Gene ANPa (Mouse)

ANPa

Species: Mouse
Alias: ANPa, Npr1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
ANPa.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 276 Kinase domain by global Sugen HMM Fasta, JSON
ANPa.NA RNA Sugen 4065 None Fasta, JSON
ANPa.AA Protein Sugen 1057 None Fasta, JSON

Protein domain

Protein domains of ANPa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor ANPa.AA ANF_receptor 50-412 25 1.3e-84 292.21 Pfam 1-364 (364) Show / Hide 
Range on Protein: 50-412
Range on HMM: 1-364/364
Sequence Identity: 25% (99 aa)

RVGPAVELALGRVKARPD-LLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHS-PAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGV--K
...||...|. ...|.|. |||| |....   ...    |||  ...||.|..|  . .....||.| |...||.|...||..|....|... .     |
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCY----CSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAK

DEYALTTRTGPSHVKL-GDFVTALHRR-LGWEHQALVLYADRL-GDDRPCFFIVEGLYMRVRERLNITVNH--QEFVEGDPDHYTKLLRTVQ----RKGR
..|  ..||.||. .. |... ..... .|| . |.. . |    ....|.| .|.... .||. .. |..  . .|. . | ....|. ..     |.|
NRYPYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYF-MEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKAR

VIYICSSPDAF----RNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPWERDDGQDRRARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKK
||..|..|| .    | .|. | ..|.....||..  | .. |. .         |..||  . ..|.|...  ..|.. | .||. ||....|      
VIVMCCYPDDMGLLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-W------WYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQRWKK-----

FNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGE---------NITQRMWN-RSFQGVTGYLKIDRNGDRDTDFSLWDMDPE
     .| . |.. | ..|. .||..|. ..| ... ...|          .....||| ..|.|||| ...| ||.| .|...|.|.. 
-----TDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD
Kinase ANPa.AA RGC 556-799 43 2.3e-143 482.57 In-house 1-300 (300) Show / Hide 
Range on Protein: 556-799
Range on HMM: 1-300/300
Sequence Identity: 43% (130 aa)

KGNLVAVKRVNRK----RIELTRKVLFELKHMRDVQNEHLTRFVGACTDPP------NICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLF
.|..|..|..|..    ....||... |||.||..|...|..|.|.|.|||      |.||..|||.||||||||||..| .||||.||. .|||||| .
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHNGAIGSHGNLKSSNCVVDGRFVLKITDYGL-----ESFR--------------DPEPEQGHTLFAKKLWTAPELLR-MASPPARG--------SQAGD
||.  |..||||||.|||||.|.|.||||.||     ..|.              . .... |. ..| ||||||.|| ...|. .|        .|.||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFGIILQEIALRSG-----VFYVE--GLDLSPKEIIERVTR----GEQPPFRPSMDLQ------SHLEELGQLMQRCWAEDPQERPP-FQQIRLALRK
|||||||..||..|.|     .|. .  ...|||.||||.| .    |.|.|||||.. .       . ..| .||..|||||| |||. |.|||..|..
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase ANPa.AA RGC 556-799 43 2.3e-143 482.57 In-house 1-300 (300) Show / Hide 
Range on Protein: 556-799
Range on HMM: 1-300/300
Sequence Identity: 43% (130 aa)

KGNLVAVKRVNRK----RIELTRKVLFELKHMRDVQNEHLTRFVGACTDPP------NICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLF
.|..|..|..|..    ....||... |||.||..|...|..|.|.|.|||      |.||..|||.||||||||||..| .||||.||. .|||||| .
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHNGAIGSHGNLKSSNCVVDGRFVLKITDYGL-----ESFR--------------DPEPEQGHTLFAKKLWTAPELLR-MASPPARG--------SQAGD
||.  |..||||||.|||||.|.|.||||.||     ..|.              . .... |. ..| ||||||.|| ...|. .|        .|.||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFGIILQEIALRSG-----VFYVE--GLDLSPKEIIERVTR----GEQPPFRPSMDLQ------SHLEELGQLMQRCWAEDPQERPP-FQQIRLALRK
|||||||..||..|.|     .|. .  ...|||.||||.| .    |.|.|||||.. .       . ..| .||..|||||| |||. |.|||..|..
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase ANPa.AA TKL 553-797 22 5.2e-50 172.46 In-house 12-364 (364) Show / Hide 
Range on Protein: 553-797
Range on HMM: 12-364/364
Sequence Identity: 22% (81 aa)

AYYKG----------NLVAVKRVNRKRIELT---------------------------RKVLFELKHMRDVQNEHLTRFVGACTDPPN------------
....|          . ||||. ...   ..                            .  .|...|.  . ... .|.|.|..||.            
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG

-ICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHN--------GAIGSHGNLKSSNCVVDGRFV--------------LKITDYGLESF
 .|| .||||.||| ..|        |  | ..  || .|| .||.         .|  | .|||.|. ||  .               .||.|.||  |
QLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPI-IHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRF

RDPEPEQGHTL------------------FA-KKLWTAPELLRMA--SPPA----------RGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSP-----
 ... .. .|                       . | |||.||..   . .            |.. |||||||.| ||. |  ..| .. .        
MSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPF

KEIIERVTRGEQPPFRPS--------MDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLAL
.|... |    ..| .|.        ..  . .... .|||.||..||..|| ||.|   |
EEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ANPa.AA TKL-Unique 591-729 36 8.7e-31 105.87 In-house 58-222 (290) Show / Hide 
Range on Protein: 591-729
Range on HMM: 58-222/290
Sequence Identity: 36% (61 aa)

LTRFVGACT----DPPNICILTEYCPRGSLQDILE---------NESITLDWMFRYSLTNDIVKGMLFLHNGA--IGSHGNLKSSNCVVDGR-----FVL
.....|.|.    .||| || .||||.||| | |          |....|..  |... .||..|| .||.    |  |..|||||  || .     .  
IVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPI-IHRDLKSSNFLVDNNSNIAEWNI

KITDYGLESFRDPE---PEQGH------TLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIA
|| | ||  |.. .   .  .|      |  .  .| |||.|||    .  |.  |||||||.| |||
KICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF--CQYSEKSDVYSFGIVLWEIA
Kinase ANPa.AA TK 555-797 16 5.9e-29 93.6 In-house 19-486 (486) Show / Hide 
Range on Protein: 555-797
Range on HMM: 19-486/486
Sequence Identity: 16% (76 aa)

YKG-------------------------------NLVAVKRVNRK-RIELTRKVL----------------FELKHMRD--VQNEHLTRFVGACTDP---
|||                                 |||| .  .   . ... .                 |.| |.    . ... |..|.||..   
YKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPK

---------PNICILTEYCPRGS----LQDILENESIT--------------------------------------------------------------
         . ..|..||.| |.    |.| | . . .                                                              
PCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLL

-------------LDWMFRYSLTNDIVKGMLFLHNGAI-----GSHGNLKSSNCVVDGRFV-----------LKITDYGLE------SFRDPEPEQGHTL
             |.   .     .| .|| .||   .       |..|   || |. . |            ||.|.||         || ....  . 
QMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYR

FA-------------------------KKL---WTAPELLRMASP-----PARGSQAGDVYSFGIILQEIALRSGVFYVEGLDL-------SPKEIIERV
                            ||   |.||| |.   .       . . . ||.|||. . ||  .  . | .|..        ...|..|..
KSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYL

TRGEQP----------PFRPSMDLQSHL-------------EELGQLMQRCWAEDPQERPPFQQIRLAL
.|| ..           .|.    . .              ||. .|||.||..||..|| |.|.. .|
RRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ANPa.AA DRK 594-677 47 1.3e-26 87.19 In-house 62-146 (258) Show / Hide 
Range on Protein: 594-677
Range on HMM: 62-146/258
Sequence Identity: 47% (40 aa)

FVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGA-IGSHGNLKSSNCVVDGRFVLKITDYGL
| |.|. || ||| .|| |||||  || .||| .||  . ..  |. ||| .||.   |  |  ||| |  ||  .  |. |.||
FMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGL
Kinase ANPa.AA RIPK 560-797 24 1.1e-24 81.06 In-house 21-290 (290) Show / Hide 
Range on Protein: 560-797
Range on HMM: 21-290/290
Sequence Identity: 24% (68 aa)

VAVKRVNRKRIELT------RKVLFELKHMRDVQNEHLTRFVGACTDP-----PN-ICILTEYCPRGSLQDILENES------ITLDWMFRYSLTNDIVK
||.| .. | .. .       ... | |||   ..||  .  | | ..     .. . | .|| . ||| . |  ..      . ..  .|  .   |. 
VAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCR--MIHEISC

GMLFLHNGA---IGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQG--H-----TLFAKKL------WTAPELLR--MASPPARGSQAGDVYSFGI
|| .||.     |  |  || .|  ||. |  || | || ...     ..  .        ..|.        .||..|   ..|    . . |||||.|
GMCYLHSMNPPII--HRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAI

ILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQS---HLEELGQLMQRCWAEDPQERPPFQQIRLAL
.. |.  .  ..  .....    |. .. .|  |.  |  .      |.|.. .||||||. ||..|| || ..   
VMWEVLTQKHPYEDRKCMM---MIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase ANPa.AA Dicty4 590-677 35 1.4e-21 68.92 In-house 59-160 (277) Show / Hide 
Range on Protein: 590-677
Range on HMM: 59-160/277
Sequence Identity: 35% (36 aa)

HLTRFVGACT----DPPNICILTEYCPRGSLQDILEN------ESITLDWMFRYS---LTNDIVKGMLFLHN-GAIGSHGNLKSSNCVVDGRFVLKITDY
..  | ||||     |. .|| |||.|.|.|  .| .      .||.|||  . .   .  |...||  ||.   .  |  |||.|  ||  .. |..| 
NICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDF

GL
||
GL
Kinase ANPa.AA Pkinase 557-797 20 3.8e-19 68.8 Pfam 24-293 (293) Show / Hide 
Range on Protein: 557-797
Range on HMM: 24-293/293
Sequence Identity: 20% (56 aa)

GNLVAVKRVNRKRIELTRKVLF----ELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRG----SLQDILE-NESITL--DWMFRYSLTNDIVKGMLF
| .||||........   ..      |.. |. .. ..  |. ....|...|.. .|||. |    .| |...  .. ..  ..    .    |..|. .
GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEY

LHNGAIGSHGNLKSSNCVVDGRFVL----KITDYGL-ESFRDPEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEG-
.|.  |  |  ||..|. .| . ..    ||.| || . |.    .  .|.     . |||..|  ...   ... |..|.|.|| | ...   |. .  
CHSMGI-IHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYY--GPKVDMWSCGCILYEMLCGRPPFP-GHC

---LDLSPKEIIERVTRGEQPPFRPSMDLQSHL---------------EELGQLMQRCWAEDPQERPPFQQIRLA--L
     ......|.|. ... .  .|  .  |                 ||. ... .|.. ||..|| ..||     .
WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ANPa.AA MLK 553-677 25 5.3e-18 59.14 In-house 18-179 (291) Show / Hide 
Range on Protein: 553-677
Range on HMM: 18-179/291
Sequence Identity: 25% (43 aa)

AYYKGNL-----VAVKRVN---RKRIELT----RKVLFELKHMRDVQNEH----LTRFVGACTDPPN-ICILTEYCPRGSLQDILENES-----------
.......     ||||||.   .  .  |    ...  | .| | .. .       .|.|.|..||.  ||..|||. ||| ..| ...           
GRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQK

----ITLDWMFRYSLTNDIVKGMLFLHNGA----IGSHGNLKSSNCVVD------GRFVLKITDYGL
    ...| ... .|  .. .|| .||. |    |  |  |||.| ..|      .  .|||.| |.
NDRVYDHDHAMNWAL--QCARGMHYLHSMAPKPII--HRDLKSHNILIDEICHDMHHGTLKICDFGT
TyrKc ANPa.AA TyrKc 543-797 25 2.2e-16 42.25 SMART 9-280 (280) Show / Hide 
Range on Protein: 543-797
Range on HMM: 9-280/280
Sequence Identity: 25% (75 aa)

EGQF-QVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDV--QNEHLTRFVGACTDP-------PNICILTEYCPRGSLQDILENESITLDWMFR
||.| .|.  |..     |||| ..       .  . |.. |. .  ..... |..|.||..       . ..|..||.| |.|.| | .   .| .   
EGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDL

YSLTNDIVKGMLFLHNGAIGSHGN-----LKSSNCVVDGRFVLKITDYGLESFRDPE------PEQGHTLF--AKK--L---WTAPELLRMASPPARG--
 |   .| .|| .||        |     |   || |. ... ||.| ||  . . .       .  ..     .|  |   |.||| .        |  
LSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI------NYGKF

SQAGDVYSFGIILQEIALRSGVFYVE---GLDLSPKEIIERVTRGEQPPFRPS--------MDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLAL
. . ||.|||. . ||  . .  | .     ..|..|.||.| .|. .|  |.        .      .|. |.|..||.||| .|| |..|.  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP-----DEMYQIMKQCWHEDPEDRPTFSEIHECF
S_TKc ANPa.AA S_TKc 546-800 16 1.3e-13 22.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 546-800
Range on HMM: 1-231/231
Sequence Identity: 16% (45 aa)

FQVFAK----------TAYYKG--NLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPR--GSLQDILENESI-----T
...  |           .. |.   .||.|...       .... |.. ..  . ... .. ... |  .... .|||.   |.| |....         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLFAKKLWTAPELLRMASPPARGSQ-AGDVYSFGIIL
..     ...  |.... ..|.  |  |  || .|  .|   ..||.| ||  .        .|.     . |||.|         .  . |..|.|.||
FPE-HARFYMYQICCALEYCHSHGI-IHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCIL

QEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRL------ALRKF
 | . .   |.       ........                  .|. .....|.  ||..||   ..        .   |
YEMLCGYPPFP------QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ANPa.AA TK-Unique 556-729 22 5.2e-13 41.32 In-house 29-233 (294) Show / Hide 
Range on Protein: 556-729
Range on HMM: 29-233/294
Sequence Identity: 22% (47 aa)

KGNLVAVKRVNRKRIELT-RKVLFELKHMRDVQ-NEHLTRFVGACTDPP-NICILTEYCPRGSLQDILENESIT-------------------------L
| . |||| ....  ... .. | |...|. .   ... ...|.||..  . .|. ||||.|.||. | .   .                         .
KQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPI

DWMFRYSLTNDIVKGMLFLHN--GAIGSHGNLKSSNCVVDGRFVLKITDYGLES----FRDPEPEQG-HTLFAKKLWTAPELLRMASPPARGSQ---AGD
.  . |.   .| .|| .|.     |  |..| ..|. . ...|.||.|.|.       .. . ... ...  .  | ||| |. .    .|      .|
SPKDLYHFAWQIACGMEYLASQRKKI-VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIR--WMAPESLKCY----HGMYHTTKSD

VYSFGIILQEIA
|.|||... ||.
VWSFGVLMWEIF
Kinase ANPa.AA Pkinase_Tyr 553-648 25 9.7e-12 40.39 Pfam 18-129 (270) Show / Hide 
Range on Protein: 553-648
Range on HMM: 18-129/270
Sequence Identity: 25% (28 aa)

AYYK------GNLVAVKRVNRKRIEL---TRKVLFELKHMRDV-QNEHLTRFVGACT--DPP-NICILTEYCPRGSLQDILENE---SITLDWMFRYSLT
...|      .  |||| .. .  .     .. . |.| |.   ..... |..|.||  . | .|.| .||.| |.| | | .       |.     .  
GTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMC

NDIVKGMLFLHN
 .| ||| .|..
WQIAKGMEYLES
Kinase ANPa.AA Pkinase_Tyr 770-797 42 1.2e-09 33.29 Pfam 243-270 (270) Show / Hide 
Range on Protein: 770-797
Range on HMM: 243-270/270
Sequence Identity: 42% (12 aa)

EELGQLMQRCWAEDPQERPPFQQIRLAL
.|. .||..||..||..|| |..|.  |
DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ANPa.AA TKL-Unique 770-797 42 5.8e-09 27.94 In-house 263-290 (290) Show / Hide 
Range on Protein: 770-797
Range on HMM: 263-290/290
Sequence Identity: 42% (12 aa)

EELGQLMQRCWAEDPQERPPFQQIRLAL
.|.  |.|.||. ||..|| |..|.  |
KEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase ANPa.AA MLK 770-797 46 9.7e-09 26.58 In-house 264-291 (291) Show / Hide 
Range on Protein: 770-797
Range on HMM: 264-291/291
Sequence Identity: 46% (13 aa)

EELGQLMQRCWAEDPQERPPFQQIRLAL
| . .||..|| .|| .|| |.||   |
EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase ANPa.AA TK-Unique 774-797 50 6.9e-08 23.42 In-house 271-294 (294) Show / Hide 
Range on Protein: 774-797
Range on HMM: 271-294/294
Sequence Identity: 50% (12 aa)

QLMQRCWAEDPQERPPFQQIRLAL
.||..|| ..|.||| | ||.  |
NLMKSCWQWEPEERPSFRQIKHRL
Kinase ANPa.AA DRK 774-799 50 1.5e-07 21.67 In-house 233-258 (258) Show / Hide 
Range on Protein: 774-799
Range on HMM: 233-258/258
Sequence Identity: 50% (13 aa)

QLMQRCWAEDPQERPPFQQIRLALRK
|||..|| |||| || .|..   |  
QLMNDCWNEDPQHRPSMQECLERLEA
Kinase ANPa.AA Dicty4 774-799 42 3.2e-07 20.32 In-house 250-277 (277) Show / Hide 
Range on Protein: 774-799
Range on HMM: 250-277/277
Sequence Identity: 42% (12 aa)

QLMQRCWAEDPQERPPFQQIRLA--LRK
.|.|.|| .||| || |..|  .  |  
HLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase ANPa.AA Dicty4 696-729 41 0.000227 10.68 In-house 182-211 (277) Show / Hide 
Range on Protein: 696-729
Range on HMM: 182-211/277
Sequence Identity: 41% (14 aa)

LWTAPELLRMASPPARGSQAGDVYSFGIILQEIA
.|.||| ..      .  .. |||||||.| ||.
CWMAPEVMMHQ----PYNEKADVYSFGIVLWEIL
Kinase ANPa.AA DRK 697-731 48 0.000518 9.52 In-house 168-198 (258) Show / Hide 
Range on Protein: 697-731
Range on HMM: 168-198/258
Sequence Identity: 48% (17 aa)

WTAPELLRMASPPARGSQAGDVYSFGIILQEIALR
||||| ||      |     |||||.|.| |.. |
WTAPEVLRN----QRYTEKADVYSFAIVLWECVTR
Kinase ANPa.AA MLK 717-728 50 0.246062 0.55 In-house 218-229 (291) Show / Hide 
Range on Protein: 717-728
Range on HMM: 218-229/291
Sequence Identity: 50% (6 aa)

DVYSFGIILQEI
||.|.|..| |.
DVWSWGVVLWEM
CYCc ANPa.AA CYCc 836-1030 47 2.7e-114 386.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 836-1030
Range on HMM: 1-231/231
Sequence Identity: 47% (110 aa)

EEKRKAEALLYQILPHSVAEQLKRGE-TVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFD-----VYKVETIGDAYMVVSGL
.||.|.. ||.|.||..||.|||.|. .|.....|.|||.|.||||||.|....||||||..|||.||.|| .||...     .|||||||||||||||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PVRNG-------------------QLHAREVARMALALLDAVRSFRIRHR----PQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGE
| ||.                   . ||...| .||  ......| ..|.    |...||.|||||||||..||||..|||||.||||||.||||||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

ALRIHLSSETKAVL-------EEFDGFELEL
. .||.|.||. .|        .. .||.| 
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc ANPa.AA Guanylate_cyc 863-1049 45 7.2e-109 372.79 Pfam 1-214 (214) Show / Hide 
Range on Protein: 863-1049
Range on HMM: 1-214/214
Sequence Identity: 45% (98 aa)

VQAEAFDSVTIYFSDIVGFTALSAEST----PMQVVTLLNDLYTCFDAVIDNF--DVYKVETIGDAYMVVSGLPVR-----NGQLHAREVARMALALLDA
|.|. .|.|||.|.|||||||......    |||.|..|||.||||| ..|..  ..|||.||||.||.|||||..     ..  ||. .| |||.....
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VRSFRIRHRPQEQ-----LRLRIGIHTGPVCAGVVG--LKMPRYCLFGDTVNTASRMESNGEAL--RIHLSSETKAVLEEFDGFELEL----RGDVEMKG
...... | ..|.     ...|||||||||.|||.|  ..|||||..|||||.||||||.|...  .||.| ||...|.. ..|. |.    ||....||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGK---VRTYWLLG
|||   . ||.| |
KGKMGEMETYFLHG
HNOBA ANPa.AA HNOBA 836-857 54 6.6e-09 33.78 Pfam 213-234 (234) Show / Hide 
Range on Protein: 836-857
Range on HMM: 213-234/234
Sequence Identity: 54% (12 aa)

EEKRKAEALLYQILPHSVAEQL
|||.| ..|||...|.|||..|
EEKKKTDDLLYSMFPKSVANRL