Gene S6kII (Fruit Fly)

S6kII

Species: Fruit Fly
Alias: fs(3)07084, p70 S6K, p70s6K, dp70s6k, dS6k, S6kII, S6K, p70S6K, dS6K, Dp70[s6k], S6 kinase, s6k11, dp70[S6k], DS6K, Dp70s6k, p70[S6k], l(3)07084, 7084, dps6k, CG10539, Dp70S6k, S6kinase, SFO179
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 64E8--11

Classification

Group: AGC
Family: RSK
Subfamily: RSKp70

Sequence

Name Sequence Type Origin Length Description Download
S6kII.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 262 Kinase domain by global Sugen HMM Fasta, JSON
S6kII.AA Protein Various 490 None Fasta, JSON

Protein domain

Protein domains of S6kII.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase S6kII.AA p70 77-338 67 1.2e-215 722.67 In-house 1-299 (299) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-299/299
Sequence Identity: 67% (201 aa)

FELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTR-------------------------AERNILEAVKHPFIVELVYAFQTD
|||.||||||||||||||||..|.|..|..|||||.||.||.|||||||||                         |||||||.||||||..|.|||||.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

GKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIV----------THTFCG
||||||||||.||||||||||.||..|||.||||||||.||.|||..|||||||||||..|..||||.|||||||||.|..| |          ||||||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAK--LNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFF
||||||||||.|.||..||||||||.||.|||||.||||.|||||||..|||.|  |.||.|||.|.|||...|.||...||.|.||||||..|.||||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase S6kII.AA AGC 77-338 36 8.20000000001e-191 498.87 In-house 1-395 (395) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-395/395
Sequence Identity: 36% (146 aa)

FELKKVLGKGGYGKVFQVRKTAGR---DANKYFAMKVLKKAS-IVTNQK-DTAHTRAE------------RNILEAVK----------HPFIVE-LVYAF
||..||.|||..|||..|||  |    | .||.|||||||.  || ..| . .|| .|            ||||| ..          |||||  | |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTDGK--LYLILEYLS---------GG-ELFMHLE---REGIFLEDTTCFYLSE-------IILALGHLHK-LGIIYRD-LKPENILLDAQGHVKLTDFG
|.. .  ||...||..         || |||.||    .||.| |....||..|       |.||| .||. .|||.|| |||||||||..||.||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEHIQEG--------------------------------------------------IVTHTFCG--TIEYMAPEILTRSGHGKAVDWWS--LGALMF
|||| ...|                                                    |.||||  | ||||||||    .|||.||||  ||.||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

DMLTGVPPFTAEN----------RKKTIETIL------KAKLNLP----------AYLTPEARDLVRRLMKRQEPQRLGSGPED-----AAAVQIHPFF
 |||| |||...|          .... . |.      . |. .|           ...|||.||...|...   .|||.|..|     |  .. ||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase S6kII.AA RSK 80-338 56 7.80000000001e-172 577.16 In-house 1-278 (278) Show / Hide 
Range on Protein: 80-338
Range on HMM: 1-278/278
Sequence Identity: 56% (157 aa)

KKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVK-HPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGI---
 ||||.|||||||..||. ..|.....|||||||| ||..||||.||..||||||... |||||.| |||||.||||||.||..|||||.||..|..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDA---QGHVKLTDFGLCKE-HIQEGIVTHTFCGTIEYMAPEILT----RSGHGKAVDWWSLGA
| ||. |||..||.||. |||..|||.|||||||||.|    .||.||||||.||. .....  |.|||.||||||||.|.    ..||.||.||||||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMFDMLTGVPPFTA---ENRKKTIETILKAK--LNLP--AYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFF
||..|||| |||..   .|||.... |.|.|  |..|  .||..||.||.|....| . .|||.||.||. .. ||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase S6kII.AA SGK 77-338 45 3.9e-150 467.15 In-house 1-283 (283) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-283/283
Sequence Identity: 45% (128 aa)

FELKKVLGKGGYGKVFQVRKTAG---------------RDANKYFAMKVLKKASIV------TNQKDTAHTRAER-NILEAVKHPFIVELVYAFQTDGKL
|...||.|||..|||.||.. .                .   | .|||||.|..|.       . |   |. ||| .||  .|||||| | |||||. ||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRS
|. ..|. |||.| || ||..|.||   || .||..||..||.. ||||||||||||||.|||..||||||||| |..   | ||||| ||.|||.|   
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFF
.|...||||.||.....|..| |||   |..   . |.. .|..| . ...|.||   | ..   .|||.  .|.. .. ||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase S6kII.AA Akt 77-338 50 3.1e-146 470.52 In-house 1-264 (264) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-264/264
Sequence Identity: 50% (136 aa)

FELKKVLGKGGYGKVFQVRKTAGRDANKYF-AMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGI
|...|||||| .||||.|.|    | .|.. |||||||  |. ...  .|| .|||||. ..||||| |.|.|||  |||....| .||||| || |...
FDFLKVLGKGSFGKVFLVKK---KDTQKWYYAMKVLKKDYII-QKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRR

FLEDTTCFYLSEIILALGHLHKLGIIYRD-LKPENILLDAQGHVKLTDFGLCKEH-IQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWS-LGALMFDM
| ||.. || .|||||..|||. .||||| |||||||.|..||..|||||||||. |... .| ||||| ||.|||||   ||.||||||. ||..|. |
FSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEM

LTGVPPFTAENRKKTIETILKAKLNLP--AYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFF
..| ||| ......  . |. .... |   .. ||..||...| ...  .|||.||.||  .. ||.|
MCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase S6kII.AA RSK 77-338 41 3.6e-129 435.41 In-house 1-271 (271) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-271/271
Sequence Identity: 41% (112 aa)

FELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIF
.||....|.| ..||. ..|  ..|.|...|||..|||...   .    . .||.||. . ||||| | |.||. ||.|.|.. . ||.|| .| ... |
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR--VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMF

LEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQ----GHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDM
 |.  .||..|| ||. .||..||..|||||||||.|..    ||.|..|||. |. . |   . |||.|..|||||.| | ||..|.||||.|.||. |
SEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEM

LTGVPPFTAENRKKTIETILKAKLNL-------PAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFF
||| .|| . .|. . . |...|| .       ......|| ||.|.. .|   .|||.||.... .  ||.|
LTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase S6kII.AA RSK-Unclassified 77-338 41 2e-120 380.16 In-house 1-283 (283) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-283/283
Sequence Identity: 41% (118 aa)

FELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLE--REG
|.  . .|.|  |||. |||   .| .. .|||||.|  ..  .| .     |.||.   .||||| | ..|||  .|||..||  ||..| ||   .| 
FIKHRLIGQGDFGKVYLVRK---KDTQQIYAMKVLHKHKMIRHNK-IKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEK

IFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEH---------------------IQEGIVTHTFCGTIEYMAPEILTR
 | ||   ||.||...|| .|||...|||||||.||.|.  |||.||||.| ..                      . .|  |  |||| ||.|||.. |
CFCEDDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRR

SGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLP--AYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFF
 ||.|||||| || .|. || |.||. ..|.  | . |.|... .|   |.  ..|||...|..| .  |||..  ||. .  ||||
CGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase S6kII.AA AktR 77-338 43 5.5e-115 388.3 In-house 1-268 (268) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-268/268
Sequence Identity: 43% (119 aa)

FELKKVLGKGGYGKVFQVRKTAGR-DANKYFAMKVLKKASIVTNQKDTAHTRAERNILE-AVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREG
|.. |.||||..|||. |.|   . | .|..|||..|| .   ...   ||. ||||.|  ..||||| |.|.|||. ||..|.||  ||||| || ...
FHVYKCLGKGAFGKVYLVQK---KRDNQKQYAMKMIKK-KKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKK

IFLEDTTCFYLSEIILALGHLHKL-GIIYRDLKPENILLDAQGHVKLTDFGLCK-EHIQ-EGIVTHTFCGTIEYMAPEILTR-SGHGKAVDWWSLGALMF
 | |... || ..|.||| .||.   ||||||||||||||  ||||.||||| | . .  .  ....|||| ||||||..|.  ||.|.||||..|.. .
KFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIY

DMLTGVPPFTAENRKKTIETILKAK---LNLPAYLTPEARDLVR-RLMKRQEPQRLGSGPEDAAAVQIHPFF
 |.|| |||...|..  .. |..      . |.|......||.  .|...   .|||.. ...  .  ||.|
EMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase S6kII.AA PKA 77-338 41 2.6e-110 372.76 In-house 1-263 (263) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-263/263
Sequence Identity: 41% (112 aa)

FELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIV-ELVYAFQTDGKLYLILEYLSGGELFMHLEREGI
||....||.| .|.| ..|.  .    .|.|||.|||. ||   | . |.  |.||| ..|||||| .. . ||.| .||...|| .|||.| .| ..| 
FEIIQTLGTGSFGRVMLCRHKHSG---NYYAMKMLKKQEIV-RLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGR

FLEDTTCFYLS-EIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRS-GHGKAVDWWSLGALMFDML
| .....||   .|.|||  ||.. ||||||||||||.| .||.|.||||  |. ...  .| | ||| ||.||||.... ||||.||||.|| | . ||
FSNPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKK-VDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEML

TGVPPFTAE--NRKKTIETILKAKLNLPAYLTPEA---RDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFF
.|.|||...  .  .. | |...|.. | .... |   .||...|. .   .|.|.  ...  .  |..|
AGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase S6kII.AA MSK 80-333 40 1e-106 360.87 In-house 1-277 (277) Show / Hide 
Range on Protein: 80-333
Range on HMM: 1-277/277
Sequence Identity: 40% (111 aa)

KKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAV-KHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLE
.||||.|||||.| .||  ..|..| .|||.|.|| .|. .| ..||..|| .||.. .||.||.| ||||.. ..||..||..||||| |. . . | |
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

DTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQ---GHVKLTDFGLCKEHIQE-GIVTHTFCGTIEYMAPEILTR-----SGHGKAVDWWSLGALM
.   ... |...|. |.|..|||.|||||||||.| .   |||||.|||. ..  |.    ....|.|..|||||.|.|     .|...|.||||||...
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

FDMLTGVPPFT--AENRKKTIET-------ILKAKLNLP----AYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQ
. ||||  ||.  .. |. . ..       |.|.. ..|        |.|.||...|  .    ||| .. .|  . 
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase S6kII.AA S_TKc 77-338 34 6.5e-101 342.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-231/231
Sequence Identity: 34% (95 aa)

FELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSG--GELFMHLEREG
.|. ...|||..|||...|..     ....|.|..|            |.| |..||.  .||.|| | ..||. ..||...||..|  |.|| .... |
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

I------FLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGK-AVDWWSLGA
       | | ...||. .|..|| ..|..|||.|||||||||||   |.|..||||...        .||||| .|||||.|   |.|| ..||||.| 
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

LMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDA--AAVQIHPFF
... ||.| |||   . ..... |.          .|||.|..|.....   .|..     .   .. .||.|
ILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase S6kII.AA Pkinase 77-338 28 4e-86 297.21 Pfam 1-293 (293) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

FELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGG----ELFMHLE-
.......|.|..|.|.. ..   ..    .|.|..|| ..  ... |.  ..|  |.  ..||.||.| ..|......|...||. ||    .|| ... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-REGIF--LEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHV----KLTDFGLCKEH-IQEGIVTHTFCGTIEYMAPEILT-RSGHGKAVDW
 |.| |   |.. .||. .|. .| ..|. |||.|||||||||.| .||.    |..||||.| . .  .  ..|||||..|||||..  ....|..||.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGALMFDMLTGVPPFTAE------NRKKTIETILKAKLNLPAYLT---------------------PEARDLVRRLMKRQEPQRLGSGPEDAAAVQIH
||.| ... ||.| |||  .      . .. |. |....|  . . .                     .|..|..... ..   .|..     |. .  |
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQH

PFF
|.|
PWF
Kinase S6kII.AA S_TK_X 339-401 34 1.7e-24 88.6 SMART 1-79 (79) Show / Hide 
Range on Protein: 339-401
Range on HMM: 1-79/79
Sequence Identity: 34% (27 aa)

KHVNWDDVLA--RRLEPPIKPLLR----SEDDVSQFDTRFTRQIPVDSPDDTTLSESANL----------IFQGFTYVA
....||....  ...|||.|| ..    |. |.|.||. ||.. |...|||..||.|..            | |||||.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase S6kII.AA Pkinase_C 358-403 40 5.3e-16 59.53 Pfam 1-46 (46) Show / Hide 
Range on Protein: 358-403
Range on HMM: 1-46/46
Sequence Identity: 40% (19 aa)

LLRSEDDVSQFDTRFTRQIPVDS-PDDTTLSESANLIFQGFTYVAPS
 ..|..|.| ||. ||.. |.|. ||.. .|..... |.|||||.|.
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase S6kII.AA TyrKc 77-338 20 5.8e-13 -13.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

FELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAV--KHPFIVELVYAFQTD-------GKLYLILEYLSGGELF
 .|.|.|| | .|.|.. . .         | |.||. .        .  . | .|.  .  .|| || |. .  ..       . |....|| ..| | 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

MHLEREGI-FLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQE-------GIVTHTF--CGT----IEYMAPEILTR
 .| . .  .  .. . .   |     .||. ..| |||   |.|......|| .||||....  .          ...   .|     |  |||| .  
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

SGHGKAVDWWSLGALMFDMLT-GVPPFTAE----NRKKTIETILKAK--LNLPAY--------LTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFF
.    . | || | .|. ..| | .|   .       . .   .|.   .  |..         ..|  .. ..  ...  .|           .|| .|
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR-------PTFSEIHECF
Kinase S6kII.AA Pkinase_Tyr 209-229 38 0.001498 12.65 Pfam 141-161 (270) Show / Hide 
Range on Protein: 209-229
Range on HMM: 141-161/270
Sequence Identity: 38% (8 aa)

NILLDAQGHVKLTDFGLCKEH
|.|.. ...|| .||||.. .
NCLVTENNVVKICDFGLARDI
Kinase S6kII.AA Pkinase_Tyr 77-166 22 0.002916 11.67 Pfam 1-94 (270) Show / Hide 
Range on Protein: 77-166
Range on HMM: 1-94/270
Sequence Identity: 22% (22 aa)

FELKKVLGKGGYGKVFQVRKT-AGRDANKYFAMKVLKKASIVTNQKD--TAHTRAERNILEAV-KHPFIVELVYAFQ-TDGK--LYLILEYLSGGEL
 .. |.||.| .|.|.. . .  . . .   | |.||     . ...   .   .| .|.    .|| || |. .    ..   .|...||  .| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL