Gene Src42A (Fruit Fly)

Src42A

Species: Fruit Fly
Alias: l(2)k10108, CG7873, SFO126, SRC 42A, Tk5: Tyrosine kinase 5, Tyrosine kinase 5, Su(phl)1, HD-29, Dtk5, DmHD-29, Suppressor of raf-like-oncogene, Su(Raf)1, Su1, dtk5, Suppressor of pole hole, src, Src41, Dm SRC41, Src42A, Su(D-raf)1, Dsrc41, SK2-4, dtk-5, Dsrc42A
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 42A1--2,

Classification

Group: TK
Family: Src
Subfamily: Frk

Sequence

Name Sequence Type Origin Length Description Download
Src42A.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
Src42A.AA Protein Various 517 None Fasta, JSON

Protein domain

Protein domains of Src42A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 Src42A.AA SH3 66-123 39 2.9e-24 87.84 SMART 1-58 (58) Show / Hide 
Range on Protein: 66-123
Range on HMM: 1-58/58
Sequence Identity: 39% (23 aa)

KIFVALYDYDARTDEDLSFRKGEHLEILNDTQGDWWLARSKKTRSEGYIPSNYVAKLK
. ..|||||.|.....|||.||. ...|... ..|| .| ..|  ||..|||||....
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 Src42A.AA SH3_1 69-116 42 7.3e-23 79.96 Pfam 1-49 (49) Show / Hide 
Range on Protein: 69-116
Range on HMM: 1-49/49
Sequence Identity: 42% (21 aa)

VALYDYDARTDEDLSFRKGEHLEILNDTQG-DWWLARSKKTRSEGYIPS
||||||.|.....|||.||. ....... . ||| .|.. |. ||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 Src42A.AA SH3_2 67-122 17 1.5e-11 43.33 Pfam 1-68 (68) Show / Hide 
Range on Protein: 67-122
Range on HMM: 1-68/68
Sequence Identity: 17% (12 aa)

IFVALYDYDA-RTDED-----LSFRKGEHLEIL---NDTQGDWWLA-RSKKTRSE--GYIPSNYVAKL
 .... ||.. .  ..     |.|.||. ....   .  ...||.. ...... .  |..||..|...
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 Src42A.AA SH2 130-207 55 2.7e-48 143.62 Pfam 1-81 (81) Show / Hide 
Range on Protein: 130-207
Range on HMM: 1-81/81
Sequence Identity: 55% (45 aa)

WYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGD---TVKHYRIRQLDEGGFFIARRTTFRTLQELVEHY
||..|| | |||. |. |.|..|.||.|.|||  .||.|||||..    ||||||...|.||..|. |..|..||||||||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 Src42A.AA SH2 128-213 48 4.1e-40 140.51 SMART 1-87 (87) Show / Hide 
Range on Protein: 128-213
Range on HMM: 1-87/87
Sequence Identity: 48% (43 aa)

EPWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIAR--RTTFRTLQELVEHYSKDSDG
.|||. .| | |||..|. |....|.||.|||||  .||.||||... |||||||..|.|...|.   |..| .| |||.||.. ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase Src42A.AA SFK-Src 248-504 67 9.1e-210 628.62 In-house 1-259 (259) Show / Hide 
Range on Protein: 248-504
Range on HMM: 1-259/259
Sequence Identity: 67% (175 aa)

LKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTL
 .  .||||||||||| | ||||| ||.||||.|.|  . ||.|||.||||||..|||||||||  ||||||||||| |||| ||.    .||||.|..|
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEP--HGRSLRMPQL

IDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLI-KEDE-YEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRI
.|||||.|.|||||| ||..||||||||||||| |..|..|||..| . ..|| |.|. ||.||||||||||.|...|||||||||||||..|.||||||
VDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRI

PYPGMTNAEVLTQVEH--GYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFY
|||||||.||| ||.   ||||| |||| ...|.||..|| . |  |||||.|.|..|||.
PYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase Src42A.AA Src 248-500 73 4.90000000001e-203 680.8 In-house 1-255 (255) Show / Hide 
Range on Protein: 248-500
Range on HMM: 1-255/255
Sequence Identity: 73% (188 aa)

LKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTL
.|..||||.||||.||.|.||..|.||.||||.|||.|..||.|||||||||| ||.||||||. ||||||.||.|.|||||.||..  |.||.|....|
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-DGEGRHLHLPQL

IDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIK--EDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRI
||||||.|.|||||||.|||||||||||||||..|..|.||||||||||  .|||.|| ||.||||||||||.|| .|.||||||||||||||.|||||.
IDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYE-IMLECWHKDPMRRPTFETLQWKL
|||||||.|||.|||.|||||.|.|| ..||| |||.||||||..|||||.|||.|
PYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Src42A.AA Frk 248-504 81 1.3e-195 656.19 In-house 1-260 (260) Show / Hide 
Range on Protein: 248-504
Range on HMM: 1-260/260
Sequence Identity: 81% (213 aa)

LKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTL
....|.|||||||.|||||||||||||.||||.|||||.|||.||||||||||.||||||||||||||||||||||.||||.||||||..|||...||.|
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

IDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLAR-LIKEDE--YEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGR
.|||||.|||||||||||||||||||||||||..||.||||||||| |.|..|  ||.|.||||||||||||||||.||.||||||||||||||..||||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

IPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFY
.|||||||||||..|.|||||||||||...||||||||||.|||.|||||||||||||..
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase Src42A.AA SrcA 248-500 66 1.1e-156 498.93 In-house 1-250 (250) Show / Hide 
Range on Protein: 248-500
Range on HMM: 1-250/250
Sequence Identity: 66% (168 aa)

LKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTL
..  |.|| |.||.|| | || || ||||||| ||| |. || |||||||||| ||.|||||   ||||||.|| | .||||..|.   ..|. ||.  |
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVS-EEPIYIVTEYMCKGSLLDFLK--DEEGKYLKLPQL

IDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPY
.|||||.|.||||.|  ||||||| | |.|||.  | |||||||||||...||.|| ||.||||||||||| | .| ||||||||||||||||| ||.||
VDMAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPY

PGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKL
||| | ||| |||.||.|| |..|   |.|.| .||.|||  ||||| ||  |
PGMNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase Src42A.AA Pkinase_Tyr 248-500 51 4.7e-156 529.15 Pfam 1-270 (270) Show / Hide 
Range on Protein: 248-500
Range on HMM: 1-270/270
Sequence Identity: 51% (138 aa)

LKFVRKLGSGQFGDVWEGLWN-----NTTPVAIKTLKSGTMDP----KDFLAEAQIMKKL-RHTKLIQLYAVCT-VEEP--IYIITELMKHGSLLEYLQA
..| .|||.|.||.|..| |.     ...|||.|.|| |.|..    .||..||.|||.| .| ....||.|||  .||  |||..|.|.||.||.||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

IAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLI-KEDEY-EARVGARFPIKWTAPEAANYSKFSIKSDVWSF
    ...|.|..|..|..|||.||.||||.|.|||||||||.||...|.|||.||||||.| ..|.|  .| |...||||.|||. ||.||..|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLTELVTYGRIP-YPGMTNAEVLTQV-EHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKL
|.|. |..|||..| ||||.|.||. .. |.|||||.|.|| . .|..|..|||.|| .||||. ....|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Src42A.AA Src-Unclassified 248-496 53 2.5e-155 522.34 In-house 1-280 (284) Show / Hide 
Range on Protein: 248-496
Range on HMM: 1-280/284
Sequence Identity: 53% (151 aa)

LKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSG---TMDPKDFL--------AEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIA
.. .|||| |||| || | | .   ||.||.. |   || |  ||        .|||||||.|| .|..|||||. |||.|||||.|  |||| .|.   
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLR--E

GKGRSLKMQTL------------IDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGN-----IVKIADFGLA--RLIKEDEYEARVGARFPIKWTAPEA
| |. | .| .            .|.|||.| || ||||  |.||||||||||.|. |     .||..|||||  .|. .|.|..| ||.||.||.|||.
GGGQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPEC

ANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQP--PNCEPRLYE-IMLECWHKDPMRRPTFETL
. | .|||||||||.|||| |. |.|..||||| | ||| .|| ||||| |    |   .|| ||. |||||| |||||.||
FIYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTL
Kinase Src42A.AA TyrKc 248-500 44 1.9e-145 490.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 248-500
Range on HMM: 1-280/280
Sequence Identity: 44% (128 aa)

LKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKL--RHTKLIQLYAVCTVE-------EPIYIITELMKHGSLLEYLQAIAGK
... .|||.|.|| |..| |.  ..||.|.||...   .||. ||.||.||  .|  ...||.||| .       ||..|..|.|.||.|..||..  .|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

GRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKED--------EYEARV--GAR--FPIKWTAPEAANYSKFSIK
   |.|..|.... |||.||.||.|.|.|||||||||.|||....|||.||||.| |..|         | ..   |..  .||.|.|||. ||.||..|
---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDVWSFGILLTELVTYGRIPYPG-----MTNAEVLTQVEHGYRMPQPPN--------CEPRLYEIMLECWHKDPMRRPTFETLQWKL
|||||||... |. |||  ||||     |.|.||. .|..|||||||||        | . .|.||..||| ||  ||||...  ..
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Src42A.AA Src-Echino1 248-500 61 2.2e-142 479.32 In-house 1-252 (252) Show / Hide 
Range on Protein: 248-500
Range on HMM: 1-252/252
Sequence Identity: 61% (156 aa)

LKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTL
|.. .|.|.|..|.||.|.||  ||||.|||| .|| | |||||| .|||.||  ..|.||||  .|||||.||||..|.|..||.   ||.. .|| ||
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLK--RGKCKHVKMTTL

IDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPY
||| |.||.|| ||.|.|..||||||||||||.||..|||||||||....|.| .. ||..|||||||||| | .| |||||||||||.||.||.||.||
IDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPY

PGMTNAEVLTQVEHGYRMPQPPNCEPRLYEI-MLECWHKDPMRRPTFETLQWKL
|||.| ||| ||..|||||.. .|   ||.. |. |||||| .||||| |   .
PGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase Src42A.AA SrcB 248-501 61 6.2e-138 464.54 In-house 1-251 (251) Show / Hide 
Range on Protein: 248-501
Range on HMM: 1-251/251
Sequence Identity: 61% (157 aa)

LKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTL
||.|.|||.||||.|| | .|| . ||.||.| ||| |. ||||| .||.| | .|..|||| | | ||||||| |..|.||..|.  . .|  |..  |
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLK--TDEGSKLSLPKL

IDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPY
|||.|||| ||||.| .||||||| | |.|| .  . |||||||||.| ..|| || ||.|||||||||| |.  | ||||||||||||.|.||||||||
IDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPY

PGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLE
|||||.||....|.|||||.| || . ||.|| .||.. |  ||||. ||  |.
PGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase Src42A.AA SRM 248-501 56 2.6e-137 461.97 In-house 1-253 (253) Show / Hide 
Range on Protein: 248-501
Range on HMM: 1-253/253
Sequence Identity: 56% (144 aa)

LKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGT-MDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQT
  . ||||.| || ||||||    .||||  |.   |  ... .| | |||||| ..| |.|||.| .|.|||||||. |.|..||    .|   |..  
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEK--ALPIPH

LIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIP
|.|.| |.| ||.|||.|||||||||||||||||.|. |..|||||||||.| |    . . |.||||||||||  .|.||||||||||| |. ||| .|
LLDFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCP

YPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLE
|||||| | . |.. ||||| |  | |  .  ||||| .||  ||.| .|  || 
YPGMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase Src42A.AA TK 248-500 26 3.7e-130 438.72 In-house 1-486 (486) Show / Hide 
Range on Protein: 248-500
Range on HMM: 1-486/486
Sequence Identity: 26% (130 aa)

LKFVRKLGSGQFG---DVWEGLWNNT--------------------------TPVAIKTLKSG-TMDPKDFLA--------------EAQIMKKLR----
.....|||.||||   .|..|.|..                           ||||.|.||.| .|....|..              ||..||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HTKLIQLYAVCTVE------------EPIYIITELMKHGS----LLEYLQAIAGKGRS-----------------------------------------
 |  ...||.||| .            ||..|..|.|.||.    |..||..  .|..                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LKMQTLIDMAAQIAAGMAYLESQ------NYIHRDLAARNVLVGDGNI-----------VKIADFG---
                               | |..|. |..|||.||.||.|.      |..||||||||.|||..|.           .||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLI-KEDEYEARV------------------------GARFPIKWTAPEAAN---------YSKFSIKSDVWSFGILLTELVTYGRIPYPG-M
     ||| | ..|.| ..                         |...||.|.|||. |         | ||..||||||||.|. |..|||. ||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------AEVLTQVEHG--------------YRMPQPPNCE--------------PRLYEIMLECWHKDPMRRPTFETLQWKL
.|         .||. ... |              .||||||.|               . .|..|..|||.|| .||||..|. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Src42A.AA Tec 248-502 46 1.8e-121 409.84 In-house 1-254 (254) Show / Hide 
Range on Protein: 248-502
Range on HMM: 1-254/254
Sequence Identity: 46% (120 aa)

LKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQT-
|.|.. ||||||| |  | | .   ||||..| |.|   ||. ||..|.|| | ||.||| ||. . ||||.|| |.||.||.||    ..   .. .. 
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHH---FQKNMA

-LIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRI
 |..|  ..  ||||||....||||||||| |||| ..||..|||..| .  |.|   ||. ||.|| .||  .||..| |||||.||.|  |  . |..
ILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKM

PYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLED
||. |.| || ..|  |.|. .|  |  ..|.|| .|||  |  ||||. |  ....
PYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase Src42A.AA S_TKc 248-504 26 3.3e-54 187.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 248-504
Range on HMM: 1-231/231
Sequence Identity: 26% (72 aa)

LKFVRKLGSGQFGDVWEGLWNN-TTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKH--GSLLEYLQAIAGKG--RSL
 ...||.|.| || |. . ...    |||| .|      .... | ||.|| .|  ...|| |.   . .|...|.. .  |.|..|..   ..|  . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

KMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSI-KSDVWSFGILLTELVT
   .   ...||. ...|. |.. |||||   |.|. .   .||.||||||..        .| ..   . |||     ...  |.|.||.|..| |...
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPW---YMAPEVL---GYGKCKCDWWSCGCILYEMLC

YGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQ----WKLEDFY
 |. |.|  . .... ..             | . ...  |..||| .||| | ||    .|.  . 
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase Src42A.AA Pkinase 248-494 25 4.7e-47 167.44 Pfam 1-285 (293) Show / Hide 
Range on Protein: 248-494
Range on HMM: 1-285/293
Sequence Identity: 25% (76 aa)

LKFVRKLGSGQFGDVWEGLWNNT-TPVAIKTLKSGTMDPKDF-----LAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHG----SLLEYLQAIAG
....||.||| || |... . .|   ||.|..|  . ...       |.|.||||.|.|   ..|| ... .  ||...|.. .|    .| .|...   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

KGRSL--KMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVG-DGNI---VKIADFGLARL--IKEDEYEARVGARFPIKWTAPEAAN-YSKFSIKSD
.....   ........ ||. |..|. |.. |||||   |.|.  .|.|   |||.|||||..  .  ...  ..| ..   . |||  . ... . |.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPW---YMAPEVIRGGQYYGPKVD

VWSFGILLTELVTYGRIPYPGM----TNAEVLTQVEHGYRMPQPPNCE-----------------------PRLYEIMLECWHKDPMRRPTFE
.||.|..| |... || |.||     . .. .  ..   . | . ...                       . . ...  |..||| .|||.|
MWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE