Gene Gyc76C (Fruit Fly)

Gyc76C

Species: Fruit Fly
Alias: DrGC-1, receptor-type guanylate cyclase, SFO193, GYC 76C, drgc, CG8742, DGC1, Gyc76C
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 76C3,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
Gyc76C.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 294 Kinase domain by global Sugen HMM Fasta, JSON
Gyc76C.AA Protein Various 1525 None Fasta, JSON

Protein domain

Protein domains of Gyc76C.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor Gyc76C.AA ANF_receptor 45-167 25 4.4e-20 71.84 Pfam 1-134 (364) Show / Hide 
Range on Protein: 45-167
Range on HMM: 1-134/364
Sequence Identity: 25% (35 aa)

AISGALTMALDEVNKDPN-LLPNVYLDLRWNDTK---GDTVLATKAITEMICDGIATIFGPEGPC---YVEAIVSQSRNIPMISYKCAEYRASA-----I
.  .|. ||....|.||. |||.. |.... |..    .   .. |  ... .|.. |.|| ...   .|  | .   ||||||. | ... .       
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHW-NIPMISWGCTCPCLTDKAKNRY

PTFARTEPPDTQV-VKSLLALLRY-YAWNKFSILYED
|.|.|| |.||.. .. ....... . |......|.|
PYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDD
ANF_receptor Gyc76C.AA ANF_receptor 217-425 15 4.2e-11 40.1 Pfam 184-364 (364) Show / Hide 
Range on Protein: 217-425
Range on HMM: 184-364/364
Sequence Identity: 15% (34 aa)

VQN-TMNRTRIYVFLGAANSL----VDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYI
... .  ..|..|. . .. .      .|  .. .|.   |.|  |..|.  .| .            ....  . ...   |.  | .    | .... 
IKDIIKMKARVIVMCCYPDDMGLLQRQIMQQAHELGM-MSGGYVWIYTDWWMHSYDMQ-W--------WYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQ

QFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDD---VIFEVASNGTRVIDTIIKN-RTYMSITGSKIKI
.|.....|                    .  ...||||.||.|.||| |...|||..  . ..        .  .|. ..   ..| ...  .||  ...
EFMQRWKK-------------------TDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIM---KW-HGWQLL-HYMWNKVNFEGVTG-DVQF

DQYGDSEGNFSVLAYKPH
|  |.   .... .. ..
DDNGGRRPDYMYWIMNWD
Kinase Gyc76C.AA RGC 574-823 41 5.6e-136 458.03 In-house 1-300 (300) Show / Hide 
Range on Protein: 574-823
Range on HMM: 1-300/300
Sequence Identity: 41% (125 aa)

RGAVVRIKELKFP---RKRDISREIMKEMRLLRELRHDNINSFIGASVEPT------RILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIY
.| .| ||....    |. |..|..|.|....|.|.|||.| |||....|.      ....|. ||..||| ||.||.|||.|. |..|.|.|..||| |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

IHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGL-----HELRQCAENE--------SIGEH---QHYRNQLWRAPELLR----NHIHG--------SQKGD
.|.|.. |||||||.|||| |||....|||||     |.......|.        ....|    .|...||.|||.||    .| .|        .||||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYAFAIIMYEIFSRKG-----PF----GQINFEPKEIVDYVKKLPLKGE-DPFRPEVESI---IEAESCPDYVLACIRDCWAEDPEERPE-FSVIRNRLK
||.|.||||||. |||     ||    |..  .|.||.. ||..|.||.  ||||... .   . .. |....|...||||||||||||. |. ||. ||
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGH-MIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLK

K
.
T
Kinase Gyc76C.AA RGC 574-823 41 5.6e-136 458.03 In-house 1-300 (300) Show / Hide 
Range on Protein: 574-823
Range on HMM: 1-300/300
Sequence Identity: 41% (125 aa)

RGAVVRIKELKFP---RKRDISREIMKEMRLLRELRHDNINSFIGASVEPT------RILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIY
.| .| ||....    |. |..|..|.|....|.|.|||.| |||....|.      ....|. ||..||| ||.||.|||.|. |..|.|.|..||| |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

IHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGL-----HELRQCAENE--------SIGEH---QHYRNQLWRAPELLR----NHIHG--------SQKGD
.|.|.. |||||||.|||| |||....|||||     |.......|.        ....|    .|...||.|||.||    .| .|        .||||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYAFAIIMYEIFSRKG-----PF----GQINFEPKEIVDYVKKLPLKGE-DPFRPEVESI---IEAESCPDYVLACIRDCWAEDPEERPE-FSVIRNRLK
||.|.||||||. |||     ||    |..  .|.||.. ||..|.||.  ||||... .   . .. |....|...||||||||||||. |. ||. ||
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGH-MIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLK

K
.
T
Kinase Gyc76C.AA TKL 571-821 20 5.2e-46 159.17 In-house 12-364 (364) Show / Hide 
Range on Protein: 571-821
Range on HMM: 12-364/364
Sequence Identity: 20% (75 aa)

GRLRG----------AVVRIKELKFPR-----------------------KRDIS---REIMKEMRLLRELRHDNINSFIGASVEPTR------------
|..||           .| .| .|                           ...|    .. .|..... |||.|| .|.|.. .|.             
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG

-ILLVTDYCAKGS-LYDIIENEDIKLDDLFI--ASLIHDLIKGMIYIHNSQL-------VYHGNLKSSNCVVTSRWM--------------LQVTDFGLH
 . .|..|| .|| |....          .    ....|  .|| | |...        . | .|||.|. | . |               . ..|||| 
QLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLS

ELRQCAENESIGE--------------HQHYR--NQLWRAPELLRNHI---------------HGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIV-
   .  .| . ..              . . .  .  | |||.||...                 |.| |||.|.|...||..|. |. .....| ..  
RFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQD

---DYVKKLPLKGEDPFRPEVESI----IEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRL
   .. ..  .||. | .|.. .        ..||. .   . |||..|||.|| |. |  ||
PFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Gyc76C.AA TKL-Unique 597-774 27 1.3e-39 137.4 In-house 44-256 (290) Show / Hide 
Range on Protein: 597-774
Range on HMM: 44-256/290
Sequence Identity: 27% (59 aa)

KEMRLLRELR-HDNINSFIGASV----EPTRILLVTDYCAKGSLYDIIE---------NEDIKLDDLFIASLIHDLIKGMIYIHNSQL-VYHGNLKSSNC
.| ...  |. |.||  ..|...     | .  .|..||  ||||| .          |. .||. . . ....|  .||.|.|...  ..|..||||| 
NEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNF

VVTSR-----WMLQVTDFGLHELRQCAENESIGEH------QHYRNQLWRAPELLRNH-IHGSQKGDVYAFAIIMYEIFSRKG------PFGQINFE-PK
 |...     |  .. ||||  ..    .....||          . .|.|||.||.   . |.| |||.|.|...||..||       |.  ...|  .
LVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWC

EIVDYV-KKLPLK
|.|.|. ......
EMVHYMEENYRPP
Kinase Gyc76C.AA RAF 598-823 26 2.9e-24 75.33 In-house 48-282 (282) Show / Hide 
Range on Protein: 598-823
Range on HMM: 48-282/282
Sequence Identity: 26% (65 aa)

EMRLLRELRHDNINSFIGASVEPT--RILLVTDYCAKGSLYDIIENEDI--KLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTD
|.  ..  ||.||  | | . .|    .  ||..|   |||  |   .   |.|   .        .|| | |  . . |  ||| |          ..|
EVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKFDMHWLIDISRQVCQGMDYLHAKNII-HRDLKSNNIFLHEDMTVKIGD

FGLHELRQCAE-NESIGEHQHYRNQLWRAPELLR-------------NHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPF
|||  ...    . .    |     || |||  |             ..   |.. |||.| |.|||. .|. |.|.   . . |.  .      |    
FGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSFQSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMC------GRGYL

RPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKK
||. . . .   ||      . |||. ..|||| |  | .|.. 
RPDLSKVRQD--CPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase Gyc76C.AA TK 578-821 13 3.5e-24 77.31 In-house 55-486 (486) Show / Hide 
Range on Protein: 578-821
Range on HMM: 55-486/486
Sequence Identity: 13% (60 aa)

VRIKELKFPRKRDISREIM----------------KEMRLLRE--LRHDNINSFIGASVEPTR------------ILLVTDYCAKGS----LYDIIENE-
| .| ||     .  ....                 || ....  ..|.|| ...|.....              ...|. |...|.    | |   .  
VAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCR

--------------------------------------------------------DIKLDDLFIAS-----------------LIHDLIKGMIYIHNSQ
                                                        .. . ||  .                    ... .|| |.|  .
PKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKN

L-----VYHGNLKSSNCVVTSRWM-----------LQVTDFGLH------ELRQCAENESIGEHQHYRNQL-------------------------WRAP
      . |..|   || |...               ..||||         |   ...    .. |.  .                         | ||
CEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAP

ELLRNHI--------HGSQKGDVYAFAIIMYEIFS--RKGPFGQINF-------EPKEIVDYVKK---------------LPLKGEDPFRPEV--ESIIE
| |. ..        . . | ||..| . |.|||.  .. . |...        ...|...|...               ....  .   . .  .    
ECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-

AESCPDYVLAC-IRDCWAEDPEERPEFSVIRNRL
 ..||. ...  ...||..|||.|| || ....|
PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Gyc76C.AA DRK 574-696 35 1.3e-22 73.4 In-house 21-146 (258) Show / Hide 
Range on Protein: 574-696
Range on HMM: 21-146/258
Sequence Identity: 35% (45 aa)

RGAVVRIKELKFPRKR--DISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQ-L
||  | .| |.       ..  |  .|  |.  ||| ||  |.|.  .|  |. .. |  .|||| |  .| |..|   . ..  |  ||||| |..   
RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPI

VYHGNLKSSNCVVTSRWMLQVTDFGL
. |  ||| |  |   |   | ||||
IIHRDLKSHNLLVDEHWQVKVADFGL
Kinase Gyc76C.AA TKL-ciliate1 719-821 29 3.8e-17 55.25 In-house 180-279 (279) Show / Hide 
Range on Protein: 719-821
Range on HMM: 180-279/279
Sequence Identity: 29% (32 aa)

WRAPELLRNHIHG----SQKGDVYAFAIIMYEIFSRKGPF-GQINFEPKEIVDYVKKLPLKGEDPFRPEV--ESIIEAESCPDYVLACIRDCWAEDPEER
|.||| .. ||      . | |.||..|.||.  .|| ||  ...      ..  .  .   | | ||    . |     ||. .   . .|| ..|  |
WMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQKMS-----VINIMCYWC---EFPGRPNLGPQFI--HFDCPQNFHNLMMRCWCQNPNKR

PEFSVIRNRL
|.|. |  .|
PNFNEIIQIL
S_TKc Gyc76C.AA S_TKc 541-822 16 2.7e-15 47.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 541-822
Range on HMM: 1-231/231
Sequence Identity: 16% (52 aa)

NEIVS-----SPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAK--G
 ||.      . .|| .    .                 | .| ||..|        . |..|...|.. .|.||  .... .. ... .|..||    |
YEILRKIGKGAFGKVYKCRHKK----------------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLG

SLYDIIENEDIK-----LDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQL----WRAPEL
.|.|.|..   .     ..   ...... ..... |.|.   . |  || .|  ...   . ..||||  .               . .     ..|||.
DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEV

LRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRN-----
|    .|  | |.... .|.|| .... ||     ..... . ..                       .. ..  || |.  |||.||    . .     
L---GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

---RLK
      
KCHPWF
TyrKc Gyc76C.AA TyrKc 567-821 23 5.8e-15 19.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 567-821
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

VTST-------------GRLRGAVVRIKELKFPRKRDISREIMKEMRLLREL--RHDNINSFIGASVEP-------TRILLVTDYCAKGSLYDIIENEDI
.|               |...   | .| ||        ...|.|.|....|  .|.||  ..|. ...         ...|. |...|.| | . .   
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIG-----EHQHYRN----QL-------WRAPELLRNH
||      |  ..  .|| |.|  ... |  |   || |...    ..||||      . .   .     ... ||     .        | ||| .. .
KLCMKDLLSFCWQIACGMEYLHSKNCI-HRDLAARNCLVGENHTVKISDFGL------SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

IHGSQKGDVYAFAIIMYEIFSR-KGPFGQ-IN--FEPKEIVDYVKKL--PLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRL
.  . | ||..| . |.|||.. . |    |    ...|.. |||.   . . ...  | . .      ||| .   ...||.||||.|| || |. ..
KF-TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSF----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Gyc76C.AA MLK 571-696 23 1.7e-14 46.79 In-house 18-179 (291) Show / Hide 
Range on Protein: 571-696
Range on HMM: 18-179/291
Sequence Identity: 23% (39 aa)

GRLRGAV-----VRIKELKFPRKRDISRE------IMKEMRLLRELRHDN----INSFIGASVEPTR-ILLVTDYCAKGSLYDIIENED-----------
|| |.       | .|. ..    |.|..      . .| |.|| |.| |    |  | |.. .|.   ..|. ||..||||... ...           
GRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQK

--IKLDDLFIASLIHDLIKGMIYIHNSQ--LVYHGNLKSSNCVVTS------RWMLQVTDFGL
  .  |  ....  ..  .|| | |. .  .. |  |||.| ...          | ..|||.
NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGT
Kinase Gyc76C.AA Dicty4 597-696 33 3e-13 40.71 In-house 47-160 (277) Show / Hide 
Range on Protein: 597-696
Range on HMM: 47-160/277
Sequence Identity: 33% (38 aa)

KEMRLLRELRHDNINSFIGASV----EPTRILLVTDYCAKGSLYDIIEN------EDIKLD-DLFIA--SLIHDLIKGMIYIHNSQ-LVYHGNLKSSNCV
||  ..  .|| ||  | ||.     .| ... || |. ||.|| .. .      . ||||  |...   .  |  .||.. |..   . |  |||.|  
KEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLL

VTSRWMLQVTDFGL
|   |   |.||||
VDKNWRVKVCDFGL
Kinase Gyc76C.AA Pkinase 587-696 20 3.3e-13 47.78 Pfam 35-158 (293) Show / Hide 
Range on Protein: 587-696
Range on HMM: 35-158/293
Sequence Identity: 20% (25 aa)

RKRDISREIMK----EMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKG----SLYDIIE-NEDIKL--DDLFIASLIHDLIKGMIYIHNSQLVYHGN
|... . .. .    | .....|.|.||  ....  ....| .|..|| .|    .|.|.|.  .. ..  ..  . . .  ...|. |.|. . . |  
RHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRD

LKSSNCVVTSRWML----QVTDFGL
||..|. . ..  .     ..||||
LKPENILIDNNGHIDACVKICDFGL
Kinase Gyc76C.AA TKL-Unique 800-821 50 1.2e-07 23.23 In-house 269-290 (290) Show / Hide 
Range on Protein: 800-821
Range on HMM: 269-290/290
Sequence Identity: 50% (11 aa)

IRDCWAEDPEERPEFSVIRNRL
|..||. ||..|| |. |..||
IQQCWHHDPSQRPSFDEIIHRL
Kinase Gyc76C.AA Pkinase_Tyr 591-696 26 1.6e-07 26.08 Pfam 46-157 (270) Show / Hide 
Range on Protein: 591-696
Range on HMM: 46-157/270
Sequence Identity: 26% (30 aa)

ISREIMKEMRLLREL-RHDNINSFIGASV---EPTRILLVTDYCAKGSLYDIIENE---DIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVV
.... |.|......| .|.|| ...|. .   || .|..|. |...|.|.|   .    . .|.   . .  ..  ||| | .. ... |  |   || |
CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCI-HRDLAARNCLV

TSRWMLQVTDFGL
|.     ..||||
TENNVVKICDFGL
Kinase Gyc76C.AA Pkinase_Tyr 790-821 46 3.2e-07 25.09 Pfam 239-270 (270) Show / Hide 
Range on Protein: 790-821
Range on HMM: 239-270/270
Sequence Identity: 46% (15 aa)

ESCPDYVLACIRDCWAEDPEERPEFSVIRNRL
| ||| .   ...||..|||.|| || |...|
ENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Gyc76C.AA TKL-ciliate1 625-680 26 8.4e-07 19.3 In-house 76-135 (279) Show / Hide 
Range on Protein: 625-680
Range on HMM: 76-135/279
Sequence Identity: 26% (16 aa)

LVTDYCAKGSLYDIIENEDI---KLDDLFIASLIHDLIKGMIYIHNSQ--LVYHGNLKSSN
... .| ||.. ||          .  . .   . |. .||.|.|  |  |. | .||. |
IIMEHCHKGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLI-HRDLKMQN
Kinase Gyc76C.AA MLK 791-821 35 9.1e-07 19.65 In-house 261-291 (291) Show / Hide 
Range on Protein: 791-821
Range on HMM: 261-291/291
Sequence Identity: 35% (11 aa)

SCPDYVLACIRDCWAEDPEERPEFSVIRNRL
.||.     . .|| .||..|| |. |   |
TCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Gyc76C.AA Pkinase 719-821 16 2e-06 24.19 Pfam 177-293 (293) Show / Hide 
Range on Protein: 719-821
Range on HMM: 177-293/293
Sequence Identity: 16% (20 aa)

WRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAE--------------SCPDYVLACIRDCW
..|||..| . . ..| |.... .|.|| .... || . .  ... .|  ... .... |.. . .  ..                  ..  .  |..|.
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

AEDPEERPEFSVIRNR--L
. ||..|| .  | .   .
CKDPKKRPTAEQILQHPWF
Kinase Gyc76C.AA Dicty4 718-754 37 6e-06 16.14 In-house 182-217 (277) Show / Hide 
Range on Protein: 718-754
Range on HMM: 182-217/277
Sequence Identity: 37% (14 aa)

LWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPF
.| ||| ....    .| ||| |.|. .||. |. |.
CWMAPEVMMHQPY-NEKADVYSFGIVLWEILTRQEPY
Kinase Gyc76C.AA DRK 719-754 47 4e-05 13.35 In-house 168-202 (258) Show / Hide 
Range on Protein: 719-754
Range on HMM: 168-202/258
Sequence Identity: 47% (17 aa)

WRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPF
| ||| |||      | ||| |||.  |.  |. |.
WTAPEVLRNQRY-TEKADVYSFAIVLWECVTRQDPY
Kinase Gyc76C.AA DRK 800-823 41 6.8e-05 12.55 In-house 235-258 (258) Show / Hide 
Range on Protein: 800-823
Range on HMM: 235-258/258
Sequence Identity: 41% (10 aa)

IRDCWAEDPEERPEFSVIRNRLKK
. ||| |||  || .  .  ||  
MNDCWNEDPQHRPSMQECLERLEA
Kinase Gyc76C.AA MLK 719-754 28 7.7e-05 12.87 In-house 199-236 (291) Show / Hide 
Range on Protein: 719-754
Range on HMM: 199-236/291
Sequence Identity: 28% (11 aa)

WRAPELL--RNHIHGSQKGDVYAFAIIMYEIFSRKGPF
|.||| .    .   | | ||. ......|...|. |.
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPY
Kinase Gyc76C.AA Dicty4 800-823 42 0.000367 9.97 In-house 252-277 (277) Show / Hide 
Range on Protein: 800-823
Range on HMM: 252-277/277
Sequence Identity: 42% (11 aa)

IRDCWAEDPEERPEFSVIRNR--LKK
| .|| .||. || |. | .|  |  
IQWCWDHDPQHRPSFEEIIQRRILEH
Kinase Gyc76C.AA Pkinase_Tyr 719-750 37 0.014023 9.36 Pfam 180-210 (270) Show / Hide 
Range on Protein: 719-750
Range on HMM: 180-210/270
Sequence Identity: 37% (12 aa)

WRAPELLRNHIHGSQKGDVYAFAIIMYEIFSR
| ||| ... .  . | ||..| . |.|||..
WMAPECINYGK-FTTKSDVWSFGVLMWEIFTY
CYCc Gyc76C.AA CYCc 860-1055 45 7.1e-102 345.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 860-1055
Range on HMM: 1-231/231
Sequence Identity: 45% (106 aa)

EEKMKTEDLLHRMLPQSVAEKLTMGQ-GVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYD-----VYKVETIGDAYMVVSGL
.||.|.. ||..|||..||. |  |.  |.| .|| |||.|.||||||......||.||||.|||.|| |||||. ..     .|||||||||||||||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PIKNGD-------------------RHAGEIASMALELLHAVKQHRIAHR----PNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGE
|  |..                   .|| .||..||. . ..|.. . |.    |...|..|||.||||||.||||..|||||.||||||.||||||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

ALKIHISNKCKLAL------DKLGGGYITEK
. .||.|   ...|       .  |.. .| 
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc Gyc76C.AA Guanylate_cyc 887-1074 42 2.8e-91 314.33 Pfam 1-214 (214) Show / Hide 
Range on Protein: 887-1074
Range on HMM: 1-214/214
Sequence Identity: 42% (91 aa)

VEPVSYDLVTIYFSDIVGFTAMSAEST----PLQVVNFLNDLYTVFDRIIRGY--DVYKVETIGDAYMVVSGLPIK-----NGDRHAGEIASMALELLHA
|.. .|| |||.|.|||||||......    |.|.|..|||.|| |||... .  ..|||.||||.||.||||| .     ..  ||  .| |||... .
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VKQHRIAHRP-NE----TLKLRIGMHTGPVVAGVVG--LTMPRYCLFGDTVNTASRMESNGEAL--KIHISNKCKLALDKLGG---GYITEKRGLVNMKG
..|... | . ..    ....|||.|||||||||.|  . |||||..|||||.||||||.|...  |||.|.  .  | ....   .. .. || ...||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGD---VVTWWLTG
||    ..|..|.|
KGKMGEMETYFLHG
HNOBA Gyc76C.AA HNOBA 855-881 59 3.4e-08 31.2 Pfam 208-234 (234) Show / Hide 
Range on Protein: 855-881
Range on HMM: 208-234/234
Sequence Identity: 59% (16 aa)

TRLLCEEKMKTEDLLHRMLPQSVAEKL
.|.| ||| ||.|||. |.| |||..|
HRELEEEKKKTDDLLYSMFPKSVANRL