Gene fray (Fruit Fly)

fray

Species: Fruit Fly
Alias: STE20-like/SPAK, Ste20-like, l(3)07551, lag, laggard, SFO155, 4624, Ste20-like protein kinase, CG7693, fray
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 91B4--5

Classification

Group: STE
Family: STE20
Subfamily: FRAY

Sequence

Name Sequence Type Origin Length Description Download
fray.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 275 Kinase domain by global Sugen HMM Fasta, JSON
fray.AA Protein Various 552 None Fasta, JSON

Protein domain

Protein domains of fray.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase fray.AA FRAY 38-312 80 1.3e-253 796.71 In-house 1-277 (277) Show / Hide 
Range on Protein: 38-312
Range on HMM: 1-277/277
Sequence Identity: 80% (224 aa)

YELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWN-TSMDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSN-CK
|||..|||.|||||||.||||||.|.||||||||||.. ||||||.||||||..|.|.|||.|||||||.||||||.|.||.||.|||.|.||.... .|
YELQEVIGEGATAVVHKAYCIPRQENCAIKRINLEKCQNTSMDELIKEIQAMCQCHHPNVVHYHTSFVVNEELWLVMRYLECGSCLDIMKFKMPQGEPHK

QGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSRQKVRHTFVGTPCWMAPEVMEQDHGYDFKADIWSFG
||||||..|||.||||||||.|||.||||||||||||||||.||||||||||||||||||.||||..|||||||||||||||||||.|||||||||||||
QGVFDEHVIATILKEVLKGLCYFHKNGQIHRDIKAGNILIGEDGTIQIADFGVSAWLATGGDLSRCCVRHTFVGTPCWMAPEVMEQVHGYDFKADIWSFG

ITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFF
|||||.|||.|||||||||||||||||||||.|.|..||||.||.||..|.||| .||||.|||||||||||||.||
ITAIELATGKAPYHKYPPMKVLMLTLQNDPPSLETDEDDKDMYKKYGHSFKKMIEKCLQKDPSKRPTASELLKHKFF
Kinase fray.AA STE20 38-312 45 1.4e-148 499.91 In-house 1-288 (288) Show / Hide 
Range on Protein: 38-312
Range on HMM: 1-288/288
Sequence Identity: 45% (134 aa)

YELRDVIGVGATAVVHGAYCIPRNEK----CAIKRINLEKWN---TSMDELLKEIQAMSSCFHENVVTYHTSFVVR----EELWLVLRLLEGGSLLDIIK
||| ..|| |.. .|. ||..| .|.    .|||..|||| .    ......|||. |. | |.|.|.|..|...     .|||.|  ...||||.||.|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

HKMRTSN-CKQG-VFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLAT--GRDLSRQKVRHTFVGTPCWMAPEVMEQ-
|.|.. . .| | ...|. ||....|||.||.| |||..|||||||.|||...|| ...|||||.|.| .  . | ..|. | ||||||.||||||... 
HCMKCGKNHK-GHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGR-D-TMQFKRNTFVGTPYWMAPEVIQCM

---DHGYDFKADIWSFGITAIEMATGTAPYHKYPPMKVLMLTL--QNDPPTLD-TGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFF
   |.|||.|.||||.||||||||.|  ||....||.......  ||.||||  .        . . . |. ..  ||||.|.||||||.|||| |.
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDD-K-----PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase fray.AA STE 38-312 33 9.69999999999e-122 410.74 In-house 1-359 (359) Show / Hide 
Range on Protein: 38-312
Range on HMM: 1-359/359
Sequence Identity: 33% (123 aa)

YELRDVIGVGATAVVHGAYCI------PRNEK---------CAIKRINLEKWN----------------TSMDELLKEIQAMSSCF--HENVVTYHTSFV
.|. ..|| ||. .|. |...      . .|.         .|||..|||. |                . |...||||. |. |   |.|.|.|. ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

V-------REELWLVLRLLEGGSLLDIIKHKMRTSN-------CKQGVFDEATIATVLKEVLKG-LEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVS
.       ..|||... ...|||| ||||||. . .       . |..|.|  ||......||| |.| ||.. ||||||..|||.     . ..||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQH-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

AWLATGRD-----------LSRQKVRHTFVGTPCWMAPEVMEQ-----DHGYDFKADIWSFGITAIEMATGTAPYHKYPPMKVLMLTLQN----------
. |.   .           ...|. | |||||| ||||||..|     |.|||.|.||||.|.|.||||||  |.|...||........|          
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

-----DPPTLDTGADDKDQ----------YKAYGKTFRKMIVECLQKEPSKRPTASELLK--HAFF
     .||.| .  .....           . . . |.  |  ||||.|.||||||.|||  | |.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase fray.AA YSK 38-312 41 4.3e-96 289.82 In-house 1-257 (257) Show / Hide 
Range on Protein: 38-312
Range on HMM: 1-257/257
Sequence Identity: 41% (115 aa)

YELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQG
.   ..|| |   .|  ..    ..  ||| |.||.     . . .|||  |.|   ..  |  |.     || .   . |||.|| .| |        |
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKY------VG

VFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLA-TGRDLSRQKVRHTFVGTPCWMAPEVMEQD-HGYDFKADIWSFG
 |||  ||..|.|.||||.| ||.  ||||||| |.|.  .| . ..||||.. .  |      |. | |||||| ||||||  |.  .||||||||| |
QFDEKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDT------QIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLG

ITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFF
|||.|||.|  || .| ||.|. |   | ||.|        . . | | |   .  || |.|..||.|.||||| | 
ITAYEMAKGEPPYCDYHPMRVMFLIPKNNPPKL--------EGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase fray.AA PAKA 38-312 38 2.7e-80 273.04 In-house 1-260 (260) Show / Hide 
Range on Protein: 38-312
Range on HMM: 1-260/260
Sequence Identity: 38% (108 aa)

YELRDVIGVGATAVVHGAYCIPRNEK--CAIKRINLEKWNTSMDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCK
|. .. || ||.  |  |. |  |..  .|||..|... . ... .. ||  | .| |.|.| |  |..| .|||.|.  .|||.| |.|..  ..    
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQP-KKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCN-

QGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSR-QKVRHTFVGTPCWMAPEVMEQDHGYDFKADIWSF
  ..||. || |..|.|.|||. ||...||||||  |||.| || . |.|||  |       |.. |  | | |||| ||||||  . . || | |||| 
--YMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCA------QLTQEQQKRNTMVGTPYWMAPEVIRR-KQYDEKVDIWSL

GITAIEMATGTAPYHKYPPMKVLMLTLQN-DPPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFF
|| ||||. |  || ..|| . . |  .|  |. .|.            ..|..    ||.... .|..|.|||.| |.
GIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDP--------DKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase fray.AA S_TKc 38-312 29 2.4e-78 267.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 38-312
Range on HMM: 1-231/231
Sequence Identity: 29% (85 aa)

YELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEG--GSLLDIIKHKMRTSNCK
||. ..|| || ..|. .. .  ....|||.|.        . ...||| ...  |.|.|... .|.  ..|..|. ...|  |.|.|.||.. |  ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

QGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSRQKVRHTFVGTPCWMAPEVMEQDHGYDF-KADIWSF
  .|.| ... ........||| ||.| ||||.|  |||. .  .| |.|||... |            .||.||| .|||||.    ||.. |.|.||.
--PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLK-------HAFF
|.. .||..|  |..   ..... . .                     . .. .|  ||||.|.||||| |.|.       | .|
GCILYEMLCGYPPFP--QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase fray.AA MST 38-268 39 1.4e-69 220.27 In-house 1-217 (254) Show / Hide 
Range on Protein: 38-268
Range on HMM: 1-217/254
Sequence Identity: 39% (91 aa)

YELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQAMSSCFHENVVTYHTSFV--VREELWLVLRLLEGGSLLDIIKHKMRTSNCK
... . .| |.  .|. | ..  ..  ||| ..    |. ..|..|||  |. |  ...|.|  |.     ...|.|    ..||..||.|   ||    
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV---NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRT----

QGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSRQKVRHTFVGTPCWMAPEVMEQDHGYDFKADIWSFG
   . |. ||..|. .|.||.| |.|  |||||||||||.  .|    ||||||. |       ..  | |..|||.|||||| ..  .|| |||||| |
---LNEQQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQL-----TDTMAKRNTVIGTPYWMAPEVIQE-IKYDCKADIWSLG

ITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTL
||||||| |  ||.   || .. .  |. |||.
ITAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTF
Kinase fray.AA KHS 38-312 39 1e-65 220.0 In-house 1-258 (258) Show / Hide 
Range on Protein: 38-312
Range on HMM: 1-258/258
Sequence Identity: 39% (110 aa)

YELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQG
|||   .| |    |. |  |  .|  |.| | .|  .  .  . .||  |  | | |.| |. |.. |. ||...    |||| || .          |
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEP-GDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHV--------TG

VFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSRQKVRHTFVGTPCWMAPEV--MEQDHGYDFKADIWSFG
   |  || | .|.|.||.|.||.|..|||||  |||. |.| ...||||||| ..    ...   |. |.||| ||||||  .|.  ||.   |||. |
PLSELQIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITAT--IAK---RKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVG

ITAIEMATGTAPYHKYPPMKVLMLTLQND--PPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFF
|||||.|    |     ||..|.|  . .  ||.|      ||. | . .|| . .  .| |.| |||||. ||.| |.
ITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKL------KDKHK-WSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase fray.AA SLK 38-312 34 1.6e-62 209.71 In-house 1-259 (259) Show / Hide 
Range on Protein: 38-312
Range on HMM: 1-259/259
Sequence Identity: 34% (97 aa)

YELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQG
.|.   .| ||   |. |    ..   | | |.... .  ... . ||. .|.| | |.|    .. . ..||...   .|| .  |.    .       
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKD-EEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEH-------

VFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSRQKVRHTFVGTPCWMAPEVM----EQDHGYDFKADIWS
.  |  |. | |... .|.. |||  ||||.||||||.  || ...|||||||     .  .  . | ||.||| ||||||.     .|. ||.||||||
PLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSA-----KNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWS

FGITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFF
.||| |||| .  |.|   ||.||.   . .||||        |   . | |. .. .||.|.| .|.|...|..|...
LGITLIEMAQMEPPHHEMNPMRVLLKIQKSEPPTL-------EQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase fray.AA Pkinase 38-312 27 1.3e-59 209.18 Pfam 1-293 (293) Show / Hide 
Range on Protein: 38-312
Range on HMM: 1-293/293
Sequence Identity: 27% (85 aa)

YELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWNTSMDELLK---EIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEGG----SLLDIIKHKMR
|..  .|| |. ..|  .. .  ... |.|.|.... . ..|. .    ||| | .. |.|.|... .|  . ....|. ..|||    .| |.|.    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

TSNCKQGVF--DEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTI----QIADFGVSAWLATGRDLSRQKVRHTFVGTPCWMAPEVMEQDHG
    ..|.|  .| ..  .....|.|||| ||.| ||||.|  |||| ..|.|     |.|||... .     . ..   .||.||| .|||||   . .
---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQY

YDFKADIWSFGITAIEMATGTAPYHKY---PPMKVLMLTLQNDPPTLDTGADDKDQYKAYG---------------KTFRKMIVECLQKEPSKRPTASEL
|. |.|.||.|.. .||..|  |.      ..    |  .... ..      ...  . |                ..... |  ||.| |.||||| ..
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

LKHAFF
|.| .|
LQHPWF
Kinase fray.AA MSN 38-312 34 8e-58 189.41 In-house 1-265 (265) Show / Hide 
Range on Protein: 38-312
Range on HMM: 1-265/265
Sequence Identity: 34% (98 aa)

YELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQAMSS-CFHENVVTYHTSFV------VREELWLVLRLLEGGSLLDIIKHKMR
.|| .|.| |.   |.        .  ||| .....     .|. .||  .    .| |..||.  |.       .. ||.|. .   ||. |..|    
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVRE--DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVK----

TSNCKQGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSRQKVRHTFVGTPCWMAPEVMEQD----HGYD
  . |     |  || . .|.|.|| . |..  ||||||  |.|. ..  ... |||||| |   |   |   | ||.||| ||||||.. |      ||
--MTKGQSLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLD--RTVGR---RNTFIGTPYWMAPEVIACDENPDATYD

FKADIWSFGITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFF
...|.|| |||||||| |  |  .  ||. |.| . | ||.|        . | . | | . . .|| |. ..||.. ..|||.| 
YRSDLWSVGITAIEMAEGQPPLCDMHPMRALFLIPRNPPPKL--------KSKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase fray.AA STE-Unique 109-312 25 8.3e-49 168.47 In-house 369-616 (616) Show / Hide 
Range on Protein: 109-312
Range on HMM: 369-616/616
Sequence Identity: 25% (66 aa)

LWLVLRLLEGGSLLDIIKHKMR--TSNCKQGVFDEATIATVLKEVLKGLEYFHSNG--QIHRDIKAGNILIGDDG-----TIQIADFGVSAWLATG----
.|... ..|.|.| .|||        |  | .| |  .. .....|.|||| || .   ||||.|..||..  ||      . |.||| .  .. .    
VWIFMEYCEHGTLQQIIKRCGCPGNPNNLQ-LFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEK

----------------------------RDLSRQKV-RHTFVGTPCWMAPEVMEQD----HGYDFKADIWSFGITAIEMATGTAPYHKYPPMKV--LMLT
                             ||.   . . . .||||.|.||| .       .|| |.||||.|.. ..|..|. |.|.. .|.    |. 
DNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCI

LQNDPPT--LDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFF
... .|   .     . .  . . . ..  |..|| ..|..||.|..||.| . 
HIHCQPPQCP-----IENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase fray.AA TyrKc 38-312 21 7.5e-21 76.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 38-312
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

YELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQAMSSC--FHENVVTYHTSFVVR-------EELWLVLRLLEGGSLLDII-KH
 .| ...| ||  .|. .  .   ...|.| .. ..    . ....|.. |..    |.|.|  .   .         | |..|. . ..|.|.| . ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KMRTSNCKQGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATG------RDLSRQKV--RHTFVGTPCWMAPEVM
. .        .  ..       . .| || ||.. ||||. | |.|.|...|. |.||| |  .  .       |  |.|      ..    |||||..
RPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

EQDHGYDFKADIWSFGITAIEMATGTAPYHKY-----PPMKVLMLTLQND-----PPT-----LDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTAS
 ... . .| |.||||..  |. |  .. .        . . ..  ...      ||                  .  . .. .. .| . .|..||| |
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---------VCCPDEMYQ-IMKQCWHEDPEDRPTFS

ELLKHAFF
|.  | .|
EI--HECF
Kinase fray.AA Pkinase_Tyr 38-189 20 3.9e-13 45.1 Pfam 1-158 (270) Show / Hide 
Range on Protein: 38-189
Range on HMM: 1-158/270
Sequence Identity: 20% (34 aa)

YELRDVIGVGATAVVHGAYCI----PRNEKCAIKRINLEKWNTS---MDELLKEIQAMSSC-FHENVVTYHTSFV-VREE--LWLVLRLLEGGSLLDIIK
 ..  ..| ||  .|. ...       . ..|.| .  |.   .   ......|.. |..   |.|.| ..   .  .|   ...|. . ..|.|||  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

HKMRTSNCKQGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVS
 .       .. ..  ..     .. ||.|| .|.. ||||. | |.|....... |.||| .
KHR----EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase fray.AA MST 292-312 57 1.5e-11 32.94 In-house 234-254 (254) Show / Hide 
Range on Protein: 292-312
Range on HMM: 234-254/254
Sequence Identity: 57% (12 aa)

CLQKEPSKRPTASELLKHAFF
||||.|..|.|| .||.| |.
CLQKNPEQRWTAEQLLQHPFI
Kinase fray.AA STE-Unique 39-99 27 2.9e-07 21.22 In-house 1-66 (616) Show / Hide 
Range on Protein: 39-99
Range on HMM: 1-66/616
Sequence Identity: 27% (18 aa)

ELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWNTS-----MDELLKEIQAMSSCFHENVVTY
.  . || |.  .|| .  .  .  |||| | |..   .        ...||..|... |.|.|.|
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKY
Kinase fray.AA Pkinase_Tyr 213-257 36 1e-06 23.3 Pfam 180-225 (270) Show / Hide 
Range on Protein: 213-257
Range on HMM: 180-225/270
Sequence Identity: 36% (17 aa)

WMAPEVMEQDHGYDFKADIWSFGITAIEMAT-GTAP-YHKYPPMKVL
|||||..     .  | |.||||..  |. | |  | |   ..  |.
WMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVY
Kinase fray.AA Pkinase_Tyr 287-312 30 0.126916 6.12 Pfam 247-270 (270) Show / Hide 
Range on Protein: 287-312
Range on HMM: 247-270/270
Sequence Identity: 30% (8 aa)

KMIVECLQKEPSKRPTASELLKHAFF
... .| ...|..||| ||.  | ..
DLMKQCWHYDPEDRPTFSEI--HEQL
FRWNK_Fray fray.AA FRWNK_Fray 455-551 64 3.7e-62 212.8 In-house 1-97 (97) Show / Hide 
Range on Protein: 455-551
Range on HMM: 1-97/97
Sequence Identity: 64% (63 aa)

APPVNLVLRMRNLRRELHDIRFEFVVGKDTAEGIATELVDAGLVDALDTQPMATHLDQLIAASATMKTITFQLSSGVQPGEVPDERSLVGYAQISIT
.||.|||||||| ..||.||||||..|||||||||.|||.|||||  |.. .| .|..||. ..|||..||||.||.||.|||||..|.|.|||||.
QPPINLVLRMRNQKKELNDIRFEFTPGKDTAEGIAQELVSAGLVDGRDLVIVAANLQKLIDNPQTMKSVTFQLNSGCQPNEVPDEKALIGFAQISIH
OSR1_C fray.AA OSR1_C 458-489 42 1.7e-12 49.08 Pfam 1-38 (38) Show / Hide 
Range on Protein: 458-489
Range on HMM: 1-38/38
Sequence Identity: 42% (16 aa)

VNLVLRMRNLRR------ELHDIRFEFVVGKDTAEGIA
.||.||||. ..      |...|.||| ..|||.|..|
INLWLRMRDPKKRKGKHKENEAIQFEFDIEKDTPEEVA