Gene CG4945 (Fruit Fly)

CG4945

Species: Fruit Fly
Alias: CT15864, PKN, CG4945, SFO026
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 53D3,

Classification

Group: Other
Family: NKF1

Sequence

Name Sequence Type Origin Length Description Download
CG4945.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 247 Kinase domain by global Sugen HMM Fasta, JSON
CG4945.AA Protein Various 577 None Fasta, JSON

Protein domain

Protein domains of CG4945.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CG4945.AA NKF1 26-272 49 7.4e-165 553.97 In-house 1-269 (269) Show / Hide 
Range on Protein: 26-272
Range on HMM: 1-269/269
Sequence Identity: 49% (134 aa)

FDIIQIVGEGWFGKILLVEHRGSQTEMVLKAVPKPYVTLRDFYREFHYGLHLGVHRHIVTTYDVAFETAG--FYVFTQEYAPLGDLTSNVT---DSGVGE
..||...|||..|||||.|||.|.|.|.||.||||...|.||.|||.||..|..|.||||||||.|.|..  .|||.|||||.|||.....   ..|..|
YEIIRQLGEGCYGKILLCEHRQSGTRMALKFVPKPQTKLKDFHREFCYGCCLSHHHHIVTTYDVMFQTMDDTYYVFAQEYAPCGDLMEMIQPTNQRGLPE

VYSKRVAKQLASAIDYMHSKDIVHRDIKLDNVLIYRS-DFQRIKLCDFGESFPTGSTVER-RNEWLPYSPPEVLEIKPEGSYKADPSHDVWQFGIVIFVC
.|.||...|||||.|.|||...||||||..|||.... |.||.||||||...|.|.||.| ...|....|....|.........||||||||||..||.|
NYCKRCVAQLASALDFMHSRNLVHRDIKPENVLVFDPNDCQRVKLCDFGHTRPRGCTVRRVKHTWPYCAPEVCQELPKNEGFPCDPSHDVWQFGVLIFCC

LTGCLPWQKAASD-DPRYVRYLAWQGG--LMMMP--LRR-TPRLF----KLLTSNAQR-----MFKRFF
||||.|||||... ||.|.....||..  ..|||  .|| |||..    ||||....|     |.....
LTGCFPWQKADWMCDPCYEWFMWWQRRKQPPMMPQPWRRFTPRAMRCFRKLLTPHPERRWPVKMMHKYM
Kinase CG4945.AA Pkinase 26-236 23 2.8e-32 115.19 Pfam 1-226 (293) Show / Hide 
Range on Protein: 26-236
Range on HMM: 1-226/293
Sequence Identity: 23% (56 aa)

FDIIQIVGEGWFGKILLVEHRGSQTEMVLKAVPKPYVTLRDFYR-----EFHYGLHLGVHRHIVTTYDVAFETAGFYVFTQEYAPLG----DLTSNVT--
. |....|.| ||.  .  |.|.. . ..| ..|.       ..     | .. ..|. | .||..||. ||. . . . .||.. |    || . ..  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDW-FEDKDHIYMVMEYCEGGLYVMDLFDYISTW

-DSGV--GEVYSKRVAKQLASAIDYMHSKDIVHRDIKLDNVLIYRSDFQR---IKLCDFGES----FPTGSTVERRNEWLPYSPPEVLEIKPEGSYKADP
 . ..   |   |....|......|.||. |.|||.|..|.||  .. .    .|.|||| .       .|    .   ..| .|||.     |. . .|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGP

SHDVWQFGIVIFVCLTGCLPWQKA----ASDDPRYV
. |.| .|....  |.| .|.. .      .|....
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQM
Kinase CG4945.AA CAMK 31-226 18 2.5e-30 94.35 In-house 1-335 (425) Show / Hide 
Range on Protein: 31-226
Range on HMM: 1-335/425
Sequence Identity: 18% (61 aa)

IVGEGWFGKILLVEHRGSQ------------TEMVLKAVPK-----------------------------PYVTLRDFYREFHYGLHLGV------HRHI
. |.| |||  |..|. ..            ..   | ..|                               .... ..|| .   .|        |..|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VTTYDVAFE-----------TAG---------FYVFTQ--EYAPLG----DLTSNVTDSG----------------VGEVYSKRVAKQLASAIDYMHSKD
.  |.|              |           .| ..   ||.. |    || . ... |                . |   .|. .|..||..|.||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKLDNVLI-YRSDFQ--------------RIKLCDFGES--FPT------------------------GSTVERRNEWLPYSP-PEVLEIKPEGS
|||||.|..|.|. ...| .               ||..||| .  |.                         |   . .   ..| . ||||. |. ..
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

YK---------ADPSHDVWQFGIVIFVCLTGCLPWQ
.           .|. |.|  |.. ...|.|..|..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY
Kinase CG4945.AA S_TKc 26-294 19 3.4e-29 104.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-294
Range on HMM: 1-231/231
Sequence Identity: 19% (56 aa)

FDIIQIVGEGWFGKILLVEHRGSQTEMVLKAVPKPYVTLRDFYREFHYGLHLGVHRHIVTTYDVAFETAGFYVFTQEYAPL--GDLTSNVTDSG------
..|....|.| |||  .. |.... .. .| ..      ....||     .   | .||. |||  .  ... .  ||..   ||| .   . |      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-VGEVYSKRVAKQLASAIDYMHSKDIVHRDIKLDNVLIYRSDFQRIKLCDFGESFPTGSTVERRNEW-----LPYSPPEVLEIKPEGSYKADP-SHDVWQ
   |   .....|...|..|.||. |.|||.| .|.|. .    .||.|||| .                  . | .||||        . .. . |.| 
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKCDWWS

FGIVIFVCLTGCLPWQKAASDDPRYVRYLAWQGGLMMMPLRRTPRLFKLLTSNAQRMFKRFFA-RISNRPKSLADVT---KFLDDRWL
.|.... .|.|. |..    .. .  . .                     .. |  . .. .    ..||      .   .   . |.
CGCILYEMLCGYPPFP----QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CG4945.AA CAMKL 26-225 25 2e-26 81.24 In-house 1-236 (297) Show / Hide 
Range on Protein: 26-225
Range on HMM: 1-236/297
Sequence Identity: 25% (62 aa)

FDIIQIVGEGWFGKILLVEH-RGSQTEMVLKAVPKPYVTLRDFYR----------------EFHYGLHLG--VHRHIVTTYDVAFETAGF------YVFT
..|..  |.| |||  | .| |  ...   | . |   ..... .                | .   .|    | .|.  |.| .||  .      ..  
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEV-IETPEHDIETKKIYLV

QEYAPLGD--LTSNVTDSG-----VGEVYSKRVAKQLASAIDYMHSKDIVHRDIKLDNVLIYRSDFQRIKLCDFGES-------FPTGSTVERRNEWLPY
 ||.. |.  |   .   |       |   .|  .|. ||..|.||..|||||||..|.|.  .. . ||..||| |       |..| . . .   .||
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

SPPEVLEI--KPEGSYKADPSHDVWQFGIVIFVCLTGCLPW
 .||...   ||   .|.    |.|  |.. .. ..| ||.
MAPEIFQGNNKPYDGPKV----DIWSCGVILYAMVCGYLPF
Kinase CG4945.AA Ciliate-E2 80-225 20 1.5e-23 77.72 In-house 91-296 (365) Show / Hide 
Range on Protein: 80-225
Range on HMM: 91-296/365
Sequence Identity: 20% (44 aa)

HRHIVTTYDVAFE--TAGFYVFTQEYAPLGDLTSNVTDS------------GVGEVYSKRVAKQLAS---------------AIDYMHSKD-IVHRDIKL
| .|.  |.. |.  .   . .  ||.  ||| .   ..               |   |.. ||...               |. |.|||  |.|||||.
HPNIIKMYEC-FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP

DNVLIYRSDFQRIKLCDFG-------------------ESFPTGSTVERRNE----------------WLPYSPPEVLEIKPEG----SYKADPSHDVWQ
.|.|.       ||..|||                   .    ..  .|                    ..| .||.|. |...    .   | . |.| 
ENILF-------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS

FGIVIFVCLTGCLPW
.|.... .|.| .|.
LGVILYEMLFGKPPF
Kinase CG4945.AA TKL 32-226 16 2.1e-22 77.49 In-house 1-290 (364) Show / Hide 
Range on Protein: 32-226
Range on HMM: 1-290/364
Sequence Identity: 16% (50 aa)

VGEGWFGKILLVEHRGSQ--------TEMVLKAVPKPYV------------------------TLRDFYREFHYGL-HLGV--HRHIVTTYDVAFETAG-
.|.| ||..   ..||          .... |  .. ..                        ... |  .. . . ..    | .||  . ....  . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FYVFTQEYAPLGDLTSNVTDSGVGEVYS--KRVAKQLASAIDYMHSKD--------IVHRDIKLDNVLIYRS------------DFQR
            ..  . ||.| |.| ....        .   | |.. |....|.||..        |.|||.| .|.|. .             .  .
CVCMHPVGPWGQLCIVM-EYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

IKLCDFGESF-PTGSTVERRNE---------------------WLPYSPPEVLEIKPE-----------GSYKADPSHDVWQFGIVIFVCLTGCLPWQ
.|.|||| |   ..|.   ...                     .. . .||||. ...           .........||. ||||.. .||.|.|..
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY
Kinase CG4945.AA CAMK-Unique 125-168 43 1.6e-19 60.91 In-house 161-218 (363) Show / Hide 
Range on Protein: 125-168
Range on HMM: 161-218/363
Sequence Identity: 43% (25 aa)

RVAKQLASAIDYMHSKDIVHRDIKLDNVLIYRS--D------------FQRIKLCDFG
..  .|.||. ||||.||||||.||.|.... |  |            . .|||||||
FIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFG
Kinase CG4945.AA MSK 129-231 34 2.6e-18 58.49 In-house 109-216 (277) Show / Hide 
Range on Protein: 129-231
Range on HMM: 109-216/277
Sequence Identity: 34% (38 aa)

QLASAIDYMHSKDIVHRDIKLDNVLIYRS-DFQRIKLCDFGESFPTGSTVERRNEW----LPYSPPEVLEI--KPEGSYKADPSHDVWQFGIVIFVCLTG
.| .|.|.||.| |.|||.|. |.|     |  ..|| ||| .  . .  | |       | | .||.|.   ...| |  |.. |.|  |.. .  |||
ELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGY--DEACDWWSLGVILYTMLTG

CLPWQKAASD
. | |. ..|
QVPFQQNEDD
Kinase CG4945.AA AGC 129-168 40 8.4e-18 41.16 In-house 161-200 (395) Show / Hide 
Range on Protein: 129-168
Range on HMM: 161-200/395
Sequence Identity: 40% (17 aa)

QLASAIDYMHS-KDIVHRD-IKLDNVLIYRSDFQRIKLCDFG
....|..|.|| ..|.||| .|..|.|. .     |||.|||
CIVLALEYLHSHMGIIHRDYLKPENILLDED--GHIKLTDFG
Kinase CG4945.AA Ciliate-E2-Unclassified 90-224 21 5.7e-17 55.41 In-house 89-269 (352) Show / Hide 
Range on Protein: 90-224
Range on HMM: 89-269/352
Sequence Identity: 21% (41 aa)

AFETAGFYVFTQEYAPLGDLTSNVTDSG------------------VGEVYSK-----RVAKQLASAIDYMHSKD-IVHRDIKLDNVLIYRSD-FQRIKL
.|..     .  ||.. |||    ....                  . |  .|     . ..|. ....|.|.|  |.|||||..|.|.  .    .||.
CFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKI

CDFGES--------------------------FPTGSTVER-RNEWLPYSPPEVLEI-KPEGS--YKADPSHDVWQFGIVIFVCLTGCLP
.||| |                            .|.     .     | .||||.  ....|  ||.    |.| .|.... .|.| .|
IDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQ-----YTAPEVLQGQNYDHSKAYKC----DIWSLGVILYEMLFGYYP
Kinase CG4945.AA ULK 80-168 26 1.1e-14 47.77 In-house 77-187 (329) Show / Hide 
Range on Protein: 80-168
Range on HMM: 77-187/329
Sequence Identity: 26% (30 aa)

HRHIVTTYDVAFETAGF--YVFTQEYAPLGDLTSNVTDSG-----------VGEVYSKRVAKQLASAIDYMHSKDIVHRDIKLDNVLIYRSDFQ------
| .||  ||. |||. .  . . .|| . ||| .     .             |   . . ||....  ..|.. |.|||||..|.||   . .      
HPNIVKLYDW-FETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKV

----RIKLCDFG
    ..|..|||
HPNGVLKIADFG
Kinase CG4945.AA TyrKc 26-288 20 6.2e-11 -45.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-288
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

FDIIQIVGEGWFGKILLVEHRGSQTEMVLKAVPKPYVTLRDFYREFHYGLHLG-VHRHIVTTYDVAFETA------GFYVFTQEYAPLGDLTSNVTDSG-
   ... ||| ||.. . . .   ..   | . .    ..||.||     .||  | .||  | |. .        . .    ||.|.||| .   ... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-VGEVYSKRVAKQLASAIDYMHSKDIVHRDIKLDNVLIYRSDFQRIKLCDFGESFPTGST--------VERR----NEW--LPY--SPPEVLEIKPEGSY
 .        . | |.  .| ||| ..|||.   |.|. .    ..| .||| |   ..         . |     ..   ||.   .||..       .
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYG

KADPSHDVWQFGIVIF-VCLTGCLPWQKAAS--DDPRYVRYLAWQGGLMMMPLR--------RTPRLFKLLTSNAQRMFKRFFAR-ISNRPKSLADVTKF
|  .  ||| ||.... ..  |  |.   .    ... |. .  ||. |. |           .. ....         |.  ..  ..||   . . .|
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIM--------KQCWHEDPEDRPTFSEIHECF
Kinase CG4945.AA AGC 26-53 28 5e-06 10.05 In-house 1-32 (395) Show / Hide 
Range on Protein: 26-53
Range on HMM: 1-32/395
Sequence Identity: 28% (9 aa)

FDIIQIVGEGWFGKILLVEHRGS----QTEMV
|... ..|.| |||  ||.....    .|. .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKY
Kinase CG4945.AA Pkinase_Tyr 127-168 35 1.1e-05 19.94 Pfam 117-156 (270) Show / Hide 
Range on Protein: 127-168
Range on HMM: 117-156/270
Sequence Identity: 35% (15 aa)

AKQLASAIDYMHSKDIVHRDIKLDNVLIYRSDFQRIKLCDFG
. | |.. .| .|| ..|||.   |.|. . ..  .| ||||
CWQIAKGMEYLESKNCIHRDLAARNCLVTE-NN-VVKICDFG
Kinase CG4945.AA AGC 186-224 26 6e-05 7.16 In-house 273-304 (395) Show / Hide 
Range on Protein: 186-224
Range on HMM: 273-304/395
Sequence Identity: 26% (11 aa)

YSPPEVLEIKPEGSYKADPSHDVWQ--FGIVIFVCLTGCLP
| .||.|          ... | |   .|....  |||. |
YMAPEIL---------YGKACDWWSFGLGCLMYEMLTGYPP
Kinase CG4945.AA ULK 186-227 28 0.001815 8.07 In-house 217-260 (329) Show / Hide 
Range on Protein: 186-227
Range on HMM: 217-260/329
Sequence Identity: 28% (14 aa)

YSPPEVLE----IKPEGSYKADPSHDVWQFGIVIFVCLTGCLP---WQK
|  |..|.     || ..||.    |.| .|.... .|.|  |   | .
YMAPQILQGQGEQKPYYDYKC----DIWSLGCIFYEMLYGKPPFYAW-F
Kinase CG4945.AA Ciliate-E2-Unclassified 26-46 38 0.002107 7.69 In-house 1-21 (352) Show / Hide 
Range on Protein: 26-46
Range on HMM: 1-21/352
Sequence Identity: 38% (8 aa)

FDIIQIVGEGWFGKILLVEHR
. ||.. |.| |||. ...|.
YKIIKQIGQGGFGKVYKCQHK
Kinase CG4945.AA Ciliate-E2 26-46 23 0.008732 5.37 In-house 1-21 (365) Show / Hide 
Range on Protein: 26-46
Range on HMM: 1-21/365
Sequence Identity: 23% (5 aa)

FDIIQIVGEGWFGKILLVEHR
...|.. |.| ||.. .....
YKFIKKIGQGNFGSVYKCKVW
Kinase CG4945.AA CAMK-Unique 26-43 27 0.143335 0.72 In-house 1-18 (363) Show / Hide 
Range on Protein: 26-43
Range on HMM: 1-18/363
Sequence Identity: 27% (5 aa)

FDIIQIVGEGWFGKILLV
 . ..|.|.| ||... .
YKMHRIIGHGNFGHVYEC