Gene BRAF (Mouse)

BRAF

Species: Mouse
Alias: BRAF, Braf
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: RAF
Subfamily: RAF

Sequence

Name Sequence Type Origin Length Description Download
BRAF.AA Protein Sugen 836 None Fasta, JSON
BRAF.NA RNA Sugen 2781 None Fasta, JSON
BRAF.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of BRAF.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RBD BRAF.AA RBD 172-244 55 1.6e-39 139.72 Pfam 1-77 (77) Show / Hide 
Range on Protein: 172-244
Range on HMM: 1-77/77
Sequence Identity: 55% (43 aa)

PIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQD---GEKKPIGWDTDISWLTG-EELHVEVL
....|.|||.||.||..|.|.||||.|.|.....|| |.||.|||..|   |||||. |.||||||.| .||.||.|
KFCCVHLPNNQRCVVEVRPGMTVRDMLMKICKRHGLNPMCCHVYRVGDPHEGEKKPLDWHTDISWLPGPQELWVENL
RBD BRAF.AA RBD 172-244 50 3.7e-36 127.35 SMART 1-76 (76) Show / Hide 
Range on Protein: 172-244
Range on HMM: 1-76/76
Sequence Identity: 50% (38 aa)

PIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQD---GEKKPIGWDTDISWLTGEELHVEVL
 ...|.||..||||| .|.|.||.|.|.|....||| ||||.|.|...   |||||. |...||.|.|.||.||..
KFCCVHLPDNQRTVVKVRPGMTVHDMLMKICKKRGLNPECCHVFRRHHPHEGEKKPLDWHQPISYLPGQELWVENR
C1_1 BRAF.AA C1_1 252-300 32 6.5e-17 65.75 Pfam 1-55 (55) Show / Hide 
Range on Protein: 252-300
Range on HMM: 1-55/55
Sequence Identity: 32% (18 aa)

HNFVRK-TFFTLAFCDFCRKLL-----FQGFRCQTCGYKFHQRCSTEVPLMCVNY
|..|.. .|   .||. |....     .||..||.|.|..|.||.. || .|   
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 BRAF.AA C1 252-297 29 5.4e-16 60.39 SMART 1-61 (61) Show / Hide 
Range on Protein: 252-297
Range on HMM: 1-61/61
Sequence Identity: 29% (18 aa)

HNFVRKTFFTLAFCDFCRKLLFQ---------GFRCQTCGYKFHQRCSTEVPL-------MC
|......| . ..|. |||....         |.||. |.||.|..|.. ||.       ||
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 BRAF.AA C1_3 263-290 20 9e-06 16.12 Pfam 1-30 (30) Show / Hide 
Range on Protein: 263-290
Range on HMM: 1-30/30
Sequence Identity: 20% (6 aa)

AFCDFCRKLLF--QGFRCQTCGYKFHQRCS
 .|. | . .    ...| .| . .|..| 
FTCNCCGLPIYRDPFYHCMQCDFMLHEDCA
Kinase BRAF.AA RAF 527-786 70 1.5e-203 666.28 In-house 1-282 (282) Show / Hide 
Range on Protein: 527-786
Range on HMM: 1-282/282
Sequence Identity: 70% (198 aa)

ITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQA---FKNEVGVLRKTRHVNILLFMGYSTKPQ---LAIVTQWCEGSSLYHHLHIIET--KF
..|..|||||||||||.|.||||||||||||..|||.|.||   |||||.|..||||.||||||||..|||   .||||||||.||||||.|..||  ||
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

EMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS--GSHQFEQLSGSILWMAPEVIR-----------MQDKNPYSF
.|..||||.||..|||||||||.||||||||||||||||.|||||||||.|||.|||  |..||||....||||||||||           |||.|||||
DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSF

QSDVYAFGIVLYELMTGQLPY-SNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIEL
|||||.||||.|||||...|| ..|.||||||||.|||||.|||||||..|||||.|||..|.|..|.|||||.|||..|..
QSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase BRAF.AA RAF 527-784 59 3.6e-186 624.79 In-house 1-275 (275) Show / Hide 
Range on Protein: 527-784
Range on HMM: 1-275/275
Sequence Identity: 59% (164 aa)

ITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP-QQLQAFKNEVGVLRKTRHVNILLFMGYSTKP---QLAIVTQWCEGSSLYHHLHIIET-KFEMI
...|.|||.|.|||||.|.||||||||.||.. ||| .||||||||| ...||||.||.||||| .||   ..|||||||.||.||||.|  .| ||.| 
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN

KLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-SRWS--GSHQFEQLSGSILWMAPEVIRMQ---------DKNPYSFQSDV
..|.||.|..||||||||| ||||||||.|||||....|.|.||||.||| .||.  ...|..| .|.|.|||||||||.         |.||.||||||
WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV

YAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI
||||.|.||||.|..||..|....|||.||.||||..|.||.|..|||.||.|..||......|||.|.||...|
YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase BRAF.AA TKL 533-784 27 1.6e-101 343.55 In-house 1-364 (364) Show / Hide 
Range on Protein: 533-784
Range on HMM: 1-364/364
Sequence Identity: 27% (104 aa)

IGSGSFGTVYKGKWHG-----------DVAVKMLNVT------------------------APTPQQLQAFKNEVG-VLRKTRHVNILLFMG--------
||||.||.||||||.|           |||||.....                        .|...... |..|.  .....|| ||..|||        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-YSTKP-----QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA--------KSIIHRDLKSNNIFLHEDLT--------------V
 .. .|     ||.||...|.| ||.|.||       . .....|...|.||.|||.        . ||||||||.||...|..|              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDFGLATVKS------------------RWSGSHQFEQLSGSILWMAPEVIRMQDK-------------NPYSFQSDVYAFGIVLYELMTGQLPYSNI
||.||||....|                  . ... .     |.. ||||||.|.|..              .|| ..|||.|||||.|..|...||...
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

NNRDQI------IFMVGRG--YLSPDLS---------KVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI
.....|      .......   | | .             ..||. ||.|| .| . . ..|| | .||  .
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase BRAF.AA Pkinase 527-784 26 5.5e-83 286.79 Pfam 1-293 (293) Show / Hide 
Range on Protein: 527-784
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

ITVGQRIGSGSFGTVYKGKWHGD---VAVKMLNVTAPTPQQLQAFKN--EVGVLRKTRHVNILLFMGYS-TKPQLAIVTQWCEGS----SLYHHLH-IIE
...|..|||||||.|||....|.   |||| ...    ....|.  .  |. .... .| ||. . ..  .|. . .|. .|||     .|.....   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TKF--EMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTV----KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDV
..|  ..  ......|...|..|.|...|||||||. ||..... ..    ||.||||| ... .  .. .  . |.. .|||||||  . ..|.  .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDM

YAFGIVLYELMTGQLPYSNI-----NNRDQIIFMVGRGYLSPDLSKVRS----------------NCPKAMKRLMAECLKKKRDERPLFPQILAS--I
...|..|||...|..|...      .. .|.|...... |. | .. .|                | ....| ..  ||.|.  .|| ..||| .  .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase BRAF.AA TKL-Unique 529-784 33 8.1e-75 254.87 In-house 1-290 (290) Show / Hide 
Range on Protein: 529-784
Range on HMM: 1-290/290
Sequence Identity: 33% (100 aa)

VGQRIGSGSFGTVYKGKWHGD-VAVKMLNV-TAPTPQQLQAFKNEVGVLRKTR-HVNILLFMGYSTK-----PQLAIVTQWCEGSSLYHHLH--------
..  ||.|..|.||||||.|. ||.| ...   . .. .| |.||| .. | . | ||...|||...     |.. ||.  |.|.||| .||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-IIETKFEMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHED-----LTVKIGDFGLATVKSRWSGSHQF-------EQLSGSILWMAPEVIRM
 . ..|. | . ...|.. ||||.||| ..  |||||||| |. . ..     . .|| ||||....|. . .          .   ||..||||||.||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

QDKNPYSFQSDVYAFGIVLYELMTGQL------PYSNINNRDQIIFMVGR--GYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI
   . || .||||.|||||.|. |...      ||... ...|.. ||      . | ..   ..|||  . |. .| .   ..|| | .|. ..
NF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYMEENYRPPIP---NHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase BRAF.AA KSR 527-784 37 2.1e-69 235.75 In-house 1-272 (272) Show / Hide 
Range on Protein: 527-784
Range on HMM: 1-272/272
Sequence Identity: 37% (102 aa)

ITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVT-APTPQQ-LQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWCEG-SSLYHHLHIIETKFEMIK
.  | .|| | ||.|..| |||.||.| ..        . | .|| ||  ...||| || ||||.   | .||||.  | |  .||||.|   .|. | .
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

LIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK---SRWSGSHQFEQLSGSILWMAPEVIRM------QDK---NPYSFQSDVY
 ..||.| .||| ||||| ||| |||| |||.     | | ||||  ..       .. .     |    .||| ||        ..   .|.| .||||
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

AFGIVLYELMTGQLPYSNINNRDQIIFMVGRG-YLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI
||| ..||...| .|. .     .||. ...|  . ..|. |   | . || .. .|     .||| | .|.  .
AFGTIWYEMICGEWPFKY-QCAESIIWQMCQGEGMRQVLRNVQ--CGREMKEILMMCWSYEPQERPTFQDIMKML
Kinase BRAF.AA Dicty4 527-786 36 4.3e-68 226.24 In-house 1-277 (277) Show / Hide 
Range on Protein: 527-786
Range on HMM: 1-277/277
Sequence Identity: 36% (105 aa)

ITVGQRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPT--PQQLQAFKNEVGVLRKTRHVNILLFMGYST----KP-QLAIVTQWCEGSSLYHHLHI-----
|...||||.||||.||||.| | .||||.|| .  .     |..|..||  . | || ||.||||..|    .|  . |||  .   .||  ||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

---IETKFEMIKL-IDIARQTAQGMDYLHA--KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLS--GSILWMAPEVIRMQDKNPYSF
   |.  .. ||  . .|. .|.|| .||.    |||||||| |.   ....||..||||.... . . .|.. | .  |. .|||||| .   ..||  
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHE-DHKDNQMTACGTPCWMAPEVMM---HQPYNE

QSDVYAFGIVLYELMTGQLPYS-NINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS--IEL
 .||| |||||.|. |.| ||.  . . .|... |..  | | ..   ..||.  |.|...|. .    || |..|.     | 
KADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIP---DWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase BRAF.AA MLK 527-784 33 4e-67 229.3 In-house 1-291 (291) Show / Hide 
Range on Protein: 527-784
Range on HMM: 1-291/291
Sequence Identity: 33% (99 aa)

ITVGQRIGSGSFGTVYKGKWHG-D-----VAVKMLNVTA----PTPQQLQAFKNEVGVLRKTRHVN----ILLFMGYSTKP-Q-LAIVTQWCEGSSLYHH
|.. . ||||||| |.||.|.. |     ||||. . ..     |  . ..|. |.  ||. .| |    |  |.| ...| . ..||...|||.|||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHIIETKFE-------------MIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHE------DLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL
|| ...| .             .  ....| | |.||.|||..    |||||||| || ..|      ..|.|| |||... ...   .  . .  |.  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTYA

WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI
|||||||     ..||  .||. .|.||.|..|...||.....  .|...|.   | |    ..|.||. .|.|| .| . .  .|| | ||.   
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRP---PIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase BRAF.AA TK 527-784 17 1.4e-66 221.91 In-house 1-486 (486) Show / Hide 
Range on Protein: 527-784
Range on HMM: 1-486/486
Sequence Identity: 17% (85 aa)

ITVGQRIGSGSFG---TVYKGKWHG----------------------------DVAVKMLNVT-APTPQQLQA--------------FKNEVGVLR--KT
||.|. .|.| ||   .||||.|.|                            .||||||  . | .... ..              . .|  ...  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHVNILLFMGYSTKPQ-------------LAIVTQWCEGSS----LYHHLHIIETK--------------------------------------------
.| ||. . |..|...             . ||. .... .    | ..|.    |                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FEMIKLIDIARQTAQGMDYLHAK------SIIHRDLKSNNIFLHEDLT-----------VKIGDFGLAT
                               . |  |. ...| |.|| |||.|       ..||||   |. ..|...           .||.||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

VKS----RWSGSHQFEQLSGS----------------------------ILWMAPEVIRMQD------KNPYSFQSDVYAFGIVLYELMT-G-QLPYSNI
..|    |  .|..    ..|                            | |||||... .       .. .. .|||..||....|..| | . .| ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NN--------RDQIIFMVGRG-YLSPD---------LSKVR-SNCP--------------KAMKRLMAECLKKKRDERPLFPQILASI
.|         .... .. ||  | .          . . .  .||              ... .|| .| ... ..|| | |..  .
SNQDVWKDGDNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase BRAF.AA S_TKc 527-787 23 3.2e-59 203.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 527-787
Range on HMM: 1-231/231
Sequence Identity: 23% (66 aa)

ITVGQRIGSGSFGTVYKGKWHG---DVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEG--SSLYHHLHIIETK----
 .... ||.|.||.|||.....    ||.|...         . ...|. .|.| .| ||  . ..     | .|.  |.|   .|.....   ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSF-QSDVYAFGIV
 |       ...|......|.| . |||||||  ||.| |  ..||.|||||..            . |.  .|||||.      .|..  .|....|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

LYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA------SIELL
|||...|. |..   . .... ..|               .. .| ..  ||.|  ..||   ..|.      . . .
LYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase BRAF.AA TyrKc 527-784 31 5.8e-55 189.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 527-784
Range on HMM: 1-280/280
Sequence Identity: 31% (91 aa)

ITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT--RHVNILLFMGYSTK--------PQLAIVTQWCEGSSLYHHLHIIET
|| |. .|.| ||.||||.|  .||||||.  |     ...| .|  ...|   .| ||. . |. |.        ..| ||.  ... .| ..|.  . 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRW-----SGSHQFE----QLS--GSILWMAPEVIRMQDKNPYSF
|. | .|.... | |.||.||| | .|||||   |. ..|..||||.||||.           |..        .      | |||||.|   ... ...
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTT

QSDVYAFGIVLYELMT-GQLPYSN-----INNRDQIIFMVGRGYLSPDLSKVRSN-------CPKAMKRLMAECLKKKRDERPLFPQILASI
.|||..||....|..| || ||..     ..|.. .|  | .||    . .  ..       ||..| ..| .| . . ..|| | .|   .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE-VIEYVKQGYR---MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase BRAF.AA TK-Unique 527-784 29 9.5e-54 183.7 In-house 1-294 (294) Show / Hide 
Range on Protein: 527-784
Range on HMM: 1-294/294
Sequence Identity: 29% (89 aa)

ITVGQRIGSGSFGTVYKGKWHG-------D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP--QLAIVTQWCEGSSLYHHLH---
..||..||.|.||.|..|.  |       .  ||||||.  |   .. . .|.      ...| ||. ..|..||.  .  |.  .|....| |.|.   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

----------IIE------TKFEM---IK---LIDIARQTAQGMDYLHA--KSIIHRDLKSNNIFLHEDLTVKIGDFGLAT-VKSRWSGSHQFEQLSGSI
          ..       ... .   |.   |. .| | |.|| ||.   | |.|||| . |..| ||...||.|||.|. |  .   | . .|   .|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

LWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNC-PKAMKRLMAECLKKKRDERPLFPQILASI
 |||||...  ... .. .|||..||....|..| |. ||... ..| |. .. .||  |    ....| ...|  || .|......||| | ||.  .
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMP----QPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase BRAF.AA STE 527-775 21 2.8e-52 180.0 In-house 1-346 (359) Show / Hide 
Range on Protein: 527-775
Range on HMM: 1-346/359
Sequence Identity: 21% (75 aa)

ITVGQRIGSGSFGTVYKGKWH----GD--------------VAVKMLNVTAPTP---------------QQLQAFKNEVGVLRKTR--HVNILLFMGYST
 .  ..||.|.||||||.. |    ..              .|.| .|.   ..               ...| ...|. ...| .  | ||  . |.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KP--------QLAIVTQWCEGSSLYHHLH-IIETKF-------------EMIKLIDIARQTAQG-MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLA
|         .| |.  ...| ||   ..   ....             | . .. |.||. .| ..||| . |||||.|. ||.|     ||. |||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQ-IAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

T--VKSRW------------SGSHQFEQLSGSILWMAPEVIRMQD---KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD---QIIFMVGRG------
.  ..|              ... .   . |.  |||||||. ..   ...|....|.. .|... |. ||. |... ..     .|.|. . .      
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----YLSPDLSKVRS----------------NCPKAMKRLMAECLKKKRDERP
      .| |    |                .. . .|  .. ||.|  ..||
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP
Kinase BRAF.AA Pkinase_Tyr 527-668 36 4.1e-47 160.19 Pfam 1-158 (270) Show / Hide 
Range on Protein: 527-668
Range on HMM: 1-158/270
Sequence Identity: 36% (57 aa)

ITVGQRIGSGSFGTVYKGKWH-------GDVAVKMLNVTAPTPQ-QLQAFKNEVGVLRKT-RHVNILLFMGYST---KP-QLAIVTQWCEGSSLYHHLHI
|| |. .|.|.||.||||.|.        .||||||. .|  .|  ...| .|. ....  .| ||. ..|  |   .| |. ||.  ... .|...|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

I---ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLA
    . .. |  |.....| |.||.||..| .|||||   |. ..|...|||.|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase BRAF.AA Pkinase_Tyr 689-784 29 2.5e-21 72.83 Pfam 180-270 (270) Show / Hide 
Range on Protein: 689-784
Range on HMM: 180-270/270
Sequence Identity: 29% (29 aa)

WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLP-YSNINNRDQIIFMV-GRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI
|||||.|.      .. .|||..||....|..| |. | | .. | . .. ..  .||    . .   |||. . .|| .| ... ..|| | .|.  .
WMAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE-VYEYIYEDGYR---MPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL