Gene AlphaK3 (Mouse)

AlphaK3

Species: Mouse
Alias: AlphaK3, Lak-pending
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Atypical
Family: Alpha
Subfamily: Alpha-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
AlphaK3.NA RNA Sugen 6369 None Fasta, JSON
AlphaK3.AA Protein Sugen 1680 None Fasta, JSON
AlphaK3.kin_dom Protein Kinase Domain None 64 None Fasta, JSON

Protein domain

Protein domains of AlphaK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
I-set AlphaK3.AA I-set 77-169 32 8.4e-22 76.49 Pfam 1-92 (92) Show / Hide 
Range on Protein: 77-169
Range on HMM: 1-92/92
Sequence Identity: 32% (31 aa)

PLFETTLKSRAVSEDSDVRFTCIVTGYPEPEVTWYKDDIELDRYCGLP--KYEITHQG-NRHTLQLYRCQEEDAAIYQASARNTKGIVSCSGVLEV
| |....|.  |.| ...||.| |||.|.|.|.|.||. .|      .  .. .|  | ...||  ...| .|. .|   |.|  | ..|.  |.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP----DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 AlphaK3.AA IGc2 89-159 29 1.4e-13 52.36 SMART 1-56 (56) Show / Hide 
Range on Protein: 89-159
Range on HMM: 1-56/56
Sequence Identity: 29% (21 aa)

SEDSDVRFTCIVTGYPEPEVTWYKDDIELDRYCGLPKYEITHQGNRHTLQLYRCQEEDAAIYQASARNTKG
 |. .|..||..||.|.|...||| . .|.              .. ||.. . ..||. .|. .||| .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG AlphaK3.AA IG 83-170 18 7.1e-08 33.41 SMART 1-58 (58) Show / Hide 
Range on Protein: 83-170
Range on HMM: 1-58/58
Sequence Identity: 18% (17 aa)

LKSRAVSEDSDVRFTCIVTGYPEPEVTWYKDDIELDRYCGLPKYEITHQGNRHTLQLYRCQEEDA---AIYQASARNTKGIVSC--SGVLEVG
 .   |.| ..|..|| |.     ...||                         |.. . |.||.   ..|.  |.  .| ...  .  |.| 
PP-VTVKEGETVTLTC-VS-----QIWWY-------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 AlphaK3.AA IGc2 1264-1330 23 0.000191 17.49 SMART 1-56 (56) Show / Hide 
Range on Protein: 1264-1330
Range on HMM: 1-56/56
Sequence Identity: 23% (16 aa)

DSSGSLKLWCQFFNIVSDSVLTWAKDQHPVGEVNRSAGDEGPAALAIVQASPTDCGVYRCTIQNEHG
 . .|. | |   .   |   .| |   |.          .   | |  ..| | |.|.|. .|..|
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP---------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG AlphaK3.AA IG 1258-1341 14 0.023245 11.44 SMART 1-58 (58) Show / Hide 
Range on Protein: 1258-1341
Range on HMM: 1-58/58
Sequence Identity: 14% (13 aa)

RVEQFPDSSGSLKLWCQFFNIVSDSVLTWAKDQHPVGEVNRSAGDEGPAALAIVQASPTDC---GVYRCTIQNEHGSAST--DFCLSPE
   .     ....| | .        ..|                     | | ...| |    |.|.|. .  ||...    . |. .
PP-VTVKEGETVTLTC-VS------QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set AlphaK3.AA I-set 1312-1336 32 0.041409 9.67 Pfam 64-88 (92) Show / Hide 
Range on Protein: 1312-1336
Range on HMM: 64-88/92
Sequence Identity: 32% (8 aa)

QASPTDCGVYRCTIQNEHGSASTDF
.. | | |.|.|. .|. |.|....
NVQPDDEGKYTCVATNSFGEAECTA
Alpha_kinase AlphaK3.AA Alpha_kinase 1395-1592 19 6.5e-49 169.73 SMART 1-255 (255) Show / Hide 
Range on Protein: 1395-1592
Range on HMM: 1-255/255
Sequence Identity: 19% (49 aa)

LQKASRAKVIYGL--EPIFESG--RTCII--------------KVSSLLVFGPSSETSL-LGRNYD----VTIQGCKIQNMSREYCKIFAAEARAASGFG
  | . . ... .  .  |. |  |.|.               ..  . .|.......  . |...    .... .. |.|.......| .||. . ...
DNKWTCQETCVKIKEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQ-HNPCP

EVPEIIPLYLIYRP-------ANNIPY-----------------ATLEEDLGKPLQTYCSRQWGCAGAPAAASS-----SEALQKCQTFQHWLYQWTNGS
.....||.|....|        .||||                 ...|. ..   . |...  |.. .... ..     .|....||.|.|| |.|.|..
KKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNN-GWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSNHQ

FLVTDLTGA----DW--KMTDVQIATKLR-GYQGLKESCFPALLDQFASSHQCNTYC
.||.|. |     ..  ..||.||.|. . ||.. .  . .. ...|...|||| .|
MLVCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC
Kinase AlphaK3.AA Alpha-Unclassified 1521-1592 46 1.2e-45 146.81 In-house 135-215 (215) Show / Hide 
Range on Protein: 1521-1592
Range on HMM: 135-215/215
Sequence Identity: 46% (38 aa)

SSEALQKCQTFQHWLYQWTNGSFLVTDLTG-AD------WKMTDVQIATKLRGYQGLKESCFPALLDQFASSH--QCNTYC
..|| |.|.|.|||.|||||....|.|| |  |      |||||.||.|....|||.|..|.....|.....|  ||| ||
EYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIRQRYQGFKTNCGMRFIDYWFNNHHVQCNHYC
Kinase AlphaK3.AA Alpha 1521-1592 35 1.9e-41 115.62 In-house 137-215 (215) Show / Hide 
Range on Protein: 1521-1592
Range on HMM: 137-215/215
Sequence Identity: 35% (28 aa)

SSEALQKCQTFQHWLYQWTNGSFLVTDLT-GAD-WKMTDVQIAT---KLRGYQGLKESCFPALLDQFASSH--QCNTYC
..|. |..|.|.|| .|..||...|.||  | . ||.||.||..   . .|.......|... ...|...|  ||| ||
DNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMKFGDGNCGYEGMFRFFYTHHVQCNHYC
Alpha_kinase AlphaK3.AA Alpha_kinase 1390-1592 16 2.7e-24 85.26 Pfam 1-225 (225) Show / Hide 
Range on Protein: 1390-1592
Range on HMM: 1-225/225
Sequence Identity: 16% (39 aa)

GGGHGLQKASRAKVIYGLEPIFESGRTCIIKVSSLLVFGPSSETSLLGRNYDVTIQGCKIQNMSREYCKIFAAEARAASGFGEVPEIIPLYLIYRPANNI
 . ... .. |.....  .| ..... |..|.    .   .. .  .  . |  .| ||.|.........| .... .  ..  .|.......|.. .. 
FAQGAMRWCFRMFDTW--DPNWRNNQNCVAKWYKKIK-NYNQKQ-SIYVEEDYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYELEDHN

P-----------------YATLEEDLGK-PLQTYCSR-QW-GCAGAPAAASSSEALQKCQTFQHWLYQWTNGSFLVTDLTGAD--W---KMTDVQIATKL
.                 |...|  .     . |..   | .     . . .... |..|.|.|. |...|| ..|.|. | .      . || || || 
KPDCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVY----DNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKD

RGY---Q--GLKESCFPALLDQFAS-SHQCNTYC
. |   .  | .. . .   ..| . .|.|| .|
GNYEMDFDEG-MGNLGQEGIEKFFQNQHKCNHIC
Kinase AlphaK3.AA Alpha-Unclassified 1472-1498 32 4.4e-07 18.96 In-house 87-114 (215) Show / Hide 
Range on Protein: 1472-1498
Range on HMM: 87-114/215
Sequence Identity: 32% (9 aa)

EVPEIIPLYLIYRPANNIP-YATLEEDL
....|.|  || |. .||. ....|. |
QIFYIPPIFLIHREDKNIKGCISVEPYL
Kinase AlphaK3.AA VWL 1529-1597 32 4.4e-05 11.2 In-house 137-206 (206) Show / Hide 
Range on Protein: 1529-1597
Range on HMM: 137-206/206
Sequence Identity: 32% (23 aa)

QTFQHWLYQWTNGSFLVTDLTGAD-WKMTDVQIATKLR-GYQGLKESCFPALLDQFASSHQCNTYCDMLGL
| | |  .| . |  .. || |..    || || .. .    |      . .|  | ..|||| ||  | |
QAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGML-RFFMTHQCNKYCQKLQL
Kinase AlphaK3.AA Alpha 1472-1496 24 0.039425 1.69 In-house 91-115 (215) Show / Hide 
Range on Protein: 1472-1496
Range on HMM: 91-115/215
Sequence Identity: 24% (6 aa)

EVPEIIPLYLIYRPANNIPYATLEE
.......  ||... .||.|...|.
QFVHCYIYELIHCHNHNIKYYSVEN