Gene CDK9 (Mouse)
CDK9
Sequence
Protein domains of CDK9.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | CDK9.AA | CDK9 | 19-315 | 70 | 2.9e-260 | 870.89 | In-house | 1-340 (340) | Show / Hide |
Range on Protein: 19-315 Range on HMM: 1-340/340 Sequence Identity: 70% (238 aa) YEKLAKIGQGTFG-----------EVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKG--SIYLVFDF ||||||||||||| |||||.|......||.|||||||||||||||||||||.||||||||||||||||||||..|||.|. ..|||||| YEKLAKIGQGTFGQVLQGRKSRNSEVFKARHKKNKRMVAMKKVLMENEKEGFPITALREIKMLQLLKHENVVNLIEICRTKATAYNRYKDRATFYLVFDF CEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR--YTNRVVTLWYRPPELLLGE |||||||||||..|||.|..||..||.|.||||||||||||||||||||||||.||.|||||||||||||..||..||| ||||||||||||||||||. CEHDLAGLLSNMNVKFSLGHIKKMMQHLMNGLYYIHRNKILHRDMKAANVLITKDGILKLADFGLARAFSQPKNDAPNRPLYTNRVVTLWYRPPELLLGD RDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKL------ELVKGQKRKVKDRLKAYVR------------- |.||||||.||||||||||||||||||||||||||.|||||||||||.||||....||..|. ||.||||||||||.|.|.. RNYGPPIDMWGAGCIMAEMWTRSPIMQGNTEQHQLQLISQLCGSITPDVWPNCENMELWNKMSSEPNSELPKGQKRKVKDRMKNYMKFDAPDSKTDPFGK ---------DPYALDLIDKLLVLDPAQRIDSDDALNHDFF |..|..||||||..||..|.|||.||.||.| NVKQHDSATDQQACHLIDKLLNIDPKKRMDSDEALDHDWF |
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Kinase | CDK9.AA | CDK | 19-315 | 42 | 8.8e-166 | 534.52 | In-house | 1-284 (284) | Show / Hide |
Range on Protein: 19-315 Range on HMM: 1-284/284 Sequence Identity: 42% (138 aa) YEKLAKIGQGTFGEVFKAKHRQTG-----QKVALKKVLMEN-----EKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKG----SIYLVFD ||||.|||.||.|.|.||...||| | |||||. ||| |||||||||.|||..|. | |.|.|.|...| ||....|. |. ..|.||. YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE FCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV-----LKLADFGLARAFSLAKN-SQP--NRYTNRVVTLWYRP ...|||..... || |..||.||.|.|.|.|.|||.| .| ||...|. ||.|||||||||. .. | . . ||..|||||||. YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRA PELLLGERDYG--PPIDLWGAGCIMAEMWT---RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKGQKRKVKDRLKAYVRDPYALDL ||||||...|. .|||.|..|||.|||.| | |...|..|..|| .|...||. |...||.| |. .. || PELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DL IDKLLVLDPAQRIDSDDALNHDFF ..|.|..||..|| ...||.|..| LNKMLCYDPKKRISAEQALQHPYF |
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Kinase | CDK9.AA | CRK7 | 19-315 | 41 | 1.4e-136 | 460.09 | In-house | 1-343 (343) | Show / Hide |
Range on Protein: 19-315 Range on HMM: 1-343/343 Sequence Identity: 41% (144 aa) YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENE---KEGFPITALREIKILQLLKHENVVNLIEICRTK--ASPYNRCKGSIYLVFDFCEHDLAGL ||... || ||.| | ||| .||. |||||| |.|| |||||||| ||||||. |.|.|.||| || | || .. |||.|.||. |||.|| YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL LSNV-LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDY------ | . ...| ....| | || |. |.|....|||| | .|.|. | .|.||||||| . .... |||||.||||||||||||| | LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYN--SEEKRRPYTNRVITLWYRPPELLLGEERYTEQHIL --------------------------------GPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKGQKRK || || |. |||..| |. || ||| | || .|...||| .|..||.|.| ... . . .|. KELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRR VKDRLK----AYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF . . .. .||| ||.|.||| |. ..|.||.| LREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF |
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Kinase | CDK9.AA | CMGC | 19-315 | 24 | 3.2e-130 | 430.47 | In-house | 1-513 (513) | Show / Hide |
Range on Protein: 19-315 Range on HMM: 1-513/513 Sequence Identity: 24% (128 aa) YEKLAKIGQGTFGEVFKAKH--------------RQTGQKVALKKVL---MEN------EKEGFPITALREIKILQLLK-----------------HENV ||.. |||.||.|.|.|... ..|...||.||. .|. ||.||||.||||||||. |. |.|. YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI VNLIEICRTKASPYNRCK---------GSIYLVFDFCEHDLAGLLSNVL--------VKFTLSE------------IKRVM------QMLLNGLY--YIH |.|..|...| | | . ..||||....|||.... | .... . || | ...|.|| |.| VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH RNK--ILHRDMKAANVLITRD--------------------GVLKLADFGLARAFSLA--KNSQPNR---------------YTNRVVTLWYRPPELLLG ... |.|||.| .|.||. . |.||..||||||... .. |... ||..|||.|||.||.||| SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG E---------RDYGPPIDLWGAGCIMAEMWTR--------SPIMQGNTE-----------QHQLALISQLCGSIT---------------PEVWPNVDKY ..|..||| |..|||.|||.|. |. .|..| ..||..| ...|..| .| |||. |. WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL ELFEK-------------------------LELVKGQKRKVKDRLKAYVR---------------------------------DPYALDLIDKLLVLDPA ..| . . . .... |. . . . || |.||..|.|..||. PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD QRIDSDDALNHDFF .|| ..||.|..| KRITAEQALQHPYF |
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Kinase | CDK9.AA | CDK7 | 19-315 | 40 | 6.30000000001e-113 | 302.14 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 19-315 Range on HMM: 1-288/288 Sequence Identity: 40% (124 aa) YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVL----MENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL |||...|| |.|. |.|| ||||.|| ||. . | | ||.||||||| ..|.||..|| | | .|.||||| . || YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKS--------NIQLVFDFMDWDLEVVI SNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTLWYRPPELLLGERDYGPPIDLW . .| ..|| | |.| ||.| ||| |||||.| | |. .|.||.|||||||.. ||| || ||| ||| |||| | | ||. .|.| KDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFY-----GSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMW GAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKG-QKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH |||.|| | |.. | . || | | | |.| |||. . . |. | . ... | | .|||. ... ..| .|. ..|.. SVGCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDD--LLDLMCGMWTMNPCKRWTCTQCLKM DFF ..| PYF |
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Kinase | CDK9.AA | CDC2 | 19-315 | 36 | 2.9e-110 | 340.17 | In-house | 1-301 (301) | Show / Hide |
Range on Protein: 19-315 Range on HMM: 1-301/301 Sequence Identity: 36% (116 aa) YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEG--FPITALREIKILQLLK-HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS |.|. ||| ||.|.|.|.|..||.| |||||. |.| || .| ||.||| .|. || |.|.| | .. ..|.||.....|| .. YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---------NKLYMVFEYLDMDLKKYMD NVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT--NRVVTLWYRPPELLLGERDYGPPI . .. ..... .| | .|.|. . |...|.||| | | || ..|..|.|||||||||. . . || |||||||.||.|||...| |. MSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPI----RTYTTEHEVVTLWYRAPEILLGCKRYSTPV DLWGAGCIMAEM---WTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYE-------LFEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP |.| |||.||| |. |. .| | || | . |. . . ||.|... ... | | ... |.. || ..||....|..|| DMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQ-SCLDPEGIDLLMQMLQYDP AQRIDSDDALNHDFF ..|| ...||.| .| QKRISAKEALQHPYF |
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Kinase | CDK9.AA | PITSLRE | 19-315 | 39 | 6.1e-105 | 354.95 | In-house | 1-295 (295) | Show / Hide |
Range on Protein: 19-315 Range on HMM: 1-295/295 Sequence Identity: 39% (120 aa) YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLME--NEKEGFPITALREIK-ILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS ...| .|. ||.|.|..|| ..|. ||||.. || ||||||||.||||. || |.|.|.||. || . . .||.|... ||||..|. FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSN------MDKIYMVMEYVEHDLKSLME NVL---VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDL | .|...||| || ||.| . | |.|.||| | .| |.. |.||..|||||| . . || ||||||| |||||| . | .|.|. NMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSP----IKPYTPCVVTLWYRAPELLLGCKKYSTPVDM WGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLE-LVKGQKRKVKDRLK--AYVRDPYALDLIDKLLVLDPAQRIDSDDA | |||.||. | |..||. | |. | .. | | || . . .. ... . . . | . ... | ..|| ..| ..|..|| .|| WSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISD-TGFDLLNQMLTYNPKNRITASDA LNHDFF | |..| LKHPWF |
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Kinase | CDK9.AA | CDK5 | 19-315 | 39 | 7.2e-97 | 306.63 | In-house | 1-287 (287) | Show / Hide |
Range on Protein: 19-315 Range on HMM: 1-287/287 Sequence Identity: 39% (117 aa) YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL |||. ||| ||.| |.||. ..|. ||||.| ...| || | ||.||| .|. |||.|.| |. . . . ||| || || . .. YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEK--------KLTLVFEFCDQDLKKYMDSCN VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCI .. . || | || || . | ...||||.| | || . | |||||||||||| . |. ||||||||| |.| . | .||.| .||| GEMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRC----YSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCI MAEMW-TRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKGQKRKVKDRLKAYVR--DPYALDLIDKLLVLDPAQRIDSDDALNHDFF .||| . | || .. || .| .. |. . . || . | . | . .. .. .. .. |. | .|| |.|...|.|||. ..||.| .| FAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDY-KPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF |
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Kinase | CDK9.AA | Pkinase | 19-315 | 30 | 1.6e-94 | 325.13 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 19-315 Range on HMM: 1-293/293 Sequence Identity: 30% (95 aa) YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALR--EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-----DLA |... |||.|.||.|.|..|. ||..||.|.. ..||.....|..| ||.|.. |.|.|.| |...... |..||.|...||. ||. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDLF GLLS-NVLVKF--TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVL----KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGER ..| .| . |.|..| .| ||.|.|...|.|||.| .|.|| ..|.. |..|||||. |. ... .| ...|.||..||...| . DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS--MTTFCGTPWYMAPEVIRGGQ DYGPPIDLWGAGCIMAEMWTRSPIMQGN----TEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP .|||..| |..|||..|| .. |. .| . |...| . | .... ||. . .|. . . ... . .. ..|.|...| .|| YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCLCKDP AQRIDSDDALNHDFF ..|. ...|.|..| KKRPTAEQILQHPWF |
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Kinase | CDK9.AA | S_TKc | 19-315 | 26 | 5.4e-94 | 319.49 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 19-315 Range on HMM: 1-231/231 Sequence Identity: 26% (82 aa) YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH---DLAGLLS ||.| |||.|.||.|.|..|. ||..||.|.. ....|||.||. .|.|.|.|...... ...|.|...|.. || .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIK NVLVK-----FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGP-P . . |. .....|. ....| |.|...|.||| | .|.|... ..|..|||||| . | ..|.||..||.| ||. . KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL----GYGKCK IDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA .| | |||..|| .. | . |.... ...| .| |.|.|.|.|. ||..|. .| CDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EA LN-------HDFF |. | .| LQDEWDIKCHPWF |
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Kinase | CDK9.AA | CDK10 | 19-315 | 37 | 1.2e-84 | 287.48 | In-house | 1-285 (285) | Show / Hide |
Range on Protein: 19-315 Range on HMM: 1-285/285 Sequence Identity: 37% (112 aa) YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL .||| ..| ||.| |..|. .. |||||| |. ||.| || .||||..| ..|||.|.| |. . ||.|| ..|| ||| || |. FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQH------LDSIFLVMQYCEQDLASLLDNMP VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCI || ...| .| .| || |.|.| ..|||.| .|.|.| .| .|.|||||||.... . | ..|||||| |||||| |. ||.| .||| QPFTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVP----VKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCI MAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF ..|. |.| || | ||. .| .| |. ..|| . . .. | | .| . . . . |.. |.. .| .| ....|. .| LGELLVHKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQS--GRRLLNFLFMYNPKKRATAEECLESSYF |
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Kinase | CDK9.AA | MAPK | 19-315 | 30 | 4.1e-76 | 259.19 | In-house | 1-328 (328) | Show / Hide |
Range on Protein: 19-315 Range on HMM: 1-328/328 Sequence Identity: 30% (101 aa) YEKLAKIGQGTFGEVFKAKHRQ------TGQKVALKKVLMENEKEGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCK---GS------IYLV |. | .|||| .| |..|... .|.|||.||. ... . ..||||.|. . .|||...|..| . .. . .| ||.| YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEM------QDDQNSLEEFNDIYIV FDFCEHDLAGLLS-NVLVKFTLSEIKRVMQMLLNG--LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLA---KNSQPNR-------YTNRV ....|.|| .. . . . |. | .|.| | ||| ..||| | .|.|.. .. ||..|||||| . ...|... | | MELMETDLHQIIKSQQ--PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYV VTLWYRPPELLLG--ERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVW---P-NVDKYELFEKLE-LVKGQKRKVKDRLKA .| ||| ||..|. ..| .| | .|||.||| | | |. .|. ..|. || ...|. ..|.. . . ..... | | | .|. .. .. ATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPN YV--RDPYALDLIDKLLVLDPAQRIDSDDALNHDFF .. .| |.||..|.||.|| .||. ..||.| .| ANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF |
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Kinase | CDK9.AA | Pkinase_Tyr | 19-173 | 30 | 1.1e-23 | 80.87 | Pfam | 1-160 (270) | Show / Hide |
Range on Protein: 19-173 Range on HMM: 1-160/270 Sequence Identity: 30% (51 aa) YEKLAKIGQGTFGEVFKAKHR----QTGQKVALKKV---LMENE--KEGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH ... |.|.| ||||.|.. . .|...|| |.. |. . .| | .||.||. | .|.|.|.|. .| . | .||.|. ...| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPH -DLAGLLSNV---LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARA || | . ..|.... . .|. | ..... ||| | |.|.|...| | .||||||. GDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD |
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Kinase | CDK9.AA | TyrKc | 19-240 | 18 | 3.7e-12 | -26.1 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 19-240 Range on HMM: 1-280/280 Sequence Identity: 18% (53 aa) YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLL--KHENVVNLIEICRTKASPYNRCK---GSIYLVFDFCEH-DLAG ... |.| | ||||.|.. . ..|| |.. . .||..|. | .|.|.|.|. .|... . ...|. ...| || ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLKD LLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLA---------KNS----QPN---------------- | . |..... . .| |.|.... ||| | |.|...... | .||||.|. . . . . YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG RYTNRV------VTLW------YRPPE---------------LLLGERDYGPPI--------DLWGAGCIMAEMWTRSPIMQGNTEQHQLAL ..| |..| |.. . |.| || || . | . | . . .. . KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |