Gene ALK4 (Mouse)

ALK4

Species: Mouse
Alias: ALK4, Acvr1b
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: STKR
Subfamily: STKR1

Sequence

Name Sequence Type Origin Length Description Download
ALK4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 288 Kinase domain by global Sugen HMM Fasta, JSON
ALK4.NA RNA Sugen 2177 None Fasta, JSON
ALK4.AA Protein Sugen 505 None Fasta, JSON

Protein domain

Protein domains of ALK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp ALK4.AA Activin_recp 32-109 27 5.3e-30 101.29 Pfam 1-121 (121) Show / Hide 
Range on Protein: 32-109
Range on HMM: 1-121/121
Sequence Identity: 27% (33 aa)

LLCA-CTS--------CL--QTN-----YTCET----------DGACMVSIFNLDG---VEHHVR----TCIPKVELVPAGKPFYCLS-----SED---L
|.|  |.         |    .|     .||||          ||.|.||... |.   .|.| |     |... |..|...||.|.|     |.     
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSYKHTHSPPHRHG

RNTHC-CY-IDFCNKIDLRVP
.|..| |.  |.||...  .|
HNHECWCCETDYCNRNLTPPP
Kinase ALK4.AA Type1 207-494 73 3e-277 760.93 In-house 1-290 (290) Show / Hide 
Range on Protein: 207-494
Range on HMM: 1-290/290
Sequence Identity: 73% (214 aa)

IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIK
|...|.|||||.||||||.||| .||||||.||.|||||||.|||||||.||||||||||||.||||.||||||..||||||||.|||||.|.....|..
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

LALSAASGLAHLHMEIVGTQ--GKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIY
||.|.|.|||||||||.|||  ||| |||||.|||||.|||||.|.||||||||||. .||.|||..|.||||||||||||||||.||..|.|.|.||||
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIY

ALGLVYWEIARRCNSGGVHEDYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL
..|||.|||||||..||..|||||||||.||.|||.|.||||||..|||||.||.||| ...|.|.|.|.||||.|..||.|||||||||
SFGLVMWEIARRCEVGGIVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase ALK4.AA STKR 207-494 58 3.5e-221 721.23 In-house 1-312 (312) Show / Hide 
Range on Protein: 207-494
Range on HMM: 1-312/312
Sequence Identity: 58% (183 aa)

IVLQEIIGKGRFGEVWRGRWRG----GDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN-GTWTQLWLVSDYHEHGSLFDYLNRYTVTI
|.|.|.|||||.||||.|.|||     .||||||.||.|.|||||.|||||.|.||||||.|||||.|.. |.|||.||...|||.|||.|||.|.|...
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

EGMIKLALSAASGLAHLHMEIV--GTQ--GKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIA-------PNQRVGTKRYMAPEVLDETI
..|...|.|.|.|||||||||.  |||  .||.|||||.||||||||..| |.|||.|||.|||. |..|||.       .|..|||||||||||||...
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

NMKHFDS-FKCADIYALGLVYWEIARRCNSGG------VHEDYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQ-SYEALRVMGKMMRECWYANGA
|...|.| ||..|.||.|||.|||||||..||       ...||.|.|| ||..||.|.|.|||| ...|||.||.|. . .|.|.| |.|.|||.....
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

ARLTALRIKKTL
||||||..|||.
ARLTALCVKKTM
Kinase ALK4.AA Type2 207-494 39 1.3e-114 379.86 In-house 1-315 (315) Show / Hide 
Range on Protein: 207-494
Range on HMM: 1-315/315
Sequence Identity: 39% (124 aa)

IVLQEIIGKGRFGEVWRGRWRGG-----DVAVKIFSSREERSWFREAEIYQT-VMLRHENILGFIAADN-KDNGT--WTQLWLVSDYHEHGSLFDYLNRY
| | |.|||||||.||...| .      .||||||. ..  ||  | .||.. ....||||| ||.|.  .  ..  | ..|||...|..||| ||| ..
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

TVTIEGMIKLALSAASGLAHLHMEIV-GTQ---GKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDT--------IDIAPNQRVGTKRYMAPEV
|.... . ..|.|.| |||||| ||  ..|    ||.|||||.||||.||| .. |.|||.|||.| .. . .         | .    |||.|||||||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LDETINMKH-FDSFKCADIYALGLVYWEIARRCNSGG---VHEDYQLPYYDLVPSD-PSIEEMRKVVCDQKLRPNVPNWWQSYEALR-VMGKMMRECWYA
|. ..| .   |.|| .|.||.|||.||.. ||.  .      .||.|.   | .  ||.|.|. .|   . ||. |. |.  ...  .    . .|| .
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDH

NGAARLTALRIKKTL
   |||||. ..  .
DAEARLTAQCVQERM
Kinase ALK4.AA TKL 213-494 30 1.2e-104 353.92 In-house 1-364 (364) Show / Hide 
Range on Protein: 213-494
Range on HMM: 1-364/364
Sequence Identity: 30% (116 aa)

IGKGRFGEVWRGRWRG----------GDVAVKIFSSRE-------------------------ERSWFREAEIYQTVM---LRHENILGFIAADNKDN--
||.|.||||..|.|||           |||||.|.|..                         | ||||. |.....|   |||.||. |.....  .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------GTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIV--GTQGKPGIAHRDLKSKNILVKKNGM--------------C
       |.|.||..| .|...|||..||.     .. ....||..|.|...||...   .|  ||.|.|||||||||||..|.               |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

AIADLGLAVRHDAVTDTIDIA---------------PNQRVGTKRYMAPEVLDETINMKH----------FDSFKCADIYALGLVYWEIARRCNSGGVHE
 |.|.||. ...  ..  |..                . ..||.|.||||||....| ..          |. .. .|.|. |.| |||. ||       
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----P

DYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQS-------YEALRVMGKMMRECWYANGAARLTALRIKKTL
 |..||.. ...|| .||| ..||| .||| .|. ||.         ... | | | .|| ..  .|.....|.|.|
YYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ALK4.AA Pkinase 207-494 21 2.3e-52 185.11 Pfam 1-293 (293) Show / Hide 
Range on Protein: 207-494
Range on HMM: 1-293/293
Sequence Identity: 21% (71 aa)

IVLQEIIGKGRFGEVWRGRWRGGD--VAVKIFSSREERSWFREA-----EIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHG----SLFDYLN
... ..||.| ||.|......|    |||||.. |.|.||....     ||.   .|.|.||. .. .        . ...| .|.|.|    .||||. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---RYTV--TIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMC----AIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVL
   . ..  . .  .. ..  ..||...| .        || |||||. |||...|| .     |.| |||  .|      .  .. ..|| .||||||.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVI

DETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEDYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQSYEAL-----------------RVM
      .. .  . .|....|.. .| . .           .|... .  ...  ......|  . .|.  .|.....                   . .
R-----GGQYYGPKVDMWSCGCILYEMLCGR----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

GKMMRECWYANGAARLTALRIKKT--L
 . .. |.  . . |.||  |..   .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ALK4.AA MLK 207-393 27 5.1e-33 111.92 In-house 1-216 (291) Show / Hide 
Range on Protein: 207-393
Range on HMM: 1-216/291
Sequence Identity: 27% (63 aa)

IVLQEIIGKGRFGEVWRGRWRGGD-----VAVKIFS-------SREERSWFREAEIYQTVMLRHEN----ILGFIAADNKDNGTWTQLWLVSDYHEHGSL
| ..|.||.| ||.||.||||. |     ||||..        . .. .|  | |...  .|.|.|    |  | .. ....    .. .|. | |.|||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP---CHFCIVMEYCEGGSL

FDYLNRYT---------------VTIEGMIKLALSAASGLAHLHMEIVGTQGKP-GIAHRDLKSKNILVK------KNGMCAIADLGLAVRHDAVTDTID
...|.  .               .. . ... ||  |.|.. ||..      .|  | ||||||.|||.       ..| . |.| |..      ...  
YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSM------APKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNM-

IAPNQRVGTKRYMAPEVL----DETINMK
     . || ..|||||.     |. ..|
---MSNAGTYAWMAPEVIQQFRCEKYSEK
Kinase ALK4.AA TKL-Unique 209-417 28 4.8e-27 92.52 In-house 1-225 (290) Show / Hide 
Range on Protein: 209-417
Range on HMM: 1-225/290
Sequence Identity: 28% (68 aa)

LQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAE-IYQTV----MLR-HENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN-------
  . || | .|.| .| ||| .||.|.|.  .| | ... .  .  |    .|. |.||. ....  ..  .  .. .|..| ..||| |.|.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

----RYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKN-----GMCAIADLGLAVRHDAVTDTIDIAPN-----QRVGTKRYM
     .. . . ..|.|. .|.|. .|| ..     .| |.||||||.|.||  |         |.| ||.   .  .... . ..      |.|. |.|
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCE-----PP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWM

APEVLDE---TINMKHFDSFKCADIYALGLVYWEIARRC
|||||     ... |       .|.|. | | |||| |.
APEVLRMNFCQYSEK-------SDVYSFGIVLWEIATRK
Kinase ALK4.AA TK 207-388 15 4.3e-25 80.42 In-house 1-359 (486) Show / Hide 
Range on Protein: 207-388
Range on HMM: 1-359/486
Sequence Identity: 15% (57 aa)

IVLQEIIGKGRFG---EVWRGRWRGG---------------------------DVAVKIFS---SREERSWFR-----------------EAEIYQTVML
|.| . .|.| ||   ||..|.|||.                           .||||.     . ...  |                  |... .  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHENILGFIAADNKDNGTW--------TQLWLVSDYHEHGS----LFDYLNRYT----------------------------------------------
.|.||. ....  .. .            ...|  | .||.    | ||| .                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VTIEGMIKLALSAASGLAHLHME---IVGTQGKPGIAHRDLKSKNILVKKNGM-----------CAIAD
                               .| . ..  .. .|.|...||            ... ||||   |.|| .|.            | |||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF-----IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIAD

LGLAV-------RHDAVTDTIDIAPNQRVGT-----------------------KRYMAPEVLDE
 ||.        | .   |    . ....|.                        |.||||.|..
FGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLND
Kinase ALK4.AA S_TKc 207-497 21 2.7e-24 87.93 SMART 1-231 (231) Show / Hide 
Range on Protein: 207-497
Range on HMM: 1-231/231
Sequence Identity: 21% (65 aa)

IVLQEIIGKGRFGEVWRGRWRG--GDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEH--GSLFDYLNRYT----
  . ..|||| ||.|...|...    ||.|| .    ..  || .| .    .|.||  .. .        . |..| .| ..  |.||||. ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHF
    .     ...   ...|...|        . || |||||  |||. .     |.| ||| .            .  .||  |||||||       ..
RFPFPE-HARFYMYQICCALEYCH-------SH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL-------GY

DSFKCADIYALGLVYWEIARRCNSGGVHEDYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKK---
. .|| |....| . .| . ..           |..        ...| |...                   .   ..| |.  . . |.||  . .   
GKCKC-DWWSCGCILYEMLCGY----------PPFP-------QMQMMFKKIG----------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEW

---TLSQL
       .
DIKCHPWF
Kinase ALK4.AA STE 207-387 20 9.6e-21 70.06 In-house 1-235 (359) Show / Hide 
Range on Protein: 207-387
Range on HMM: 1-235/359
Sequence Identity: 20% (50 aa)

IVLQEIIGKGRFGEVWRGRWRGGD-----------------VAVKIFSSREERS---------------WFRE---AEIYQTVMLR--HENILGFIAADN
  ..|.|||| ||.| ... .  .                 .|.|. . .....                 ..    ||     ..  |.||  .. .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD---NGTWTQLWLVSDYHEHGSLFDYLN-RYTVTI-------------EGMI-KLALSAASG-LAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCA
|.   ..  ..||..  | . ||| | .. .| .               |  | . . .   | |..||           | |||.|. |||.     . 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--------IIHRDIKPANILL-----VK

IADLGLAVRHDAVTD------------TIDIAPNQRVGTKRYMAPEVLD
..| |.. . .   .            |..   |  |||  .|||||..
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQ
GS ALK4.AA GS 177-207 70 1.2e-16 62.53 SMART 1-31 (31) Show / Hide 
Range on Protein: 177-207
Range on HMM: 1-31/31
Sequence Identity: 70% (22 aa)

KTLQDLVYDLSTSGSGSGLPLFVQRTVARTI
||..|...|..||||||||||.|||||||.|
KTMHDMMEDTCTSGSGSGLPLLVQRTVARQI
TGF_beta_GS ALK4.AA TGF_beta_GS 177-205 72 2e-16 57.07 Pfam 1-29 (29) Show / Hide 
Range on Protein: 177-205
Range on HMM: 1-29/29
Sequence Identity: 72% (21 aa)

KTLQDLVYDLSTSGSGSGLPLFVQRTVAR
||.||...| .|||||||||| ||||.||
KTMQDMMEDFCTSGSGSGLPLLVQRTIAR
Kinase ALK4.AA TyrKc 207-494 25 1.5e-15 28.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 207-494
Range on HMM: 1-280/280
Sequence Identity: 25% (78 aa)

IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVML--RHENILGFIAADNKD--NGTW---TQLWLVSDYHEHGSLFDYL--NRY
|.| ...| | ||||..|.|.  .||||   .  ..   |||.|    .|  .|.||. ....  ..  |  .    .|..|  | .||.| |||  .| 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMC--KLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYLRKHRP

TVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAV----TDTIDIAPNQRVGTK-----RYMAPEVLDE
... . ... .. .|.| ..||          .. ||||   |.||..|. . |.| ||.  ..        .  . . .. |.|     | ||||..  
KLCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

TINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEDYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPN-----WWQSYEALRVMGKMMRECWYANGAA
   ...  ..|  |... | . |||  ..         | ||.. .  . | .|... | . . .|  ||          ..   | ..|..|| .. . 
---NYGKFTTKS-DVWSFGVCMWEIFTYG---------QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPED

RLTALRIKKTL
| |   |.. .
RPTFSEIHECF
Kinase ALK4.AA CAMK 212-294 16 3.8e-15 44.56 In-house 1-155 (425) Show / Hide 
Range on Protein: 212-294
Range on HMM: 1-155/425
Sequence Identity: 16% (26 aa)

IIGKGRFGEVWRGRWR-GGD-------------VAVKIFS-------------------------------SREERSWFREAEIYQTVM-----LRHENI
..|.|.||.| ... .  .              ||.|| .                                . ... .|| || ...      |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LGFIAADN--------KDNG-TWTQ--------LWLVS---DYHEHG----SLFDYL
. .. .           | . | ..        ...|    .| . |     ||||.
IKLYEVYEDPHYFKNTND-YET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYI
Kinase ALK4.AA Pkinase_Tyr 207-319 26 1.5e-14 49.92 Pfam 1-128 (270) Show / Hide 
Range on Protein: 207-319
Range on HMM: 1-128/270
Sequence Identity: 26% (35 aa)

IVLQEIIGKGRFGEVWRGRWR------GGDVAVKIF--SSREE----RSWFREAEIYQTVML-RHENILGFIAADN-KDN-GTWTQLWLVSDYHEHGSLF
|.. . .|.| ||||..|.|.      . .||||.   .. .|    .. .|||.|     | .|.||. ....   ..  .   |...|  | .||.| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMK--QLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLL

DYLNRY-----TVTIEGMIKLALSAASGLAHLH
||| .       .|.. ... ..  |.|...|.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase ALK4.AA Dicty4 207-239 51 1.5e-13 41.7 In-house 1-33 (277) Show / Hide 
Range on Protein: 207-239
Range on HMM: 1-33/277
Sequence Identity: 51% (17 aa)

IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSR
|. ...|||| |||| .|.||| .||||.. ..
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNH
Kinase ALK4.AA Dicty4 305-386 36 1.6e-10 31.48 In-house 115-189 (277) Show / Hide 
Range on Protein: 305-386
Range on HMM: 115-189/277
Sequence Identity: 36% (31 aa)

IKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTID--IAPNQRVGTKRYMAPEVL
...|..|| |...||  .      | | |||||| |.|| ||    ..|.||. .   ..|  |   ..   .||  .|||||.
MRMAFDAARGMNWLHCCN------PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA---CGTPCWMAPEVM
Kinase ALK4.AA CAMK 330-400 24 3.7e-10 28.18 In-house 199-315 (425) Show / Hide 
Range on Protein: 330-400
Range on HMM: 199-315/425
Sequence Identity: 24% (29 aa)

GIAHRDLKSKNILVKKN-----------------GMCAIADLGLAVRHDAVTDTI-------------------DIAPNQRVGTKRYMA-PEVLDE--TI
.|.|||||  |||. .|                 .   |.| |.| . |   .                     .   . ..||  ||| ||||    . 
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

NM-------KHFDSFKC
||       |  ...||
NMQNATDEEKPYYGPKC
Kinase ALK4.AA Pkinase_Tyr 333-357 52 0.011672 9.63 Pfam 134-158 (270) Show / Hide 
Range on Protein: 333-357
Range on HMM: 134-158/270
Sequence Identity: 52% (13 aa)

HRDLKSKNILVKKNGMCAIADLGLA
||||  .|.||..|. . |.| |||
HRDLAARNCLVTENNVVKICDFGLA
Kinase ALK4.AA TK 472-494 26 0.012232 3.81 In-house 464-486 (486) Show / Hide 
Range on Protein: 472-494
Range on HMM: 464-486/486
Sequence Identity: 26% (6 aa)

MMRECWYANGAARLTALRIKKTL
.|..|| .. . | |   ... |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase ALK4.AA Dicty4 439-459 38 0.156042 1.08 In-house 223-243 (277) Show / Hide 
Range on Protein: 439-459
Range on HMM: 223-243/277
Sequence Identity: 38% (8 aa)

SIEEMRKVVCDQKLRPNVPNW
.... .  ||. |||| .|.|
PYMQFVRAVCNKKLRPPIPDW