Gene CaMK2a (Mouse)

CaMK2a

Species: Mouse
Alias: CaMK2a, Camk2a
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: CAMK2

Sequence

Name Sequence Type Origin Length Description Download
CaMK2a.NA RNA Sugen 4992 None Fasta, JSON
CaMK2a.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
CaMK2a.AA Protein Sugen 489 None Fasta, JSON

Protein domain

Protein domains of CaMK2a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CaMK2a.AA CAMK2 13-271 92 1.1e-221 742.8 In-house 1-259 (259) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-259/259
Sequence Identity: 92% (239 aa)

YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADA
||||||||||||||||||||...||||||||||||||||||||||||||||||.|||||||||||||.|||.|||.||||||||||||||||||||||||
YQLFEELGKGAFSVVRRCVKKCTGQEYAAKIINTKKLSARDHQKLEREARICRKLKHPNIVRLHDSIQEEGFHYLVFDLVTGGELFEDIVAREYYSEADA

SHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPP
|||||||||.| ||||.|.|||||||||||||||.||||||||||||||||.|.|||||||||||||||||||||||||||||.||||||||||||||||
SHCIQQILESVNHCHQNGIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPP

FWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI
|||||||||||||||||||.|||||||||||||.|||.||||||.|||||.||||||||
FWDEDQHRLYQQIKAGAYDYPSPEWDTVTPEAKNLINQMLTINPKKRITADEALKHPWI
Kinase CaMK2a.AA CAMK1 13-271 43 5.70000000001e-150 439.18 In-house 1-276 (276) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-276/276
Sequence Identity: 43% (120 aa)

YQLFEELGKGAFSVVRRCVKVLA---GQEYAAKIIN-TKKLSARDH---QKLEREARICRL---LKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIV
|....|.|.||||.|..|..      |..|| |.|.  | ..  |    ..||.|  | .    ..||||. ...   .. | ||. .||||||||. ||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

AREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVK--LADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK---DPYGKPVDLW
 ...|.| ||.|...|||.|| ..|..|.|||||||||||...|  .. .|  .|||||.  ....    .   |||||  ||||     .||.|..|.|
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMW

ACGVILYILLVGYPPFWDED-QHRLYQQIKAGAYDFPSPEWDTVTPE-AKDLINKMLTINPSKRITAAEALKHPWI
 .|||.||||.|||||.||. .. |...|| . |.||||.|| .  . |||.|..||. .|.||.|....|.||||
SIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase CaMK2a.AA CAMK 18-271 25 2.4e-134 435.61 In-house 1-425 (425) Show / Hide 
Range on Protein: 18-271
Range on HMM: 1-425/425
Sequence Identity: 25% (110 aa)

ELGKGAFSVVRRCVKVLAG------------QEYAAKIINTKKLS--------------------------ARDHQKLEREARICRL-------LKHPNI
.||.|.|..|..|.  . .            |..|.|||..|||.                          ..| ....|| .|...       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLHDSISEEGH-------------------HYLIF---DLVTGGEL----FEDIVAREY---------------YSEADASHCIQQILEAVLHCHQMGV
..|.. .  . .                    |...   ....||||    |. ||....               ..|..|.....||..|| .||....
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENLLLASKLKG--------------AAVKLADFGLAIEVEG-----------------------EQQAWFGFAGTPGYLS-PEVLRK------
|||||||||.|| .. ..              . .|..|||.|.....                       | |    | |||.| . ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------DPYGKPVDLWACGVILYILLVGYPPFWDE-------------DQHRLYQQIKAGAYDFPSPE------------WDTVTPE--------AKD
        ..||...| |.|||||||.|.|||||...             ....|...|..| ||||.|.            || .. |        .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LINKMLTINPSKRITAAEALKHPWI
||.|||. .|.||.|....|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CaMK2a.AA RAD53 13-271 35 3.3e-112 335.61 In-house 1-305 (305) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-305/305
Sequence Identity: 35% (109 aa)

YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLS---ARD---HQKLEREARICRLLKHPNIVRLHDSISE-EGHHYLIFDLVTGGELFEDIVARE
| . .|||.|.|..|.....   .| .| |||..||..    ..      ...|..| . |.||.|.|..|.. . .   |..  |.||||||..||...
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

Y----YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGA---------------AVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR
.    ..|...     |...||.  | .| .|||||||| |.... ..                ..|..||||.  | ||..    . ||| |. |||..
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFV-GEGSFMKTMCGTPQYVAPEVIT

KD---------------PYGKPVDLWACGVILYILLVGYPPFWDE-DQ----HRLYQQIKA-GAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEA
.                 |.| ||.|  |.||||.| ||||| |. .|      |..|||  | | ||.|.|| .. ||||||..||...| ||.|..||
SKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEA

LKHPWI
| |||.
LNHPWM
Kinase CaMK2a.AA S_TKc 13-271 36 2.1e-109 370.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-231/231
Sequence Identity: 36% (100 aa)

YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTG--GELFEDIVAREY----
|.. ...|||||..|..|...  |...| |||.         ....|| .|..  .|||||.|.|.. . .| |...... |  |.||. |. | .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGK-PVDLWACGVIL
  ..| .| . ..||..|. .||..|..||||||||.|| .      .|..||||| ..         | ||| |..||||   .||| ..| |.||.||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

YILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALK-------HPWI
|..|.|||||.  ........|.              .|||||.|.|.|. .|.||.|| |||.       |||.
YEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CaMK2a.AA CDPK 13-271 39 2.6e-109 336.39 In-house 1-271 (271) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-271/271
Sequence Identity: 39% (107 aa)

YQLFEELGKGAFSVVRRCVKV-LAGQEY-AAKIINTKKLSARDH-QKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFD--LVTGGELFEDIVAREYY
|.. ..||||.|..||....    .||  | |||. ....  .  |.. .|  | . | ||||...      | ..|...   ..||||||. |... ..
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

SEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGA----AVKLADFGLAIEVEGE----QQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWAC
.| .|.  ..||| || .||. ..|||||||||.|. || ...     .|. |.|.. . ...     .    ..||| |..||||.|  | . .|.| |
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSC

GVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI
||||||||.|||||. . .   ....| | |.|  |||| .. ||||||.|||. .| ||..|..||.|||.
GVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase CaMK2a.AA DCAMKL 13-271 38 5.8e-103 321.2 In-house 1-279 (279) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-279/279
Sequence Identity: 38% (109 aa)

YQLFEELGKGAFSVVRRCVKVLAG-QEYAAKI-----------------INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTG
||.    |.| |.||  |..   | ..|| ||                 |. .|.    |   . | .| ...|||.|..|... . | | ||.. .|.|
YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGKEHM-IDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQG

GELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLAS-KLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKP
| ||. |.    ..| ||.  . .. .|  . | |..||||.||||||.     .   .||.||||| .|.|.    .   ||| |  ||.|..  ||  
GDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILMETGYGCK

VDLWACGVILYILLVGYPPFWDE--DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI
|| || ||||||||.|.|||  .  || .|  || .|...||.|.|| ..  |||||..||  .| || || . ..|||.
VDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV
Kinase CaMK2a.AA Pkinase 13-271 34 1.6e-100 345.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-293/293
Sequence Identity: 34% (101 aa)

YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLER--EARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGG----ELFEDIV--AR
|.. . .|.|.|..|..|...  |...| |||. .. .   .| . |  |..| . |.|||||||.|.  ...| |...... ||    .||. |   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

EYY--SEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLA-SKLKGAAVKLADFGLAIEV-EGEQQAWFGFAGTPGYLSPEVLR-KDPYGKPVDLWAC
  .  || .. ... |||... .||.||..||||||||.|.      .| ||..|||||  . .  ..   .|.|||.|..|||.|   .||..|| |.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILYILLVGYPPFWDE------DQHRLYQQIKAGAYDFPSPEWDTVT-----------------PEAKDLINKMLTINPSKRITAAEALKHPWI
|.|||..| |.|||...      ||  ....|. . ..|..|.|...                  .|.||.|...|. .|.||.||...|.|||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CaMK2a.AA CAMKL 13-271 34 6.2e-95 303.39 In-house 1-297 (297) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-297/297
Sequence Identity: 34% (104 aa)

YQLFEELGKGAFSVVRRCVK-VLAGQEYAAKIINTKKLS--------------ARDHQKLEREARICRLLK---HPNIVRLHDSISEEGH------HYLI
|.. ..||||.|..|. ..   . |...| |||. ||..               .|  ...||..| ..|.   ||||..|.. |  . |       ||.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

FDLVTGGE--LFEDIVAREY----YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIE---V-EGEQQAWFGFAGTPG
  .. |||  ||. ||....     .| .| .  .||..|| .||..|.||||.||||.|| .. .   .|..|||....   .  |. |    | |.| 
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YLSPEVLRK--DPYG-KPVDLWACGVILYILLVGYPPFWDE--------DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALK
| .||.. .  .||  ..|| |.|||||| ...|| || |.        .. .|| .|. | | .|   |  |  ...||| |||. ||.||.|. . ..
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN

HPWI
||| 
HPWM
Kinase CaMK2a.AA CAMK-Unique 13-271 24 7e-92 303.6 In-house 1-363 (363) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-363/363
Sequence Identity: 24% (88 aa)

YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLS-ARDHQ-----------------KLEREARICRLLKHPNIVRLHDS----ISEEG-------
| . . .|.|.|..|..|     | ..| |... .. .  . .|                 ||.||..| ....||||..| |        .        
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------HHYLIFDLVTGGELFEDIVA--------------------REYYSE--ADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLK-----
        . |.. ....||.||. |..                    . ..||  .|..  .|..|.|| . |. ..||||||.||... . .|     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------GAAVKLADFGLAIEVEGEQQA--WFGFAGTPGYLSP--------------EVLRKDPYGKPV----DLWACGVILYILLVGYPPFWDEDQH-
           .||.||||. .... .       . ||| |..|              ||.  ..|. ..    |.|..|||.|..|.|.|||  |.   
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------RLYQQIKAGAY-DFPSPEWDT---VTPEAKDLINKMLTINPSKRITAAEALKHPWI
       .... |..| | .|... |.    ...||||.. . .|. |..|..|.|.|.|.||
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase CaMK2a.AA RSK 15-271 33 2e-90 306.7 In-house 1-278 (278) Show / Hide 
Range on Protein: 15-271
Range on HMM: 1-278/278
Sequence Identity: 33% (93 aa)

LFEE--LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH-QKLER-EARICRLLK-HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY---
| .   .|.|.....|.|.   .||.|| |... .|. .|.  ..  . | .|  . . ||.||.||..  .||. ||| ... |||||. .  ...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKG-AAVKLADFGLAIE-VEGEQQAWFGFAGTPGYLSPEVLR---KDP-YGKPVDLWACG
 || .|.  . .|  || | || |..|||||||| |....  . . .|| |||.. . .  . |    | .|  |. ||.|.   ..  ..| .|.|  |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VILYILLVGYPPFWD---EDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRIT-----AAEALKHPWI
|..| .|.|.|||     .... . ..|. | .....|.|.....||||||.|||. .|.||..     |.| ..|||.
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase CaMK2a.AA Ciliate-E2 13-271 24 4.6e-87 295.55 In-house 1-365 (365) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-365/365
Sequence Identity: 24% (94 aa)

YQLFEELGKGAFSVVRRCVKVL-----------------------AGQEYAAKIINTKKLSARDH-QKLEREAR----------ICRLLKHPNIVRLHDS
| . . .|.|.|..|..| . .                       ....|| ||.. ... .    ... || .          |...|.||||......
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IS--EEGHHYLIFDLVTGGELFEDIV------------AREYYSEADASHCIQQILE---------------AVLHCHQMG-VVHRDLKPENLLLASKLK
     . . ||..... ||.||. |             . .|..|  ... ..|||.               |. ..|. . ..|||.||||.|.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

GAAVKLADFGLAIEVEGE-------------------------------QQAWFGFAGTPGYLSPEVLRKDP---------YGKPVDLWACGVILYILLV
   .|..||||. ..  .                               |.  . ..|||||..||.|.. .         |.. .|.|..|||||..| 
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GYPPFWDEDQHRLYQQIKAGAYDFPSPE--------------WDTVTPEAKDLINK----MLTINPSKRIT-AAEALKHPWI
|.|||        .|||| . .|||.||              |. ...|.||||.|    ||  .|.|||| . ..|.|||.
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CaMK2a.AA TyrKc 13-271 20 6.5e-15 18.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLL--KHPNIVRLHDSISEE-------GHHYLIFDLVTGGELFEDIVA
 .| ..|| ||| .|....     .. | | ..  .     .. . ||||| . |  .|||||||.  ....       . ..... .. .| | . . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

REY-YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGE-----QQAWFGFA---GTPG-----YLSPEVLRKDP
..   . .|  .   || .   . |.....||||   | |.....    || .||||. ... .      .     .   |. .      ..||....  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YGKPVDLWACGVILY-ILLVGYPPFWD-----EDQHRLYQQIKAGAYDFPSPE-----WDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI
.    | |. || .. |.  | .| ..      .  ......|.| .  . |.       . ..|  ... .    .|..| | .|   |  .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CaMK2a.AA Pkinase_Tyr 13-97 24 1.4e-08 29.72 Pfam 1-94 (270) Show / Hide 
Range on Protein: 13-97
Range on HMM: 1-94/270
Sequence Identity: 24% (23 aa)

YQLFEELGKGAFSVVRRCVKV----LAGQEYAAKIINTKKLSARD--HQKLEREARICRLL-KHPNIVRLHDSIS-EEGH--HYLIFDLVTGGEL
 .. ..||.||| .|....        ... | |..   . . ..  .... |||.| . | .|||||||.  .. ....  .|... .. .| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase CaMK2a.AA Pkinase_Tyr 127-166 32 0.230861 5.24 Pfam 128-164 (270) Show / Hide 
Range on Protein: 127-166
Range on HMM: 128-164/270
Sequence Identity: 32% (13 aa)

HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGE
.... .||||   | |...   .  || .|||||  .. .
ESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYND
CaMKII_AD CaMK2a.AA CaMKII_AD 357-484 64 2.9e-92 317.61 Pfam 1-128 (128) Show / Hide 
Range on Protein: 357-484
Range on HMM: 1-128/128
Sequence Identity: 64% (83 aa)

RKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPR
.||||.||||..||||..||...|||.|.|.||.||.||.||||||..|||||||..|....|.||||.||||.|..||..||.||.|.|||.|  |...
EKQEIWKVTERWIEAIYCGDWHTYTKLCHPDMTCFEWEACGNLVEGMEFHRFYFEMHWTKRCKAVHTTMLNPHVHMYGDDAACCAYVRLTQYMDKNGMAH

TAQSEETRVWHRRDGKWQIVHFHRSGAP
|.|||||||||.||||||.||.|||..|
TRQSEETRVWHKRDGKWQCVHHHRSAMP