Gene CDC7 (Mouse)
CDC7
Sequence
Protein domains of CDC7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | CDC7.AA | CDC7 | 52-559 | 57 | 0.0 | 1163.63 | In-house | 1-522 (522) | Show / Hide |
Range on Protein: 52-559 Range on HMM: 1-522/522 Sequence Identity: 57% (300 aa) FKIKDKIGEGTFSSVYLATAQLQEG-----------HEEKIALKHLIPTSHPMRIAAELQCLTVAGGQDNVMGLKYCFRKNDHVVIAMPYLEHESFLDIL .|..||||||||||||.||.|.|.. ...|.|.||.||||||.||..||||||..||..||||...|||.||||.|.|||..|.||.|.. YKVHDKIGEGTFSSVYKATCQRQPHVNKFASHFWNYCRRKFAIKHHIPTSHPERIMNELQCLTRMGGHHNVMGMCCCFRYNDHVHIVMPYFPHCSFQDFY NSLS--FQEVREYMYNLFVALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTRDTKIELLKFVQSEAQQEDCSRNKYHGVVGHKGLLSRPAPK .... ..|...||||||.||...|||||.||||||||||||||.||..||||||||...|.........||..|||.|..||||...|.|.||.||.|| FHMNRDMEEIKHYMYNLFYALRHVHQFGIIHRDVKPSNFLYNRRTKKFLLVDFGLAQHMMDYNECSRSHQQSKMQQERCNQNKYHSISGNKALLRRPPPK TVDQQCTPKTSVKRSYT--QVHIKQGKDGKERSVGLSVQRSVFGERNFNIHSSISHESPAEKLIKQSKTVDIISRKLATKKTAISTKAMNSVMRETARSC |.|||...|..|||.|. |.|||||||.|......||.|.|||.||||.||..||..|..|..||...||...||..|.|...||||||..||..|.|| TQDQQHSNKNNVKRNYNNNQHHIKQGKDDKNDHNNFSVMRNVFGNRNFNMHSNNSHNNPNNKNMKQNNNVDNNNRKNNTQKRICSTKAMNGTMRKNAMSC PAVLTCDCYGSDRVCSVCLSRRQQVAPRAGTPGFRAPEVLTKCPDQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKAFGK .....|.||.||..|..|....||.|.|||||||||||||.||||||||||.||.||||||||||||||..|.||.|||||||||.||.|.|..|..||| DPQCCCCCYKSDKCCNCCMCPKQQHANRAGTPGFRAPEVLLKCPDQTTAIDIWSCGVIFLSLLSGRYPFFMAPDDMTALAQIMTIFGSEEIIKMAHFFGK SVLCSKEVPAQDLRALCERLRGLDSTTPRSASGPPGNASYDPAASKNTDHKASRVQAAQAQHSEDSLYKRDNDGYWSHPKDCTSNSEGWDSVPDEAYDLL ...||.|.||||.|.||......||...| .|...|.|...||.||.|||||||||..|.|||.||.||||.|..|.....|......|...|||||||| KIECSHEFPAQDWRELCRCYWYMDSLPNR-TSDIQGHAQHQPAKSKQTDHKASRVQRSQNQHSPDSFYKRDSDECWHCGPICSKHMWKWEEFPDEAYDLL DKLLDLNPASRITAEAALLHAFF |..|..||..|||||.||.|.|| DRCLEMNPHKRITAEEALKHPFF |
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| Kinase | CDC7.AA | S_TKc | 52-559 | 13 | 9.2e-59 | 202.45 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 52-559
Range on HMM: 1-231/231
Sequence Identity: 13% (73 aa)
FKIKDKIGEGTFSSVYLATAQLQEGHEEKIALKHLIPTSHPMRIAAELQCLTVAGGQDNVMGLKYCFRKNDHVVIAMPYLEH--ESFLDILNS-------
..| .|||.|.|..||... .. |.| . .| |.|.| . .|. |...|. ||. . | |... . .|.. .
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR
--LSFQEVREYMYNLFVALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTRDTKIELLKFVQSEAQQEDCSRNKYHGVVGHKGLLSRPAPKTV
.. ..| ||| .. ||. .|. ||.|||.||.| | .. . |||||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------------------------------------------
DQQCTPKTSVKRSYTQVHIKQGKDGKERSVGLSVQRSVFGERNFNIHSSISHESPAEKLIKQSKTVDIISRKLATKKTAISTKAMNSVMRETARSCPAVL
----------------------------------------------------------------------------------------------------
TCDCYGSDRVCSVCLSRRQQVAPRAGTPGFRAPEVLTKCPDQTT-AIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKAFGKSVL
||| ..||||| .. ..|.|| |.|. .|.|. ||. .. .. ...
---------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-------------------
CSKEVPAQDLRALCERLRGLDSTTPRSASGPPGNASYDPAASKNTDHKASRVQAAQAQHSEDSLYKRDNDGYWSHPKDCTSNSEGWDSVPDEAYDLLDKL
..|| |...|.
-----------------------------------------------------------------------------------------SPEAKDFIRKC
LDLNPASRITAEAALL-------HAFF
|. .|. |.|| || | .|
LQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | CDC7.AA | CMGC | 371-559 | 14 | 8.2e-25 | 77.68 | In-house | 292-513 (513) | Show / Hide |
Range on Protein: 371-559
Range on HMM: 292-513/513
Sequence Identity: 14% (41 aa)
RAPEVLTKCPDQT---------TAIDMWSAGVIFLSLLSG-------RYPFYK-----------ASDDLTALAQIMTIRG------------------SR
||||.| ... | |.|||||.| || .. | ..|. . .... |..|. . | ..
RAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEE
ETIQ-------------------------AAKAFGKSVLCSKEVPAQDLRALCERLRG---------LDSTTPRSASGPPGNASYDPAASKNTDHKASRV
| .. |. . .| . ...| .... |. ... . .. . .
EWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVF-NW-IY-E-----------------------
QAAQAQHSEDSLYKRDNDGYWSHPKDCTSNSEGWDSVP--------------DEAYDLLDKLLDLNPASRITAEAALLHAFF
.. ..| |||.|.| ..|. ||||| || | .|
----------------------------------EKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
|
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| Kinase | CDC7.AA | CAMK | 366-559 | 16 | 5e-23 | 70.41 | In-house | 281-425 (425) | Show / Hide |
Range on Protein: 366-559
Range on HMM: 281-425/425
Sequence Identity: 16% (38 aa)
GTPGFRA-PEVLTK-------------CPDQTTAIDMWSAGVIFLSLLSGRYPFYKAS--DDLTALAQIMTIRGSRETIQAAKAFGKSVLCSKEVPAQDL
|||.. | |||| . | . ..||||.||| .|.|..||| . ... . .
GTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D-E-W------------------------------
RALCERLRGLDSTTPRSASGPPGNASYDPAASKNTDHKASRVQAAQAQHSEDSLYKRDNDGYWSHPKDCTSN-----SEGWDS---------VPDEAYDL
. .. |... | .. | . |. .. |.. | .|. ||
----------------------------------------------IGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDL
LDKLLDLNPASRITAEAALLHAFF
. |.| .| |.|.| .| | ..
IRKMLQVDPEKRMTIEQCLNHPWM
|
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| Kinase | CDC7.AA | CK2 | 52-194 | 29 | 6.5e-23 | 64.58 | In-house | 1-143 (288) | Show / Hide |
Range on Protein: 52-194 Range on HMM: 1-143/288 Sequence Identity: 29% (43 aa) FKIKDKIGEGTFSSVYLATAQLQEGHEEKI--ALKHLIPTSHPMRIAAELQCLTVAGGQDNVMGLKYCFRKNDHVVI--AMPYLEHESFLDILNSLSFQE ... ||| | .| |. . .||. | | | .| |.. |. | |.. | . . | .| . | . |. . YEVIRKIGRGKYSEVFEGINIKN---NEKCKIVIKILKPVKK-KKIKREIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEYVNNTDFRQLYQTLTDYD VREYMYNLFVALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLA .| ||..| || | ||.||||||.| . . . .| |.| ||| IRYYMFELLKALDYCHSMGIMHRDVKPHNIMIDHEKRKLRLIDWGLA |
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| Kinase | CDC7.AA | Ciliate-E2 | 52-195 | 17 | 2e-22 | 73.76 | In-house | 1-204 (365) | Show / Hide |
Range on Protein: 52-195
Range on HMM: 1-204/365
Sequence Identity: 17% (38 aa)
FKIKDKIGEGTFSSVYLATAQLQEGHE----------------------------EKIALKHLIPTSHPM--------RIAAELQCLTVAGGQDNVMGLK
.|. |||.|.|.|||... .. . .| .... | | .| |.. | .|.. ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLN-HPNIIKMY
YCFR--KNDHVVIAMPYLEHESFLDILN--------------SLSFQEVREYMYNLFV---------------ALKRIHQFG-IVHRDVKPSNFLYNRRL
.|| ..... . | |... . .|... ... .|....|. .. ||. .|. . |.||| ||.| |.
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----
KKYALVDFGLAQ
..||||..
--IKIIDFGLSK
|
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| Kinase | CDC7.AA | Ciliate-E2 | 365-559 | 16 | 6.4e-22 | 72.01 | In-house | 248-365 (365) | Show / Hide |
Range on Protein: 365-559
Range on HMM: 248-365/365
Sequence Identity: 16% (36 aa)
AGTPGFRAPEVLTKCPD--------QTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKAFGKSVLCSKEVPAQDLRALCERL
.||||. |||.| . .. ....|.||.|||. .|.|..||
CGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------------------------------------------------
RGLDSTTPRSASGPPGNASYDPAASKNTDHKASRVQAAQAQHSEDSLYKRDNDGYWSHP-----KDCTSNSE-----GWDSVPDEAYDLLDK----LLDL
.. .. .. | || | . |.....|. ||. | .|.
-----------------------------------------------QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQK
NPASRIT-AEAALLHAFF
.| ||| .| .| | .|
DPEKRITGWEQILNHPWF
|
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| Kinase | CDC7.AA | CMGC | 52-194 | 16 | 4.4e-21 | 65.19 | In-house | 1-251 (513) | Show / Hide |
Range on Protein: 52-194 Range on HMM: 1-251/513 Sequence Identity: 16% (43 aa) FKIKDKIGEGTFSSVYLATAQLQEGH-----------EEKIALK-----HLIPTS---------HPMRIAAELQCLTVAG----------------GQDN ..| .||||||.. || .. .. .. .|..|.| . .. |.|. |...| | YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VMGLKYCFRKND-----------------HVVIAMPYLEH--ESFLDI----------------------------LNSLSFQEVREYMYNLFVALK--R . .|...|. .. |. . . |..| ... ... .| ||| .. .|| IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY IHQFG--IVHRDVKPSNFLYNRRLKKY-------------------ALVDFGLA .|. . |.||| ||.| | | . . . . ||||| CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA |
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| Kinase | CDC7.AA | Pkinase | 52-194 | 25 | 3.7e-20 | 72.35 | Pfam | 1-159 (293) | Show / Hide |
Range on Protein: 52-194
Range on HMM: 1-159/293
Sequence Identity: 25% (42 aa)
FKIKDKIGEGTFSSVYLATAQLQEGHEEKIALKHLIPTSHPM--RIAA----ELQCLTVAGGQDNVMGLKYCFRKNDHVVIAMPYLEHE----SFLDILN
..|. |||.|.|..||... . . . |.| . . . .... |.| . . .|. |...|. .||. . |.|.|. . |..
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS
-----SL--SFQEVREYMYNLFVALKRIHQFGIVHRDVKPSNFLYNRRLKK---YALVDFGLA
.. | .|.. ||| .. .|. .|. ||.|||.||.|.|.... . |||||
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
|
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| Kinase | CDC7.AA | Ciliate-E2-Unclassified | 364-559 | 16 | 5.9e-19 | 62.4 | In-house | 222-352 (352) | Show / Hide |
Range on Protein: 364-559
Range on HMM: 222-352/352
Sequence Identity: 16% (37 aa)
RAGTPGFR----APEVLTKCPDQT---TAIDMWSAGVIFLSLLSGRYPFYKASDDL---------------TALAQIMT--IRGSRETIQAAKAFGKSVL
..|||.. ||||| .. . ..|.|| |||. .| |.|||| ... . .|. | . . |
FCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQ---------
CSKEVPAQDLRALCERLRGLDSTTPRSASGPPGNASYDPAASKNTDHKASRVQAAQAQHSEDSLYKRDNDGYWSHPKDCTSNSEGWDSVPDEAYDLLD--
. ...|| |..
------------------------------------------------------------------------------------IPKHWSPEAKDFINDL
--KLLDLNPASRITAEAALLHAFF
|.|. || .|||.| .| | .|
LQKMLKKNPNKRITFEQILNHPWF
|
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| Kinase | CDC7.AA | Ciliate-E2-Unclassified | 52-194 | 18 | 3.7e-18 | 59.61 | In-house | 1-194 (352) | Show / Hide |
Range on Protein: 52-194 Range on HMM: 1-194/352 Sequence Identity: 18% (36 aa) FKIKDKIGEGTFSSVYLATAQLQ-------EGHEEKIALKHLIPTSHPMRIAA--ELQCLTVAGGQD----------------NVMGLKYCFRKNDHVVI .|| .||.| |..||.. | . . .| ...| ... . |.... |. ... . |||.. ... | YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI AMPYLEHESFLDILNS--------------------LSFQEVR-----EYMYNLFVALKRIHQFG-IVHRDVKPSNFLYNRRLK--KYALVDFGLA | |.|. . ...... .. |... |.. . ..|. .|. . |.||| ||.| |.. | . . |||.. VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS |
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| Kinase | CDC7.AA | CAMK | 57-195 | 14 | 1.4e-16 | 49.27 | In-house | 1-244 (425) | Show / Hide |
Range on Protein: 57-195 Range on HMM: 1-244/425 Sequence Identity: 14% (36 aa) KIGEGTFSSVYLATAQLQEGHE---------EKIALKHLIPTSHP------------------------------MRIAAELQCLTVAGG------QDNV ..|.|.|. |.|.. . | | .| | | . . .. .. |.... | |. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI MGLKYCFRK-------------------NDHVVIAM---PYLEHE----SFLDILNS------------------LSFQEVREYMYNLFVALKRIHQFGI | . ..|... | | . .| . . .. .|.| |. . |.. .|. .| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI VHRDVKPSNFLYNRRL----------------KKYALVDFGLAQ |||| || | |.. . . ..|||.|. VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFAN |
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| Kinase | CDC7.AA | Pkinase | 364-419 | 33 | 6e-14 | 50.4 | Pfam | 171-231 (293) | Show / Hide |
Range on Protein: 364-419 Range on HMM: 171-231/293 Sequence Identity: 33% (21 aa) RAGTPGFRAPEVLTKCPDQTTAIDMWSAGVIFLSLLSGRYPFYKAS------DDLTALAQIM ..|||...||||. .... ....||||.|.|. .|.|| ||. . |.. ...|| FCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDNHDQMQMICRIM |
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| Kinase | CDC7.AA | Ciliate-E2a | 525-559 | 42 | 1.6e-13 | 36.23 | In-house | 241-275 (275) | Show / Hide |
Range on Protein: 525-559 Range on HMM: 241-275/275 Sequence Identity: 42% (15 aa) WDSVPDEAYDLLDKLLDLNPASRITAEAALLHAFF | ...|..||. |.|. .| ||||. || | .| WEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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| Kinase | CDC7.AA | Ciliate-E2a | 363-406 | 46 | 2.2e-13 | 35.78 | In-house | 169-217 (275) | Show / Hide |
Range on Protein: 363-406 Range on HMM: 169-217/275 Sequence Identity: 46% (23 aa) PRAGTPGFRAPEVLTKCPD---Q---TTAIDMWSAGVIFLSLLSGRYPFY .. ||||. ||||| . .. . .| ||||.|||| ||.|. ||. QKCGTPGYVAPEVL-NNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFK |
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| Kinase | CDC7.AA | CDK | 478-559 | 20 | 3.2e-13 | 38.48 | In-house | 250-284 (284) | Show / Hide |
Range on Protein: 478-559 Range on HMM: 250-284/284 Sequence Identity: 20% (17 aa) PAASKNTDHKASRVQAAQAQHSEDSLYKRDNDGYWSHPKDCTSNSEGWDSVPDEAYDLLDKLLDLNPASRITAEAALLHAFF | .| |. |||.|.| ..|. ||.||.|| | .| PGVTKLPDY-----------------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF |
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| Kinase | CDC7.AA | GSK | 146-182 | 40 | 6.9e-12 | 32.0 | In-house | 116-152 (328) | Show / Hide |
Range on Protein: 146-182 Range on HMM: 116-152/328 Sequence Identity: 40% (15 aa) QEVREYMYNLFVALKRIHQFGIVHRDVKPSNFLYNRR .... ||| .| .|. .| .||.|||.||.| |.... IHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPD |
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| Kinase | CDC7.AA | CK2 | 521-559 | 38 | 1.5e-11 | 29.96 | In-house | 250-288 (288) | Show / Hide |
Range on Protein: 521-559 Range on HMM: 250-288/288 Sequence Identity: 38% (15 aa) NSEGWDSVPDEAYDLLDKLLDLNPASRITAEAALLHAFF ..| . . .|| |.|||.| .. |||| |. |..| HQENKHLAHPEAIDFLDKMLRYDHQERITAKEAMEHPYF |
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| Kinase | CDC7.AA | CAMK1 | 525-559 | 33 | 3.1e-11 | 28.84 | In-house | 241-276 (276) | Show / Hide |
Range on Protein: 525-559 Range on HMM: 241-276/276 Sequence Identity: 33% (12 aa) WDSVPDE-AYDLLDKLLDLNPASRITAEAALLHAFF ||.. |. | |.. ..|...| |.|.| .| | .. WDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | CDC7.AA | Ciliate-E2a | 146-195 | 35 | 3.4e-11 | 29.22 | In-house | 101-157 (275) | Show / Hide |
Range on Protein: 146-195 Range on HMM: 101-157/275 Sequence Identity: 35% (20 aa) QEVREYMYNLF-VALKRIHQFGIVHRDVKPSNFLYN---RR---LKKYALVDFGLAQ ||....| .|. .| .|| .|.||| || |.|.. ... ..|||||. QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLAT |
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| Kinase | CDC7.AA | CAMK1 | 364-406 | 51 | 4.1e-11 | 28.48 | In-house | 173-217 (276) | Show / Hide |
Range on Protein: 364-406 Range on HMM: 173-217/276 Sequence Identity: 51% (23 aa) RAGTPGFRAPEVLTK--CPDQTTAIDMWSAGVIFLSLLSGRYPFY . ||||. |||||. |.||||.|||. || | ||| ACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCGYPPFY |
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| Kinase | CDC7.AA | CK2 | 364-426 | 26 | 2.3e-10 | 26.37 | In-house | 155-217 (288) | Show / Hide |
Range on Protein: 364-426 Range on HMM: 155-217/288 Sequence Identity: 26% (17 aa) RAGTPGFRAPEVLTKCPDQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRE | .. ...|| | . ..|||| |..| |.. . ||.. .| ..| .|... | . RVASRYYKGPELLVDYQYYDYSLDMWSLGCMFASMIFKKEPFFHGHDNYDQLVKIVKVLGTED |
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| Kinase | CDC7.AA | Pkinase | 513-559 | 25 | 1.4e-09 | 34.96 | Pfam | 251-293 (293) | Show / Hide |
Range on Protein: 513-559 Range on HMM: 251-293/293 Sequence Identity: 25% (12 aa) SHPKDCTSNSEGWDSVPDEAYDLLDKLLDLNPASRITAEAALLHAFF .| . .. ... . ...|. |.....|...|..|.||| .| | .| RH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | CDC7.AA | GSK | 519-559 | 28 | 2.6e-09 | 23.96 | In-house | 287-328 (328) | Show / Hide |
Range on Protein: 519-559 Range on HMM: 287-328/328 Sequence Identity: 28% (12 aa) TSNSEGWDSVPDE-AYDLLDKLLDLNPASRITAEAALLHAFF | . | ... ..||. |.| .| .|... |..| || TVYMFKWCHTDMQDWIDLISKCLVYDPKKRLSPLEACAHPFF |
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| Kinase | CDC7.AA | CDK | 124-194 | 30 | 2.6e-08 | 22.51 | In-house | 93-160 (284) | Show / Hide |
Range on Protein: 124-194 Range on HMM: 93-160/284 Sequence Identity: 30% (24 aa) VVIAMPYLEHE--SFLDILNSLSFQEVREYMYNLFVALKRIHQFGIVHRDVKPSNFLYNRR-------LKKYALVDFGLA ... ..|..| ...| .. ||. | .| .|. .|.||| ||.| |.|.. || . ||||| LYMVFEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLK---IADFGLA |
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| Kinase | CDC7.AA | CAMK1 | 52-70 | 47 | 3.1e-08 | 19.99 | In-house | 1-19 (276) | Show / Hide |
Range on Protein: 52-70 Range on HMM: 1-19/276 Sequence Identity: 47% (9 aa) FKIKDKIGEGTFSSVYLAT ......||.|.|| |||.| YEFGKEIGRGAFSEVYLCT |
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| Kinase | CDC7.AA | Ciliate-E2a | 52-70 | 57 | 3.8e-08 | 20.1 | In-house | 1-19 (275) | Show / Hide |
Range on Protein: 52-70 Range on HMM: 1-19/275 Sequence Identity: 57% (11 aa) FKIKDKIGEGTFSSVYLAT .|...|||.|.| |||||. YKFIKKIGKGNFGSVYLAQ |
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| Kinase | CDC7.AA | CDK | 371-405 | 37 | 3.2e-07 | 18.97 | In-house | 186-225 (284) | Show / Hide |
Range on Protein: 371-405 Range on HMM: 186-225/284 Sequence Identity: 37% (15 aa) RAPEVLTKCPDQT--TAIDMWSAGVIFLSLLS---GRYPF ||||.| . . . |.|||||.| || .. ... | RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLF |
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| Kinase | CDC7.AA | TyrKc | 52-261 | 14 | 4.8e-07 | -108.7 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 52-261
Range on HMM: 1-280/280
Sequence Identity: 14% (42 aa)
FKIKDKIGEGTFSSVYLATAQLQEGHEEKIALKHLIPTSHPMRIAAELQCLTVAG-GQDNVMGLKYCFRKN-------DHVVIAMPYLEHESFLDIL--N
. ..|.||| | ||..|. .. | | | . . . . |.. .. | .|. | . .. . . | | | .| . .| | .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH
S--LSFQEVREYMYNLFVALKRIHQFGIVHRDVKPSNFLYNRRLKKYALV---DFGLAQGTRDT---------KIE----LLK------------FVQS-
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RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK
---------------------EAQQED-----CSRNKYHGVVGHKGLLSRPAP--------KTVD-----QQCTPKTSVKR-SYTQVHIKQ
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FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | CDC7.AA | GSK | 52-84 | 26 | 2e-06 | 14.86 | In-house | 1-38 (328) | Show / Hide |
Range on Protein: 52-84 Range on HMM: 1-38/328 Sequence Identity: 26% (10 aa) FKIKDKIGEGTFSSVYLATAQLQEGHEEKI-----ALK ......|| |.|. || |... ....| | | YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIK |
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| Kinase | CDC7.AA | CDK | 52-84 | 34 | 3e-06 | 15.63 | In-house | 1-35 (284) | Show / Hide |
Range on Protein: 52-84 Range on HMM: 1-35/284 Sequence Identity: 34% (12 aa) FKIKDKIGEGTFSSVYLATAQLQEG--HEEKIALK ... .||||||. || | ... . .. .||| YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALK |
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| Kinase | CDC7.AA | CAMK1 | 162-195 | 43 | 4e-06 | 13.8 | In-house | 124-161 (276) | Show / Hide |
Range on Protein: 162-195 Range on HMM: 124-161/276 Sequence Identity: 43% (17 aa) IHQFGIVHRDVKPSNFLYNRR-----LKKYALVDFGLAQ .|. |||||| || | || .|. . ||||.. MHSKGIVHRDLKPENLLYYDKDEDSKIKR-SIADFGLSK |
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| Kinase | CDC7.AA | GSK | 371-392 | 50 | 2.3e-05 | 11.7 | In-house | 185-206 (328) | Show / Hide |
Range on Protein: 371-392 Range on HMM: 185-206/328 Sequence Identity: 50% (11 aa) RAPEVLTKCPDQTTAIDMWSAG |||| . .| . |..||.||.| RAPELIFGCTNYTCQIDVWSCG |
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| Kinase | CDC7.AA | Pkinase_Tyr | 52-84 | 29 | 0.000104 | 16.57 | Pfam | 1-34 (270) | Show / Hide |
Range on Protein: 52-84 Range on HMM: 1-34/270 Sequence Identity: 29% (10 aa) FKIKDKIGEGTFSSVYLATAQ-LQEGHEEKIALK .. |.||| | .||..|. ...... . | | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK |
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