Gene trbl (Fruit Fly)
trbl
Sequence
Protein domains of trbl.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | trbl.AA | Trbl | 142-397 | 55 | 2.4e-200 | 638.67 | In-house | 1-256 (256) | Show / Hide |
Range on Protein: 142-397 Range on HMM: 1-256/256 Sequence Identity: 55% (142 aa) CVDIFTGEQFLCRIVNEPLHKVQRAYFQLQQHDEELR-RSTIYGHPLIRPVHDIIPLTKDRTYILIAPVPQERDSTGGVTGVYENLHTYIRHAKRLCETE |...|.||...|.|.....|..|...|..|...|||| .....||..||..|..| |.....||.....|||||||||||||....|.|.||.|||||.| CLEPFEGEHVYCAIHCHTGHEYQCKVFPIQCYQEELRPYFCLPGHQHIRRIHEVI-LGEQKAYIFFERTPQERDSTGGVTGVHGDMHSYVRHRKRLCEEE ARAIFHQICQTVQVCHRNGIILRDLKLKRFYFIDEARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVGQ |...|||.||.|..||..||.||||||.||.|.||.|||||.||||.|.|..||||.|.||.|||.|..||.||.|..|.||.||||||||.|||||||. AARLFHQMCQAVAHCHQHGIVLRDLKLRRFVFKDEERTKLQLESLEDSCIMTGEDDSLWDKHGCPAYVSPEILCTQGSYSGKAADMWSLGVMLYTMLVGR YPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWL |||.....|||.|.||.|...||..||...|.|...|||....|||||.||.|.||. YPFHDSEPCNLFTKIRRGQFCIPEHLSPKARCLIRCLLRREPSERMTAQHILLHPWF |
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Kinase | trbl.AA | CAMK | 223-397 | 21 | 1.5e-46 | 147.63 | In-house | 148-425 (425) | Show / Hide |
Range on Protein: 223-397 Range on HMM: 148-425/425 Sequence Identity: 21% (60 aa) YENLHTYIRHA---------------KRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKRFYFIDEAR---------------TKLQYESLEGSMILD .. | ||. .|..| ||| .|.|||. |. || ..|. ||||. . | . .. . ..| FDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFD G-----------------------EDDTLSDKIGCPLYTA-PELLCPQ------------QTYKGKPADMWSLGVILYTMLVGQYPFYEK---------- . |.. ... |.| | | ||.| . ..| |...||||.|||||.||.| .|||.. PGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEW ---ANCNLITVIRHGNVQ-IPLT-----------------------LSKSVRWLLLSLLRKDYTERMTASHIFLTPWL .| |. |. . .| .|.... |. ..|..| ..|||.. . ||. IGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | trbl.AA | SgK495 | 225-395 | 34 | 8.5e-32 | 95.82 | In-house | 1-171 (171) | Show / Hide |
Range on Protein: 225-395 Range on HMM: 1-171/171 Sequence Identity: 34% (60 aa) NLHTYIRHAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKRFYFIDEARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPA || .. | ||| | |. ||| . . | |. |. ||||| . .. | | | | |. | | | .|. | . |.|||. NLQHHVIHEKRLSERETVYIFHDVVRIVEALHQKNIVHRDLKLGNMVLNCHTH-QITITNFCLGKHLVSEHDLLKDQRGSPAYISPDVLS-GRPYRGKPS DMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIPL--TLSKSVRWLLLSLLRKDYTERMTASHIFLTP ||| |||.|.||| ||.|||. . | |. || | |. .|| | .|.||. . . DMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPQDGRVSENTVCLIRKLLVLDPQQRLTATQVIEAV |
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Kinase | trbl.AA | CAMKL | 292-397 | 27 | 7.2e-30 | 92.38 | In-house | 184-297 (297) | Show / Hide |
Range on Protein: 292-397 Range on HMM: 184-297/297 Sequence Identity: 27% (32 aa) DGEDDTLSDKIGCPLYTAPELLCP-QQTYKGKPADMWSLGVILYTMLVGQYPFY----------EKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRK .|....|. | | | |||.. .. | |...|.||.|||||.|..|..|| . . ... . .. |.. .| ..| |. ..| . FGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQV DYTERMTASHIFLTPWL . ..|.|. | ||. NPEKRPTIHQIMNHPWM |
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Kinase | trbl.AA | MARK | 303-397 | 38 | 5.2e-26 | 82.15 | In-house | 167-262 (262) | Show / Hide |
Range on Protein: 303-397 Range on HMM: 167-262/262 Sequence Identity: 38% (37 aa) GCPLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVGQYPFYEKA--NCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWL | | | |||.. .. | |...|.|||||.||.|..|..|| .. . .| |..|. .|| .||. | |. .|| . ||.|.. | ||. GTPPYMAPEIFL-KKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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Kinase | trbl.AA | MELK | 225-397 | 30 | 4.2e-25 | 82.47 | In-house | 83-254 (254) | Show / Hide |
