Gene CG10951 (Fruit Fly)

CG10951

Species: Fruit Fly
Alias: SFO172, NEK1, CG10951
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 96A23--24,

Classification

Group: Other
Family: NEK
Subfamily: NEK8

Sequence

Name Sequence Type Origin Length Description Download
CG10951.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON
CG10951.AA Protein Various 841 None Fasta, JSON

Protein domain

Protein domains of CG10951.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CG10951.AA NEK8 105-359 52 3.5e-230 664.57 In-house 1-278 (278) Show / Hide 
Range on Protein: 105-359
Range on HMM: 1-278/278
Sequence Identity: 52% (147 aa)

YEKVRVVGQGSFGIAILYRRKSDG--HQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHF
||..||||.|.|||..|||||.|.  |....||||....|...|..|.||..|.|.|.||||.||...|..||||.|||||||||||.|.|...|.||..
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

PER----------------YIIAVFEQISSAINYMHSENILHRDLKTANVFLNRR-GIVKIGDFGISKIMNTKIHAQT---VLGTPYYFSPEMCEGKEYD
.||                .|...|.|..||...||..|||||||||.|.|..|. ..|||||||||||||||.|.||   |.|||||.||||||||.|.
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

NKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAG-NYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIP
.|||.|||||.|.||||||..|.||||..||.|||.. .|.|....|....|.|..|.||.....||.||......  
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase CG10951.AA NEK 105-359 42 6.4e-139 467.81 In-house 1-286 (286) Show / Hide 
Range on Protein: 105-359
Range on HMM: 1-286/286
Sequence Identity: 42% (121 aa)

YEKVRVVGQGSFGIAILYRRKSDGHQ-----IVFKQINLSELSPPGRDLAM-NEVDVFSKLHHPNIVSYLGSFIKDN--TLLIEMEYAD-GGTLAQI---
||.....|||||| . ..|||||| .      | |.||....|.  .. |. ||| . ..|.|||||.|  ||| ..  .| |.|||.. ||.|.|    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IAERQG-KLHFPERYIIAVFEQISSAINYMHSE-----NILHRDLKTANVFLNRRGI----VKIGDFGISKIMNTK-IHAQT-VLGTPYYFSPEMCEGKE
| .... . .|.|..|  .| |...|..|||..     .|||||.|..|.||.....    ||||||||||..|..  .|.| . ||||| |||.|..| 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDNKSDIWALGCILGEMCCL--KKTFAAS--NLSELVTKIMAG-NYTPVPSG--YTSGLRSLMSNLLQVEAPRRPTASEVLVYWIP
|.||||||.|||.| |||.|  |. | |.  |. .|..||| | .| |.||   | . |..|.|..||..   ||.....|  .. 
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase CG10951.AA NEK1 105-354 43 3.1e-105 355.93 In-house 1-271 (276) Show / Hide 
Range on Protein: 105-354
Range on HMM: 1-271/276
Sequence Identity: 43% (117 aa)

YEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYLGSFIKDNT--LLIEMEYADGGTLAQIIAER--QGKL
|.. ...|.|||| |.| ..|.|| . | | ||... ..  |  .|||| . .|. |||||.|  ||.      | | |||.||| |.| | ..  .|||
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

HFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLN--RRG---------------IVKIGDFGISKIMN-TKIHAQTVLGTPYYFSPEMCEGKEYD
 |.|  |   | ||. | |..|...|||||.|. |.||   . |               .||.|||||....| |  .|.|..||||| |||.|. | |.
-FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYN

NKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVL
||||||.|||.| | | ||  | | |.  || ||  | |.|.|. |   |.|| | .... .  || .  .|
NKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQIL
Kinase CG10951.AA NEK4 105-361 39 2.2e-78 266.71 In-house 1-257 (257) Show / Hide 
Range on Protein: 105-361
Range on HMM: 1-257/257
Sequence Identity: 39% (102 aa)

YEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYLGSFIKDNT--LLIEMEYADGGTLAQIIAERQGKLHF
|. ..|||.||.|   | | . |. | | | ..| . |   |  |  |. . |.| |||||.|  |.  .|   | | | . .|| | .   .. ...  
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQF-L

PERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISKIMN-TKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLK
.|. ..  | ||  |  |||  .|||||||| |.|| .. |.||||||||...|     |.|..||||| |||.   . || |||||.||| . ||  ||
EEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLK

KTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPLI
  | | ..  |. .|. |   |.|  |   |  |.  .|.    .||   ...    | |
HAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQ--MPYI
Kinase CG10951.AA S_TKc 105-358 31 4.9e-76 259.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 105-358
Range on HMM: 1-231/231
Sequence Identity: 31% (84 aa)

YEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADG--GTLAQIIAERQG-KLH
||..|..|.|.||   . | |..|..   |.|.         . ...|... .| |||||| ....|   . | . |||.||  |.| ..| .|.. .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDN-KSDIWALGCILGEMC
  |||  .  .. || .|..|.|| .|.||||| .|..|..   .||.|||.....       |. |||.| .||..    |.  |.|.|..|||| ||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

CLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLV--------YWI
| .  |   .. ..  ||.           .. ........||..  .|||| |.|          |.
CGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CG10951.AA Pkinase 105-358 26 1.2e-68 239.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 105-358
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

YEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMN--EVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGG----TLAQIIA-ERQ
|...|..|.||||   . ..|..|.. . |.|.... ..  .  . .  |. .  .|.||||| ....|  .. . . |||..||     |. .|  .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIV----KIGDFGISKIM-NTKIHAQTVLGTPYYFSPEMCE-GKEYDNKSDIWALG
|.. |.|. .. .. || ....|.||..|.||||| .|......| .    ||.|||..| . . . ...|. |||.| .|| .  |..|. |.|.|..|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG

CILGEMCCLKKTFAAS------NLSELVTKIMA-GNYTPVPSGYT-------------------SGLRSLMSNLLQVEAPRRPTASEVLVY-WI
||| ||.| .  |  .      .  ... .||   .  . |  ..                   . ........|..   .|||| ..|   |.
CILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CG10951.AA NEK2 105-361 30 3.7e-63 211.49 In-house 1-319 (319) Show / Hide 
Range on Protein: 105-361
Range on HMM: 1-319/319
Sequence Identity: 30% (99 aa)

YEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYLGSFI--KDNTLLIEMEYADGGTLAQIIAE-RQGKLH
||   . |.||||     ||||||   | | |.  ..    ...  .|. . ..| ||||| |    |  .  || | |||  || |.|.|   |. .  
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

FPERYIIAVFEQISSAINYMHS------------------EN---ILHRDLKTANVFLNRRGI-------------------------------------
..| .|  .. |. .|    |                    .   |||||.| ||.||   .                                      
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--VKIGDFGISKIMN-TKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLL
  || ||||  .. |     |.|  ||||| |||  .|  |. |||||..||.. ||| |.  | | |  .| .||  | . ..|. | ..|  . .  .
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

QVEAPRRPTASEVLVYWIPLI
 |    ||   | | .  |.|
NVDHYHRPSIEEILQH--PQI
Kinase CG10951.AA STE 105-352 23 1.6e-57 197.46 In-house 1-350 (359) Show / Hide 
Range on Protein: 105-352
Range on HMM: 1-350/359
Sequence Identity: 23% (83 aa)

YEKVRVVGQGSFGIAILYRRK------SDGHQ---------IVFKQINLSELSP---------------PGRDLAMNEVDVFSKLH--HPNIVSYLGSFI
.|.....|.|.||   . ...      . | .         .  ||.||.. ..                 ..  ..|... .|..  ||||| |.|...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD-------NTLLIEMEYADGGTLAQIIA---ERQGKLH--------FPERYIIAVFEQISSA-INYMHSENILHRDLKTANVFLNRRGIVKIGDFGISK
|.       ..| | ||| |||.| .||    .... |.        |||  |...  ||  .  .| || .| |||.| ||..|     ||. |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

IMNTKI-----------------HAQTVLGTPYYFSPEMCEG------KEYDNKSDIWALGCILGEMCCLKKTFAA-SNLSELVTKIMA-----------
... ..                 . .|. ||| . .||. ..      |.|| |.||| ||| . ||.. |  ..  .... .  ...            
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GNYTPVPS-------------------GYTSGLRSLMSNLLQVEAPRRPTASE
   |.  | |.                    ... ..  ... || .   |||||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase CG10951.AA NEK-Unclassified 105-354 34 3.3e-55 181.09 In-house 1-253 (258) Show / Hide 
Range on Protein: 105-354
Range on HMM: 1-253/258
Sequence Identity: 34% (89 aa)

YEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIAERQGK-LHFP
|.|.  .|||  |   | |     |||  . .         .    | . . |.| || || |  ||     |    .| ||| | . |  . .|   | 
YDKITTLGQGGGGAVYLVR-----HQISKRHLVQQISKRKKKKKRQNKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFD

ERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISKIMN-TKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKK
|  |   . |.  |. | |.  |.|||||. |.||    .| .||||||.||. |.  |.|  ||. . ||| |. . |.|.||.|.||||. |||    
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEP

TFAASNLSELVTKIMAGNY------TPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVL
 | . |. |.  ||  .         || . |   |  ..  .|. .  .|| | |..
FFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIV
Kinase CG10951.AA CAMK 110-358 20 3.4e-55 175.94 In-house 1-425 (425) Show / Hide 
Range on Protein: 110-358
Range on HMM: 1-425/425
Sequence Identity: 20% (88 aa)

VVGQGSFGIAILYRRKSDG------------HQIVFKQINLSELS--------------------------PPGRDLAMNEVDVFSK-------LHHPNI
. |.||||.  | ..|...            ..   | |. . |.                          |  |.  ..|... .|       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSYLGSFI------------KDNT--------LLIEM---EYADGG----TLAQIIAERQGKL------------HFPERYIIAVFEQISSAINYMHSEN
.. .  .               ..        . . |   ||..||     | . | |. ..             .|.||    .| || ||..|.|| |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDLKTANVFLNRR-----------------GIVKIGDFGISKIMNT------------------------KIHAQTVLGTPYYFS-PEMCEGKE---
| |||||  |. |. .                 . .|| ||| .....                             .|. |||.| . ||. .||    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YDNKSDIWALGCILGEMCCLKKTFAAS-------------NLSELVTKIMAGNYTPVPSGYTS-----------------------GLR
           |. |.|.|..|.||  | | .  | ..             |..||  |||.|.|.  |.  .                          .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

SLMSNLLQVEAPRRPTASEVLV-YWI
.| ...|||.  .|.|....|   |.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CG10951.AA NEK11 105-361 39 2e-53 183.78 In-house 1-259 (259) Show / Hide 
Range on Protein: 105-361
Range on HMM: 1-259/259
Sequence Identity: 39% (105 aa)

YEKVRVVGQGSFGIAILYRRK--SDGHQI-VFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIAE--RQGK
|     .| ||||   |   |    |  . | | |   || |     |  |  . |.|||| || .  ||.  ..  |  || .|  | . | |  . ||
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQAGK

LHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISK-IMNTKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMC
. |||  ||  | |.   . |||   |||||||  |.|| .  ..||||||.|. .|     | |. ||| | |||    . || |||||.| ||| |||
I-FPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMC

CLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPLI
|.   || ||   .| .|. |.   .|  |   | ..|  .|  .   || | ..|   || .
CMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILK--IPYM
Kinase CG10951.AA ULK 105-317 27 5e-50 172.53 In-house 1-268 (329) Show / Hide 
Range on Protein: 105-317
Range on HMM: 1-268/329
Sequence Identity: 27% (73 aa)

YEKVRVVGQGSFGIAILYR-RKSD---GHQIVFKQINLSELSPPGRD--------LAMNEVDVFSKLH--------HPNIVSYLGSFIKD--NTLLIEME
|.. .. |.||||     |  |..   . ... |.| .....    .        | .||...  ||.        ||||| ..  |  .  | . | ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YADGGTLAQIIAERQG-------KLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRR------------GIVKIGDFGISKIMNT----KI
| .||.| |.| ....       | ...|  .| .| || ..  ..|..|| |||.| .|. ..              |..||.||| .| ..     . 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

HAQTVL------GTPYYFSPEMCE----GKEYDNK-SDIWALGCILGEMCCLKKTFAASNLSELVTKIM
 ..| .      |||.| .|.  .    .|.|... .||| ||||. ||   |  | |.  .... .|.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQII
Kinase CG10951.AA TyrKc 105-357 22 2e-17 58.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 105-357
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

YEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKL--HHPNIVSYLGSFIKD-------NTLLIEMEYADGGTLAQIIAE
 .. .. | | ||.  . . |    |   | .. .      |   |.|  . .||  ||||||  .|  ...         |.| |||...| | . . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISKIMNTK-----IHAQTVL----GTP-----YYFSPEMCEGKEY
...||  ..   ...  ||..  .| || |. |||| . |. ......|||.||| |.    .      .   .     |.         .||    ...
HRPKLCMKDLLSFCW--QIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DNKSDIWALGCILGEMCCLKKTFAAS------NLSELVTKIMAGNYTPVPSG--------YTSGLRSLMSNLLQVEAPRRPTASEVLVYW
  |||.|. |  . |.. . ..          . .|.. ....|.. | |           .. . ..|.   . ..  ||| ||.  ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CG10951.AA Pkinase_Tyr 150-253 29 5.9e-17 58.05 Pfam 51-159 (270) Show / Hide 
Range on Protein: 150-253
Range on HMM: 51-159/270
Sequence Identity: 29% (33 aa)

MNEVDVFSKL-HHPNIVSYLGSFI-KDNT--LLIEMEYADGGTLAQIIAER---QGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRG
|.|. . ..| ||||||...|  . ..    ..| |||. .| |     ..   ...|  ..   ...  ||... .| .| |. |||| . |. ... .
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCW--QIAKGMEYLESKNCIHRDLAARNCLVTENN

IVKIGDFGISK
.|||.||| ..
VVKICDFGLAR
RCC1 CG10951.AA RCC1 470-520 29 8.3e-17 57.44 Pfam 1-52 (52) Show / Hide 
Range on Protein: 470-520
Range on HMM: 1-52/52
Sequence Identity: 29% (16 aa)

DGSAYAWGEGTHGQLG-LTALEAWKHYPSR-MESVRN-YHVVSACAGDGFTILV
||. |.|| ...|||| ..  .  .|.|..  |.  . ..||....|. .|...
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 CG10951.AA RCC1 523-572 37 3.8e-13 45.54 Pfam 1-52 (52) Show / Hide 
Range on Protein: 523-572
Range on HMM: 1-52/52
Sequence Identity: 37% (20 aa)

AGSLLSCGSNAHLALG--QDEQRNYHSPKL-IARLAD-VRVEQVAAGLQHVLAL
 |.. ..|.| .  ||  ..   | | |.. .  | . ||| |||.| ||..||
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 CG10951.AA RCC1 575-626 25 3e-07 26.41 Pfam 1-52 (52) Show / Hide 
Range on Protein: 575-626
Range on HMM: 1-52/52
Sequence Identity: 25% (14 aa)

EGAVYVWGTSTCGALG-LGNYQQQQKFPQKILLSHVKT--KPSKIYCGPDTSAVL
.| || ||  . | || ...    .  ||.| ..      . ... || . ...|
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQI-VEFL-GNVRVVQVACGWQHTMAL
RCC1 CG10951.AA RCC1 629-676 22 2.8e-05 20.02 Pfam 1-52 (52) Show / Hide 
Range on Protein: 629-676
Range on HMM: 1-52/52
Sequence Identity: 22% (12 aa)

NGELHVCGSNDYNKLG-FQRSAKITAF-KK-VQLPHK---VTQACFSSTHSVFL
.|..  .|.|||  ||  . .       .. |... .   |.|..  ..|...|
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 CG10951.AA RCC1 679-728 27 1.6e-07 27.3 Pfam 1-52 (52) Show / Hide 
Range on Protein: 679-728
Range on HMM: 1-52/52
Sequence Identity: 27% (15 aa)

GGYVYTMGRNAEGQRG--IRHCNSVDHPTL-VDSVKS-RYIVKANCSDQCTIVA
 | |||.|.| .|| |    .. .. .|.. | .  . . .|.. | .| |.. 
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL