Gene Mkk4 (Fruit Fly)

Mkk4

Species: Fruit Fly
Alias: SEK1/MKK4, DMKK4, D-MKK4, Drosophila MAP kinase kinase 4, MKK4, SFO035, JNK kinase 2, CG9738, JNKK2, Mpk4, CT27508, Mkk4, MAP kinase kinase 4
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 85A5,

Classification

Group: STE
Family: STE7
Subfamily: MEK4

Sequence

Name Sequence Type Origin Length Description Download
Mkk4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 266 Kinase domain by global Sugen HMM Fasta, JSON
Mkk4.AA Protein Various 424 None Fasta, JSON

Protein domain

Protein domains of Mkk4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Mkk4.AA MEK4 122-387 66 3.8e-219 722.2 In-house 1-275 (275) Show / Hide 
Range on Protein: 122-387
Range on HMM: 1-275/275
Sequence Identity: 66% (183 aa)

LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIR-STVD-----EKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEK
|.|.||||.||||.||||..|...|.||||||| ..||     .||||.|||...|||||..|.|||.||||.||||||||||||||.|.||||||.|..
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

QQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAK-GYDVRSDVWSLGI
|...|||.|...|||.||.|||||||..||||||||||||||.|.|..|||||||.||||||||||.||||||||||||||||... |||.|||||||||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

TLMEVATGNFPYRKWD--SVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI
|..|||||.||||||.  |||.|.|.||.|.||.|......|..|.....|.||||.|....||||..|...||.
TMYEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase Mkk4.AA STE7 122-387 53 2e-182 612.36 In-house 1-288 (288) Show / Hide 
Range on Protein: 122-387
Range on HMM: 1-288/288
Sequence Identity: 53% (157 aa)

LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDE-KEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGD--CWICMELMD-TSLDKFYKYIYEK--
||. ||.|.|..| |.|| .|. .|.|||||||.|... .||||.||.|.|..|.|.| ||||||||...|||  .|||||.|| ..||||||.....  
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

--QQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSI-AKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSL
  ....|||.||.||.||....|.||.|..|||||||||||||...||..|||||||.||||||. |.|...||.|||||||||.   ..||||||||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG-NKQHYDVRSDVWSL

GITL-MEVATGNFPYRKWDS-----------------VFEQLCQVVQG-EPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLE-MPFI
|||. .|.||| .||..|..                 .||||...|.. .||||       .||.||.||||.||.| ...||||..|.. .|||
GITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP------KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase Mkk4.AA MEK3 122-387 56 8.60000000001e-162 543.8 In-house 1-264 (264) Show / Hide 
Range on Protein: 122-387
Range on HMM: 1-264/264
Sequence Identity: 56% (150 aa)

LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIP
..   | ||||.| | ||  .  . .|||||||.||  .|||..|||. . | |  |.| |.||||.|.||| |||||.|||.|||||.  |. .  |||
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP

ESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAK-GYDVRSDVWSLGITLMEVA
|.|| || .  | ||.|..| ||.|||||||||.|. . | .|.|||||||.||||.||| ||||.|||||||||||    ||||.|||||||||. |.|
EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMA

TGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI
.| .|| .|   |.|| ||| . ||.|     .  || ...||.| || |    ||.| .|.|.||.
IGRYPYDNWHTPFQQLKQVVEEPPPQL---PMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase Mkk4.AA MEK7 122-387 50 1e-124 420.6 In-house 1-269 (269) Show / Hide 
Range on Protein: 122-387
Range on HMM: 1-269/269
Sequence Identity: 50% (136 aa)

LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIP
|.  |..| |  | | || .|.   .||||  | |    | |  |||| |. ....| |||| .|..  . | |||||.| | .||  | |.. .   ||
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIP

ESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDP--ERAKGYDVRSDVWSLGITLMEV
| |. |..||..|||.||||   |.|||||||||||  || |||||||||| .||| |.|. ||| .|||||||||  .    ||.|.||||||||| | 
EQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVEL

ATGNFPYRKWDSVFEQLCQVVQG--EPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI
||| .||   |  || .  . .   |||. |    .  || .| .||. || |   .|||| .|.. |||
ATGQYPYPGCDMEFEMMTKILNDNLEPPC-LPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase Mkk4.AA STE 122-387 31 6.30000000001e-107 361.53 In-house 1-359 (359) Show / Hide 
Range on Protein: 122-387
Range on HMM: 1-359/359
Sequence Identity: 31% (117 aa)

LEDEGEIGRGAFG-AVNKMTFK-----KLDKV---------MAVKRIR----------------STVDEKEQKQLLMDLEVVMKSNE-CIYIVQFYGALF
.|. ..||.||||  . .|  |     | ..|         ||.|...                ......|..|.|..... .|.|  . .||..||. |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KEG-------DCWICMELMD-TSLDKFYKYIYEKQQ---------RHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISG
|||       ..|||||.||  |||...|  |....          ..|||..|.|..... .| |......|||||.||.||||     .||||||..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLVDSIA----------------KT-KDAGCRPYMAPERIDPER---AKGYDVRSDVWSLGITLMEVATGNFPYRKWDSV---------------FEQLC
||.||.|                |.  ..|.  .||||.|....    ||||...|.||||.|..| |||. |. .                   |||| 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

QVVQGEPPRLLTSYN--------------GMEFSKEFVDFVNTCLIKKESDRPKYSRLLE--MPFI
..|.|.||.| .                   ..|.|| ||.| ||.|  ..||..| ||.   |||
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Mkk4.AA STE7-Unclassified 122-387 37 1.8e-88 300.21 In-house 1-301 (301) Show / Hide 
Range on Protein: 122-387
Range on HMM: 1-301/301
Sequence Identity: 37% (114 aa)

LEDEGEIGRGAFGAVNKMTFKK------LDKVMAVKRIR-STVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGD---CWICMELMDT-SLD---K
||  ...|.|..| | |   |.       .|.|| | |.    |.. .||.|. |... | . . |||..||| . |.      ||||.||  |||   .
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

FYKYIYE----KQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSI--AKTKDAGCRPYMAPERIDPE--R
 ||  ||    .  . |||..|.||. .  ..| ||.|...|||||.||.|||.  .| .|.||||..|||....  |||  .||  ||.||||  .   
IYKKMYERGPIRGGW-IPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKT-WVGCQMYMSPERIQGQMPH

AKGYDVRSDVWSLGITLMEVATGNFPY-------RKWDSV------FEQLCQVVQGEP-PRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLE-M
  .| |.||.||||.|. |.||| .||        . ...      | .| . . ..| |||      . .|||| ||.. |..| . .|| .. ||.  
RPSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEH

PFI
|.|
PWI
Kinase Mkk4.AA MEK5 122-387 45 4.4e-71 242.48 In-house 1-254 (254) Show / Hide 
Range on Protein: 122-387
Range on HMM: 1-254/254
Sequence Identity: 45% (123 aa)

LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMD-TSLDKFYKYIYEKQQRHI
.     .| |  |.| |       |..||| |   .  . |||.. .||.. |  .  ||. |||| | |    || | ||  |||     .|    | |
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSPYIIGFYGAFFVENRISICTEFMDGGSLD-----MY----RCI

PESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVA
||.|| ..||| |  ||||  .|||.||||||||.|   .|.|||||||.| |||.||..|   |   |||||||  ..   | . |||||||| .||.|
PEHILGRMTVAIVKGLNYLW-NLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERISGDQ---YGIHSDVWSLGIFFMEMA

TGNFPYRKWDSVF-----EQLCQ-VVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI
|| ||| . .         || | .|. .||||       .||. ||.|.| |. |.  ||||   |.. |||
TGRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPV----DKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase Mkk4.AA S_TKc 122-387 27 9.4e-66 225.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 122-387
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQRH--
 |   .||.|||| | | . || ....|.|.|.        ....  ... .|   . .||..|..    .. ...||..|..|   ..|| ... .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDV-RSDVWSLGITL
  .||   ....  ...||.|. .  .|||||.||.|||| .   ||.||||.. ||      |   | . ||||| .      ||.  ..|.||.|..|
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCIL

MEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLE-------MPFI
 | ..|  |..      ... ...                |.|. ||.. || |  ..||    .|.       .|..
YEMLCGYPPFP----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Mkk4.AA MEK1 122-325 44 6.9e-64 217.12 In-house 1-195 (297) Show / Hide 
Range on Protein: 122-325
Range on HMM: 1-195/297
Sequence Identity: 44% (92 aa)

LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMD-TSLDKFYKYIYEKQQRHI
.| .||.| |  | |.|.  ..   .|| | |.  .    ..|.. .|.|. . |   ||| |||| . .|.  |||| ||  |||   | .       |
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSP-YIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-----GRI

PESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVA
||.|| |..|| .  | ||... ||.||||||||||   ||.|||||||.||||.||.|     | | ||.|||.   .   | |.||.||.|. |.|.|
PEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERL---QGTHYTVQSDIWSMGLSLVEMA

TGNFP
 | .|
IGRYP
Kinase Mkk4.AA STE20 122-387 31 2.8e-51 176.69 In-house 1-288 (288) Show / Hide 
Range on Protein: 122-387
Range on HMM: 1-288/288
Sequence Identity: 31% (91 aa)

LEDEGEIGRGAFGAVNKMTFKKLDKV----MAVKRIRSTVDEK----EQKQLLMDLEVVMKSNECIYIVQFYGALFKE----GDCWICMELMDT-SLDKF
 |.  .||.|..|.| | . |. ...     |.|..   ....    .......  ...||   . .||..||. .|.     . ||.||...  ||   
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMN--LEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDI

YKYIYEKQQR----HIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVD----SIA-K-TKDAGCRPYMAPERIDPE
.|  .....      . |.  | |.  .. .|.|| .. .|||||.|  ||||  .|..||.||| ..|| .    ... |     |   .|||| |  .
MKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCM

RA--KGYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQG--EPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI
.   |||| ..|.||||||..| |.|. ||..  . .  . .. ..  .||.|  .     .|.|| |||..|| |  ..||  | ||. |||
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFD-MHPMRAMFMIPKNQNPPPTLKDD-KPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase Mkk4.AA Pkinase 122-387 23 2.5e-46 164.88 Pfam 1-293 (293) Show / Hide 
Range on Protein: 122-387
Range on HMM: 1-293/293
Sequence Identity: 23% (72 aa)

LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLL---MDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDT-----SLDKFYKYIY
.. .. ||.|.|| | | . |.  |. |||.|.   ......| .   . ...  .   . .||..|..   .......||...      .|     || 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF---DYIS

EKQQRHI--PESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDI----KLCDFGISGQ--LVDSIAKTKDAGCRPYMAPERIDPERAKGYDV
 .... .  .|  . ..   .. .|.|. .  .|||||.||.|||....|.|    |.||||.. |  .  .   |  .| ..||||| |    ...|. 
TWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--GGQYYGP

RSDVWSLGITLMEVATGNFPYR------KWDSVFEQLCQVVQGEPPRL-LTSYNGM--------------EFSKEFVDFVNTCLIKKESDRPKYSRLLEM
..|.||.|..| |...|..|..      . ..  . .|.. ......   ......              . |.|. ||.. || |. ..||    .|. 
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PFI
|..
PWF
Kinase Mkk4.AA SLK 123-387 31 1.6e-44 148.02 In-house 2-259 (259) Show / Hide 
Range on Protein: 123-387
Range on HMM: 2-259/259
Sequence Identity: 31% (84 aa)

EDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIPE
|  ||.| |||| | |   |   ||.|  ..  . || | .  ....... . .   .||. |.| . ... |. .|  |         |    .. . |
EIIGELGDGAFGKVYKAQHK-EQKVFAAAKMIEIKDEEELEDYMVEIDILSECK-HPNIVKLYEAYYYDNKLWMMIEFCDGGA---VDNIMVELEHPLTE

SILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPY-MAPERIDPERAKG--YDVRSDVWSLGITLMEV
. .. .   ...|||.| .. |.||||.|  |||.   ||..| |||.| ..   . |       || |||| .  |  |   || ..|.|||||||.|.
DQIQYVCKHMCEALNWLHSN-KVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEM

ATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI
| .  |.    ..   | .. . |||.|..     ..|||| ||.  || |    |.  ..|.. ...
AQMEPPHHEM-NPMRVLLKIQKSEPPTLEQP---SHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase Mkk4.AA TyrKc 122-385 22 1.3e-14 13.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 122-385
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSN--ECIYIVQFYGALFKE-------GDCWICMELMDT-SLDKFYKY
.. . ..|.|||| | | | |      ||| ...       .. .|.   .|..   .   ||..||.  ..       .  .| ||.|.  .|... ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

IYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDS-------IAKTKDA--GCRP-----YMAPERIDP
  .|    .. . | .. .   .  .|| .. ..||||    |.|..... .| .||| |  . |          ..|    |..       |||| |  
HRPK----LCMKDLLSFCWQIACGMEYL-HSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

ERAKGYDVRSDVWSLGITLMEVATGNFPYRKW-----DSVFEQLCQVVQG---EPPRLLTSYNGM---EFSKEFVDFVNTCLIKKESDRPKYSRLLEMP
 . . .   ||||| |... |. |   .          | .| . .| ||   ..|        |   . ..|  .   .|   . .|||  | . |  
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Mkk4.AA MEK1 332-387 39 3.6e-10 30.44 In-house 246-297 (297) Show / Hide 
Range on Protein: 332-387
Range on HMM: 246-297/297
Sequence Identity: 39% (22 aa)

VFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI
.|| |  .|.. ||.|        ||.||.|||. ||||. ..|    .|.  .||
IFEMLDYIVNEPPPKLPHRV----FSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase Mkk4.AA Pkinase_Tyr 122-326 23 9e-08 26.95 Pfam 1-216 (270) Show / Hide 
Range on Protein: 122-326
Range on HMM: 1-216/270
Sequence Identity: 23% (53 aa)

LEDEGEIGRGAFGAVNKMTFK----KLDKVMAVKRIRSTVDEKE--QKQLLMDLEVVMKSNECIYIVQFYGALF-KEGD--CWICMELMDTSLDKFYKYI
..   ..|.|||| | | | |    . .   ||| .. . ....  .. ..  ... ..   .  ||..||.   ...    .| ||.|       ..| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG--DLLDYL

YEK--QQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQL-VDS---IAKTKDAGCRPYMAPERIDPERAKGYDVR
 ..  ...... . | .. .   ....|| |. ..||||.   |.|... . .| |||| .  .  |.    ....     . |||| |   .   . . 
RKHREDKQPLTMKDLLQMCWQIAKGMEYL-ESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK---FTTK

SDVWSLGITLMEVAT-GNFP-Y
||||| |... |. | |  | |
SDVWSFGVLMWEIFTYGEQPTY