Gene CG4523 (Fruit Fly)

CG4523

Species: Fruit Fly
Alias: CG4523, SFO124
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 6C6,

Classification

Group: Other
Family: NKF2

Sequence

Name Sequence Type Origin Length Description Download
CG4523.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 275 Kinase domain by global Sugen HMM Fasta, JSON
CG4523.AA Protein Various 721 None Fasta, JSON

Protein domain

Protein domains of CG4523.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CG4523.AA NKF2 332-634 54 1.4e-195 656.01 In-house 58-365 (365) Show / Hide 
Range on Protein: 332-634
Range on HMM: 58-365/365
Sequence Identity: 54% (171 aa)

YPLALKMMFNYDIQSNALSILRAMYKETVPARQRGMNEAADEWERLLQNQTVHLPR----HPNIVCMFGFFCDEVRNFPDGHLLYPVAQPQRINPQGYGR
.||| |||.| .  .    .|  |  . ||.     | .. |   .   .    |.    ||||||||..|||.||..||.|..||....||..|.|||.
FPLAIKMMWNFEHDRDSDAHLNKMMQNEVPPYR---NALKGEYGQMTYRRSRTFPKQPAPHPNIVCMFRAFCDSVRVLPDAHEDYPDMLHQRYWPEGYGH

NMSLYLLMKRYDHSLRGLLDSQ-DLSTRNRILLLAQMLEAVNHLSRHGVAHRDLKSDNVLIELQDD--AAPVLVLSDFGCCLADKVHGLRLPYVSHDVDK
||..||.||||...||..|..| ..|...|....||||||..||..|||||||.||||.|.|...|  |.|.||..|||||||.|.||..|||.|.|||.
NMTMYLVMKRYRCTLRQYLWMQCHPSYWTRMMMIAQMLEACDHLHQHGVAHRDMKSDNILVEYDFDDGACPWLVIADFGCCLACKHHGWQLPYSSWDVDR

GGNAALMAPEIFN-TMPGPFAVLNYGKADLWACGALAYEIFGNRNPFYSSSGGMARERGEMTLSLRNSDYRQDQLPPMSDACPPLLQQLVYNILNPNPSK
||||.|||||||. ..||...|..|.|||.|||||.||||||..|||||||||||||.|||.|...||||..||||.|...|||.|.|||||.|...|||
GGNACLMAPEIFTGAHPGCNHVHDYEKADTWACGAIAYEIFGQKNPFYSSSGGMAREQGEMHLDSCNSDYQEDQLPQMPQSCPPVLRQLVYNLLQRDPSK

RVSPDIAANVV
|.||.|||||.
RPSPQIAANVL
Kinase CG4523.AA Pkinase 384-505 19 8.1e-14 49.94 Pfam 56-159 (293) Show / Hide 
Range on Protein: 384-505
Range on HMM: 56-159/293
Sequence Identity: 19% (26 aa)

HLPRHPNIVCMFGFFCDEVRNFPDGHLLYPVAQPQRINPQGYGRNMSLYLLMKRYDH-----SLRGLLD---SQDL--STRNRILLLAQMLEAVNHLSRH
.| .||||| ....| |                           . ..|. |   ..     .|  ..    .  .  | .  .  . |.|...... ..
RL-NHPNIVRLYDWFED---------------------------KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM

GVAHRDLKSDNVLIELQDDAAPVLVLSDFGCC
|. |||||..|.||  ... .. . ..|||..
GIIHRDLKPENILIDNNGHIDACVKICDFGLA
S_TKc CG4523.AA S_TKc 194-638 12 8.6e-14 25.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 194-638
Range on HMM: 1-231/231
Sequence Identity: 12% (61 aa)

LEIGPPIAKGCAAVVYAADFKK----------DVASDGASLHTDAQPQATPAFAPNSWSTHEMMSPLQNMSRFVHNFGGSVDNVFHYSQPSAASDFVGAQ
 ||. .| ||  ..|| .  ||          .                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

SREQDQRHHEQQQHQNQEQEQHQNQEPSSSAFNVTSPANSNINSSVDSYPLALKMMFNYDIQSNALSILRAMYKETVPARQRGMNEAADEWERLLQNQTV
                                                                                    . .  | . | .    
------------------------------------------------------------------------------------EHIRREIQILKK----

HLPRHPNIVCMFGFFCDEVRNFPDGHLLYPVAQPQRINPQGYGRNMSLYLLMKRYDH---SLRGLLDSQD-------LSTRNRILLLAQMLEAVNHLSRH
   .||||| ....| |                             .||. |   |.   .|. .....        ..      ...|...|.... .|
---HHPNIVKLYDVFQD----------------------------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH

GVAHRDLKSDNVLIELQDDAAPVLVLSDFGCCLADKVHGLRLPYVSHDVDKGGNAALMAPEIFNTMPGPFAVLNYG--KADLWACGALAYEIFGNRNPFY
|. ||||| .|.|.        .. ..||| .                    |    ||||..           ||  |.| |.|| . || .  . ||.
GIIHRDLKPENILLDE------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL----------GYGKCKCDWWSCGCILYEMLCGYPPFP

SSSGGMARERGEMTLSLRNSDYRQDQLPPMSDACPPLLQQLVYNILNPNPSKRVSPDIAAN-----VVQLFL
     | .  |                       .| . ... ..|. .|.|| .   | .         ..
-QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CG4523.AA Ciliate-E2 447-628 16 6.5e-13 40.65 In-house 139-357 (365) Show / Hide 
Range on Protein: 447-628
Range on HMM: 139-357/365
Sequence Identity: 16% (40 aa)

DSQDLSTRNRILLLAQMLE---------------AVNHLSRHG-VAHRDLKSDNVLIELQDDAAPVLVLSDFGC----------CLADKVHGLRLPYVS-
| . .. . .. . .| |.               |...|   . . |||.| .|.|.         . ..|||           ..  |..   ... . 
D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KN

-HDVDKG---------------GNAALMAPEIFNTMP------GPFAVLNYG-KADLWACGALAYEIFGNRNPFYSSSGGMARERGEMTLSLR-NSDYRQ
  ..  |               |..  |||||.|  .      .      |. |.|.|..| . ||   .. ||             .   .  . |...
DTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKG----YDYKCDIWSLGVILYEMLFGKPPF-------------QQQIKQCKIDFPC

D--------------QLPPMSDACPPLLQQLVYN--ILNPNPSKRVS-PD
                    |. |  |...   .  .|. .|.|| . ..
PEWQKDTQCIQCKWKSWKKWSQECKDLIKK-F-GKRMLQKDPEKRITGWE
Kinase CG4523.AA CMGC 430-503 18 1.3e-11 33.5 In-house 129-249 (513) Show / Hide 
Range on Protein: 430-503
Range on HMM: 129-249/513
Sequence Identity: 18% (23 aa)

SLYLLMKRYDHSLRGLLDSQD----------LSTRN------------RILLL------AQMLEAVN--HLSRHG--VAHRDLKSDNVLIELQDD-----
.||| .   ||.| ......           ||                  ..       |.|....  .. .|.  . |||||  |.||  . .     
HLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRM

-----------AAPVLVLSDFG
              .| . |||
MWKSEDWNPCQKNGRLKICDFG
Kinase CG4523.AA STE 460-505 31 1.2e-10 33.98 In-house 157-194 (359) Show / Hide 
Range on Protein: 460-505
Range on HMM: 157-194/359
Sequence Identity: 31% (15 aa)

LAQMLEA-VNHLSRHGVAHRDLKSDNVLIELQDDAAPVLVLSDFGCC
. | |..  ..| .|.. |||.|..|.|.           |.|||.|
CRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVC
Kinase CG4523.AA CAMKL 462-503 35 1.7e-10 29.59 In-house 135-174 (297) Show / Hide 
Range on Protein: 462-503
Range on HMM: 135-174/297
Sequence Identity: 35% (15 aa)

QMLEAVNHLSRHGVAHRDLKSDNVLIELQDDAAPVLVLSDFG
|...|||.. .||..|||.| .|.|.  ...   .. ..|||
QIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFG
Kinase CG4523.AA CAMK 462-503 27 2e-10 29.05 In-house 187-241 (425) Show / Hide 
Range on Protein: 462-503
Range on HMM: 187-241/425
Sequence Identity: 27% (15 aa)

QMLEAVNHLSRHGVAHRDLKSDNVLIELQDDAAP-------------VLVLSDFG
|...||...  |...||||| .|.|.   .|  .              . ..|||
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFG
Kinase CG4523.AA C8 462-537 31 1.1e-09 29.96 In-house 131-204 (226) Show / Hide 
Range on Protein: 462-537
Range on HMM: 131-204/226
Sequence Identity: 31% (24 aa)

QMLEAVNHLSRHGVAHRDLKSDNVLIELQDDAAPVLVLSDFGCCLADKVHGLRLPYVSHDVDKGGNAALMAPEIFN
||.. || .  . . |||.| .| |. |.    .   |.|||  .|..|   .  . |... . |. | .|||| .
QMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFG--FASQVSKNKSHIQSKKMNTCGTWAYFAPEIEK
Kinase CG4523.AA GEK 460-574 31 4.9e-09 26.03 In-house 106-210 (269) Show / Hide 
Range on Protein: 460-574
Range on HMM: 106-210/269
Sequence Identity: 31% (36 aa)

LAQMLEAVNHLSRHGVAHRDLKSDNVLIELQDDAAPVLVLSDFGCCLADKVHGLRLPYVSHDVDKGGNAALMAPEIFNTMPGPFAVLNYGKA-DLWACGA
.| |. |.. . . .  |||.| ||||.    |    . | ||| ||  .  |     |       |    ..|||   | .     .||.  | |. | 
IAEMVMAIDSVHQLHYVHRDIKPDNVLL----DMNGHIRLADFGSCLRMNKDGMVQSNVAV-----GTPDYISPEILQAMEDG--KGRYGPECDWWSLGV

LAYEIFGNRNPFYSSS
..||..  . |||. |
CMYEMLYGETPFYAES
Kinase CG4523.AA Trio 460-503 34 1.6e-08 17.31 In-house 101-144 (258) Show / Hide 
Range on Protein: 460-503
Range on HMM: 101-144/258
Sequence Identity: 34% (16 aa)

LAQMLEAVNHLSRHGVAHRDLKSDNVLIELQDDAA--PVLVLSDFG
. ||||||. |  ....| |.|..|....  ...|  | . . |||
MWQMLEAVHYLHNCHILHLDIKPENMMMW--HYNAGRPQIKICDFG
Kinase CG4523.AA TyrKc 344-637 17 3.9e-07 -107.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 344-637
Range on HMM: 1-280/280
Sequence Identity: 17% (61 aa)

IQSNAL-------SILRAMYKETVPARQR----GMNEAADEWERLLQNQTV---HL-PRHPNIVCMFGFFCDEVRNF---PDGHLLYPVAQPQRINPQGY
|. .          . ....|      .      ..| |   .. . .      .| ..|||||...|   .. |||   .   ..   .          
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMP---------

GRNMSLYLLMKRYDHSLRGLLDSQDLSTRNRILLLAQMLEAVNHLSRHGVAHRDLKSDNVLIELQDDAAPVLVLSDFGCCLADKVH---GLRLPYVSHDV
. .   ||  .| .           |...  .    |  .  ..|..... ||||   |.|.  .     .   |||| . . . .   |     .|.|.
HGDLKDYLRKHRPK-----------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQG-----ESKDY

DK-----GGNAAL----MAPEIFNTMPGPFAVLNYG----KADLWACGALAYEIFGNRNPFYSSSGGMARERGE----MTLSLRNSDYRQDQLPPMSDA-
 .     ||.. |    |||| .          |||    | | |. | . .|||         . |.    |.    |. .    . .|   .|  .  
YRKKEHKGGKTMLPIRWMAPECI----------NYGKFTTKSDVWSFGVCMWEIF---------TYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPND

-------CPPLLQQLVYNILNPNPSKRVSPDIAANVVQLF
       ||. . |.     . .|..| .    ......|
YPMSFVCCPDEMYQIMKQCWHEDPEDRPT---FSEIHECF
Kinase CG4523.AA Pkinase 550-637 16 1e-06 24.63 Pfam 192-293 (293) Show / Hide 
Range on Protein: 550-637
Range on HMM: 192-293/293
Sequence Identity: 16% (17 aa)

KADLWACGALAYEIFGNRNPFYSS----SGGMARERGEMTLSLRNSDYRQDQLPPMSD------------ACPPLLQQLVYNILNPNPSKRVSPDIAANV
|.| |.|| . || .  | ||...    .    ... ..... ...  ..   ... .            . .. ........|...|.|| .   |. .
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQI

VQL--F
.|   |
LQHPWF
Kinase CG4523.AA AGC 460-487 29 5e-06 9.95 In-house 152-188 (395) Show / Hide 
Range on Protein: 460-487
Range on HMM: 152-188/395
Sequence Identity: 29% (11 aa)

LAQ-------MLEAVNHLSR-HGVAHRD-LKSDNVLI
.|.       .. |. .| . .|. ||| || .|.|.
AAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILL
Kinase CG4523.AA CAMK 550-624 19 1.5e-05 13.09 In-house 314-413 (425) Show / Hide 
Range on Protein: 550-624
Range on HMM: 314-413/425
Sequence Identity: 19% (20 aa)

KADLWACGALAYEIFGNRNPFYSSSGGMARERG--------EMTLSLRNSDYRQD--QLPP------------MSDA----CPPLLQQLVYNILNPNPSK
|.| |.|| . |     . |||.... . .| .        |.    .. .|. .  ...|             ||     . .  ..|. ..|...|.|
KCDMWSCGVILYIMLCGYPPFYGDCDNEICE-DEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEK

R
|
R
Kinase CG4523.AA AGC 531-624 26 0.000199 5.78 In-house 274-373 (395) Show / Hide 
Range on Protein: 531-624
Range on HMM: 274-373/395
Sequence Identity: 26% (29 aa)

MAPEIFNTMPGPFAVLNYGKA-DLWA--CGALAYEIFGNRNPFYSSSGG----MARERGEMTLSLRNSDYRQDQLPPMS----------DACPPLLQQLV
|||||.           |||| | |.   |.| ||    . |||. . .      | . ||  . .| .| . . ...           .   | .. |.
MAPEIL-----------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLI

YNILNPNPSKR
   |...|.||
KKLLCKDPEKR
Kinase CG4523.AA NKF2 195-211 52 0.004025 6.82 In-house 2-18 (365) Show / Hide 
Range on Protein: 195-211
Range on HMM: 2-18/365
Sequence Identity: 52% (9 aa)

EIGPPIAKGCAAVVYAA
|.|  | .|| | || |
EFGQFIGQGCNAAVYEA