Gene CG7125 (Fruit Fly)

CG7125

Species: Fruit Fly
Alias: CG7125, SFO152, PKCm
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 91A2,

Classification

Group: CAMK
Family: PKD

Sequence

Name Sequence Type Origin Length Description Download
CG7125.AA Protein Various 811 None Fasta, JSON
CG7125.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of CG7125.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PKD_Nterm_DUF CG7125.AA PKD_Nterm_DUF 6-91 49 4.6e-54 178.18 In-house 1-87 (87) Show / Hide 
Range on Protein: 6-91
Range on HMM: 1-87/87
Sequence Identity: 49% (43 aa)

VTFLFQFGSVRDAVCVPANSLTLKTLKDLACDFINTKIPDSGLTY-LSERILLFVHDYSTPNVLHIINSAAEVVDETLVEIVLTASP
..|.||.|..|..|||....|||..||.|||.||..|.||.|... |...|.||.|||..||.|..|.||..|....|.||||.|.|
CHFHFQCGFHREMVCVEGHELTLTALKELACQFIEQKYPDCGCCNRLYDKIYLFRHDYNSPNILQMITSASDVTEGCLIEIVLSACP
C1_1 CG7125.AA C1_1 105-157 43 9.6e-16 61.45 Pfam 1-55 (55) Show / Hide 
Range on Protein: 105-157
Range on HMM: 1-55/55
Sequence Identity: 43% (24 aa)

HSLNVH-SYKGPTFCDFCGEMLFG-LVRQGLKCDGCGQNYHKRCVVKIPNNCNRS
|   .| ..|.||||. |||...| | .||.||. |. |.|.||. | |..|  .
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 CG7125.AA C1 105-154 27 1.8e-15 58.65 SMART 1-61 (61) Show / Hide 
Range on Protein: 105-154
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HSLNVHSYKGPTFCDFCGEMLFGLVRQ-----GLKCDGCGQNYHKRCVVKIPN-------NC
|.   ... .||.|. |..|..|. .|     |..|  |. ..||.|..|.|.       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 CG7125.AA C1_3 116-147 21 5.3e-05 14.23 Pfam 1-30 (30) Show / Hide 
Range on Protein: 116-147
Range on HMM: 1-30/30
Sequence Identity: 21% (7 aa)

TFCDFCGEMLFGLVRQGLKCDGCGQNYHKRCV
 .|. ||. . .  . . .|  |  . |..|.
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
C1 CG7125.AA C1 223-272 37 5.9e-19 70.21 SMART 1-61 (61) Show / Hide 
Range on Protein: 223-272
Range on HMM: 1-61/61
Sequence Identity: 37% (23 aa)

HTFMVHTYGIPTVCQLCKKLLKGLFKQ-----GLQCRDCQYNTHKKCMDKVPH-------DC
|... ...  || |..|.|...|.|||     |..|..|.|. ||||.||||        .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 CG7125.AA C1_1 223-275 36 3.3e-16 63.17 Pfam 1-55 (55) Show / Hide 
Range on Protein: 223-275
Range on HMM: 1-55/55
Sequence Identity: 36% (20 aa)

HTFMVH-TYGIPTVCQLCKKLLKG-LFKQGLQCRDCQYNTHKKCMDKVPHDCTGE
| ...| ..  || | .|.... | |..||..|..|.|| |..|. |||  | . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1_3 CG7125.AA C1_3 234-265 18 0.000276 12.4 Pfam 1-30 (30) Show / Hide 
Range on Protein: 234-265
Range on HMM: 1-30/30
Sequence Identity: 18% (6 aa)

TVCQLCKKLLKGLFKQGLQCRDCQYNTHKKCM
  |..|.. ...    .  |  | .. |..| 
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
PH CG7125.AA PH 383-460 17 0.000306 17.94 Pfam 1-72 (92) Show / Hide 
Range on Protein: 383-460
Range on HMM: 1-72/92
Sequence Identity: 17% (14 aa)

ALKEGWLVHYTSLDKAVKRYYWRLDSKTITLFVSEQGSKYHKELPLAELLSIESHLGDPRPECNYCFELRLPNL-SYFV
  |||||  ..   |  |...  | .... .. ... ... . .|| .. ... .      . ..||..|  .  .|..
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDN---KRPHCFQIRT-DRRTYYF
PH CG7125.AA PH 383-502 13 0.000844 19.87 SMART 1-82 (82) Show / Hide 
Range on Protein: 383-502
Range on HMM: 1-82/82
Sequence Identity: 13% (16 aa)

ALKEGWLVHYTSLDKAVKRYYWRLDSKTITLFVSEQGSKYHKELPLAELLSIESHLGDPRPECNYCFELRLPNLSYFVGQDPQVGAKEEQAVRLPPPDSG
 .||||| ...      |... .|........ ..   |. ...|| .. ...            |||..  .               .  .. .     
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDC-TVRE-P---------CFEIHH-DR--------------TYYFQCE-----

IGSDIAKSWETSIRQAFMHV
  .. ...| ..|..|  . 
-SEEEMQEWMQAIQKAIHNN
Kinase CG7125.AA PKD 523-779 85 2.7e-231 774.7 In-house 1-260 (260) Show / Hide 
Range on Protein: 523-779
Range on HMM: 1-260/260
Sequence Identity: 85% (221 aa)

IFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQ--EAQLKNEVAILQNISHCGVVNLERMFETPERIFVVMEKLKGDMLEMILSHARGRLSE
|||||||||||||.||||.|..|.|.||.||||||||||||  |.|..|||||||...|.|||.||.|.|||.||||||||..|||||||||...|||.|
IFPDEVLGSGQFGIVYGGIHRHTGRHVAVKVIDKLRFPTKQSGEEQMRNEVAILQQVCHPGVVCLECMCETPDRIFVVMEKMHGDMLEMILSSEKGRLNE

RVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSSD-AEFPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSG
|||||||||||.||||||.|||||||||||||||||. ..||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
RVTKFLITQILCALKYLHHQNIVHCDLKPENVLLSSMGSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSG

TFPFNEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLLHYWL
||||||.|||||||||||||||||||||||.|||||||||||||.||||||||.| |.||
TFPFNEDEDINDQIQNAAFMYPPNPWKEISENAIDLINNLLQVKMRKRYTVDKCLSHPWL
Kinase CG7125.AA CAMK 528-779 22 9.1e-106 341.86 In-house 1-425 (425) Show / Hide 
Range on Protein: 528-779
Range on HMM: 1-425/425
Sequence Identity: 22% (97 aa)

VLGSGQFGVVYGGVHKKTQ------------REVAIKVIDK----------------LRFP----------TKQEAQLKNEVAILQN-------ISHCGV
.||.|.||.|. ..||.|.            ..||||.|||                ...            | ......|..|...       ..|  .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLERMFE------------TPER--------IFVVM---EKLKG-----DMLEMILSHAR-------------GRLSERVTKFLITQILIALKYLHSQN
..|  ..|            | ..        .. ||   |   |     |....| .| .             ||..|| ..... ||. |..|.||.|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHCDLKPENVLLSSDAEFP--------------QVKLCDFGYARIIGE------------------------KSFRRSVVGTPAYLA-PEVLRN-----
|||.||||||.||... .                ..|..||| |... .                            . ..|||.| | ||||.      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KGYNRSLDMWSVGVIIYVSLSGTFPFNEE---------------EDINDQIQNAAFMYPPNP------------WKEISSN--------AI
         ..|... ||||.||| |. |.|..||...               ...  .|... . .|| .            |..|| .        ..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLINNLLQVKQRKRYTVDKSLLHYWL
|||...|||   ||.|..  | | |.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CG7125.AA RAD53 526-779 33 1.4e-97 291.24 In-house 4-305 (305) Show / Hide 
Range on Protein: 526-779
Range on HMM: 4-305/305
Sequence Identity: 33% (103 aa)

DEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFP------TKQEAQLKNEVAILQNISHCGVVNLERMFETP-ERIFVVMEKLKG-DMLEMILSHARGR
...|||| ||.|. .. ||| . |||| ||| .|       .| . |. ||| ||....|  .....  |.|| .  . |.|.  | . .. | |  ..|
SKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVS--NKR

----LSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSSDAEFP---------------QVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNK
    ..|   |..  |.. |.||||...|.| ||||||.|.....|                 ..|. ||| ....||.|| .   |||.|.||||...|
CQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSK

---------------GYNRSLDMWSVGVIIYVSLSGTFPFNEE-------EDINDQIQN-AAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLL
               ||... |.|| |.| |..|.|. || ..        ....|| | . . .|.  |..||..| |||...|.|   ||||.|. | 
GHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALN

HYWL
| |.
HPWM
Kinase CG7125.AA S_TKc 523-779 32 5.9e-90 306.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 523-779
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

IFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEVAILQNISHCGVVNLERMFETPERIFVVMEKLKG---DMLEMILSHARGR--
    ...|.| ||.|| ..||||.|.||||.|.          ....|..||..  |  .|.|  .|.. .....||| . |   |....| .. |..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSSDAEFPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNR-SLDMWSVGVIIY
  ..| ...|.. ||. ||.|.||..|.|.||||||.||..     ..|.|||| ||..      ....||| |.|||||   ||.. . |.||.|.|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

VSLSGTFPFNEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLL-------HYWL
  |.|  ||    ...  ...             |. |.|.|...||.  .||.|. . |        | |.
EMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CG7125.AA CAMK1 521-779 33 1.5e-86 251.59 In-house 1-276 (276) Show / Hide 
Range on Protein: 521-779
Range on HMM: 1-276/276
Sequence Identity: 33% (95 aa)

YQIFPDEVLGSGQFGVVYGGVHKKT---QREVAIKVID-KLRFPTKQE---AQLKNEVAILQN---ISHCGVVNLERMFETPERIFVVMEKLK-GDMLEM
|...  ...|.| |..|| ..||.|   ....|||.|| |    .| .   ..|.||..|...   |.|  .....  .|... .  ||| .. |. .. 
YEFG--KEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDR

ILSHARGRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSSDAEFPQVK--LCDFGYARIIGEKS-FRRSVVGTPAYLAPEVLRN---KGYNRS
|.   .|  .|.    .. ||| |..|.||..|||.|||||| |...  |  ..|  ..||| ..|..... .   ..||| | ||||| .   |.|  .
IV--EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKA

LDMWSVGVIIYVSLSGTFPFNEEE-D--INDQIQNAAFMYPPNPWKEISSN-AIDLINNLLQVKQRKRYTVDKSLLHYWL
 ||||.||| |. | |  ||..|  |  . ..| .. . .| . | .||.  | |.|...| |   ||||....| | |.
CDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase CG7125.AA AGC 523-767 22 1.6e-84 217.64 In-house 1-373 (395) Show / Hide 
Range on Protein: 523-767
Range on HMM: 1-373/395
Sequence Identity: 22% (84 aa)

IFPDEVLGSGQFGVVYGGVHK------KTQREVAIKVIDKLR--FPTK--QEAQLKNE------------VAILQNIS----------HCGVVN-LERMF
     |.| | || ||   .|       |..  |.||..| .    .|  .... ..|              ||....          |  .|. |   |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETPER--IFVVME----KLK-----GD-MLEMILSH--ARGRLSERVTKFLITQ-------ILIALKYLHS-QNIVHCD-LKPENVLLSSDAEFPQVKLC
.....  .. |||     ..     |. .| ..| .   .||..| ...| . .       |. || |||| ..|.| | |||||.|| .|     .||.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLT

DFGYARIIG---------------------------------------------------EKSFRRSVVG--TPAYLAPEVLRNKGYNRSLDMWS--VGV
||| . ..                                                    ..    . .|  || |.|||.|    |... | ||  .|.
DFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGC

IIYVSLSGTFPFNEEE------------DINDQIQ------NAAFMYPPN------PWKEISSNAIDLINNLLQVKQRKR
..|  |.|  ||. ..            .. ..|.      |    .|..      .....|..| |||. ||..  .||
LMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKR
Kinase CG7125.AA Pkinase 523-779 31 1.5e-80 278.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 523-779
Range on HMM: 1-293/293
Sequence Identity: 31% (92 aa)

IFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKN--EVAILQNISHCGVVNLERMFETPERIFVVMEKLKGD----MLEMILS-HAR
.   ...||| ||.|| ..||.|...||.|.|.| .   ... .. .  |..|.....|. .| | ..||.. .| .||| . |.     |  ..| ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRL--SERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSSDAEF-PQVKLCDFGYARI--IGEKSFRRSVVGTPAYLAPEVLR-NKGYNRSLDMWSV
|..  ||.. || ..||| .|.|.||..|.|.||||||.|.... .  . ||.|||| |.   .  .|   ...||| |.||||.| ...| .. ||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVIIYVSLSGTFPFNEE--------EDINDQIQNAAFMYPPNPWKEIS-----------------SNAIDLINNLLQVKQRKRYTVDKSLLHYWL
|.|.|  |.| .|| ..          . ..|  . ....   | .||                 ....|.|...|...  ||.| .  | | |.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CG7125.AA CAMKL 521-779 29 4.6e-76 242.2 In-house 1-297 (297) Show / Hide 
Range on Protein: 521-779
Range on HMM: 1-297/297
Sequence Identity: 29% (88 aa)

YQIFPDEVLGSGQFGVVYGGVH-KKTQREVAIKVID--KLRFPTKQEAQ-----------LKNEVAILQNIS---HCGVVNLERMFETPER------IFV
|.|   ..|| | ||.|  ..| . |...||||.||  |..  .. ..            .. |..|.. ..   |  .. |  ..||||       |. 
YRI--GKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

VMEKLKGD---MLEMILSHAR--GRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSSDA-EFPQVKLCDFGYARIIGE-----KSFRRSVVGT
|||   |    ....| .| .  ||..|. .... .||. |..|.||..||| |.||||.||...  .  ..|..||| . .. .       . .   |.
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGS

PAYLAPEVLRN--KGYN-RSLDMWSVGVIIYVSLSGTFPFNEEEDI-------NDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLLH
|.| |||..    | |. .  |.|| ||| |. . |..||... .        .   ..    | |..|...|  ..|||  .|||.  ||.|..  . |
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

YWL
 |.
PWM
Kinase CG7125.AA Ciliate-E2 527-779 23 1.9e-69 237.04 In-house 5-365 (365) Show / Hide 
Range on Protein: 527-779
Range on HMM: 5-365/365
Sequence Identity: 23% (88 aa)

EVLGSGQFGVVYGGVHKKTQR------------------EVAIKVIDKLRFPTKQEAQLKNEVAILQNISHCG-----------------VVNLERMFE-
...|.|.||.|| . ..|.|.                  .|.|| . . ..  .|  |.|.|  |.. | . .                 ....   |. 
KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYECFQE

-TPERIFVVMEKLKG-DMLEMILSH----------ARGRLSERVTKFLITQIL---------------IALKYLHSQN-IVHCDLKPENVLLSSDAEFPQ
 . . |. ||| ..| |... | ..          . ....|.  |....|||                ||.||||.| |.| |.||||.|.        
KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------

VKLCDFGYARIIGEKSFRRS--------------------------------VVGTPAYLAPEVLRNKG---------YNRSLDMWSVGVIIYVSLSGTF
.|..|||..... ... .|.                                ..||| |.|||.|..|.         |. . |.||.|||.|  |.| .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFNEEEDINDQIQNAAFMYPPN--------------PWKEISSNAIDLINN----LLQVKQRKRYT-VDKSLLHYWL
||       .||..  . .|..               ||..| ...|||..    .||... ||.|  .. | | |.
PF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CG7125.AA DCAMKL 521-779 36 4.7e-68 210.62 In-house 1-279 (279) Show / Hide 
Range on Protein: 521-779
Range on HMM: 1-279/279
Sequence Identity: 36% (104 aa)

YQIFPDEVLGSGQFGVVYGGVHKKTQ-REVAIKV-----------------IDKLRFPTKQEAQLKNEVAILQNISHCGVVNLERMFETPERIFVVMEKL
|||    . | | | ||.  .|..|. .. | |.                 ||| .   | |    |||.|.| |.|  .. |   ..|.. .. |||  
YQIG--RIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGK-EHMIDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYV

K-GDMLEMILSHARGRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSS--DAEFPQVKLCDFGYARIIGE---KSFRRSVVGTPAYLAPEVLR
. ||  . | .   .. .||    ..|..  ||||||. |||| |.|||| |.    | |.  .|||||| | .. .     ..  | ||| | |||.|.
QGGDLFDAITEN--TKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEK-SLKLCDFGLACHVNGDFGPLYT--VCGTPTYVAPEILM

NKGYNRSLDMWSVGVIIYVSLSGTFPF----NEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLLHYWL
 .||    |.|..||| |. | |  ||    |..|.  |||. ..| .|   |..||. | |||...||| . ||||    . | | 
ETGYGCKVDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV
Kinase CG7125.AA ULK 523-779 27 1.8e-62 213.82 In-house 1-324 (324) Show / Hide 
Range on Protein: 523-779
Range on HMM: 1-324/324
Sequence Identity: 27% (91 aa)

