Gene CG4527 (Fruit Fly)

CG4527

Species: Fruit Fly
Alias: SFO068, CG4527, SLK
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 60D3

Classification

Group: STE
Family: STE20
Subfamily: SLK

Sequence

Name Sequence Type Origin Length Description Download
CG4527.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
CG4527.AA Protein Various 1726 None Fasta, JSON

Protein domain

Protein domains of CG4527.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CG4527.AA SLK 37-295 78 4.6e-185 621.11 In-house 1-259 (259) Show / Hide 
Range on Protein: 37-295
Range on HMM: 1-259/259
Sequence Identity: 78% (204 aa)

WEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIA
||..||||||||||||||||||||.||||||....|||.|.|.|||||||||.||||||.||||...|.||||.||.|||||.|.||||||.||||.||.
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

YVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEP
||||||.|.|..||.||||||||||||.|.||.|.|.||||||||||||||||.|||||||||||||.|.||||.|.|||.|.|||||||||||.|||||
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFI
|..||.||||||||||||||.|||||.|||||.|||||.||||||.|.||..||||...
PHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase CG4527.AA STE20 37-295 45 6.00000000001e-146 491.17 In-house 1-288 (288) Show / Hide 
Range on Protein: 37-295
Range on HMM: 1-288/288
Sequence Identity: 45% (132 aa)

WEMVGELGDGAFGKVYKAQHKEQKRF----AAAKMCQLEDE----ENLSDHMVEIDILSEIKHPNIVELYEAFSID----DKLWMLIEYCDGGALDSIMV
.|.. ..| |..|||||| ||. ..     .| |.  ||..    . . |.. ||.|... ||||||. |...  |    |.||...|||.|| |  || 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---ELEK-----PLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKH----TMQ-KHDTFIGTPYWMAPELVLCETFR
   ...|     |..|.||||.|. . .|| .||.|..||||.||.|.|||..| ||||||||.|.  .    ||| | .||.|||||||||...|....
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

DNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQ--KSEPPKLEQ--PSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFI
|..||.|.||||||||.||.|  |||...|.|||....|   . .||.|..  |..||.||.||..| |.|||. |||.. |..| ||
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase CG4527.AA STE 37-295 33 7.4e-117 394.53 In-house 1-359 (359) Show / Hide 
Range on Protein: 37-295
Range on HMM: 1-359/359
Sequence Identity: 33% (121 aa)

WEMVGELGDGAFGKVYKAQHKE---------------QKRFAAAKMCQLEDE-----------------ENLSDHMVEIDILSEIK--HPNIVELYEAFS
|| ....| ||||.|||| ...               .... | |   ||..                 |.. . . ||.|... .  |||||. | .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ID-------DKLWMLIEYCDGGALDSIMV---ELEKPLT----------EPQIAYVCKHMTEG-LTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSA
 .       |.||.  ||.||| ||.|.    .  |||.          |.||||.|.   .| | .||....||||.|..|.||     |||.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KNKH---------------TMQ-KHDTFIGTPYWMAPELVLCETFR-DNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKS-----------
.  .               ||| | .||.||| ||||| .....   |..|| |.||||||.|.||.|  .|| ..|.|||... |...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----EPPKLEQ-----------------PSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQ--HAFI
    .||.|..                 |..||.||.||..| |.|||. |||.. |..  | ||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase CG4527.AA MST 37-295 45 3.8e-108 344.88 In-house 1-254 (254) Show / Hide 
Range on Protein: 37-295
Range on HMM: 1-254/254
Sequence Identity: 45% (119 aa)

WEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFS--IDDKLWMLIEYCDGGALDSIMVELEKPLTEPQ
 . |. || |..|.|||| ||. .   | ||     .| |...  || |... | ..|| .|  .    .  .|  .|||..| .  ||    ..|.| |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQM
|| ...    ||  ||.|| ||||.|||| ||  ||  ||||||||.   .|| | .|.|||||||||| |. |    . || |.|||||||| ||.|  
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPE-VIQE----IKYDCKADIWSLGITAIEMAEG

EPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFI
.|| |.  |||.. .|... ||..  |..|| |||||..| |.|.|. |.|   | || ||
MPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase CG4527.AA YSK 37-295 42 4.4e-100 302.06 In-house 1-257 (257) Show / Hide 
Range on Protein: 37-295
Range on HMM: 1-257/257
Sequence Identity: 42% (111 aa)

WEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLE-DEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVE-LEKPLTEPQ
.      | | || |||.  .  .|  | |   || .|.   |   || .||. . |.|   | ..  | |||   ||| || . . |      .. |..
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQM
|| . .  . || .|| ...|||| || ||||. .| |||.||||...   |..| .||.|||||||||.. .|      || |.|||||||| .|.|  
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEV---SYYDFKADIWSLGITAYEMAKG

EPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFI
|||.... ||||.  | |..|||||  . .|| | .|    |.|||. ||. . |  | ||
EPPYCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase CG4527.AA KHS 37-295 44 4.1e-91 306.7 In-house 1-258 (258) Show / Hide 
Range on Protein: 37-295
Range on HMM: 1-258/258
Sequence Identity: 44% (115 aa)

WEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIA
.|..  .| | .| ||||.... .  || |. ..| .....    || .. . .|||||  . ..   ||||. .||| ||.|  |  ..  ||.| |||
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIY-HVTGPLSELQIA

YVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEP
|||.   .|| .|| .. .|||.|  |.||| .| ||||||||||.   |. |   |||||||||||    |  |   |..  |||..||| |||| . |
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE--RKGGYNQLCDIWAVGITAIELAELQP

PNSEMSPMRVLLKIQKS--EPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFI
|  .. |||.|. . ||  .||||.. ..||. | .|.| .|.|.|. ||| . |.|| |.
PMFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase CG4527.AA PAKA 37-295 38 2.4e-88 299.81 In-house 1-260 (260) Show / Hide 
Range on Protein: 37-295
Range on HMM: 1-260/260
Sequence Identity: 38% (101 aa)

WEMVGELGDGAFGKVYKAQHKEQKRF--AAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEK----PL
 ... ..| || |.||.|  .. .     | |  .....      . || .. | ||.|||  .... .||.||. .|| .|| |  .  . ..    ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

TEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIE
.| ||||||.    || |.|....||||.|  |.|| |.| ||..|||  |      || .|  |||||||||..     | . ||.||||||||| .||
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVI-----RRKQYDEKVDIWSLGIMAIE

LAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFI
..  |||  .. | | .  | .   |.. .| .||.||.|||.| | .|.. |.... |..| |.
MIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase CG4527.AA S_TKc 37-295 32 5.6e-86 292.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 37-295
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

WEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDG--GALDSIMVELEKP-----
.|.. ..| ||||||||..||. .|  | |.          . . ||.||.. .||||| ||..|   |.|.|  |||||  | | .....  ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDH-KVDIWSLGITL
..| ....... . ..| ..|....||||||  |.||.    .|..|||....        .||.|||..||||..        .|.. |.|.||.|..|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCIL

IELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQ-------HAFI
.|..  .|| .    | ...|. .            |.|. ||..| |.|||. |||   ..|       | ..
YEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CG4527.AA NinaC 37-295 41 5.2e-84 285.41 In-house 1-267 (267) Show / Hide 
Range on Protein: 37-295
Range on HMM: 1-267/267
Sequence Identity: 41% (110 aa)

WEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEI-KHPNIVELYEAFSID-----DKLWMLIEYCDGGALDSI---MVELE
|| . . | | .|||.|.. |.  . || |  |  ...   .   |  || .   |||.|. |  .        |.||. .||| ||    .   .  ..
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKI-QHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKCG

KPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGIT
. . |. |||. .    ||  ||.|.||||| |  |.||| |||||| ||||||    |  .  | .|||.||||| . |.  .|  ||   |.||||||
RRMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGIT

LIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFI
 |||.  .||  .| ||| . ||    ||.| .|  |..|||||  ..| ||   ||.   ...| ||
AIELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase CG4527.AA MSN 37-295 42 1.4e-83 275.88 In-house 1-265 (265) Show / Hide 
Range on Protein: 37-295
Range on HMM: 1-265/265
Sequence Identity: 42% (113 aa)

WEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEI-KHPNIVELYEAF------SIDDKLWMLIEYCDGGAL-DSIMVELEK
.|.|  .| |..|.||| .|.   ..|| |. .....|.  .   ||..|     | ||.  | ||        |..||| .|.|  |.. | .    ..
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEE-EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQ

PLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITL
 | |  |||.|. .  ||..|| .||||||.|  ||||| .  ||| ||||||.  .|. .  |||||||||||| . |.   |  ||.. |.||.||| 
SLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITA

IELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFI
||.|  .||  .| ||| |. | .  ||||   ..||| |..|. | |.|. . ||.|. ...|.||
IEMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase CG4527.AA PAKL 37-295 39 3.2e-78 266.19 In-house 1-256 (256) Show / Hide 
Range on Protein: 37-295
Range on HMM: 1-256/256
Sequence Identity: 39% (104 aa)

WEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSID-DKLWMLIEYCDGGALDSIMVELEKPLTEPQI
 |.   ||.|..| |||| ||.     | |   .       |   ||.||   | ||||  .   .   ...| | .||  |    .|   .| |.| ||
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

AYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQ-KHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQM
. . .    ||  ||   .|||| || |.||.  . ||.|||||| .   .        |||||||||| ..       .|. |.||||||||.||.|  
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQ-----NYNNKCDIWSLGITAIEMADG

EPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFI
.||...| ||| .. |    ||..  |  ||..||||| . .||||  |.    |  | ||
FPPHYDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase CG4527.AA Pkinase 37-295 28 5.8e-73 253.51 Pfam 1-293 (293) Show / Hide 
Range on Protein: 37-295
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

WEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMV----EIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGG----ALDSIMV-ELE
.. .. .| |.||.|||..||   .  | |   ...|.   |       || |. ...|||||.||..|  .|...|  |||.||     | ...  . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KPL--TEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGV----KLADFGVSAK--NKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKV
...  .| ..  ... . .|| ..|....||||||  |.|.  .| .    |..|||....  . .     .|| |||..||||...     ...|..||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIR----GGQYYGPKV

DIWSLGITLIELAQMEPPNSEM----SPMRVLLKIQKSEPPKLEQPSRWS---------------------KEFNDFLKKSLVKDPQVRPTTDVLMQHAF
|.||.|..|.|..  .|| ..     . .. . .|..  .|.|. .. |.                     .|. ||.|. | |||. ||| . ..|| .
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

I
.
F
Kinase CG4527.AA Pkinase_Tyr 37-180 30 4.6e-26 88.9 Pfam 1-158 (270) Show / Hide 
Range on Protein: 37-180
Range on HMM: 1-158/270
Sequence Identity: 30% (48 aa)

WEMVGELGDGAFGKVYKAQHK----EQKRFAAAKMC--QLEDEE--NLSDHMVEIDILSEI-KHPNIVELYEAFS-IDDK--LWMLIEYCDGGALDSIMV
 ..  .|| ||||.|||.  |    ..|   | ||.  .  .|.    .    |. |.... .||||| || . .  ..   ...  ||. .| |..   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

EL---EKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVS
.    ..||| ...   |    .|. .|.... ||||| | |.|.| .. || .||| .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase CG4527.AA TyrKc 37-293 24 7.7e-25 89.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 37-293
Range on HMM: 1-280/280
Sequence Identity: 24% (73 aa)

WEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEI--KHPNIVELYEAFSID-------DKLWMLIEYCDGGALDSIMVELE
 ..  .|| ||||.|||.. |   .  | ||.. .    . | | |. |....  .||||| || . . .       . |... ||...|.|..   . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

KPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHT--------MQKHDTFIGTP-----YWMAPELVLCETFRDNP
. |. ..  . |    .|  .||....||||| | |.|.. .. || .||| | . ..         . .. .  |.       |||||       ... 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYGK

YDHKVDIWSLGITLIELAQM-EPPNSE-----MSPMRVLLKIQKSEPPKLEQPSR--------WSKEFNDFLKKSLVKDPQVRPTTDVLMQHA
. .| |.|| |... |.    ..| ..     ||. .|. .... .   ..||           ..|  .  |.    ||  |||   . .  
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY--RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CG4527.AA Pkinase_Tyr 199-285 27 8.6e-05 16.86 Pfam 180-262 (270) Show / Hide 
Range on Protein: 199-285
Range on HMM: 180-262/270
Sequence Identity: 27% (25 aa)

WMAPE-LVLCETFRDNPYDHKVDIWSLGITLIELAQME-PP-NSEMSPMRVLLKI-QKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPT
||||| .  ..      . .| |.|| |... |.      |   .||. .|. .| .. .   ...|   ..|  | .|.   .||. |||
WMAPECINYGK------FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR--MPCPENCPDEIYDLMKQCWHYDPEDRPT
PKK CG4527.AA PKK 980-1119 39 2.6e-54 191.57 Pfam 1-144 (144) Show / Hide 
Range on Protein: 980-1119
Range on HMM: 1-144/144
Sequence Identity: 39% (57 aa)

KEQQAKEQQDRRFEQERSSLEKTYEADMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIFRENLKQEIR--LLKQEVDLFP--KDKRKDEFK
|.|..|||. ..|.|.| ...|..| .|. ..||.||..||.||.|..|.| ..||||.|||...|.|.|.||.|..  ..||||...|  . .|||..|
KHQLQKEQMKDQFFQQRHQMLKRHEKEMEQMERQQKQQIEKMEQRQTQERRRLPKRIRAEQEKRMKMFKESLKIEKKNMEPKQEVEKMPQFREQRKDRMK

QRRSAMELDHEEKERAFLDSLKERHELLLRRLSEKHRDHLATIN
|..  ||..|.|.|..|. ...| ||.........|| .|. ..
QEMEEMEQKHQEQEQEFVAQCEENHEEMMQQMQNEHRHMLMEHE
PKK CG4527.AA PKK 1148-1289 45 5.9e-57 200.34 Pfam 1-144 (144) Show / Hide 
Range on Protein: 1148-1289
Range on HMM: 1-144/144
Sequence Identity: 45% (66 aa)

RHQLSKRHVKELCFMQRHQMIIRHEKELDQVKRMLQRKEEDMVKKQTMEKRALPKRIRAERKARDLMFRESLRISTN-LDPEIERDRLKKFQEQEKKRYM
.||| |...|. .|.|||||..|||||..|..|. ....|.| ..||.|.| ||||||||.. |. ||.|||.|.   ..|. |......|.||.|.|..
KHQLQKEQMKDQFFQQRHQMLKRHEKEMEQMERQQKQQIEKMEQRQTQERRRLPKRIRAEQEKRMKMFKESLKIEKKNMEPKQEVEKMPQFREQRKDRMK

QEERRFEVKHQKQLEELRATRESAIKE-LEQLQNEKRRALVEHE
||  ..| |||.|..|..|. |....| ..|.|||.|. |.|||
QEMEEMEQKHQEQEQEFVAQCEENHEEMMQQMQNEHRHMLMEHE