Gene Pkc53E (Fruit Fly)

Pkc53E

Species: Fruit Fly
Alias: PKC 53E, Pkc1, PKC 53B, CG6622, Pkc53E, Dpkc1, dPKC53E(br), PKC, PKC1, DPKC, protein kinase C, dPKC, SFO115
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 53E9--F1,

Classification

Group: AGC
Family: PKC
Subfamily: PKCa

Sequence

Name Sequence Type Origin Length Description Download
Pkc53E.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
Pkc53E.AA Protein Various 670 None Fasta, JSON

Protein domain

Protein domains of Pkc53E.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C1_1 Pkc53E.AA C1_1 46-98 47 1e-22 86.59 Pfam 1-55 (55) Show / Hide 
Range on Protein: 46-98
Range on HMM: 1-55/55
Sequence Identity: 47% (26 aa)

HCFIAR-FFKQPTFCSHCKDFIWG-FGKQGFQCQVCSYVVHKRCHEYVTFICPGK
| .... .|||||||.||..|.|| .|.||..||.| |..|.|||. |.  |...
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 Pkc53E.AA C1 46-95 35 2.1e-15 58.41 SMART 1-61 (61) Show / Hide 
Range on Protein: 46-95
Range on HMM: 1-61/61
Sequence Identity: 35% (22 aa)

HCFIARFFKQPTFCSHCKDFIWGFGKQ-----GFQCQVCSYVVHKRCHEYVTF-------IC
| .... | .||.|.||...|||. ||     |..|..| |..||.||. |.         |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 Pkc53E.AA C1_3 76-88 30 0.096601 5.93 Pfam 18-30 (30) Show / Hide 
Range on Protein: 76-88
Range on HMM: 18-30/30
Sequence Identity: 30% (4 aa)

CQVCSYVVHKRCH
|  | ...|..| 
CMQCDFMLHEDCA
C1_1 Pkc53E.AA C1_1 111-163 43 2.7e-24 91.83 Pfam 1-55 (55) Show / Hide 
Range on Protein: 111-163
Range on HMM: 1-55/55
Sequence Identity: 43% (24 aa)

HNFEPF-TYAGPTFCDHCGSLLYG-IYHQGLKCSACDMNVHARCKENVPSLCGCD
|..... .. .||||.|||....| ..|||.||..| .|.|.|| ..||..|||.
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 Pkc53E.AA C1 111-160 27 2.1e-20 75.04 SMART 1-61 (61) Show / Hide 
Range on Protein: 111-160
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HNFEPFTYAGPTFCDHCGSLLYGIYHQ-----GLKCSACDMNVHARCKENVPS-------LC
|...  .. .||.|.||.....|...|     |..||.|....| .|...||.        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 Pkc53E.AA C1_3 122-152 29 0.000261 12.46 Pfam 1-29 (30) Show / Hide 
Range on Protein: 122-152
Range on HMM: 1-29/30
Sequence Identity: 29% (9 aa)

TFCDHCGSLLYGIYHQGLKCSACDMNVHARC
 .|. ||  .|.  . . .|. || ..| .|
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDC
C2 Pkc53E.AA C2 182-269 54 1e-39 137.93 Pfam 1-90 (90) Show / Hide 
Range on Protein: 182-269
Range on HMM: 1-90/90
Sequence Identity: 54% (49 aa)

LTVQIKEGRNLIPMD--PNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALS
|.| ..|.||| |||  .||.|||||||.| .|.||..|.||..|| .||||||||.|.|. |.| .... ..|||||| .|.||.|  .
LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGRDDFIGQCC
C2 Pkc53E.AA C2 181-284 29 2e-28 101.66 SMART 1-92 (92) Show / Hide 
Range on Protein: 181-284
Range on HMM: 1-92/92
Sequence Identity: 29% (37 aa)

LLTVQIKEGRNLIPMDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACL---NPVWNE---TLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFG---
.||| |.|.|||.        ||||||.           ||...| .|   ||||||   |...|. |    . . .||||.      ||.| ....   
TLTVHIIEARNLP--------DPYVKVY-----------KTKVVKNTLSGFNPVWNEWMETFYFDVHP----Q-LRFEVWDH------DFIGHCCIPPNN

-----------ISEIIKNPTNGWF
           .|.|. ..   | 
PHWHQWDGCIHLSDIL-GYRH-WW
Kinase Pkc53E.AA Alpha 341-599 83 1.2e-232 779.22 In-house 1-259 (259) Show / Hide 
Range on Protein: 341-599
Range on HMM: 1-259/259
Sequence Identity: 83% (216 aa)

FNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEP
|||..||||||||||.||||||..|||||||||||||||||||||||.|||||||..|||||||.||||||||||.||||||||||||..|||.||||||
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

VAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPF
.|||||||||.||||||.|||.|||||||||.|||.||.|||||||||||...|.||.||||||||||||||.||||||||||||.|||||||..|||||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

DGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFF
|||||.|||.||..||||||||.||||...|||||||.||||||||..||.|.| ||||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase Pkc53E.AA PKC 341-599 73 8.49999999999e-217 709.52 In-house 1-262 (262) Show / Hide 
Range on Protein: 341-599
Range on HMM: 1-262/262
Sequence Identity: 73% (192 aa)

FNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEP
|||.|||||||||||.||||||..|.||||.||||||||||||||||.|||||||..|.|||..||.||||||||||||||||||||||.|||...|||.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

VAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPF
.|.||||||. .|.|||.||| ||||||||||||..||.|||||||||||.....||.|||||||||||||. ||.|||||||||.|||.|||..||.||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

DGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSG---EEDVRLHPFF
.||||.||| .|...|..||..|||||.. ||||.||.|.|||||. ..   |.|.| ||||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase Pkc53E.AA AGC 341-599 33 1.2e-187 490.52 In-house 1-395 (395) Show / Hide 
Range on Protein: 341-599
Range on HMM: 1-395/395
Sequence Identity: 33% (133 aa)

FNFIKVLGKGSFGKVLLAERK------GSEELYAIKILKKDV-IIQDD--DVECTMIE------------KRVLALGEK---------PPFLVQ-LHSCF
|.|.||.|||||||| |...|      .....||.|.|||.. |....  .||.||.|            ...|..  .          ||.|. ||..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTMDR--LFFVME----YVN-----GG-DLMFQIQ---QFGKFKEPVAVFYAAE-------IAAGLFFLHT-KGILYRD-LKLDNVLLDADGHVKIADFG
|. |.  |.||||    |||     || .|....|   . |.| |..| |||||       |. .| .||  .|| .|| ||..|.|||.|||.|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKENIVGD--------------------------------------------------KTTKTFCG--TPDYIAPEIILYQPYGKSVDWWA--YGVLLY
.|||.. ..                                                  ..|.||||  ||.|.||||.    |||..|||.  .|.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLVGQPPFDGE----------DEEELFAAIT------DHNVSYP----------KSLSKEAKEACKGFLTKQPNKRLGCGSS-----GEEDVRLHPFF
|||.|.||| |.          ...|.|  |        ..| .|          ...|.|||  .|..|.| |.|||||| .     | |... ||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase Pkc53E.AA Eta 341-599 68 1.2e-160 540.02 In-house 1-261 (261) Show / Hide 
Range on Protein: 341-599
Range on HMM: 1-261/261
Sequence Identity: 68% (178 aa)

FNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEP
|||||||||||||||.|||||| .|.||||.|||||||||||||||| |||.|.| .| ||| |||.|||| ||||||||||||||||||||.  || ||
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

VAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPF
 | |||||. . | |||..|..||||||||.|||..|| |.|||||||| |. ..|| |||||||||||||.  . || |||||| |||.|||. |||||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

DGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGS--SGEEDVRLHPFF
. . |..|| .| . .| ||  |.||| .  |.|.|| |.|||||     ||...| ||||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase Pkc53E.AA Delta 341-599 63 2.2e-147 495.9 In-house 1-259 (259) Show / Hide 
Range on Protein: 341-599
Range on HMM: 1-259/259
Sequence Identity: 63% (165 aa)

FNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEP
|.| |||||||||||.||| || .. |||| |||||...||||||||.|.|||||. . ||| .|   ||| . |||||||.||||||. ||| ..|.| 
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

VAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPF
 | |||.||  || |||.|||.|||||||||||| |||.|||||||||||..|.|...||||||||||||||  | | .|||||..|||.||||.|| ||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

DGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFF
 ||||.||| .|   .  ||. ..||||.  |. . ..|.||||   . . |.| |.||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase Pkc53E.AA SGK 341-599 40 2.3e-126 392.4 In-house 1-283 (283) Show / Hide 
Range on Protein: 341-599
Range on HMM: 1-283/283
Sequence Identity: 40% (116 aa)

FNFIKVLGKGSFGKVLLAERKGS------------------EELYAIKILKKDVII-------QDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRL
| |.||.||||||||.....|.                   . .||.|.|.|. ||       .   .  .|.|. |.    | ||.|.||  ||| . |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQ
.|||.|||||.. . .|  ..|.|..| ||||||.  |  || . | ||||| .|.|||..||... ||| |||.|   .||.|||||| | |||... |
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

PYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSS-GEEDVRLHPFF
|....||||  | .||||..| |||   . ....  |       |.. | .|..  .| |.| | |||  |.  . .... ||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRL--GTKRDFMEIKNHPFF
Kinase Pkc53E.AA Akt 341-599 47 1.3e-125 403.59 In-house 1-264 (264) Show / Hide 
Range on Protein: 341-599
Range on HMM: 1-264/264
Sequence Identity: 47% (127 aa)

FNFIKVLGKGSFGKVLLAERKGSEELY-AIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKE
|.|.|||||||||||.|.. | ....| |.|.||||.||| . || |. |...|      ||.|.||  ||| |.|.|||.|.|||.| . .|. ..|.|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

PVAVFYAAEIAAGLFFLHTKGILYRD-LKLDNVLLDADGHVKIADFGMCKENIVGD-KTTKTFCGTPDYIAPEIILYQPYGKSVDWWA-YGVLLYEMLVG
. | ||.|||  .. .|| |.| ||| ||. |.|.|.|||....|||.|||||. |  .|||||||| |.||||.. . ..|.||||.  |...|||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

QPPFDGEDEEELFAAITDHNVSYP--KSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFF
.|||  .| ...|  |   .| .|  . .|.|.|   .| |.|.|.|||| |... .... ||.|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase Pkc53E.AA Iota 341-599 51 2.5e-113 378.96 In-house 1-271 (271) Show / Hide 
Range on Protein: 341-599
Range on HMM: 1-271/271
Sequence Identity: 51% (139 aa)

FNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEP
|. |.|.|.||. |||..| |  . .||.|..||... .|.|..    || |       |||| |||||||  |||||.|.|||||||| .|.  |  | 
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

VAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPF
 | ||.|||.  | ||| .||.||||||||||||..||.|. |.|||||.|    || |||||| ||||||.  . || |||||| |||..||. |  ||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF

D--G-------EDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSG---EEDVRLHPFF
|  |         |. ||  | ....  |.|||  | .  |||| |.|  ||||        .|.. ||||
DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase Pkc53E.AA PKN 341-599 52 4.6e-112 378.6 In-house 1-260 (260) Show / Hide 
Range on Protein: 341-599
Range on HMM: 1-260/260
Sequence Identity: 52% (138 aa)

FNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGE--KPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFK
| .| |||.| ||||||.. |...|.||||.|||  |.  |.||  |.|||...  .  . ||||.|..|||| .  .|||||. ||||| .| .   |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHE-DVFS

EPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENI-VGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQ
|| |.|||| .  || .|| . |.||||||||.|||..|.|||||||.|||..  ||.|  ||||||...|||..  . | . ||||  |||.|||||| 
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTS-TFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGE

PPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFF
.|| |.||||.| .| ...| ||. || || .  .  | | |..||| |    ||.. .|||
CPFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase Pkc53E.AA AktR 341-599 42 2.4e-110 372.87 In-house 1-268 (268) Show / Hide 
Range on Protein: 341-599
Range on HMM: 1-268/268
Sequence Identity: 42% (115 aa)

FNFIKVLGKGSFGKVLLAERK-GSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKE
| ..|.|||| |||| |...|  . ..||.|..||  ||.    . |  |. ...   . ||.|.|| |||| . |||.|||. ||.| . ... .||.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PVAVFYAAEIAAGLFFLHTK-GILYRDLKLDNVLLDADGHVKIADFGMCK-ENIV-GDKTTKTFCGTPDYIAPEIILY-QPYGKSVDWWAYGVLLYEMLV
 .| ||.|.|  .| .|| .  | ||||| .| ||| ||||||.|||. | ...   | ....||||| |.|||.|.  ....||||||| |...|||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQPPFDGEDEEELFAAITDHN---VSYPKSLSKEAKEACK-GFLTKQPNKRLGCGSSGEEDVRLHPFF
|.|||. .. ...|  |  ..   . ||. .|...|. .. . | | |||||| ...| |... ||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase Pkc53E.AA S_TKc 341-599 36 3.6e-100 340.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 341-599
Range on HMM: 1-231/231
Sequence Identity: 36% (98 aa)

FNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNG--GDLMFQIQQFGK--
. .....|||.|||| ..  |.. ...||||.|          | .. | ..|    . |..|.|. .||. |.|..||||..|  |||.  |.. |.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGK-SVDWWAYGVLLY
    | | .| ||...|. .| ..| .||..|||| .|.|||   |.||.|||....        .||||||.|.|||..   .||| ..|||. |..||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGE--EDVRLHPFF
|||.|.|||.  .....|  |           |.|||.  .. |.| |.||...    .  .|...||.|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Pkc53E.AA Pkinase 341-599 32 2.1e-78 271.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 341-599
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

FNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTM-IEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGG----DLMFQIQ--Q
. .....|.||||.| .. .||.....|.||.||. .  . |.. .   | ....   . |. |.|. .|.. |.. .||||..||    ||.  |.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

FGKF--KEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHV----KIADFGMCKEN-IVGDKTTKTFCGTPDYIAPEIIL-YQPYGKSVDWWA
 |.|   | .. ||. .|. || ..| .||..||||..|.|.| .||.    ||.||| .|   .  .  ..||||||.|.|||.|. .|.||..||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

YGVLLYEMLVGQPPFDGE------DEEELFAAITDHNVSYPKSLS---------------------KEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPF
.|..||||| |.|||.|.      |. .... | .  .... . .                     .|.|. .|. |.| |.||..      |..  ||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase Pkc53E.AA S_TK_X 600-663 41 1.6e-29 105.36 SMART 1-79 (79) Show / Hide 
Range on Protein: 600-663
Range on HMM: 1-79/79
Sequence Identity: 41% (33 aa)

RRIDWEKIEN--REVQPPFKPKIK----HRKDVSNFDKQFTSEKTDLTPTDKVFMMNLDQSE---------FVGFSYMN
| |||.|..|  .|..||||||||    .  |.||||. ||.|. .|||.|.. ... .|.|         | ||.|..
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase Pkc53E.AA Pkinase_C 619-665 44 4e-18 66.98 Pfam 1-46 (46) Show / Hide 
Range on Protein: 619-665
Range on HMM: 1-46/46
Sequence Identity: 44% (21 aa)

KIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMNLDQSEFVGFSYMNPE
..|.. |.||||..||.|.  .|| |.  |.. ||..|.||.| ||.
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase Pkc53E.AA TyrKc 341-593 23 1.1e-14 14.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 341-593
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)

FNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALG-EKPPFLVQLHSCFQTM-------DRLFFVMEYVNGGDLMFQIQ
  ..|.|| | ||.| ... |   .  |.| ||.|       .|  | | |..     . | .|.|. .  .        . |. ||||. .|||   ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QFGK-FKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVG-------DKTTKTFCGTPD------YIAPEIILYQPYG
  .. .. .  . ..  ||.|  .|| |..  |||   |.|......|||.|||....   .       |  .|.  .  .        ||| | |  . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KSVDWWAYGVLLYEML-VGQPPFDG-----EDEEELFAAITDHNVSYPKSL---------SKEAKEACKGFLTKQPNKRLGCGSSGEEDV
   | |..||...|..  ||.|  |      . .|... . . .   .            ..|  .  |     .|..|        |. 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase Pkc53E.AA Pkinase_Tyr 400-488 27 1.7e-09 32.8 Pfam 64-159 (270) Show / Hide 
Range on Protein: 400-488
Range on HMM: 64-159/270
Sequence Identity: 27% (26 aa)

PFLVQLHSCFQ-TMDR--LFFVMEYVNGGDLMFQIQQ----FGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCK
| .|.|. .     .   .. ||||. .|||    ..     .... .  . ....||.|. .|. |..  |||   |.|.. ...|||.|||...
PNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase Pkc53E.AA Pkinase_Tyr 341-375 33 3.4e-05 18.22 Pfam 1-39 (270) Show / Hide 
Range on Protein: 341-375
Range on HMM: 1-39/270
Sequence Identity: 33% (13 aa)

FNFIKVLGKGSFGKVLLAERK----GSEELYAIKILKKD
  |.|.||.|.||.| ... |    . .   |.|.|| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase Pkc53E.AA Pkinase_Tyr 524-554 35 0.010257 9.82 Pfam 198-231 (270) Show / Hide 
Range on Protein: 524-554
Range on HMM: 198-231/270
Sequence Identity: 35% (12 aa)

WAYGVLLYEMLV-GQPP-FDGEDEEELFAAI-TD
|..|||..|..  |. | . | . ||....|  |
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED