Gene BUBR1 (Mouse)

BUBR1

Species: Mouse
Alias: BUBR1, Bub1b
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: BUB

Sequence

Name Sequence Type Origin Length Description Download
BUBR1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 266 Kinase domain by global Sugen HMM Fasta, JSON
BUBR1.NA RNA Sugen 3669 None Fasta, JSON
BUBR1.AA Protein Sugen 1052 None Fasta, JSON

Protein domain

Protein domains of BUBR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Mad3_BUB1_I BUBR1.AA Mad3_BUB1_I 49-173 48 1.1e-72 248.67 SMART 1-133 (133) Show / Hide 
Range on Protein: 49-173
Range on HMM: 1-133/133
Sequence Identity: 48% (64 aa)

LQQQKRAFESEI--RFYSGDDPLDVWDRYINWTEQNYPQG--GKESNMSALVERAIEALQGETRYYNDPRFLSLWIKLGHLC----NEPLDMYSYLQSQG
|.||...||.||  ..|.||||||||.|||.|||||||||  .|.|..  | ||.......  ||.||||.|..||.. ..|    .||.....|....|
LEQQRQEFEQEIQDDSYEGDDPLDVWYRYIKWTEQNYPQGQQTKQSGLQTLLERCTRYFWDDERYKNDPRYLKIWIWYMDMCYNYFDEPREIFQYMYRHG

IGVSLAQFYISWAEEYEARENFKKADIIFQEGI
||...|.||..||..||...|..||| |.| ||
IGTQCALFYEEWAQWYENMGNYQKADEIYQLGI
Mad3_BUB1_I BUBR1.AA Mad3_BUB1_I 49-173 44 1.3e-67 235.78 Pfam 1-134 (134) Show / Hide 
Range on Protein: 49-173
Range on HMM: 1-134/134
Sequence Identity: 44% (60 aa)

LQQQKRAFESEIRFYS---GDDPLDVWDRYINWTEQNYPQ--GGKESNMSALVERAIEALQGETRYYNDPRFLSLWIKLGHLCN----EPLDMYSYLQSQ
||||...||.||..|.   |||||..|.|||.|.|..|||  |.|.|..  | ||........ ||.||||.| .|...  .||    ||.|...|. .|
LQQQRQQFEEEIQNYECEEGDDPLQPWYRYIKWMEEAYPQGGGTKQSGLPTLLERCVKYFWHDERYKNDPRYLKIWLWYMNYCNNNFDEPRDIFQYMYNQ

GIGVSLAQFYISWAEEYEARENFKKADIIFQEGI
|||...|.||..||. .|......||| .||.||
GIGTKCALFYEEWAQYLESMGKWQKADEVFQLGI
Kinase BUBR1.AA BUB 742-1009 33 1.9e-150 506.13 In-house 1-311 (311) Show / Hide 
Range on Protein: 742-1009
Range on HMM: 1-311/311
Sequence Identity: 33% (103 aa)

LEIGKEIELGPEDYVIKQEHLTCDDYRLFWVAPRSSAELTMIKASSQPIPWDFYINLKLKERLNED--------YDQLCSCCQYQDGHVVWYQYI-NCST
..|.|||..|...||.|.||..|.||||||||||.||.....|....|.||.|||.....|||.|.        ....|||..|||....|..|. ...|
FCIQKEIGEGSYAYVYKAEHSDCGDYRLFWVAPRKSAHWVACKVQKPPNPWEFYICDQMHERLKERSETMMHCCFMHICSCHYYQDKSCMWMEYHIDYGT

LQNLLQHSE--------FVTHEIIVLIIYNLLTIVEKLHRAEIVHGDLSPRSLILRNRIHDPYDYVNKDDHA-------VRIMDFSYSVDLRVQLDAFAY
|.....|..        ..............|..||.|||.||.|||..|....|.|||||..|...|....       ....||..|.|.....|....
LLDVINHMKEKAQVNNKVMHEYWVMFFCCQMLKMVEHLHRCEIIHGDIKPDNFMLMNRIHDDWDCWHKMSCGEAWKNKGLKLIDFGRSIDMTLFPDGQRF

SGFRTAQI--LEGQKIL----ANCSSPYHVDLLGIADLAHLLLFKEHLHVF--WDGLLWKLSQSTSELKDSE-------LWNKFFVRILN----ASDKST
......|.  .|.....    .||...|.||..|||...|..||.....|.  ||| .|||.|.........       .|||||.|.||    ..|..|
KFNCETQQDPFECWEMQQSSTTNCPWTYQVDYFGIAATMHCMLFGKYMQVKQKWDGQYWKLEQNFRRYWQKDSFSELDTMWNKFFHRMLNHNGEIPDCQT

VSVLGELAAEM
.....||.. .
LPMWHELRQQF
Kinase BUBR1.AA SgK495 833-884 32 7.1e-05 11.3 In-house 2-53 (171) Show / Hide 
Range on Protein: 833-884
Range on HMM: 2-53/171
Sequence Identity: 32% (17 aa)

LQNLLQHSEFVTHEIIVLIIYNLLTIVEKLHRAEIVHGDLSPRSLILRNRIH
||    |   .     | | .    ||| ||.  ||| ||    ..|  . |
LQHHVIHEKRLSERETVYIFHDVVRIVEALHQKNIVHRDLKLGNMVLNCHTH