIFALGIIIWAMI
...      |.  ||||....|.     |. .|.||. ||.|.  |.
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEML

Kinase CLIK1.AA TKL 213-269 26 2.2e-08 26.28 In-house 1-90 (364) Show / Hide
Range on Protein: 213-269
Range on HMM: 1-90/364
Sequence Identity: 26% (24 aa)

IGRGSYGVVYEA-VAG-------RSGARVAVKKIRCD------------------------APENVELALAEFWALTSLKR-RHQNIVQF
||.|..|.|| .   |       ..|  |||||.. .                        .||.  .   |   . ...| ||.|||||
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQF

Kinase CLIK1.AA ULK 207-272 25 2.6e-07 22.08 In-house 1-83 (324) Show / Hide
Range on Protein: 207-272
Range on HMM: 1-83/324
Sequence Identity: 25% (21 aa)

YSLLAEIGRGSYG-VVYEAVAGRS---GARVAVKKIR----CDAPENVE------LALAEFWALTSLKR-RHQN--IVQFEEC
|.|  ..| ||.| .||..   ..   .  ||.|.|      . . . |      |   |   .  ||. .|.|  ||.. ..
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDW

Kinase CLIK1.AA ULK 207-272 25 3.1e-07 21.42 In-house 1-86 (329) Show / Hide
Range on Protein: 207-272
Range on HMM: 1-86/329
Sequence Identity: 25% (22 aa)

YSLLAEIGRGSYGVVYEAVAGRS----GARVAVKKIR---CDAPENV-------ELALAEFWALTSLKR--RHQN----IVQFEEC
|.|  ..| ||.|.||..   ..    .  ||.|.|    ..  .|        .|   |   .  ||.  ||.|    ||.. ..
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDW

Kinase CLIK1.AA Pkinase_Tyr 207-244 23 4e-06 21.52 Pfam 1-42 (270) Show / Hide
Range on Protein: 207-244
Range on HMM: 1-42/270
Sequence Identity: 23% (10 aa)

YSLLAEIGRGSYGVVYEAVAG----RSGARVAVKKIRCDAPE
 ... ..|.|..|.||....       .  ||||... .| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMH

Kinase CLIK1.AA Ciliate-E2 207-224 38 0.00091 8.79 In-house 1-18 (365) Show / Hide
Range on Protein: 207-224
Range on HMM: 1-18/365
Sequence Identity: 38% (7 aa)

YSLLAEIGRGSYGVVYEA
| ..  ||.|..|.||..
YKFIKKIGQGNFGSVYKC

Kinase CLIK1.AA CAMKL 502-529 28 0.007683 4.73 In-house 266-292 (297) Show / Hide
Range on Protein: 502-529
Range on HMM: 266-292/297
Sequence Identity: 28% (8 aa)

SMSEGVKQLLKDMLAANPQDRPDAFELE
..|  ...|.. ||  || .|| . ...
HVS-DCRDLIRKMLQVNPEKRPTIHQIM

Kinase CLIK1.AA TK 509-532 25 0.030014 2.48 In-house 463-486 (486) Show / Hide
Range on Protein: 509-532
Range on HMM: 463-486/486
Sequence Identity: 25% (6 aa)

QLLKDMLAANPQDRPDAFELETRM
.|...  ...|.|||.  .|  ..
DLMQQCWHYDPEDRPTFSQLHEQL

Kinase CLIK1.AA CAMK 504-527 29 0.031608 2.17 In-house 395-418 (425) Show / Hide
Range on Protein: 504-527
Range on HMM: 395-418/425
Sequence Identity: 29% (7 aa)

SEGVKQLLKDMLAANPQDRPDAFE
|. .|.|.. ||  .|..|. . .
SQECKDLIRKMLQVDPEKRMTIEQ