Range on Protein: 225-397 Range on HMM: 83-254/254 Sequence Identity: 30% (53 aa) NLHTYIRHAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKRFYFIDEARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPA .. || . .|| | |.| .| || . | | |||| . | .. . || | . | | | | ||||. .| |.| | EMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQ-YIGSEA DMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWL |.||.|..||....| || . . | | . | || . . || .| | . |. .. ||. DVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV |
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Kinase | trbl.AA | CAMKK | 288-397 | 27 | 3e-24 | 73.5 | In-house | 246-396 (396) | Show / Hide |
Range on Protein: 288-397 Range on HMM: 246-396/396 Sequence Identity: 27% (41 aa) SMILDGEDDTLSD-----------KIGCPLYTAPELLCP-QQT-------------YKGKPADMWSLGVILYTMLVGQYPFYEKANCNLIT---VIRHGN |.|..|.|.|||. | | ..||||. |. |.||.||.|.||| ||... |. ||... . | | . SHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYKYRFRFIYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDP VQIPL-------------TLSKSVRWLLLSLLRKDYTERMTASHIFLTPWL .. | .| |.. .|.|. |.|.|.. | ||. IKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKNPTKRITIPQIKVHPWV |
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Kinase | trbl.AA | Ciliate-E2 | 302-397 | 26 | 1.6e-20 | 67.14 | In-house | 248-365 (365) | Show / Hide |
Range on Protein: 302-397 Range on HMM: 248-365/365 Sequence Identity: 26% (34 aa) IGCPLYTAPELLC-PQ------QTYKGKPADMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIP------------------LTLSKSVRWLLLS .| | | ||| | . |.. .. .|.|||||||| || |..|| . | .....| . .|... |. CGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK ----LLRKDYTERMT-ASHIFLTPWL .| || .|.| .. |. ||. FGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | trbl.AA | Ciliate-E2-Unclassified | 295-397 | 26 | 3.1e-20 | 66.9 | In-house | 216-352 (352) | Show / Hide |
Range on Protein: 295-397 Range on HMM: 216-352/352 Sequence Identity: 26% (37 aa) DDTLSDKIGCPLYT----APELLCPQQTYKG--KPADMWSLGVILYTMLVGQYPFY------------EKANC-----NLITVIRHGNVQIPL------- .. .....| | | |||.|. |. .. . .|.|||||||| || |.|||| .. . .|. | .|.|.| QQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIP -TLSKSVRWLLL----SLLRKDYTERMTASHIFLTPWL ..|... .. ..| |. .|.|.. |. ||. KHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | trbl.AA | ULK | 303-397 | 29 | 1.7e-19 | 65.88 | In-house | 209-324 (324) | Show / Hide |
Range on Protein: 303-397 Range on HMM: 209-324/324 Sequence Identity: 29% (34 aa) GCPLYTAPELLCPQ--QTYKG-KPADMWSLGVILYTMLVGQYPFYEKANCNLI--------------TVIRHGNVQIPL-----TLSKSVRWLLLSLLRK | ||| ||..| | | . . .|.||||.|.| || |.|||.. ..... . |. ..|.|. .|. .. |. .| . GTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQY DYTERMTASHIFLTPWL | ..|.. || ||. DEKDRISWEEIFNHPWF |
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Kinase | trbl.AA | Pkinase | 305-397 | 25 | 1.1e-15 | 56.52 | Pfam | 175-293 (293) | Show / Hide |
Range on Protein: 305-397 Range on HMM: 175-293/293 Sequence Identity: 25% (31 aa) PLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVGQYPFYEK------ANCNLITVIRHGNVQIPLTLS---------------------KSVRWLLLSL | | |||.. ..| |...||||.|.||| || |. ||... .| |... . . . .. . .. .. PWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC LRKDYTERMTASHIFLTPWL |.|| ..| || .|. ||. LCKDPKKRPTAEQILQHPWF |
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S_TKc | trbl.AA | S_TKc | 129-397 | 19 | 1.2e-14 | 38.11 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 129-397 Range on HMM: 1-231/231 Sequence Identity: 19% (61 aa) YRHLVDL----TASNLRCVDIFTGEQFLCRIVNEPLHKVQRAYFQLQQHDEELRRSTIYGHPLIRPVHDIIPLTKDRTYILIAPVPQ---ERDSTGGVTG |. | . .. .|... ||... . |.. .. |.. .|| | .|.. |. |. ... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGD--------- VYENLHTYIRHAKR------LCETEARAIFHQICQTVQVCHRNGIILRDLKL-----------------KRFYFIDEARTKLQYESLEGSMILDGEDDTL |..||.. .| . | .|| ...|||. .. ||..||| |||| ... ----LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL---------------------------- SDKIGCPLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFL----- . .| | | |||.| | ....|.||.|.||| ||.|. ||. .. ..... |.... .. .|.|| ..|.|| .. TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI --TPWL ||. KCHPWF |
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Kinase | trbl.AA | MARK | 225-267 | 44 | 3.4e-12 | 36.34 | In-house | 88-132 (262) | Show / Hide |
Range on Protein: 225-267 Range on HMM: 88-132/262 Sequence Identity: 44% (20 aa) NLHTYIRHA--KRLCETEARAIFHQICQTVQVCHRNGIILRDLKL .|. ||. . ||.| |||.||.||. |. ||...|. ||.|. ELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKP |
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Kinase | trbl.AA | CAMKL | 226-267 | 41 | 1.2e-08 | 23.51 | In-house | 110-155 (297) | Show / Hide |
Range on Protein: 226-267 Range on HMM: 110-155/297 Sequence Identity: 41% (19 aa) LHTYIRHA----KRLCETEARAIFHQICQTVQVCHRNGIILRDLKL |. ||. .|. | ||| .| ||. |. ||..||. ||.|. LFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKP |
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Kinase | trbl.AA | Ciliate-E2-Unclassified | 225-267 | 24 | 3e-06 | 17.69 | In-house | 107-172 (352) | Show / Hide |
Range on Protein: 225-267 Range on HMM: 107-172/352 Sequence Identity: 24% (16 aa) NLHTYIRH-----------------AKRLCETEAR-----AIFHQICQTVQVCHRNG-IILRDLKL .|. ||.. |.. | .|. .| ||.| . .|... || ||.|. DLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKP |
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Kinase | trbl.AA | Ciliate-E2 | 225-267 | 22 | 1.6e-05 | 14.92 | In-house | 120-189 (365) | Show / Hide |
Range on Protein: 225-267 Range on HMM: 120-189/365 Sequence Identity: 22% (16 aa) NLHTYIRHAKRLC-----------ETEARAIFHQICQ---------------TVQVCHRNG-IILRDLKL .| ||.. | . | |.. |. ||.| .. .| .. || ||.|. DLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP |
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Kinase | trbl.AA | Pkinase | 226-267 | 34 | 1.8e-05 | 20.45 | Pfam | 91-136 (293) | Show / Hide |
Range on Protein: 226-267 Range on HMM: 91-136/293 Sequence Identity: 34% (16 aa) LHTYIR--HAKRL--CETEARAIFHQICQTVQVCHRNGIILRDLKL |..||. ... | |.. .. ||.. .. ||..||| ||||. LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKP |
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Kinase | trbl.AA | ULK | 225-267 | 36 | 0.000147 | 12.17 | In-house | 103-154 (324) | Show / Hide |
Range on Protein: 225-267 Range on HMM: 103-154/324 Sequence Identity: 36% (19 aa) NLHTYIR---------HAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKL .| .|| ||| | ||. .|.|||. . | ..|| ||.|. DLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKP |
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Kinase | trbl.AA | CAMKK | 234-266 | 12 | 0.012193 | 3.7 | In-house | 150-223 (396) | Show / Hide |
Range on Protein: 234-266 Range on HMM: 150-223/396 Sequence Identity: 12% (9 aa) KRLCETE---------------------ARAIFHQICQTVQVCH-RNG-------------------IILRDLK . ..|.. |. .| .... .. .| .. || ||.| SIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIK |