Gene Gyc32E (Fruit Fly)

Gyc32E

Species: Fruit Fly
Alias: GYC 32E, Gyc32E, Gyc-r: Guanylate cyclase receptor-type, SFO105, Guanylate cyclase receptor-type, Cyg1, GC, DMRGC, CG6275, Gyc-r: Guanylate cyclase recepto
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 32D5,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
Gyc32E.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 269 Kinase domain by global Sugen HMM Fasta, JSON
Gyc32E.AA Protein Various 1298 None Fasta, JSON

Protein domain

Protein domains of Gyc32E.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor Gyc32E.AA ANF_receptor 192-533 18 1.9e-38 136.78 Pfam 1-364 (364) Show / Hide 
Range on Protein: 192-533
Range on HMM: 1-364/364
Sequence Identity: 18% (71 aa)

VTLGGLPLAIEDVNKNPN-LLPGKKLAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGPDESC--TTEALLASAWNTPMLSFKCSDPIVSN--KSTF
  ......||||.|..|. |||| .| ..  |.    |        |. ..   || |.|||  |.  .. | .|..|| ||.|. |..| ...  |. .
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCY-CSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKNRY

HTFARTLAPASKV-SKSVISLLNA-FHWNKFSIVVSSKPI-WGSDV---ARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDKIIEE-TYATTRIYVF
 .|.||....... .. ......  | |.........     .  .   ..|.|....... .. .. | | .||...  ....|.| . .. ..|..|.
PYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARVIVM

IGEHIAM----VDFVRGLQNRRLLESGDYIVVSVDD--EIYDSNRRVNIMERNYLDPYIRKEKSKSL--DKISFRSVIKISMTYPQNP------------
 ...  |      ...  .....  ||.|  . .|   . ||.                . .... .  ..  . .|. . |  | .|            
CCYPDDMGLLQRQIMQQAHELGM-MSGGYVWIYTDWWMHSYDMQ-W-------------WYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQRWKKT

HIRVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGN---------LVMSHIFN-RSYHSIQGFDVYIDSNGDAEGNYTVITLQN
   . .|....||.|. |..|. ..|| ......|.          ..... | ...  . |  .. |..|. .. . .|  ..
DTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD
Kinase Gyc32E.AA RGC 687-935 38 2.8e-130 439.12 In-house 1-300 (300) Show / Hide 
Range on Protein: 687-935
Range on HMM: 1-300/300
Sequence Identity: 38% (114 aa)

RGNIVAMKKIHKK----SVDITRSIRKELKLMREVRHENIINFIGASTDHG------SVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIY
.|. |..||....    ..|.|||...|||.||...|.|...|||...|.        ..|.. ||.||||.|.|.|.|...|.||..|.. ||.||| |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHDSEIISHGNLRSSNCLIDSRWVCQISDFGL-----HELKAGQEEP--------NKSEL----ELKRALCMAPELLR-DAYRPGRG--------SQKGD
||.|.|..||||.|.||..|||||..|.||||     |..|.||..|        ....     . |. |..|||.|| ..  . .|        .||||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFGILLYEMIGRKG-----PW----GDTAYSKEEIIQFVKCPEM-LQHGVFRPALTHTH----LDIPDYIRKCLCQCWDEDPEVRPD-IRLVRMHLKE
|||||| .||.|.|||     |.    |... | .|||. ||.|..  .. .||| . ...    ....... .....||.||||.||| .. .| .||.
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase Gyc32E.AA RGC 687-935 38 2.8e-130 439.12 In-house 1-300 (300) Show / Hide 
Range on Protein: 687-935
Range on HMM: 1-300/300
Sequence Identity: 38% (114 aa)

RGNIVAMKKIHKK----SVDITRSIRKELKLMREVRHENIINFIGASTDHG------SVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIY
.|. |..||....    ..|.|||...|||.||...|.|...|||...|.        ..|.. ||.||||.|.|.|.|...|.||..|.. ||.||| |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHDSEIISHGNLRSSNCLIDSRWVCQISDFGL-----HELKAGQEEP--------NKSEL----ELKRALCMAPELLR-DAYRPGRG--------SQKGD
||.|.|..||||.|.||..|||||..|.||||     |..|.||..|        ....     . |. |..|||.|| ..  . .|        .||||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFGILLYEMIGRKG-----PW----GDTAYSKEEIIQFVKCPEM-LQHGVFRPALTHTH----LDIPDYIRKCLCQCWDEDPEVRPD-IRLVRMHLKE
|||||| .||.|.|||     |.    |... | .|||. ||.|..  .. .||| . ...    ....... .....||.||||.||| .. .| .||.
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase Gyc32E.AA TKL 684-933 22 4.5e-45 156.06 In-house 12-364 (364) Show / Hide 
Range on Protein: 684-933
Range on HMM: 12-364/364
Sequence Identity: 22% (81 aa)

ALFRG----------NIVAMKKIHKKSVD---------------------------ITRSIRKELKLMREVRHENIINFIGASTDHGS------------
. .||          . ||.||......|                           .   ...|...|.  ||.||. |.|.... ..            
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG

-VIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEI-------ISHGNLRSSNCLIDSRWV--------------CQISDFGLHELK
   | . || .|||...|        .  . ... || .|| ||| ..        | | .| |.|.|.|. |               | |.||||   .
QLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM

AGQEEPNKSE--------------LELKRA---LCMAPELLRDA--YRP----------GRGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEE------
 . .. |...                 ..      ||||.||..  |.           .  |.| |||||||.|.|.. |. |. |  |. ..      
SQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFE

IIQFVKCPEMLQ---------HGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHL
... . | . |.         |.   .       |.|. ..| . .|||.||| ||    .  .|
EMFMMVCDKGLRPPIPPIWQNHH---K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Gyc32E.AA TKL-Unique 684-865 30 1.5e-38 133.55 In-house 16-225 (290) Show / Hide 
Range on Protein: 684-865
Range on HMM: 16-225/290
Sequence Identity: 30% (66 aa)

ALFRGNIVAMKKIHK---KSVDITRSIRKELKLMREVR-HENIINFIGAST----DHGSVIIFTTYCARGSLEDVLA---------NEDLHLDHMFISSL
. .|| .||.|..|.   .| ....  ..|...|   . |.||  ..|...    . .  .|.. || .||| |||.         |. . |.   . ..
GKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKM

VSDILKGMIYLHDSEI-ISHGNLRSSNCLIDSR-----WVCQISDFGLHELKAGQEEPNKS-------ELELKRALCMAPELLRD---AYRPGRGSQKGD
. || .||.||| .|  | |..|.||| |.|..     |  .|.||||  ...   . ...       . ... .. ||||.||.    |     |.| |
AIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQY-----SEKSD

VYSFGILLYEMIGRK
|||||| |.|.. ||
VYSFGIVLWEIATRK
Kinase Gyc32E.AA TK 691-933 15 1.6e-28 92.09 In-house 55-486 (486) Show / Hide 
Range on Protein: 691-933
Range on HMM: 55-486/486
Sequence Identity: 15% (67 aa)

VAMKKIHKK-SVDITRSIR----------------KELKLMRE--VRHENIINFIGASTDH------------GSVIIFTTYCARGS----LEDVLANED
|| | .... . . .. .                  |.|.|..   .|.||....|..|..            . ..| . |.. |.    | | | . .
VAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCR

LHLDHMFISS--------------------------------------------------------------------------LVSDILKGMIYLHDSE
 .  |.  ..                                                                             .| .|| |||.  
PKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKN

I-----ISHGNLRSSNCLIDSRWV-----------CQISDFGLH------ELKAGQEEPNKSELELKRALC--------------------------MAP
.     . |..|   |||.... |           | |.||||         .. ... .    . ... .                          |||
CEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAP

ELLRDAYR-----PGRGSQKGDVYSFGILLYEMI--GRKGPWGDTAYSK-------EEIIQFVKCPEML--------QHGVFRPALTHTH----------
| |.|         |. . | ||.|||.|..|.   |.. . |.   ..       .|......   .|         ..  .|.  | .          
ECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPP

LDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHL
   |. .   ..|||..||| ||. . ..  |
HCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Gyc32E.AA DRK 687-808 34 7.3e-26 84.6 In-house 21-146 (258) Show / Hide 
Range on Protein: 687-808
Range on HMM: 21-146/258
Sequence Identity: 34% (44 aa)

RGNIVAMKKIHKKSVD---ITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSE-I
|| .|| |.     ..   .    ..|  ||   || ||. |.|. .   .. | . |  ||||  .| .| . .|   . ..  |. ||||||| .. |
RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPI

ISHGNLRSSNCLIDSRWVCQISDFGL
| |  | | | |.|  |   ..||||
IIHRDLKSHNLLVDEHWQVKVADFGL
Kinase Gyc32E.AA RAF 708-935 27 1.9e-22 69.36 In-house 46-282 (282) Show / Hide 
Range on Protein: 708-935
Range on HMM: 46-282/282
Sequence Identity: 27% (66 aa)

RKELKLMREVRHENIINFIGASTDHG--SVIIFTTYCARGSLEDVLANEDL--HLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQI
. |.  ..  || ||. | | ...    .. | | .|   ||   .   .   ..| . .      . .|| |||  .|| |  |.| | . .      |
KNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKFDMHWLIDISRQVCQGMDYLHAKNII-HRDLKSNNIFLHEDMTVKI

SDFGLHELKAGQE--EPNKSELELKRALCMAPELLRDAYRPGRG----------SQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQHG
 ||||  .|         . |      | ||||  |.     ||          |.. ||||||| .||.. |. | |    ... ||       |   |
GDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSFQSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIF------MCGRG

VFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKE
  || |     |.|  ... .  ||  ..| ||  . .   .. 
YLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase Gyc32E.AA TK-Unique 690-861 25 1.1e-20 68.13 In-house 31-232 (294) Show / Hide 
Range on Protein: 690-861
Range on HMM: 31-232/294
Sequence Identity: 25% (52 aa)

IVAMKKIHKKSVDITR--SIRKELKLMREVR-HENIINFIGASTDHG-SVIIFTTYCARGSLEDVLA----N-----------EDLHLDHMFIS-SLVS-
...  | .|.... |.     ||...|.|.  |.||....|..|. . .. |   ||..|.|.. |     .           .|.| . .. . . .| 
KCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISP

--------DILKGMIYLHD--SEIISHGNLRSSNCLIDSRWVCQISDFGLH-ELKAGQEEPNK-SELELKRALCMAPELLRDAYRPGRGSQ---KGDVYS
        .| .|| ||.    .|. |..| ..|.|. .. || |.|||.  .. ....  .. |. ..  .  |||| |. .    .|     |.||.|
KDLYHFAWQIACGMEYLASQRKKIV-HRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRW-MAPESLKCY----HGMYHTTKSDVWS

FGILLYEM
||.|..|.
FGVLMWEI
Kinase Gyc32E.AA Dicty4 687-808 32 5.8e-19 60.04 In-house 21-160 (277) Show / Hide 
Range on Protein: 687-808
Range on HMM: 21-160/277
Sequence Identity: 32% (46 aa)

RGNIVAMKKI--HKKS--VDITRSIRKELKLMREVRHENIINFIGAST----DHGSVIIFTTYCARGSLEDVLAN------EDLHLDHMFISS---LVSD
|| .|| ||   |.     ..  . ||| ..|   || ||. | ||.|      |.. | | |. .|.|. .| .      .   ||   | .   .  |
RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFD

ILKGMIYLHDSE-IISHGNLRSSNCLIDSRWVCQISDFGL
. .||..|| .  .| |  | |.| |.|  |.  ..||||
AARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGL
Kinase Gyc32E.AA MLK 686-808 24 2e-18 60.62 In-house 20-179 (291) Show / Hide 
Range on Protein: 686-808
Range on HMM: 20-179/291
Sequence Identity: 24% (40 aa)

FRGNI-----VAMKKIH-KKSVDITRS------IRKELKLMREVRHEN----IINFIGASTDHGS-VIIFTTYCARGSLEDVLANED-------------
.|...     || |...  .  |. ..      ...| .. | ..|.|    || | |....... . | . ||. ||| .||....             
WRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKND

LHLDHMFISSLVSDILKGMIYLHDSEI--ISHGNLRSSNCLIDS------RWVCQISDFGL
   || .. .   .. .|| |||  .   | |  | |.| |||         .. |.|||.
RVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGT
Kinase Gyc32E.AA Pkinase_Tyr 691-808 28 3e-18 62.43 Pfam 31-157 (270) Show / Hide 
Range on Protein: 691-808
Range on HMM: 31-157/270
Sequence Identity: 28% (36 aa)

VAMKKIHKKSVDI---TRSIRKELKLMREV-RHENIINFIGAST-DHGS--VIIFTTYCARGSLEDVLANE---DLHLDHMFISSLVSDILKGMIYLHDS
|| |..  .. .     ..  .|.|.|..  .|.||....|. | . ..  ..| . |.. |.| | | .    . .|..  . .   .| ||| ||.. 
VAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK

EIISHGNLRSSNCLIDSRWVCQISDFGL
 .| |  |.  |||...  |. |.||||
NCI-HRDLAARNCLVTENNVVKICDFGL
TyrKc Gyc32E.AA TyrKc 640-933 20 1e-15 31.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 640-933
Range on HMM: 1-280/280
Sequence Identity: 20% (69 aa)

VDMKDV------TVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIALFRGNIVAMKKIHKKSVDITRSIRKELKLMREV--RHENIINFIGASTD
. ....       .. .|...                                    || |.... .    . ...|...|...  .|.||....|. |.
ITLGKKLGEGAFGEVYKGTWK----------------------------------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQ

H-------GSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQ-----EEPN
.       . . | . |.. |.| | | .   .| .    |   .| .|| |||.  .| |  |   |||.... .. ||||||            ..  
QGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCI-HRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDY

KSELE--LKRALC----MAPELLRDAYRPGRGSQKGDVYSFGILLYEMI--GRKGPWGDTA--YSKEEIIQFVKCPEMLQHGVFRPAL-----THTHLDI
..  |   ....     |||| .    . |. . | ||.|||....|.   | . ..|..    | .|.|..||  ...     .|.             
YRKKEHKGGKTMLPIRWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMP----QPPNDYPMSF---VCC

PDYIRKCLCQCWDEDPEVRPDIRLVRMHL
|| . .   |||.|||| ||  . ..  .
PDEMYQIMKQCWHEDPEDRPTFSEIHECF
S_TKc Gyc32E.AA S_TKc 670-934 19 1.1e-15 53.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 670-934
Range on HMM: 1-231/231
Sequence Identity: 19% (57 aa)

LVVGEP-------NKRSFTNIALFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCAR--GSLEDVLANEDLH---
  ....         .  ...    | |||.|.|.       ..||.|...... .|.||......  | ... ... ||    |.| |.. .   |   
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALC-----MAPELLRDAYRPGRGSQKGD
  ..   . ...  |.... |.|.  || |  |  .| |.|.  .  |.||||  .               . .|     ||||.|      | |  | |
FPFPE-HARFYMYQICCALEYCHSHGII-HRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL------GYGKCKCD

VYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVR-------MHLK
..|.|..||||. .. |.       ..... ..                     ..  .  ...|.. ||| || . . .       .   
WWSCGCILYEMLCGYPPFP----QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase Gyc32E.AA Pkinase 688-808 25 7.5e-15 53.6 Pfam 24-158 (293) Show / Hide 
Range on Protein: 688-808
Range on HMM: 24-158/293
Sequence Identity: 25% (35 aa)

GNIVAMKKIHKKSVDITRSIRK----ELKLMREVRHENIINFIGASTDHGSVIIFTTYCARG----SLEDVLA-NEDLHL--DHMFISSLVSDILKGMIY
| |||.|.| |.. .    ...    |...|....|.||. .... .|.... . . ||  |    .| |..   ..  .  .   . . .  ||.|. |
GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEY

LHDSEIISHGNLRSSNCLIDSRWVC----QISDFGL
.|. . | |  | ..|.|||.. ..     |.||||
CHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGL
Kinase Gyc32E.AA Dicty4 847-867 57 2.4e-05 13.95 In-house 196-216 (277) Show / Hide 
Range on Protein: 847-867
Range on HMM: 196-216/277
Sequence Identity: 57% (12 aa)

QKGDVYSFGILLYEMIGRKGP
.| |||||||.|.|.  |. |
EKADVYSFGIVLWEILTRQEP
Kinase Gyc32E.AA MLK 903-933 38 2.9e-05 14.37 In-house 261-291 (291) Show / Hide 
Range on Protein: 903-933
Range on HMM: 261-291/291
Sequence Identity: 38% (12 aa)

DIPDYIRKCLCQCWDEDPEVRPDIRLVRMHL
..|. . | . |||..||. ||. | . .||
TCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Gyc32E.AA MLK 831-867 42 6.8e-05 13.06 In-house 200-235 (291) Show / Hide 
Range on Protein: 831-867
Range on HMM: 200-235/291
Sequence Identity: 42% (16 aa)

MAPELL-RDAYRPGRGSQKGDVYSFGILLYEMIGRKGP
|||| . .   | .. | | ||.|.|..|.||. |. |
MAPEVIQQ--FRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase Gyc32E.AA DRK 848-867 55 0.000511 9.54 In-house 182-201 (258) Show / Hide 
Range on Protein: 848-867
Range on HMM: 182-201/258
Sequence Identity: 55% (11 aa)

KGDVYSFGILLYEMIGRKGP
| |||||.| | |.. |. |
KADVYSFAIVLWECVTRQDP
Kinase Gyc32E.AA Pkinase 831-868 39 0.001818 13.34 Pfam 178-212 (293) Show / Hide 
Range on Protein: 831-868
Range on HMM: 178-212/293
Sequence Identity: 39% (15 aa)

MAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPW
||||..|   ... |. | |..|.|..||||. .. |.
MAPEVIR--GGQYYGP-KVDMWSCGCILYEMLCGRPPF
Kinase Gyc32E.AA TK-Unique 914-933 40 0.004515 6.58 In-house 275-294 (294) Show / Hide 
Range on Protein: 914-933
Range on HMM: 275-294/294
Sequence Identity: 40% (8 aa)

QCWDEDPEVRPDIRLVRMHL
.|| ..|| ||..| ..  |
SCWQWEPEERPSFRQIKHRL
Kinase Gyc32E.AA Pkinase_Tyr 831-862 37 0.015635 9.2 Pfam 181-208 (270) Show / Hide 
Range on Protein: 831-862
Range on HMM: 181-208/270
Sequence Identity: 37% (12 aa)

MAPELLRDAYRPGRGSQKGDVYSFGILLYEMI
|||| ...       . | ||.|||.|..|..
MAPECINYGK----FTTKSDVWSFGVLMWEIF
Kinase Gyc32E.AA Dicty4 915-924 70 0.017316 4.31 In-house 255-264 (277) Show / Hide 
Range on Protein: 915-924
Range on HMM: 255-264/277
Sequence Identity: 70% (7 aa)

CWDEDPEVRP
|||.||..||
CWDHDPQHRP
Kinase Gyc32E.AA TKL-Unique 903-933 32 0.025766 4.19 In-house 260-290 (290) Show / Hide 
Range on Protein: 903-933
Range on HMM: 260-290/290
Sequence Identity: 32% (10 aa)

DIPDYIRKCLCQCWDEDPEVRPDIRLVRMHL
..|  .|. . |||. ||. ||    ..  |
HCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase Gyc32E.AA Pkinase_Tyr 905-933 41 0.133102 6.05 Pfam 242-270 (270) Show / Hide 
Range on Protein: 905-933
Range on HMM: 242-270/270
Sequence Identity: 41% (12 aa)

PDYIRKCLCQCWDEDPEVRPDIRLVRMHL
|| | . ..|||..||| ||  . .. .|
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL
CYCc Gyc32E.AA CYCc 972-1166 48 2e-115 390.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 972-1166
Range on HMM: 1-231/231
Sequence Identity: 48% (111 aa)

EEKKKTDMLLYQMLPRPVAELLKRG-DPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYD-----VYKVETIGDAYMVVSGL
.||.|.| ||.||||| ||. ||.| .||...|.|||||||.||||||.|| ..||..||.||||.||..|.||....     .|||||||||||||||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PLQNGS-------------------RHAGEIASLALHLLETVGNLKIRHK----PTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGD
|  |..                   .|| .||. ||. .|........|.    | .....|||.|.||...||||..|||||.||||||.|||||||||
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

SMRIHISEATYQLL-------QVIGSYVCIE
 ..||.||.||..|       .  | ... .
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc Gyc32E.AA Guanylate_cyc 999-1185 43 8e-88 302.87 Pfam 1-214 (214) Show / Hide 
Range on Protein: 999-1185
Range on HMM: 1-214/214
Sequence Identity: 43% (93 aa)

VEAECFDCVTILFSDIVGFTELCTTST----PFEVVEMLNDWYTCCDSIISNY--DVYKVETIGDAYMVVSGLPLQ-----NGSRHAGEIASLALHLLET
|.|. .|||||.|.||||||..|. ..    |...|.|||| ||| |......  ..|||.||||.||.|||||       ..  ||  .|  || ..|.
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VGNLKIRHKP-TE----TVQLRIGVHSGPCAAGVVG--QKMPRYCLFGDTVNTASRMESTGDSM--RIHISEATYQLLQVIGSYVCI----ERGLTSIKG
..   . |.. ..    ..|.|||.|.||. |||.|  |.|||||..|||||.||||||||.    .||.||.||..|.  .....     .||  ..||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGD---MRTYWLTK
||    | ||.|. 
KGKMGEMETYFLHG
HNOBA Gyc32E.AA HNOBA 964-993 53 6.7e-09 33.74 Pfam 205-234 (234) Show / Hide 
Range on Protein: 964-993
Range on HMM: 205-234/234
Sequence Identity: 53% (16 aa)

QERTNLLYEEKKKTDMLLYQMLPRPVAELL
.. ...| ||||||| |||.|.|..||. |
EQMHRELEEEKKKTDDLLYSMFPKSVANRL