Gene phl (Fruit Fly)

phl

Species: Fruit Fly
Alias: l(1)2Fe, raf-like-oncogene-1, 11-29, l(1)raf, DRaf, l(1)ph, RAF, rafl, raf, pole-hole, D-raf1, l(1)ph: pole-hole, l(1)phl, Draf, ph: polyhomeotic, ph, CG2845, D-Raf, raf1: raf-like-oncogene-1, phl, Draf1, D-raf, Raf1, EG:BACH48C10.3, Raf, l(1)polehole, l(1)pole hole, SFO059, Draf-1, D-RAF, C110, raf1
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 3A1,

Classification

Group: TKL
Family: RAF
Subfamily: RAF

Sequence

Name Sequence Type Origin Length Description Download
phl.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON
phl.AA Protein Various 739 None Fasta, JSON

Protein domain

Protein domains of phl.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RBD phl.AA RBD 141-212 36 5.4e-32 113.66 Pfam 1-77 (77) Show / Hide 
Range on Protein: 141-212
Range on HMM: 1-77/77
Sequence Identity: 36% (28 aa)

ILLRAHLPNQQRTSVEVISGVRLCDALMKALKLRQLTPDMCEVSTTH----SGRHIIPWHTDIGTLHV-EEIFVRLL
.....||||.||..|||..|....|.|||..| ..|.|..|.|....    .......|||||..|.. .|..|..|
KFCCVHLPNNQRCVVEVRPGMTVRDMLMKICKRHGLNPMCCHVYRVGDPHEGEKKPLDWHTDISWLPGPQELWVENL
RBD phl.AA RBD 141-212 34 3.1e-28 101.06 SMART 1-76 (76) Show / Hide 
Range on Protein: 141-212
Range on HMM: 1-76/76
Sequence Identity: 34% (26 aa)

ILLRAHLPNQQRTSVEVISGVRLCDALMKALKLRQLTPDMCEVSTTHS----GRHIIPWHTDIGTLHVEEIFVRLL
.. . |||..|||.|.|..|....|.|||..| |.|.|..|.| ..|.    ......||..| .|. .|..|...
KFCCVHLPDNQRTVVKVRPGMTVHDMLMKICKKRGLNPECCHVFRRHHPHEGEKKPLDWHQPISYLPGQELWVENR
C1_1 phl.AA C1_1 223-271 25 8.1e-15 58.05 Pfam 1-55 (55) Show / Hide 
Range on Protein: 223-271
Range on HMM: 1-55/55
Sequence Identity: 25% (14 aa)

HQIIRK-TFFSLVFCEGCRRLL-----FTGFYCSQCNFRFHQRCANRVPMLCQPF
|..... .| . .||. |. ..     ..|. |..|....|.||...||..|.. 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 phl.AA C1 223-268 22 1.6e-11 45.52 SMART 1-61 (61) Show / Hide 
Range on Protein: 223-268
Range on HMM: 1-61/61
Sequence Identity: 22% (14 aa)

HQIIRKTFFSLVFCEGCRRLLFT---------GFYCSQCNFRFHQRCANRVPM-------LC
|. ....| .  .|. || ....         |. || |....|..|. .||         |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 phl.AA C1_3 234-261 30 1.1e-09 26.17 Pfam 1-30 (30) Show / Hide 
Range on Protein: 234-261
Range on HMM: 1-30/30
Sequence Identity: 30% (9 aa)

VFCEGCRRLLF--TGFYCSQCNFRFHQRCA
 .|. | . .    ...|.||.| .|..||
FTCNCCGLPIYRDPFYHCMQCDFMLHEDCA
C1_2 phl.AA C1_2 235-261 34 0.000191 14.59 Pfam 1-32 (32) Show / Hide 
Range on Protein: 235-261
Range on HMM: 1-32/32
Sequence Identity: 34% (11 aa)