IFPDEVLGSGQFG-VVYGGVHKKT---QREVAIKVIDKLRF-PTKQEA-------QLKNEVAILQNIS------HCGVVNLERMFETPER--IFVVMEKL
.  ...||.|.|| .|| | .|||   .  ||.|.|||  .   |.|.       .||||. |.. .       |  .| |  .|||.    |. .||  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

KG-DMLEMILSHAR-------GRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSS-DAEF--------PQVKLCDFGYARIIGE----KSFRR
 | |  . |  . .       .||||  ..  . ||. ..|.||..||.|.|.||.| |..  .. .        ...|..||| |... .    .  . 
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

SVV------GTPAYLAPEVLR----NKGYNRS-LDMWSVGVIIYVSLSGTFPFNEEEDINDQ----------------IQNAAFMYPPN-PWKEISSNAI
. |      ||| | ||..|     .| |. .  |.||.|.|.|  | |  ||..    ...                |.|  . .|.. . . ||.. .
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

DLINNLLQVKQRKRYTVDKSLLHYWL
|||  .||.....| . .  . | |.
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase CG7125.AA ULK 523-779 27 3.2e-62 213.03 In-house 1-329 (329) Show / Hide 
Range on Protein: 523-779
Range on HMM: 1-329/329
Sequence Identity: 27% (92 aa)

IFPDEVLGSGQFGVVYGGVHKKT----QREVAIKVIDKLRF-PTKQEAQ-------LKNEVAILQNIS--------HCGVVNLERMFETPER--IFVVME
.  ...||.|.||.|| | .|||    .  ||.|.|||  .   ..|..       ||||. |.. .         |. .| |  .|||.    |. .||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

KLKGDMLEMILSHARG---------RLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSS-DAEF--------PQVKLCDFGYARIIG----EKS
   |  || ...  ..         ||||  ..  . ||| ..|.||..||.|.|.||.|.|..  .. .        ...|..||| |. .     |. 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

FRRSVV------GTPAYLAPEVLR----NKGYNRS-LDMWSVGVIIYVSLSGTFP----FNEEE-----DINDQ-------IQNAAFMYPPN-PWKEISS
   . |      ||| | ||..|     .| |. .  |.||.|.|.|  | |  |    ||..      .  ..       |..  . .|.. . . ||.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

NAIDLINNLLQVKQRKRYTVDKSLLHYWL
. .|||  .||.....| . .  . | |.
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase CG7125.AA TyrKc 523-759 20 1.1e-13 -1.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 523-759
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

IFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEVAILQNI--SHCGVVNLERMFETP-------ERIFVVME--KLKGDMLEMIL
|  ...||.|.||.|| |. |   ..||.|.. .       .. . .|  |. ..  .|  .|.|     ..       | ...|||  .. || .. . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLR

SHARGRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSSDAEFPQVKLCDFGYARIIGEK--------SFRRSV-VGTP-----AYLAPEVLRN
.| .  |. .      .||     ||||.|..| ||   |.|....    .|| .||| .| |...          | .   |.        .|||... 
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

KGYNRSLDMWSVGVIIY--VSLSGTFPFN------EEEDINDQIQNAAFMYPPNP--------------------WKEISS---NAIDLINNL
. ..   | || || ..   .. .. . .      . ...  ....   | .|                      |.|  .   .  ...  .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CG7125.AA Pkinase_Tyr 526-579 29 9.7e-08 26.84 Pfam 4-63 (270) Show / Hide 
Range on Protein: 526-579
Range on HMM: 4-63/270
Sequence Identity: 29% (18 aa)

DEVLGSGQFGVVYGGVHK----KTQREVAIKVIDKLRFPTKQ--EAQLKNEVAILQNI-SH
...||.|.||.|| |. |    .|. .||.|.. |     .|   . . .|..|. .. .|
GKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHH
Kinase CG7125.AA Pkinase_Tyr 633-701 28 0.000719 13.73 Pfam 123-192 (270) Show / Hide 
Range on Protein: 633-701
Range on HMM: 123-192/270
Sequence Identity: 28% (21 aa)

ALKYLHSQNIVHCDLKPENVLLSSDAEFPQVKLCDFGYARIIGEKSFRRSVVGT-----PAYLAPEVLRNKGYN
.. ||.|.|..| ||   |.|...     .|| |||| || | ...   .....        .|||..... ..
GMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFT