Gene CG2905 (Fruit Fly)

CG2905

Species: Fruit Fly
Alias: CG2905, SFO296
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 41C4--5,

Classification

Group: Atypical
Family: PIKK
Subfamily: TRRAP

Sequence

Name Sequence Type Origin Length Description Download
CG2905.AA Protein Various 3741 None Fasta, JSON
CG2905.kin_dom Protein Kinase Domain None 12 None Fasta, JSON

Protein domain

Protein domains of CG2905.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT CG2905.AA FAT 2716-3053 21 2.2e-107 359.76 Pfam 1-408 (408) Show / Hide 
Range on Protein: 2716-3053
Range on HMM: 1-408/408
Sequence Identity: 21% (91 aa)

MFLILESSWRVPDWNL--MKIALAKTE------------QCYLKHYGFKINLYKGYLSI--LHQEERQTGNIERYVEIASSLCIREWRR-LPNIVSHIHL
  | .|..||...|..  |.  ....             . . ...... ......|..  .|......   .||.. | .|...||.. ||. ... |.
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTY-EAHRYIDKARQLLDTEWTACLPGESYNRHY

PYLQASQQIMELHEASQIHQGLAQS----RNNSLHDMKAIVKTWRNRLPII-SDDLSHWSDIFTWRQHHYQIITQHLEQQSDQGSTMLGVHASAQAIISF
|...  |...||.|..|......|     ..||....|....||..|||..  .....|..|.|||||....|.|...    . . ..| |  .. .| |
PVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYM----NSFCYRGPHEDMWMWIKF

GKIARKHNLTGVCQETLSRIYT------------IPSVPI------------VDCFQKIRQQVKCYLQMP-STSGKNEINEAL----EVIESTNLKYFTG
 ...|||.....|. ||...||            .|.. .            ...||..|....|..|..  .. .|||| .|    |||..|||.||  
ANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEIN-GLTYNLEVINNTNLEYFYT

EMNA-EFYALKGLLLAQI----------GRSEEAGKSFSVAAQLHDGLTK-AWAMWGDYMEQIFLKER-------------KITLAVDALICYLQASRNQ
...| ..|...|  ....          ....|. .... | .... . | ||..|. | ...| ...              |...| |. |.... . .
KLLAMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALS

IESKTRKYIAKVLW
 .|. |......||
QGSNSRQDTLRLLW
Kinase CG2905.AA PIKK 3376-3653 23 5.3e-67 228.91 In-house 1-290 (290) Show / Hide 
Range on Protein: 3376-3653
Range on HMM: 1-290/290
Sequence Identity: 23% (69 aa)

IARFMPRVEIVQKNNTAARRLYIRGTNGKIYPYLVVLDSGLGDARREERVLQLKRMLNYYLEKQKETSRRFLNITVPRVVPISPQMRLAEDNPNSISLLK
..|||.|...|.. .......|||| .||.||||.    |. | |...||.|| ...|  |.| .|...|.|.|....|.| |....| |...|. .|  
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCK---GHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKE

IFKKCCQSMQVDYDMPIVK---------------YYDRLSEVQARGTPTTHTLLREIFSEIQWTMVPKTLLKHWALKTFLAATDFWHFRKMLTLQLALAF
| |. ||  .  .. ..                 ||... ..|....   .   ...  . |  ..|  ..| |.. .|. ....| .|.. | ..|.  
IYKQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMC

LCEHALNLTRLNADMMYLHQDSGLMNISYFKFDVNDDKCQLNQHRPVPFRLTPNVGEFITHFGITGPLSAAIVATARCFIQPNYKLSSILQTI
  . .| | ... ..  . ...|  .  .| .. .. .  |.  ..||||||.|  .. . .|..|.. .. .....|. |.. .| ... . 
MVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase CG2905.AA TRRAP 3376-3421 80 4.8e-27 93.23 In-house 1-46 (46) Show / Hide 
Range on Protein: 3376-3421
Range on HMM: 1-46/46
Sequence Identity: 80% (37 aa)

IARFMPRVEIVQKNNTAARRLYIRGTNGKIYPYLVVLDSGLGDARR
||||||||||||| ||||||||||| |||||||||. |  . .|||
IARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDICKINARR
Kinase CG2905.AA PI3Kc 3410-3730 16 2.9e-09 -16.72 SMART 1-336 (336) Show / Hide 
Range on Protein: 3410-3730
Range on HMM: 1-336/336
Sequence Identity: 16% (58 aa)

VVLDSGLGDARREERVLQLKRMLNYYLEKQKETSRRFLNITVPRVVPISPQMRLAEDNPNSISLLKIFKKCCQSMQVDYDMPIVKYYDRLSE--------
 |.  .  | |...|..|. |. |  . |.||..|| | .. ....|..|.... |. ||. .| .| || .  . .. |  . .. |.|          
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMY

---------VQARGTPTTHTLLREIFSEIQWTMVPKTLLKHWALKTFLAA-TDFWHFRKMLTLQLALAFLCEHALNLT-RLNADMMYLHQDSGLMNISY-
         . .  ..... . .... | .  ....  |..| ...|  .  |.| .|.  |...|      . |..  | |  .|   ..  .. |.. 
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

FKFDVNDDKCQLNQHRPV----PFRLTPNVGEFIT----HFGITGPLSAAIVATARCFIQPNYKLSSILQTILRDEI-IALQKKGFRECKLIEGSEDRYS
. |.    |  . .|.      |||||..  . .       |  |      . . | . ..  .. ..... ..|.| . ....     | |.  ..|  
HIFGHG-PKKPGFKHH-HRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM----EKDIKYLRQRFR

DGNCMEHSVNIVNSAVDIIMTRFNKISYFDSIENKKISVLVQSATNIDNL
  .        .. |   .| . ... .  .  . ... ..... |. ..
LDH------LSDEEAAQYFMQT-MCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase CG2905.AA FATC 3717-3741 44 2e-07 26.79 Pfam 9-33 (33) Show / Hide 
Range on Protein: 3717-3741
Range on HMM: 9-33/33
Sequence Identity: 44% (11 aa)

ISVLVQSATNIDNLCRMDPAWHPWL
.. |.|.||...|||.|.. | ||.
VDRLIQEATDPENLCQMYIGWCPWW
Kinase CG2905.AA PI3_PI4_kinase 3415-3557 16 4.6e-07 27.81 Pfam 1-172 (300) Show / Hide 
Range on Protein: 3415-3557
Range on HMM: 1-172/300
Sequence Identity: 16% (29 aa)

GL------GDARR---EERVLQLK-----------------------RMLNYYLEKQKETSRRFLNITVPRVVPISPQMRLAEDNPNSISLLKIFKKCC-
.       || .|   ..|..|.                        |. |  . | ... || .... .|..| .|.... |. ||. .. .| .... 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

-QSMQVDYD---MPIVKYYDRLSEVQARGTPTTHTLLREIFSEIQWTMVPKTLLKHWALKTFLAA-TDFWHFRKMLTLQLA
  ..  ...   | .....|... .          . .... |.. ...||  | .| .|..  | ...|..|.  ....|
KCKHKHFNKEHKMWMKMWPDWWHLM---------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCA
Kinase CG2905.AA FRAP 3409-3458 34 2.5e-05 15.69 In-house 2-51 (251) Show / Hide 
Range on Protein: 3409-3458
Range on HMM: 2-51/251
Sequence Identity: 34% (17 aa)

LVVLDSGLGDARREERVLQLKRMLNYYLEKQKETSRRFLNITVPRVVPIS
 . |  |  | |  |||.||  ..|  |. . || .. |.|.   ..|.|
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLS
Kinase CG2905.AA ATR 3607-3653 23 0.000267 10.08 In-house 221-267 (267) Show / Hide 
Range on Protein: 3607-3653
Range on HMM: 221-267/267
Sequence Identity: 23% (11 aa)

VPFRLTPNVGEFITHFGITGPLSAAIVATARCFIQPNYKLSSILQTI
|||||| |.   .  ..  |    |.. . .|. .    . |.... 
VPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase CG2905.AA ATR 3374-3479 25 0.000466 9.24 In-house 1-102 (267) Show / Hide 
Range on Protein: 3374-3479
Range on HMM: 1-102/267
Sequence Identity: 25% (27 aa)

VRIARFMPRVEIVQKNNTAARRLYIRGTNGKIYPYLVVLDSGLGDARREERVLQLKRMLNYYLEKQKETSRRFLNITVPRVVPISPQMRLAEDNPNSISL
  || |   |||.       ... ..|..||.|   ...     | |.. |  .   ..|. . |. |  |||...    |.|.  |  . |   | ..|
AYIAGFDDMVEILASLQ-KPKKISLKGSDGKFY---IMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATL

LKIFKK
  | .|
RPILDK