Gene ALK1 (Mouse)

ALK1

Species: Mouse
Alias: AI427544, ALK1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: STKR
Subfamily: STKR1

Sequence

Name Sequence Type Origin Length Description Download
ALK1.AA Protein Sugen 502 None Fasta, JSON
ALK1.NA RNA Sugen 1851 None Fasta, JSON
ALK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 288 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of ALK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp ALK1.AA Activin_recp 31-102 17 1.3e-18 63.34 Pfam 1-121 (121) Show / Hide 
Range on Protein: 31-102
Range on HMM: 1-121/121
Sequence Identity: 17% (21 aa)

VNCT-CESPH------CK--R-------PFCQ-----------GSWCTVVLVREQGR--HPQVYR----GCGSLNQ-------ELCLG----RPTE---F
..|  |. ..      |.  .         |.           . .|.| . . ...  ..|..|    || |||.       . |..    ....   .
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSYKHTHSPPHRHG

LNHHC-CY-RSFCNHNVSLML
 ||.| |. ...||.|.. ..
HNHECWCCETDYCNRNLTPPP
Kinase ALK1.AA Type1 201-488 70 1.4e-269 739.71 In-house 1-290 (290) Show / Hide 
Range on Protein: 201-488
Range on HMM: 1-290/290
Sequence Identity: 70% (205 aa)

VALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALR
....||.|||||||||||.|.||.||||||.||||.|||||||||.||..||.|||||||.||....|.|||||||.|||||||||.|.|.||..| .||
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

LAVSAACGLAHLHVEIFGTQ--GKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEHIRTDCFESYKWTDIW
||.|.||||||||.||||||  |||||||||.||.|..||.|.|||||||||||.|.|..|..|||.|||||||||||||||||.....||||||..||.
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIY

AFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTL
.||||.||||||....||||||..|.||.||||||||||.|||||....|.||||....|.....|..|.||||.||.||.|||||||||
SFGLVMWEIARRCEVGGIVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase ALK1.AA STKR 201-488 56 5.5e-211 687.75 In-house 1-312 (312) Show / Hide 
Range on Protein: 201-488
Range on HMM: 1-312/312
Sequence Identity: 56% (177 aa)

VALVECVGKGRYGEVWRGSWHG----ESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSR-NSSTQLWLITHYHEHGSLYDFLQRQTLEP
. |.||.|||||||||.|.|.|    |.||||||.||||||||||||||.|...||.|||.|||.||... .| ||.||||.|||.|||.|.|.|.|. .
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

QLALRLAVSAACGLAHLHVEIF--GTQ--GKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIG-------NNPRVGTKRYMAPEVLDEHI
. ..|.| |.|||||||| ||.  |||  .||||||||.||.|.|||....|||||.|||..|..... .||.       .|..|||||||||||||. .
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

RTDCFES-YKWTDIWAFGLVLWEIARRTIING------IVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLA-ADPVLSGLAQMMRECWYPNPS
  .|||| .|..|..|.|||.||||||.. .|      ||..|..||||.|||.||||||.||||...| |.||||   ..|.. .....|.|||...|.
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

ARLTALRIKKTL
||||||..|||.
ARLTALCVKKTM
Kinase ALK1.AA TKL 207-488 27 1.7e-107 363.4 In-house 1-364 (364) Show / Hide 
Range on Protein: 207-488
Range on HMM: 1-364/364
Sequence Identity: 27% (103 aa)

VGKGRYGEVWRGSWHG----------ESVAVKIFSSRD-------------------------EQSWFRETEIYNTVL---LRHDNILGFIASDMTSRN-
.|.|..|||..| |.|          . ||||.|.|..                         |.||||..|.. ...   |||.||. |..... ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------SSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIF--GTQGKPAIAHRDLKSRNVLVKSNLQ--------------C
        ...||.... |...|||...|.     ... .|.| ..|.|...|| ...  .|  ||.|.||||||.|.||..|..              |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

CIADLGLAVMHSQSSDYLDIG---------------NNPRVGTKRYMAPEVLDEHIRTDC----------FESYKWTDIWAFGLVLWEIARRTIINGIVE
.|.|.||. ..|||..  |..               .....||.|.||||||.... ...          ||  . .|...||.|||||. | .      
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------

DYR-PPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAA-------DPVLSGLAQMMRECWYPNPSARLTALRIKKTL
 |. .|...|...|| ||.| ..||.... |.||..          .... .... | .|| ..|..|.....|.|.|
PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ALK1.AA Type2 201-488 39 7e-99 327.13 In-house 1-315 (315) Show / Hide 
Range on Protein: 201-488
Range on HMM: 1-315/315
Sequence Identity: 39% (123 aa)

VALVECVGKGRYGEVWRGSWHGE-----SVAVKIFSSRDEQSWFRETEIYNT-VLLRHDNILGFIASDM---TSRNSSTQLWLITHYHEHGSLYDFLQRQ
  | | .||||.|.||...||..      ||||||. .| |||  | .|| . ....|.||| ||...       .   ..||.| .|..|||.|.| . 
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

TLEPQLALRLAVSAACGLAHLHVEIF-GTQ---GKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDY--------LDIGNNPRVGTKRYMAPEV
|.    ..|.| |.| |||||| ||  ..|    ||.|||||.||.|||||... |||||.|||.  . ..           |  |   |||.|||||||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LDEHIR-TDCFESYKWTDIWAFGLVLWEIARRTIING---IVEDYRPPFYDMVPND-PSFEDMKKVVCVDQQTPTIPNRLAADPVLS-GLAQMMRECWYP
|.  .  .|| .. | .|. |.||||||.. |.   .    | .|..||   | .  ||||||. .|  . . |..|.   . | .  .|   . .||  
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDH

NPSARLTALRIKKTL
 . |||||. ..  .
DAEARLTAQCVQERM
Kinase ALK1.AA Pkinase 201-488 20 2.2e-63 221.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 201-488
Range on HMM: 1-293/293
Sequence Identity: 20% (68 aa)

VALVECVGKGRYGEVWRGSWHGES--VAVKIFSSRDEQSWFRET-----EIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHG----SLYDFLQ
  .....|.| .|.|... ..|..  |||||.. |.| ||...|     ||.    |.|.||. .. . ..    .. ..... |.|.|    .|.|...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---RQTL--EPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQC----CIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVL
   . ..  ... . . .   ..||...| .         | |||||. |.|...| ..    .|.| |||  ..      .  .. ..|| .||||||.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVI

DEHIRTDCFESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVL-----------------SGL
      .. .  .  |.|..|..|.| . .           |||.. . ....  |.....| . ..|.  ..   ...                  . .
R-----GGQYYGPKVDMWSCGCILYEMLCGR----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

AQMMRECWYPNPSARLTALRIKKT--L
 . .. |. ..|. |.||  |..   .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ALK1.AA MLK 201-407 24 4.1e-33 112.26 In-house 1-229 (291) Show / Hide 
Range on Protein: 201-407
Range on HMM: 1-229/291
Sequence Identity: 24% (63 aa)

VALVECVGKGRYGEVWRGSWHGES-----VAVKIFS-------SRDEQSWFRETEIYNTVLLRHDN----ILGFIASDMTSRNSSTQ-LWLITHYHEHGS
  . | .|.| .|.||.| |...      ||||..        . ....|  |.|..    |.| |    |  | .      ..... . ....| |.||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGV----CLQPPCHFCIVMEYCEGGS

LYDFLQRQT---------------LEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKS------NLQCCIADLGLAVMHSQS-----
||..|  ..                 ...|.. |.  | |.. ||      . ...| ||||||.|.|.        .... |.| |.. . .|.     
LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLH-----SMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMM

SDYLDIGNNPRVGTKRYMAPEVLDEHIRTDCFESYKWT---DIWAFGLVLWEI
|         . || ..|||||.        |.. |..   |.| .|.||||.
S---------NAGTYAWMAPEVIQQ------FRCEKYSEKCDVWSWGVVLWEM
Kinase ALK1.AA TK 201-407 16 8.3e-32 103.32 In-house 1-387 (486) Show / Hide 
Range on Protein: 201-407
Range on HMM: 1-387/486
Sequence Identity: 16% (65 aa)

VALVECVGKGRYG---EVWRGSWHG---------------------------ESVAVKIFS---SRDEQSWFR-----------------ETEIYNTVLL
. |..  |.| .|   ||..| |.|                           . ||||.     . ...  |                  | .. .  |.
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHDNILGFIASDMTSRNSS--------TQLWLITHYHEHGS----LYDFLQRQ-----------------------------------------------
.|.||. ...  . .....          ..... | .||.    | |.|..                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------TLEPQLALR-------------------LAVSAACGLAHLHVEIF-GTQGKPAI---AHRDLKSRNVLVKSNLQ-----------CCIAD
          .|  .  |.                    .. .|||...||   . .      |    ||||  ||.|| .|..           | |||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEF------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIAD

LG--------LAVMHSQSSDYLDIGNNPRV-------------------GTKR---YMAPEVLDEHIRTDC---FESYKWTDIWAFGLVLWEI
 |        ||  . ...||   ..  .                    |.|    .||||.|.... . .         .|.|.|| ..|||
FGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase ALK1.AA TKL-Unique 203-488 27 2e-31 108.14 In-house 1-290 (290) Show / Hide 
Range on Protein: 203-488
Range on HMM: 1-290/290
Sequence Identity: 27% (88 aa)

LVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETE-IYNTV----LLR-HDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQ-------
 .. .| | ||.| .| |.|..||.|.|.   | | .....  .| |     |. |.||. ...  |    .  .. ... | ..||||| |.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

----RQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSN-----LQCCIADLGLAVMHSQSSDYLDIGNN-----PRVGTKRYM
      .| .|. ...|  .| |. .||     . ..| |.||||||.|.|| .|     ..  |.| ||.   |....   ....      |.|. |.|
NNNNNCKLNMQQRVKMAIDIAQGMYYLH-----HCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWM

APEVLDE---HIRTDCFESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCV--DQQTPTIPNRLAADPVLSGLAQMMREC
|||||     .. . .       |...|| |||||| |.|       |. |. .|     ..|  ...| .  . . |.|||..        .   ...|
APEVLRMNFCQYSEKS-------DVYSFGIVLWEIATRKI----TKTYKKPYQGM-----DQEQWCEMVHYMEENYRPPIPNHC-----PKEYRDLIQQC

WYPNPSARLTALRIKKTL
| ..|| | .   | . |
WHHDPSQRPSFDEIIHRL
Kinase ALK1.AA S_TKc 201-490 20 2e-27 98.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 201-490
Range on HMM: 1-231/231
Sequence Identity: 20% (63 aa)

VALVECVGKGRYGEVWRGSWHG--ESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEH--GSLYDFLQRQT----
  ... .||| .|.|... ...  . ||.|| .    ..  || .|      .|.||  .. .  .     . |.... | ..  |.|.|.....     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEHIRTDCF
   . .  | ...   .|.|...|        .  | |||||  |.|. .  .  |.| |||              .  .||  |||||||         
RFPFPE-HARFYMYQICCALEYCH-------SH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---------

ESYK--WTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK-
 .|     |.|..| .|.| . .          .|||.         . | |...                  . . ...| |.  .|. |.||  . . 
-GYGKCKCDWWSCGCILYEMLCG----------YPPFP-------QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

------TLQK
          
EWDIKCHPWF
Kinase ALK1.AA UTK 201-407 24 5.1e-20 65.18 In-house 1-233 (296) Show / Hide 
Range on Protein: 201-407
Range on HMM: 1-233/296
Sequence Identity: 24% (63 aa)

VALVECVGKGRYGEVWRGSWHGES-------VAVKIFS----SRDEQS----WFRET-EIYNTVLLR-HDNILGFIASDMTSRNSSTQLWLITHYHEHGS
|.| .. |.|..||| ....  .|       ||||  .    ...|.     . .|. |.     .. | |.|....  . .      ....| | | |.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP----WMIVTEYMENGD

LYDFLQ--RQTLE-PQLALR------LAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSN-------LQCCIADLG---LAVMHS-------QS
| ..|.  |.|.. ....|.       |.  |.|...||   |         ||||  ||.|| ..       ..| |||.|   .. . .       ..
LRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGF--------VHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYW

SDYLDIGNNPRVGTKRYMAPEVLDEHIRTDCFESYKWT---DIWAFGLVLWEI
..|.   .. .  . | ||||.|..|         . |   |.|.|| |.|||
ESYYYMAQHQDRWPIRWMAPEALTHHT--------RFTTKSDVWSFGVVCWEI
Kinase ALK1.AA STE 201-481 18 5.3e-19 63.84 In-house 1-348 (359) Show / Hide 
Range on Protein: 201-481
Range on HMM: 1-348/359
Sequence Identity: 18% (71 aa)

VALVECVGKGRYGEVWRGSWH-----------------GESVAVKIFSSRDEQS---------------WFRE---TEIYNTVLLR--HDNILGFIASDM
  ..|..||| .|.| ..  |                 || .|.|. . .....                 ..    ||     ..  |.||  .. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TSR--NSS-TQLWLITHYHEHGSLYDFLQR-----QTL-----------EPQLALRLAVSAACG-LAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQC
     ... ..||..  | . ||| |....     ..|           |.|.| . ...   | |..||           | |||.|. |.|.     .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIA-YICRQILKGLLYYLHSHH--------IIHRDIKPANILL-----V

CIADLGLAVMHSQSSD------------YLDIGNNPRVGTKRYMAPEVLDEHIRTDCFESY-KWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPN
 ..| |..   ..|..              .  .|  |||  .|||||..   ..     |    ||| .|....| |          . .||. || | 
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMA----------TGKPPWHDMHPM

DPSFEDMKKVVCVD---------QQTPTIPNRLA--------------ADPVLSGLAQMMRECWYPNPSARLTA
   |. ... ....         .. |..|..|                . . . . . .. |   .|. | ||
RAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTA
Kinase ALK1.AA RIPK 207-407 27 1.4e-17 56.5 In-house 1-221 (290) Show / Hide 
Range on Protein: 207-407
Range on HMM: 1-221/290
Sequence Identity: 27% (63 aa)

VGKGRYGEVWRGS--WHGESVAVKIFS---------SRDEQSWFRETEIYNTVLLRH-DNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQT--
||.|  ||| .     .|. ||.|.           .....  ..| .. .    .|   |.||.       ..   . . . | |.||| .||....  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCK-LYGIVMEYMENGSLWHFLHTKWPY

----LEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQS---SDYL-----DI-GNNPRVGTKRYMAPEV
    .   |  |. .  .||   ||        .| | |||||  |.|| .|.   |||.|||    .|   .|       .. .  .| ||  ||.|  
QHHPDPWPLRCRMIHEISCGMCYLHSM------NPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPP--

LDEHIRTDCFES----YKWTDIWAFGLVLWEI
  ||.|||   .     .  |.  |. |.||.
--EHFRTDNKKPIKVVTPKYDVYSFAIVMWEV
Kinase ALK1.AA TyrKc 201-488 25 2e-17 59.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 201-488
Range on HMM: 1-280/280
Sequence Identity: 25% (79 aa)

VALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLL--RHDNILGFIASDMTS-RN--SSTQLWLITHYHEHGSLYDFLQRQT--L
. | .  | | .|||..| |  . ||||   .  ..   || .|     |  .|.||. ...  ... ||  .. .|.... | .||.| |.|..    |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCK--LGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

EPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQS------SDYLDIGN--NPR-VGTKRYMAPEVLDEHI
 ..  |  .. .||| ..||           . ||||  ||.||..|... |.| ||.  .         .|| .     . . .   | ||||..    
CMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----

RTDCFESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAADP-----VLSGLAQMMRECWYPNPSARL
.. .| .   .|.|.|| ..|||  .           .| ..|. .. | ... . |      |  || .   |       . . |.|..||  .|. | 
NYGKFTTK--SDVWSFGVCMWEIFTYG---------QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQIMKQCWHEDPEDRP

TALRIKKTL
|   |.. .
TFSEIHECF
GS ALK1.AA GS 171-201 61 3.6e-16 60.96 SMART 1-31 (31) Show / Hide 
Range on Protein: 171-201
Range on HMM: 1-31/31
Sequence Identity: 61% (19 aa)

SMLGDFLDSDCTTGSGSGLPFLVQRTVARQV
... | ....||.|||||||.|||||||||.
KTMHDMMEDTCTSGSGSGLPLLVQRTVARQI
TGF_beta_GS ALK1.AA TGF_beta_GS 171-199 58 8.9e-16 54.91 Pfam 1-29 (29) Show / Hide 
Range on Protein: 171-199
Range on HMM: 1-29/29
Sequence Identity: 58% (17 aa)

SMLGDFLDSDCTTGSGSGLPFLVQRTVAR
....|.....||.|||||||.|||||.||
KTMQDMMEDFCTSGSGSGLPLLVQRTIAR
Kinase ALK1.AA Pkinase_Tyr 201-313 23 3.3e-12 41.99 Pfam 1-128 (270) Show / Hide 
Range on Protein: 201-313
Range on HMM: 1-128/270
Sequence Identity: 23% (31 aa)

VALVECVGKGRYGEVWRGSWH------GESVAVKIF--SSRDE----QSWFRETEIYNTVLL-RHDNILGFIASDM-TSRNSSTQLWLITHYHEHGSLYD
. . .  |.| .|||..| |.      .  ||||.   .. .|    .. .|| .|  .  | .|.||. ...  .  .. .  |..... | .||.|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQ--LGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLD

FLQRQ-----TLEPQLALRLAVSAACGLAHLH
.|...      | ..  |  ..  |.|...|.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase ALK1.AA Pkinase_Tyr 327-407 34 4.1e-11 38.26 Pfam 134-207 (270) Show / Hide 
Range on Protein: 327-407
Range on HMM: 134-207/270
Sequence Identity: 34% (28 aa)

HRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYL-DIGNNPRVGTKRYMAPEVLDEHIRTDCFESYKWTDIWAFGLVLWEI
||||  ||.||..|... |.| |||  . .. ||    . . .    . ||||.. . .    | .   .|.|.|| ..|||
HRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGK-LPIKWMAPECINYGK----FTTK--SDVWSFGVLMWEI
Kinase ALK1.AA UTK 463-488 19 7e-06 16.1 In-house 271-296 (296) Show / Hide 
Range on Protein: 463-488
Range on HMM: 271-296/296
Sequence Identity: 19% (5 aa)

LAQMMRECWYPNPSARLTALRIKKTL
. ..|..||...|. | .. .. ...
VYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ALK1.AA TK 421-488 12 8e-05 11.27 In-house 392-486 (486) Show / Hide 
Range on Protein: 421-488
Range on HMM: 392-486/486
Sequence Identity: 12% (12 aa)

RPPFYDMVPN------DPSFEDMKKVVCVDQQTPTI--------PNRLAADPVLS--------------GLAQM-MRECWYPNPSARLTALRIKKTL
. |.| ...|      . . ... . ..  ... .          .|... |  .               . .  |..|| ..|. | |   ... |
QEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ALK1.AA Pkinase_Tyr 463-488 30 0.013191 9.45 Pfam 245-270 (270) Show / Hide 
Range on Protein: 463-488
Range on HMM: 245-270/270
Sequence Identity: 30% (8 aa)

LAQMMRECWYPNPSARLTALRIKKTL
. ..|..|| ..|. | |   |   |
IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ALK1.AA RIPK 436-488 15 0.019335 4.09 In-house 234-290 (290) Show / Hide 
Range on Protein: 436-488
Range on HMM: 234-290/290
Sequence Identity: 15% (9 aa)

DMKKVVCVD-QQTPTIPNRLAADP---VLSGLAQMMRECWYPNPSARLTALRIKKTL
.| ...|.. .. | ..    . |    .... . |..||  .| .| . . ..   
MMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase ALK1.AA MLK 462-478 29 0.286055 0.32 In-house 265-281 (291) Show / Hide 
Range on Protein: 462-478
Range on HMM: 265-281/291
Sequence Identity: 29% (5 aa)

GLAQMMRECWYPNPSAR
.....| .|| ..|. |
HWKKLMKQCWNQDPHKR