FCEGCRRLLFT---GFYCSQCN--FRFHQRCA
 |. ||| .     ...|. |.  |  | |||
WCDVCRRKIDGFYWFYHCKKCCCDFTVHVRCA
Kinase phl.AA RAF 429-688 65 4e-194 635.24 In-house 1-282 (282) Show / Hide 
Range on Protein: 429-688
Range on HMM: 1-282/282
Sequence Identity: 65% (185 aa)

ILIGPRIGSGSFGTVYRAHWHGPVAVKTLNVKTPSPAQLQA---FKNEVAMLKKTRHCNILLFMGCVSKPS---LAIVTQWCEGSSLYKHVHVSET--KF
. ...||||||||||||.||||.||||.|||..|.|.|.||   ||||||..|||||||||||||..|||.   .||||||||.||||.|.||.||  ||
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

KLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWS--GEKQANQPTGSILWMAPEVIR-----------MQELNPYSF
....||||.|||.||||||||||||||||||||||||||..||||||||.|.|||||  |..|..|||..||||||||||           ||. |||||
DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSF

QSDVYAFGIVMYELLAECLPY-GHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLEN
|||||.||||||||.....|| .||.|.|||.||.|||.||||.|.||.|.|.|..||.|||.|.....||||...|.... 
QSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase phl.AA RAF 429-686 57 1.3e-181 609.6 In-house 1-275 (275) Show / Hide 
Range on Protein: 429-686
Range on HMM: 1-275/275
Sequence Identity: 57% (159 aa)

ILIGPRIGSGSFGTVYRAHWHGPVAVKTLNVKTPSP-AQLQAFKNEVAMLKKTRHCNILLFMGCVSKP---SLAIVTQWCEGSSLYKHVHVSET-KFKLN
..|| |||.|.||||||.||||.|||||||.|.|.| .|||||||||.|.|||||.||.||||...||   ..|||||||.||.||.|.|| .| ||..|
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN

TLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAK-TRWS--GEKQANQPTGSILWMAPEVIRMQ---------ELNPYSFQSDV
..|.| .|..||||||||||||||||||.|||||....|.|.||||.| | .||.  ...|..||.|.|.|||||||||.         . ||.||||||
WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV

YAFGIVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNML
||||.|.|||.|...||.||....||..||.|| ||.|.|..|...|...|.| ..|..|.|..||.|. ...|.
YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase phl.AA TKL 435-686 26 2.7e-95 322.88 In-house 1-364 (364) Show / Hide 
Range on Protein: 435-686
Range on HMM: 1-364/364
Sequence Identity: 26% (98 aa)

IGSGSFGTVYRAHWHG-----------PVAVKTLNVK------------------------TPSPAQLQAFKNEVA-MLKKTRHCNILLFMG-CVSKPS-
||||.||.||...|.|           .||||.....                         | . ... |..|.. |....|| ||..||| | . |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHA--------KNIIHRDLKSNNIFLHEDLS--------------V
            |.||...|.| ||. ..|       .. .... ...|.||.|||.        ..||||||||.||...|..               .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDFGLATAKT------------------RWSGEKQANQPTGSILWMAPEVIRMQEL-------------NPYSFQSDVYAFGIVMYELLAECLPYGHI
||.||||.. ..                  . ...|. . . |.. ||||||.|.|.               .|| ..|||.||||..|.|. |.|| ..
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

SNKDQI------LFMVGRG--LLRPDMS---------QVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNML
 . ..|      .......   ||| .          .  .|.|. .|.|..|| .. |..|| |  .|  |
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase phl.AA KSR 429-686 38 2.4e-74 252.85 In-house 1-272 (272) Show / Hide 
Range on Protein: 429-686
Range on HMM: 1-272/272
Sequence Identity: 38% (105 aa)

ILIGPRIGSGSFGTVYRAHWHGPVAVKTLNVK-TPSPAQ-LQAFKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEG-SSLYKHVHVSETKFKLNT
...|..|| | ||.|.|.|||| ||.|... .      . | .|| ||.|.|.||| || |||| |.. | ||||.  | |  .|| |.||  .|. .|.
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

LIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAK---TRWSGEKQANQPTGSILWMAPEVIRMQEL---------NPYSFQSDVY
 ..| .| .||| ||||| ||| |||| |||.     | | ||||   .       .| ..  | |    .||| ||             .|.| .||||
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

AFGIVMYELLAECLPYGHISNKDQILFMVGRG-LLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNML
||| . ||...  .|. .     .|.. ...|  .|.....|   . . .| .   |  | | .|| |  .. ||
AFGTIWYEMICGEWPF-KYQCAESIIWQMCQGEGMRQVLRNVQ--CGREMKEILMMCWSYEPQERPTFQDIMKML
Kinase phl.AA Pkinase 429-686 25 1.2e-73 255.74 Pfam 1-293 (293) Show / Hide 
Range on Protein: 429-686
Range on HMM: 1-293/293
Sequence Identity: 25% (76 aa)

ILIGPRIGSGSFGTVYRAHWHGP---VAVKTLNVKTPSPAQLQAFKN--EVAMLKKTRHCNILLFMGCV-SKPSLAIVTQWCEGS----SLYKHVH-VSE
. || .|||||||.||..|..|    ||||...... .. ..|.  .  |....|. .|.||. . ... .|... .|. .|||     .|. ...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TKF--KLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSV----KIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDV
..|    ...... .|...|..|.|...|||||||. ||.....  .    ||.|||||  .  .     .. ..|.. .|||||||  . ..|.  .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDM

YAFGIVMYELLAECLPYGHI-----SNKDQILFMVGRGLLRPDMSQVRSDA----------------PQALKRLAEDCIKYTPKDRPLFRPLLNM--L
...|...||.|   .|. .       ...|........ |. | .. .|                  ....| . ..|... ||.|| .. .|.   .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase phl.AA TKL-Unique 431-686 31 3.1e-65 223.03 In-house 1-290 (290) Show / Hide 
Range on Protein: 431-686
Range on HMM: 1-290/290
Sequence Identity: 31% (94 aa)

IGPRIGSGSFGTVYRAHWHG-PVAVKTLNV-KTPSPAQLQAFKNEVAMLKKTR-HCNILLFMG-CV----SKPSLAIVTQWCEGSSLYKHVH--------
..  ||.|..|.||.. |.| |||.|....   .|.  .| |.|||  .|| . | ||...|| |.    . | . ||.  |.|.|||.. |        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-VSETKFKLNTLIDIGRQVAQGMDYLHAKN--IIHRDLKSNNIFLHED-----LSVKIGDFGLATAKTRWSGEKQANQ-------PTGSILWMAPEVIRM
  ...|. ..  ... ...||||.||| ..  |||||||| |. . ..     ...|| ||||.. ... . ..  .        . ||..||||||.||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

QELNPYSFQSDVYAFGIVMYELLAECL------PYGHISNKDQILFMVGR--GLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNML
 . . || .||||.||||..|..  ..      || .. . .|.. ||      .||  ..   . |. .. | ..| .  | .|| |   .. |
NF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYMEENYRPPIPN---HCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase phl.AA Pkinase_Tyr 429-686 28 1.1e-62 212.99 Pfam 1-270 (270) Show / Hide 
Range on Protein: 429-686
Range on HMM: 1-270/270
Sequence Identity: 28% (81 aa)

ILIGPRIGSGSFGTVYRAHWH-------GPVAVKTLNVKTPSPAQ--LQAFKNEVAMLKKT-RHCNILLFMGCVS--KPS--LAIVTQWCEGSSLYKHVH
| .|  .|.|.||.||...|.        |||||.|   . .. |  ...| .|....|.  .| ||. ..|...  . .  . ||.  ... .|... .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

VS---ETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQAN-QPTG----SILWMAPEVIRMQELNPYS
     . .... .|... .|.|.||.||..||.|||||   |. ..|.. |||.||||| .      ..    . .|     | |||||.|.  .   ..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI----YNDDYYYRKRGGGKLPIKWMAPECINYGK---FT

FQSDVYAFGIVMYELLAEC-LP-YGHISNKDQILFMV--GRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNML
 .|||..||..|.|..  .  | |  .|| . . .    |. . .|.      ..|. . .|  .| .| |.||| |. ....|
TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPE------NCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase phl.AA TK 429-686 17 1.3e-61 204.96 In-house 1-486 (486) Show / Hide 
Range on Protein: 429-686
Range on HMM: 1-486/486
Sequence Identity: 17% (83 aa)

ILIGPRIGSGSFG---TVYRAHWHG----------------------------PVAVKTLNVK-TPSPAQLQA--------------FKNEVAMLK--KT
| .|  .|.| ||   .||.. |.|                            |||||.|  . . |... ..              . .| .|..  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHCNILLFMGCVSKPS-------------LAIVTQWCEGSS----LYKHVHVSETK--------------------------------------------
.| ||. . |.....              . ||. .... .    | .. . .  |                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FKLNTLIDIGRQVAQGMDYLHAK------NIIHRDLKSNNIFLHEDLS-----------VKIGDFGLAT
                               . . .|. . .|.|.|| |||.|      |..||||   |. ..|..            .||.||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

AKT----RWSGE-----KQANQPTGS-----------------------ILWMAPEVIRMQE------LNPYSFQSDVYAFGIVMYELLAEC-LPYGH-I
...    |  ..     .. .. ||                        | |||||... ..       . .. .|||..||..|.|..  .  ||.  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN--------KDQILFMVGRG--------------LLRPDMSQVR----------SDAPQALKRLAEDCIKYTPKDRPLFRPLLNML
||         .... .. ||              . .|   .            . .|... .|  .| .| |.||| |. |...|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase phl.AA Dicty4 429-688 34 5.3e-60 198.87 In-house 1-277 (277) Show / Hide 
Range on Protein: 429-688
Range on HMM: 1-277/277
Sequence Identity: 34% (99 aa)

ILIGPRIGSGSFGTVYRAHWHG-PVAVKTL-NVKTP-SPAQLQAFKNEVAMLKKTRHCNILLFMG-CV----SKPSLAIVTQWCEGSSLYKHVHV-----
| |. |||.||||.||.. | |  |||| | | ..  . . |..|..||. ..| || ||.|||| |      .... |||  .   .||.  |      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-SETKFKLNTLID---IGRQVAQGMDYLHAKN--IIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQ-ANQPTGSILWMAPEVIRMQELNPYSFQ
 ...|  . . .    ... .|.|| .||. |  |||||||| |.   ... ||..||||.. . . .  |. .  . |. .|||||| . |   ||   
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQ---PYNEK

SDVYAFGIVMYELLAECLPYG-HISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNM--LEN
.||| |||| .|.|    ||  |... .|. . |..  ||| ...   . |  .|.| ..|    |. || |   ..   || 
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPD---WCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase phl.AA S_TKc 429-690 23 3.5e-56 193.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 429-690
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

ILIGPRIGSGSFGTVYRAHWHG---PVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGCVSKPSLAIVTQWCEG--SSLYKHVHVSETK----
  |.  ||.|.||.||......    ||.| ..         . ...|...||| .| ||  . ..    .| .|.  |.|   .|... .   ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSF-QSDVYAFGIV
 |   .   . .|......|.| ..|||||||  ||.| |   .||.|||||.           .   |.  .|||||.      .|..  .|....|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

MYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLN-----MLENML
.||.|. . |.    . .... ..|               .. .| . . | .. |..||    .|.     ..   .
LYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase phl.AA MLK 429-686 29 8.5e-55 188.36 In-house 1-291 (291) Show / Hide 
Range on Protein: 429-686
Range on HMM: 1-291/291
Sequence Identity: 29% (87 aa)

ILIGPRIGSGSFGTVYRAHWHGPV-AVKTLNVKTPSP---------AQLQAFKNEVAMLKKTRHCN----ILLFMGCVSKP-S-LAIVTQWCEGSSLYKH
|..   ||||||| |... |..    .|.. ||             .. ..|. |.  |.. .| |    |  |.|. ..| . ..||...|||.|||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

VHVSET-------------KFKLNTLIDIGRQVAQGMDYLHAKN---IIHRDLKSNNIFLHE------DLSVKIGDFGLATAKTRWSGEKQANQPTGSIL
 |  ..               ..  ....  |.|.||.|||..    |||||||| || ..|      .. .|| |||... ...   .   ... |.  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTYA

WMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYG-HISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNML
|||||||   . ..||  .||. .|.|..|.|.  .||  |...   .  ..  || .|    ..|..|  .|.| ..| .  |..|| ||  .  |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPP----IPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase phl.AA STE 430-628 23 9.5e-49 168.27 In-house 1-268 (359) Show / Hide 
Range on Protein: 430-628
Range on HMM: 1-268/359
Sequence Identity: 23% (65 aa)

LIG-PRIGSGSFGTVYRAHWHGP------------------VAVKTLNVKTPSP---------------AQLQAFKNEVAMLKKTR--HCNILLFMGCVS
. |  .||.|.|||||.|  | .                  .|.| .|... ..                ..| ...|. ..|| .  | ||  . ||  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KP--------SLAIVTQWCEGSSLYKHVH-VSETKFK------------LNTLIDIGRQVAQG-MDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLAT
|         .| |.  ...| || . .. . ....              . .. | ||. .| ..||| ..|||||.|. ||.|     ||. |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

AKTR--------------WSGEKQANQPTGSILWMAPEVIRMQE---LNPYSFQSDVYAFGIVMYELLAECLPY
  |                .. .. |  .|.  |||||||. ..    ..|....|.. .|... |..  . |.
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW
Kinase phl.AA TyrKc 429-686 26 1.3e-48 168.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 429-686
Range on HMM: 1-280/280
Sequence Identity: 26% (78 aa)

ILIGPRIGSGSFGTVYRAHWHGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKT--RHCNILLFMGCVSK--------PSLAIVTQWCEGSSLYKHVHVSET
|  |  .|.| ||.||...|  .||||.|.  .     ...| .|  ...|   .| ||. . |....        . | ||.  ... .| .. . .. 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRW------SGEKQAN---QPT--GSILWMAPEVIRMQELNPYSF
|... .|...  |.|.||.||| ||.|||||   |. ..|.. |||.||||. . .        .  . .    .      | |||||.|     . ...
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTT

QSDVYAFGIVMYELLAEC-LPYGH-----ISNKDQILFMVGRGLLRPDMSQVRSD-----APQALKRLAEDCIKYTPKDRPLFRPLLNML
.|||..||..|.|..  .  ||       .||.. ..  | .|  .| .  .        .|... .. ..| .. |.||| |. .   .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE-VIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase phl.AA LRRK 429-688 24 5.2e-47 162.51 In-house 1-351 (351) Show / Hide 
Range on Protein: 429-688
Range on HMM: 1-351/351
Sequence Identity: 24% (85 aa)

ILIGPRIGSGSFG-TVYRAHWHG-----------------------------PVAVKTLNV--------------------------------KTPSPAQ
. |.. ||.|.|| .|||| | |                             .||.|..|.                                 . ..  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LQAFKNEVAMLKKTRHCNILLFMGCVSKPSLAIVTQWCEGSSLYKHVH---VSE-----TKFKLNTLIDIGRQVAQGMDYLHAKN--IIHRDLKSNNIFL
.. | .||... . .| ||.  .|   .| |..|.      .||.. |    ..     .... .... |  |.| ||.||| .|  |||||||| ||.|
FREFRHEVWIMSHLNHPNIVSLKGFCIHP-LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

--H----------EDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQ-ELNPYSFQSDVYAFGIVMYELLAEC-LPYGHISNKDQILFMVG
  .          ..  .||.|||. .      ... |.  .| ..|||||..|   | . |. ..|.|.||....|||    .|..... .|.. .|  
WSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEE-YTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQ

RGL-----LRPDMS---QVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLEN
  .     |||  .   . .   .  .. | ..| .  ||.|| |   .  |. 
IEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