Gene mbt (Fruit Fly)

mbt

Species: Fruit Fly
Alias: CG18582, anon-fast-evolving-1G7, Ste20, dPAK2, SFO141, STE20, mbt, Pak2, anon-EST:fe1G7
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 14F2

Classification

Group: STE
Family: STE20
Subfamily: PAKB

Sequence

Name Sequence Type Origin Length Description Download
mbt.AA Protein Various 639 None Fasta, JSON
mbt.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of mbt.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD mbt.AA PBD 11-46 39 5.6e-14 53.68 SMART 1-38 (38) Show / Hide 
Range on Protein: 11-46
Range on HMM: 1-38/38
Sequence Identity: 39% (15 aa)

ISMPS-NFEHRVHTG-FDKRENKYVGLPLQWASIVGNN
||.|. ||.|.|| | .| .. ...|||.||.......
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
PBD mbt.AA PBD 10-63 21 9e-11 40.37 Pfam 1-60 (60) Show / Hide 
Range on Protein: 10-63
Range on HMM: 1-60/60
Sequence Identity: 21% (13 aa)

LISMP-SNFEHRVHTGFDKRENKYVGLPLQWASIVGNN-----QILKSSNRPLPLVDPSE
 || | .||.|..| |.|  .....|.| .|....  .     .  ..... .. |.  .
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
Kinase mbt.AA PAKB 368-619 86 1.6e-227 762.18 In-house 1-252 (252) Show / Hide 
Range on Protein: 368-619
Range on HMM: 1-252/252
Sequence Identity: 86% (217 aa)

LDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHSRMDEEQIATV
||...||||||||.|||||.|.|||||||||||||||||||||||||||||||.||||||.|||.||.||||||||..|||||||||||.||.|||||||
LDNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATV

CKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPP
|.|.|.||||||.|||||||||||||||..||||||||||||||||.|.|||||||||||||.||||||||||.||||||||||||||||||||.|||||
CRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPP

LQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFL
||||.|||||.||.|||.|||||||..||||||||||.||.||.|||.||||
LQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase mbt.AA STE20 368-619 46 7.6e-154 517.39 In-house 1-288 (288) Show / Hide 
Range on Protein: 368-619
Range on HMM: 1-288/288
Sequence Identity: 46% (133 aa)

LDHFNKIGEGSTGTVCIATDKSTGRQ----VAVKKMDLRKQ----QRRELLFNEVVIMRDYHHPNIVETYSSFLVN----DELWVVMEYLEGGALTDIVT
 . . |||.||.|.|. |..|.||..    ||.|||.|.|.    ...|....|..||....|||||. | |.|..    ||||.||||..|| ||||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

HS----------RMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQ-----ELPKRKSLVGTPYWMSPEVISR----
|.          .|.|||||..|...|..|.||||...||||||.| |||  ||.|||.|||.|||...     . .||...|||||||.||||..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-LPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIR--DMQPPNLKN--AHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFL
  .|.  .|||||||. |||..||||.|...|..|| .|   ...|| ||.   || || .. |.|..|..||..|.|| .|| |||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase mbt.AA PAKA 369-619 52 4.2e-138 465.1 In-house 2-260 (260) Show / Hide 
Range on Protein: 369-619
Range on HMM: 2-260/260
Sequence Identity: 52% (137 aa)

DHFNKIGEGSTGTVCIATDKSTGRQ--VAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHSR------MD
. ..|||.|..|.| .||...|. .  ||.|.|.. .| . ||. ||  .|....|.|||  ..|.||.|||||||||.||| |||..|. .      ||
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD

EEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEP
|.||| ||..||..| ..||...|||||||| ||| .||.||. ||||||| .||  ||.. |||||||.||||.|  |.. |||||||||.|||..|||
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEP

PFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFL
|. ||||| ||  |     | .|...|.|. .. |||. |  |. .||.| |||.||||
PYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase mbt.AA STE 368-619 31 9.20000000001e-124 417.46 In-house 1-359 (359) Show / Hide 
Range on Protein: 368-619
Range on HMM: 1-359/359
Sequence Identity: 31% (115 aa)

LDHFNKIGEGSTGTVCIATDK------STGRQ---------VAVKKMDLRKQ-----------------QRRELLFNEVVIMRDYH--HPNIVETYSSFL
...  |||.|..|||. | ..      .||..         .|.|.|.|...                 . .. . .|. ||....  |||||. | ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VN-------DELWVVMEYLEGGALTDIVTH---------------SRMDEEQIATVCKQCLKA-LAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCA
..       ||||..|||..|| |.||. |               .|..|.|||..|.|.||. |.||||...||||||.. |||     |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QVSQELP----------------KRKSLVGTPYWMSPEVISR------LPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDM-----------
|......                ||...|||| ||.||||..       .|.  .||||||...|||..|.||.....|..|| .| ..           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----QPPNLKNA-----------------HKVSPRLQSFLDRMLVRDPAQRATAAELLA--HPFL
    .|| |..                  ||.|| .. |... |..|| .|.|| .||   |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase mbt.AA S_TKc 368-619 32 2.3e-98 333.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 368-619
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

LDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEG--GALTDIVTHSR-------
 .  .|||.|. |.|. ...|.|||.||.|...       | . .|. |..  ||||||  | .|   |.|..||||..|  | | |.  . .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGP-EVDIWSLGIMVIEMVD
..| ... ...| ..||.|.||.|.||||.| . |||    ..|..|||...|.       ....|||..|.|||.   .||. ..|.||.|....||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLA-------HPFL
|.|||    . . ...|.             || . .|....|..||..| || |.|.       ||..
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase mbt.AA Pkinase 368-619 31 3.9e-92 317.18 Pfam 1-293 (293) Show / Hide 
Range on Protein: 368-619
Range on HMM: 1-293/293
Sequence Identity: 31% (93 aa)

LDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRREL--LFN--EVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGG----ALTDIVT---H
.    |||.|| |.|.....|.||..||||....|..   ..  ...  |. ||.  .|||||..| .|  .|....||||.|||     | |...   |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

SRM--DEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRV----KLSDFGFCAQV-SQELPKRKSLVGTPYWMSPEVIS-RLPYGPEVDIWSL
 ..  .|...  ...| |..|.|.||.|.||||.|.. ||.  .| .    |..|||...|.     .  ....|||..|.||||  . .|||.||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMVIEMVDGEPPFFNE----PPLQAMRRIRDMQPPNLKNAHKVS---------------------PRLQSFLDRMLVRDPAQRATAAELLAHPFL
|....||. |.||| ..    . .  | .|.   .| |.     .                     . ...|....| .||..| ||...| ||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase mbt.AA YSK 369-619 39 1.3e-81 245.48 In-house 2-257 (257) Show / Hide 
Range on Protein: 369-619
Range on HMM: 2-257/257
Sequence Identity: 39% (102 aa)

DHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRR-ELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTH---SRMDEEQI
    .|| || | |  . |. |.| ||.|  || .     |..  |. .  .   |.|   | |.|    ||..|||. || . |         .||..|
TKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYI

ATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISR--LPYGPEVDIWSLGIMVIEMVDGEPPF
|.. .  ||.| ||||. .||||||.  .|| ..| ||| |||  .|. .   ||   ||||||| ||||      |   .|||||||  .||  |||| 
AIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPY

FNEPPLQAMRRIRDMQPPNLKN-AHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFL
    |. .| .|   .|| |.   .  |  .  | .  |. ||.|| .| ||| | | 
CDYHPMRVMFLIPKNNPPKLEGRSY--SKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase mbt.AA MST 369-619 40 2e-80 255.31 In-house 2-254 (254) Show / Hide 
Range on Protein: 369-619
Range on HMM: 2-254/254
Sequence Identity: 40% (102 aa)

DHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFL--VNDELWVVMEYLEGGALTDIV--THSRMDEEQI
|   |.|.|| | |  |..|.||  ||.|..        . . .|  || .   ..||  | |..   | ..| |||| ..| . ||.  |     |.||
DIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQI

ATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFN
|..... |. |.|||.   ||||||.  |||  .|  ||.|||  .| .    || ...||||||.||||  . |   .|||||||  |||  |.||...
ACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSD

EPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFL
  |  ||  |    ||..|. .. |. .  |. . |...| ||.|| .|| ||| 
IHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase mbt.AA CAMK 373-619 19 1e-76 246.58 In-house 1-425 (425) Show / Hide 
Range on Protein: 373-619
Range on HMM: 1-425/425
Sequence Identity: 19% (84 aa)

KIGEGSTGTVCIATDKSTG------------RQVAVKKMDLRKQQR----------------------------RELLFNEVVIMRD-------YHHPNI
..|.|| |.|  ...|.|.            ..||.| .| .| .                             |. ...|. ||.         .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VETYSSFLV-------------------NDELWVVM---EYLEGG----A-LTDIVTH---------------SRMDEEQIATVCKQCLKALAYLHSQGV
.  |  .                     ..... ||   || .||      .  || |                |..|.. ... .| . |..|.||...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKSDSILLAAD-----------------GRVKLSDFGFCAQVSQEL-----------------------PKRKSLVGTPYWMS-PEVISR------
.|||.| . |||  .                 . .|..|||| ... .                         .| |  .|||. |. |||...      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------LPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMR-------------RIR----DMQPPNLKN---------AHKVSPR--------LQS
         .|||..|.||.|..   |. |.|||  .   . .              .|.    |. || ...          ...|           ..
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FLDRMLVRDPAQRATAAELLAHPFL
.. .||..|| .|.|... |.||..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase mbt.AA KHS 369-619 40 2.2e-75 252.96 In-house 2-258 (258) Show / Hide 
Range on Protein: 369-619
Range on HMM: 2-258/258
Sequence Identity: 40% (105 aa)

DHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHS-RMDEEQIATV
.   ..| |  | |  | |. ..  .||| . .  ..  ...  |...|.| .|||||  . |.| .| ||..|||  ||.| ||      . | ||| |
ELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV

CKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVIS---RLPYGPEVDIWSLGIMVIEMVDGEPPFFN
|.. |..|.||||.| .|||||   |||. .| ||| |||  ||... . |||| .|||||| ||| .   .  |.   |||..||  ||. .  ||.|.
CRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMFD

EPPLQAMRRIR--DMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFL
  |..|.  .   . ||| ||. || |.    |.   |...| .| ||  || |||.
LHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase mbt.AA PAKL 373-619 38 2e-71 243.63 In-house 6-256 (256) Show / Hide 
Range on Protein: 373-619
Range on HMM: 6-256/256
Sequence Identity: 38% (96 aa)

KIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVN-DELWVVMEYLEGGALTDI--VTHSRMDEEQIATVCK
| |.|| |.|  |. |.|.   |.| . .    . . . .|. |      ||||  . |     ...|. |.|   |   |.  ..   ..|.||. . .
KLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQISVILQ

QCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELP-KRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPL
| || | ||||...||||||.  |||  |. ||. |||   |   |.    ....|||||| ||.| . .|   .||||||| .||| ||.||    || 
QTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPHYDMPPM

QAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFL
 ||  |  . || ..| .. || . .||.. .| || .|. . .|| |||.
RAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase mbt.AA SLK 369-619 36 3e-71 239.62 In-house 2-259 (259) Show / Hide 
Range on Protein: 369-619
Range on HMM: 2-259/259
Sequence Identity: 36% (94 aa)

DHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVT--HSRMDEEQIAT
.    .|.|  | |  | .| ...  | | ......   |  . |. |. . .|||||. |... ....||...|. .|||.  |.   .  . |.||. 
EIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQY

VCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVI-----SRLPYGPEVDIWSLGIMVIEMVDGEPP
|||. . || .|||. |||||.|   ||.. || |.| |||  |.  ... || . .|||||| |||.        ||   .||||||| .||| ..|||
VCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPP

FFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFL
  .  |.  . .|.  .|| |..  . |   . || . ||.|| .| |.|.|. |...
HHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase mbt.AA Pkinase_Tyr 373-576 28 2.1e-23 79.89 Pfam 6-231 (270) Show / Hide 
Range on Protein: 373-576
Range on HMM: 6-231/270
Sequence Identity: 28% (65 aa)

KIGEGSTGTVCIATDK----STGRQVAVKKM--DLRKQQ--RRELLFNEVVIMRDY-HHPNIVETYSSFL-VNDE--LWVVMEYLEGGALTDIVTHS---
|.|||. |.|. .| |    .|. .||||..  .  ..|  |....  |. ||. . ||||||  |   .   .   ...|||| ..| | |        
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRED

--RMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQV--SQEL-PKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMV
  . . ...   | |  |...||.|.. ||||.    .|.. .. || .||| .  .    .   ||..      ||.||.|.   .  . |.|| |.  
KQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLM

IEMVD-GEPP-FFNEPPLQAMRRI-RD
 |..  || | . . .. . ...| .|
WEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase mbt.AA TyrKc 368-619 26 2.1e-20 75.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 368-619
Range on HMM: 1-280/280
Sequence Identity: 26% (76 aa)

LDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDY--HHPNIVETYSSFLVN-------DELWVVMEYLEGGALTDIVTHSR
.    |.|||  |.|. .| |   .|||||..   .   || . .|  ||. .  ||||||  |   .         . |..|||| ..|.| |    .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--MDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQE-------LPKRKSL-VGTP-----YWMSPEVISRLPYGPEV
     ..    | |  .  .||||...||||.    .|......|| |||| .  .  .         .||.   |.       ||.||.|    . .. 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSLGIMVIEMV-DGEPPFFN-----EPPLQAMRRIRDM----QPPN-----LKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFL
|.|| |..  |.  .|..|  .      .. ........     ||||            .. . .   .   .||..| | .|.  | ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF