Gene CG6535 (Fruit Fly)
CG6535
Sequence
Protein domains of CG6535.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | CG6535.AA | ATM | 2109-2356 | 58 | 8.99999999999e-128 | 410.55 | In-house | 2-248 (304) | Show / Hide |
Range on Protein: 2109-2356 Range on HMM: 2-248/304 Sequence Identity: 58% (145 aa) QLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLVVEGKGGAHARYRPNDWNNNKCRKLSSDHLKSP |||||.||||||||||||| . | || | ||| . |||| ||| |||.||||| .|.. .| . ||| ||||||. .| | . | QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFL-INNEDGAHKRYRPNDFSAFQCQKKMMEVQKKS KETRYAIYKKICENIKPVFHYFLLEKFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTTPETVPFRLTR | .| .. .| | .||| || .||| | .|||.||||| |||| |.|||.||||||| ||||. | ||..||| |.||||||| ||||||||||| FEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTR DFVAPMGICGTKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIW | | ||| | ||| . || || ..| . || ||||||||| | DIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDW |
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| Kinase | CG6535.AA | PIKK | 2091-2348 | 35 | 3.8e-99 | 335.69 | In-house | 15-290 (290) | Show / Hide |
Range on Protein: 2091-2348 Range on HMM: 15-290/290 Sequence Identity: 35% (98 aa) LNAPVKIMCVCSDGKIRAQLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLVVEGKGGAHARYRPN . .| ||. .|||. .|.||..|||||....|.|...| .| .|.| |.| .|||.|.|.|.|.|..||..|.|. . .. . . ..|.|.... KQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYKQWCQ-KKHIRHEQE DWN-----------------NNKCRKLSSDHLKSPKETRYAIYKKICEN-IKPVFHYFLLEKFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNI . ... . . . ..| . .... ....| ..|......||| | |.||| .|| |.|. .||||.|||||||..|| AQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENI LVDQQTAEVIHIDFGIAFE-QGKIQTTPETVPFRLTRDFVAPMGICGTKGVFAKSCEATMHILRRYKSVFTTILEVL ..|.||.|..||||| .|| .... .||.|||||||..| ||..|. ||| ..||..|...|. . .|..||. MIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | CG6535.AA | PI3Kc | 2108-2418 | 25 | 9.5e-80 | 272.17 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 2108-2418 Range on HMM: 1-336/336 Sequence Identity: 25% (91 aa) AQLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLV-VEGKGG-------------------AHARY | ..|..||||||. |.|.|...| .. .|.| |.|..|.||. |.. ..|..||..|.... .. ... . ..| AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQK-NMY RPNDWNNNKCRKLSSDHLKSPKETRYAIYKKICENIKPVFHYFLLEKFPIP-GVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDF ...|. . | . . .. |. . . ...| . .||.. ...|.|| | ..|.|.| .| |.| .||.|.||.||||..||..| .| ...|||| -MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDF GIAFEQGKIQTTP-----ETVPFRLTRDFVAPMG----ICGTKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPL-FIWGVLKKKQSPQQSGEESVNLV | .|..|. .. |.||||||.|.| || . | | | . |. .. ..|... ......|...|||. . | |.... . GHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM----------EKDIKYL AQRALLLVQNKLDGREAGTMG---------DSNVEAQVERLINEATLPSNL || | . | .|| .. ...|.. |..... . .. RQRFRLDH---LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY |
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| Kinase | CG6535.AA | PI3_PI4_kinase | 2105-2358 | 19 | 7.2e-59 | 206.69 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 2105-2358
Range on HMM: 1-300/300
Sequence Identity: 19% (68 aa)
KIRAQLVKGKDDLR--QDAVMQQVF-----------------------GIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLVVEG
. ....||.|||| ||. | | . ...| .. .|.. .|.. ...|.. |.. ..|..|
WY-PFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIE----------------
KGGAHARYRPNDWNNNKCRKLSSDHLKSPKETRYAIYKKICENIK---------------------------------------PVFHYFLLEKFPIP-G
. ..| | .. ....| |... ......| . .
-------------------------WVPNCTTFHEIPRTYMVKCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYE
VWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILV--DQQTAEVIHIDFGIAFE--QGKIQTTPETVPFRLTR------DFVAPM------GICGTKGVF
|.|.| .. |.| ..|.|.||.|||| ||.| | | ...|||||..|. ..| ||.||||.|. ..| | . | | |
EWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWF
AKSCEATMHILRRYKSVFTTIL-------EVLLYDPLFIWGV
..|. .. .|||.. .... | | ...|.|. |
RDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
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| Kinase | CG6535.AA | ATR | 2225-2348 | 39 | 4.1e-41 | 137.59 | In-house | 144-267 (267) | Show / Hide |
Range on Protein: 2225-2348 Range on HMM: 144-267/267 Sequence Identity: 39% (49 aa) PVFHYFLLEKFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTTPETVPFRLTRDFVAPMGICGTKGVFA |.|| . . .|| | |. | .| | | .||||..|||||||.|||.|. . |..|.|. . | .|. ||.||||||. | || .|.|.| PIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFR KSCEATMHILRRYKSVFTTILEVL . || .| ..| . ... RACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | CG6535.AA | FRAP | 2234-2358 | 46 | 6.9e-40 | 138.84 | In-house | 126-251 (251) | Show / Hide |
Range on Protein: 2234-2358 Range on HMM: 126-251/251 Sequence Identity: 46% (59 aa) KFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQG-KIQTTPETVPFRLTRDFVAPMGICGTKGVFAKSCEATMH | | .||||| || | || ||.||.||||||| ||. . .| ..||||| || . || .|||||| | | .|| | . || | KSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMK ILRRYKSVFTTILEVLLYDPLFIWGV ..| | .|| ||||| | . VIREHKESVMAVLEAFVYDPLFYWRL |
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| Kinase | CG6535.AA | SMG1 | 2238-2300 | 50 | 2.8e-20 | 63.77 | In-house | 180-242 (242) | Show / Hide |
Range on Protein: 2238-2300 Range on HMM: 180-242/242 Sequence Identity: 50% (32 aa) PGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTTPE | |. .| | | |||||..|||||| |.|.| | ||.|||. | ||.|| || PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE |
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| Kinase | CG6535.AA | DNAPK | 2259-2358 | 32 | 5.6e-20 | 69.24 | In-house | 201-301 (301) | Show / Hide |
Range on Protein: 2259-2358 Range on HMM: 201-301/301 Sequence Identity: 32% (33 aa) GYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFE-QGKIQTTPETVPFRLTRDFVAPMGICGTKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWG ...|| |||| | .| . ..| |||| .| . || |||||| |. | . |.. . | .|. . . | .| ||.| | HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK V N |
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| Kinase | CG6535.AA | FATC | 2397-2429 | 51 | 4.9e-14 | 47.99 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2397-2429 Range on HMM: 1-33/33 Sequence Identity: 51% (17 aa) GDSNVEAQVERLINEATLPSNLCMLFPGWDPHL .||.||.|||.||| |.|||....|| | . EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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| Kinase | CG6535.AA | FRAP | 2108-2167 | 36 | 6e-14 | 47.74 | In-house | 3-62 (251) | Show / Hide |
Range on Protein: 2108-2167 Range on HMM: 3-62/251 Sequence Identity: 36% (22 aa) AQLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTN | ||..|.||| | ||..| ||. . | . | .. | . ||||..|.. | . HFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHH |
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| Kinase | CG6535.AA | DNAPK | 2076-2169 | 30 | 8.4e-13 | 42.75 | In-house | 2-95 (301) | Show / Hide |
Range on Protein: 2076-2169 Range on HMM: 2-95/301 Sequence Identity: 30% (29 aa) ISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSV . . . | | | .|. | . ..|| ||||| | | . | . .|. | |.|||| . |. | | .|| | | VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTV |
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| Kinase | CG6535.AA | ATR | 2077-2169 | 31 | 8.7e-13 | 39.48 | In-house | 2-94 (267) | Show / Hide |
Range on Protein: 2077-2169 Range on HMM: 2-94/267 Sequence Identity: 31% (29 aa) SVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSV . . . | | || ||||. . | |||||.| ... ..| .. .| | | ...||| | || ...|.|| | . YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTA |
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| Kinase | CG6535.AA | SMG1 | 2086-2164 | 34 | 7.3e-08 | 21.96 | In-house | 2-80 (242) | Show / Hide |
Range on Protein: 2086-2164 Range on HMM: 2-80/242 Sequence Identity: 34% (27 aa) TQCGGLNAPVKIMCVCSDGKIRAQLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEW | | |.. . |||| | || .|| | . | ||| . . | | |||| |||.. | TILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQW |
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| Kinase | CG6535.AA | ATM | 2372-2387 | 50 | 0.176313 | 0.03 | In-house | 289-304 (304) | Show / Hide |
Range on Protein: 2372-2387 Range on HMM: 289-304/304 Sequence Identity: 50% (8 aa) SVNLVAQRALLLVQNK | | || | |. .| | SFNKVAERVLMRLQEK |
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