Gene ChaK2 (Mouse)
ChaK2
Sequence
Protein domains of ChaK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Ion_trans | ChaK2.AA | Ion_trans | 880-1000 | 7 | 0.000176 | 18.93 | Pfam | 1-116 (199) | Show / Hide |
Range on Protein: 880-1000 Range on HMM: 1-116/199 Sequence Identity: 7% (10 aa) LVIIYIFTNAIEKVREICISEP-SKFKQKVKMWLSEYWNLMETVAIGLFAVGFGLRWGHPPLQTAGRLIYCIDIIFWFSR---LMDFFAVNQH-AGPY-V . ..... ..| . . . . . . . .||.. ... .. ... .. .. .. . .. |. | .. .| . .. ... | FDYVFTVWFTFEMILKFWAFGFKF----HPFHYFRDWWNWFDFFVVIPSYIDLIWFFFNWD------WFRVLRVFRWL-RVLRPLRLFRRWPGWMRTLWV TMIAKMAANMFYIVIIMAIVLLSFGVA |. .. ...|........... |... WMLMRSMPSIFNVMLLCFFFWFIFAII |
|||||||||
| Kinase | ChaK2.AA | ChaK | 1760-1978 | 86 | 3.6e-187 | 628.09 | In-house | 1-219 (219) | Show / Hide |
Range on Protein: 1760-1978 Range on HMM: 1-219/219 Sequence Identity: 86% (190 aa) SMSSWSQHGRAAMIQVLSQEEMDGGLRKAMRVISTWSEDDVLKPGQVFIVKSFLPEVVQTWYKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIP ||||||| ||.||||.||.||||||||.|||| .||||.|.||||.|.|.||||||||.|| ||.||.|||||||||||||||||||||||||.|||||| SMSSWSQRGRCAMIQFLSREEMDGGLRRAMRVQCTWSEHDILKPGHVYIIKSFLPEVVRTWHKIYQEDTVLHLCLREIQQQRAAQKLIYTFNQMKPQTIP YTPRFLEVSLVYCHSANQWLTIEKYMTGEFRKYNNNNGDEIAPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEDKQSRGMVFGPAN |||||||| |.||||||||.||||.|||||||||||||||| |||||||.||||||||||||||||||||||||||||||||||||| |||..||||||| YTPRFLEVFLIYCHSANQWFTIEKCMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEEKQSCDMVFGPAN LGEDAIRSFIAKHRCNSCC ||||||| |.||| ||||| LGEDAIRNFRAKHHCNSCC |
|||||||||
| Kinase | ChaK2.AA | Alpha | 1769-1978 | 37 | 5e-131 | 375.13 | In-house | 1-215 (215) | Show / Hide |
Range on Protein: 1769-1978 Range on HMM: 1-215/215 Sequence Identity: 37% (81 aa) RAAMIQVLSQEEMDGGLRKAMRVISTWSEDDVLKPGQVFIVKSFLPEVVQTWYKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYTPRFLEVS ....||..|...|.|..|.||.. ..|.... .|.......||| ..|...| |......|.|.|.||..|....|.....|||.|||.|......... QCTKIQMSSYPFMEGAMRYAMHAWDCWLHQKMVKKQHKKQWKSF-KYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYE LVYCHSAN-QWLTIEKYMTGEFRKYNNNNGDE--IAPTNTLEELMLAFSHWTYEYTRGELLVLDLQ-GVG-ENLTDPSVIKPEDKQSRGMVFGPANLGED | .||..| .. ..|.||.||..|||||.|.. . ..|....||.||||||..|..|.|.|.||| ||| ..||||....| |...||.||..|.|.. LIHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCP-AKLDQGMKFGDGNCGYE AIRSFIAKH--RCNSCC ... |...| ||..| GMFRFFYTHHVQCNHYC |
|||||||||
| Kinase | ChaK2.AA | Alpha_kinase | 1761-1978 | 28 | 5.8e-89 | 302.78 | SMART | 1-255 (255) | Show / Hide |
Range on Protein: 1761-1978 Range on HMM: 1-255/255 Sequence Identity: 28% (74 aa) MSSWSQHGRAAMIQVLSQEEMDGGLRKAMRVISTWSEDDVL-KPGQVFIVKSFLPEVVQTW--YKIFQESTVLHLCLREIQQQRAAQKLIYTFNQ---VK ...|.. .| .. . |..|.... .|||.... ..|.....|.|..|...|| . | | | ||||||....|...... ||| . DNKWTCQETCVKI-KEPKPFAKGAMRWCYW-GCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHE-T-LHLCLRDVEMQMMCKHWANEFNQEAQHN P--QTIPYTPRFLEVSL-----VYCHSANQW----------------LTIEKYMTGEFRKYNNNNGDEIAPTNTLE---------ELMLAFSHWTYEYTR | | ..| .. . . .|... .| ...| .|.|||.|||||||....... .. |...||||||||... PCPKKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSN GELLVLDLQGV----GE--NLTDPSVIKPEDKQSRGMVFGPANLGEDAIRSFIAKHRCNSCC ...|| |.||| |. ..||| ... ... |. ||..|||...|. |...|.||..| HQMLVCDIQGVIHKNGDLYYYTDPQIHTEDQN---GYGFGMGNLGQEGIEKFFQTHQCNQIC |
|||||||||
| Kinase | ChaK2.AA | Alpha_kinase | 1780-1978 | 25 | 7.7e-70 | 242.98 | Pfam | 1-225 (225) | Show / Hide |
Range on Protein: 1780-1978
Range on HMM: 1-225/225
Sequence Identity: 25% (60 aa)
EMDGGLRKAMRVISTWSEDDVLKPGQVFIVKSFLPEVVQTWYKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKP--QTIPYTPRFLEVSLVYCHSANQ
..|..|.. |.. || |......|....| ..... ... |. ..... .........|. .|... ||| .. . .|....|.....||... ..
FAQGAMRWCFRMFDTW--DPNWRNNQNCVAKWYKKIK-NYNQKQ-SIYVEEDYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYELEDHN
------------------WLTIEKYMTG-EFRKYNNNNG---DEIAPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVG--E---NLTDPSVIKPEDKQS
. ..| |..| ||.||||| | |. .... ....| ||||.||....|...| |.|||| . ||||.. .. ..
KPDCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKD-GNY
RGMVF--GPANLGEDAIRSFIA-KHRCNSCC
. |.| |..|||...|..|.. .|.|| .|
E-MDFDEGMGNLGQEGIEKFFQNQHKCNHIC
|
|||||||||
| Kinase | ChaK2.AA | Alpha-Unclassified | 1880-1978 | 30 | 2e-23 | 73.14 | In-house | 109-215 (215) | Show / Hide |
Range on Protein: 1880-1978 Range on HMM: 109-215/215 Sequence Identity: 30% (34 aa) TIEKYMTGEFRKYNNNNGDEIAPTNTLEE---LMLAFSHWTYEYTRGELLVLDLQG-VG------ENLTDPSVIKPEDKQSRGMVFG--PANLGEDAIRS ..| |. |||.||.|| | || . | ......||||. | . ..| |||| |. .||| . . .. | | | SVEPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIH------TIRQRYQGFKTNCGMRFIDY FIAKH--RCNSCC ... | || | WFNNHHVQCNHYC |
|||||||||
| Kinase | ChaK2.AA | VWL | 1881-1940 | 40 | 7.9e-20 | 55.86 | In-house | 107-167 (206) | Show / Hide |
Range on Protein: 1881-1940 Range on HMM: 107-167/206 Sequence Identity: 40% (25 aa) IEKYMTGEFRKYNNNNGDEIAPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVG-ENLTDP .|.|. |.. ||||| | . .. | |||| |. |. | ... ||||.. |||| VENYIEGDYQKYNNNAGWCNQTDMEYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDP |
|||||||||
| Kinase | ChaK2.AA | VWL | 1972-1983 | 58 | 0.078355 | 1.35 | In-house | 195-206 (206) | Show / Hide |
Range on Protein: 1972-1983 Range on HMM: 195-206/206 Sequence Identity: 58% (7 aa) HRCNSCCGKLRL | || | || | HQCNKYCQKLQL |
|||||||||