Gene Nrk (Fruit Fly)

Nrk

Species: Fruit Fly
Alias: Nrk, nrtk_dros, neurospecific receptor tyrosine, neurospecific receptor tyrosine kinase, SFO019, Dnrk, l(2)k14301, DNRK, Drosophila neurospecific recepto, HD-434, CG4007, Drosophila neurospecific receptor kinase, DmHD-434
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 49F11--12,

Classification

Group: TK
Family: Musk

Sequence

Name Sequence Type Origin Length Description Download
Nrk.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 271 Kinase domain by global Sugen HMM Fasta, JSON
Nrk.AA Protein Various 708 None Fasta, JSON

Protein domain

Protein domains of Nrk.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Fz Nrk.AA Fz 54-187 23 1.7e-54 168.11 Pfam 1-143 (143) Show / Hide 
Range on Protein: 54-187
Range on HMM: 1-143/143
Sequence Identity: 23% (35 aa)

CAPYS--GKVCKEYLTGQVW--YSLEDPTGGWKNEQVT----TALWDELISD---LTGLCREAAEKMLCAYAFPNCHMEGGRAVK-APLCFEDCQATHLQ
|.|..  ...|.... .. |  ..|...||..|.....    ...|..|..    |...|.......||...||.| ..|... .  |.|.. |.|.. |
CQPIRNDIPMCHGMPYNMTWMPNLLHHETGTQKEAELQWEMMIHQWWPLVHTSTHLSPKCHPHIQFFLCSMYFPMC-TDGFHHPPPIPPCRSMCEAVKEQ

FCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCS
.|.. .  .|.||.|.|.. ........||...||...  .|..| 
GCEPVMQMMEDKKHRRMYPFGFHWPEMLNCNKFPHHHD--DRHMCM
KR Nrk.AA KR 201-283 50 1.9e-46 161.53 SMART 1-90 (90) Show / Hide 
Range on Protein: 201-283
Range on HMM: 1-90/90
Sequence Identity: 50% (45 aa)

YDCRNG--NGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQPPLVFHQLL----EGENYCRNAGGEEPHPWCYTVDESVR-WQHCDIPMCPD
.|| .|  ||..|.||.|...||.|||||| ||||.| ..|  |...      ..||||| .|....|||||.|. || |..||||.|.|
RDCYWGDDNGESYRGTVNTTWSGHPCQRWDSQYPHLHWFYPEWFPCAGQLGLLEHNYCRNPDGDSEGPWCYTMDPNVRDWEYCDIPQCED
Kringle Nrk.AA Kringle 203-281 51 7.7e-27 94.37 Pfam 1-85 (85) Show / Hide 
Range on Protein: 203-281
Range on HMM: 1-85/85
Sequence Identity: 51% (44 aa)

CRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQ-PPLVFHQLLEGE---NYCRNAGGEEPHPWCYT-VDESVRWQHC-DIPMC
|  |||. |.||.....||.|||||| |.||.| .  |  |     ||   |||||  |.|  |||||  | .|||. | ||| |
CYHGNGENYRGTWSTTESGRPCQRWDSQTPHRHPFYTPENFPCKGLGEGKHNYCRNPDGDERGPWCYTQTDPRVRWEYCSDIPRC
Kinase Nrk.AA Musk 425-695 69 3.6e-228 761.48 In-house 1-282 (282) Show / Hide 
Range on Protein: 425-695
Range on HMM: 1-282/282
Sequence Identity: 69% (197 aa)

IVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYA
|.|||..|.||||||||||||||||..|...|||||||||||.||||||.||||..|||||||||.|||||..||||||||||||.|||.|||..|||..
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

THQAPTQDR-----------LQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESI
|.....|||           .||...|.|.||..||.||.||||..|||||||||||||||||.|||||||||..||.||||||.|||.|||||||.|||
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

LYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCI
.||.|..||||||||.||||.||.|||||.|.||||||.||..||.|.||.|.|..||.||||||...|..||.|..|.|||
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase Nrk.AA Pkinase_Tyr 425-695 42 1.1e-131 446.6 Pfam 1-270 (270) Show / Hide 
Range on Protein: 425-695
Range on HMM: 1-270/270
Sequence Identity: 42% (120 aa)

IVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQM--QMDFEREACLLAEF-DHPNIVRLLGVCA-LGRP--MCLLFEYMAPGDLSEFLR
|.  . ||.||||.|..... |  ||.... |||||||..|...   . || ||| .. .. .|||||||.|||   |.|  ... .|||. ||| ..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

ACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYY-KGDENDFIPIRWMPLESILYNK
. .          |. .|.  .||||.. ||.|| ||......|||||.||||..| . |||.||||.  ||  ||| .  ..  .||.||..|.| |.|
KHR---------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK

FSLESDVWAYGICLWEVFSFALQP-YFGLTHEEVIKYI-KEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCI
|. .||||..|...||.|..  || | |.. |||..|| ..|. . ||.|.|  .| ||..||. .|..|| |.|| ...
FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Nrk.AA TyrKc 425-695 38 7.89999999999e-127 428.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 425-695
Range on HMM: 1-280/280
Sequence Identity: 38% (117 aa)

IVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEF--DHPNIVRLLGVCALG-------RPMCLLFEYMAPGDLSE
|.  . || ||||.|.....         . |||||||.||    ..|| ||| .. ..  .|||||||.|||  .        |.....|||. ||| .
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQ-------DYYKG----DENDFIP
.||.. |             |.  .||...  ||.|| ||......|||||.||||..|   |||.||||| .||         |||.     .... .|
YLRKHRPK------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

IRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFG-----LTHEEVIKYIKEGNVLGCPDN--------TPLSVYALMRRCWNRKPSERPGFAEI
||||..|.| |.||. .||||..|.|.||.|..  ||| |     .. .|||.|.|.|. . .|.|         |  .| .|..||...|..|| |.||
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

NHCI
 .|.
HECF
Kinase Nrk.AA TK 425-695 23 8.60000000001e-114 383.01 In-house 1-486 (486) Show / Hide 
Range on Protein: 425-695
Range on HMM: 1-486/486
Sequence Identity: 23% (116 aa)

IVYVRSLGQGAFG---RVFQARAPGLVPDQED--------------------LLVAVKMLK--DDASDQMQMD--------------FEREACLLAE--F
|.... ||.|.||   .|..... |. |....                      |||||||  |..|.....|              . .|.... .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHPNIVRLLGVCALG------------RPMCLLFEYMAPGD----LSEFLRACSPYATH-----------------------------------------
.|||||||.|||  |            .|.... |||. ||    | ..||.|.|...|                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------QAPTQDRLQ------------LNELHLLQMAANIAAGMLYLSER------KFVHRDLATRNCLINEHMA-----------VKIADFG---
          . .|.| ||            |.  .|| |.. ||.|| ||...      .|||||||.||||..|..            .||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSHKIYL------------------------QDYYKGDENDFIPIRWMPLESIL---------YNKFSLESDVWAYGICLWEVFSFA-LQPYFGL
     |. .||                         ||||. . .. .|||||. |...         |.||. .||||..|...||.|...  ..| |.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TH---------EEVIKYIKEG--------------NVLGCPDNTP--------------LSVYALMRRCWNRKPSERPGFAEINHCI
..         .||..|...|              . . .|.. |                .| ||..||...|..|| |... ...
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Nrk.AA Trk 425-695 44 1.3e-111 377.05 In-house 1-275 (275) Show / Hide 
Range on Protein: 425-695
Range on HMM: 1-275/275
Sequence Identity: 44% (122 aa)

IVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYA
||  . || ||||.|| |    |.|.|. ..|||| || |||..   ||.||| || . .|..||.. |||  ..|. . ||||  ||| ..||.  | |
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLK-DASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

THQAPTQD---RLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYL-QDYYKGDENDFIPIRWMPLESILYNKFSL
   |  |.   .. |    .|  |  ||.|| |. .  |||||.||||||. .   |||.|||.|  .|   |||. .     |||||| |||.| ||. 
MCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTY

ESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNV-LGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCI
||||| .|. .||.|..  ||...|   ||| .| .| . | .|   |  ||..|. || | | .|    .| . |
ESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase Nrk.AA Ror 425-691 45 1.6e-106 360.18 In-house 1-271 (308) Show / Hide 
Range on Protein: 425-691
Range on HMM: 1-271/308
Sequence Identity: 45% (124 aa)

IVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYA
.     || ..|| |.     |. . ..  .||.| .|.||| . . ||..|. | |...||||| |||||    |.| |||||. ||| |||   || .
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPHS

THQ-APTQD---RLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSL
 |      |      | ..  |. |. ||||| ||| . |||||||.||||..||  |||.||||.  ||  |||.   .   |||||. |.|.| ||| 
DHGCSSDDDRMVKSSLDHPDFLHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAIMYGKFSE

ESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEI
.||.| .|. |||..|. .||| |    |||  |    .| ||.| |  .|.||  ||.  || || | .|
DSDIWSFGVVLWEIWSYGMQPYYGYSNQEVIEMIRNRHLLPCPHNCPTWIYSLMIECWHEIPSRRPRFKDI
Kinase Nrk.AA InsR 425-697 42 5.3e-99 333.18 In-house 1-278 (278) Show / Hide 
Range on Protein: 425-697
Range on HMM: 1-278/278
Sequence Identity: 42% (117 aa)

IVYVRSLGQGAFGRVFQARAPGLVPDQEDL--LVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSP
||  | .|||.|| |    | |.||| |.    .|.| ....||.    .|  ||    ||.. ..|||||||  | ||    | |. |||  .||.  |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

YAT-HQAPTQDRLQLNEL-HLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSL
 .     . ... .   |  ..|||| |. || ||  .|||||||| |||..|.   |||.|||.   ||  |||.       |.|||. ||.   .|. 
EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTT

ESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYI-KEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQH
 |||| .|. |||. ... ||| ||  |.| ||| ..||||  |.| |  ...||..||  .|. || | .|.| .. 
HSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase Nrk.AA UTK 425-695 35 1.6e-97 330.28 In-house 1-296 (296) Show / Hide 
Range on Protein: 425-695
Range on HMM: 1-296/296
Sequence Identity: 35% (106 aa)

IVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMD----FEREAC---LLAEFD-HPNIVRLLGVCALGRPMCLLFEYMAPGDLSEF
.   | ||||||| |. ||.    .  ....|||| .. .|..| ...    | .||    ... |. |||..||.|||  . |.... |||. |||. .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEH-------MAVKIADFG---LSHKIY---------LQDYYKG
|| ..| .      .....|.. ..|.||..||.|| ||....||||||| ||||...|       | .||||||   .|. ..          ..||. 
LRRHRPTPP-----ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMA

DENDFIPIRWMPLESILYN-KFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEG--NVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHC
...| .|||||  |.. .. .|.. ||||..|. .||..... .|| |.....|.. . .|    . ||.  |..|| ||.|||.  |.||| | ..   
QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQ

I
.
M
Kinase Nrk.AA TK-Unique 425-695 34 1.5e-85 290.53 In-house 1-294 (294) Show / Hide 
Range on Protein: 425-695
Range on HMM: 1-294/294
Sequence Identity: 34% (100 aa)

IVYVRSLGQGAFGRVFQARAPGLV-PDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFD-HPNIVRLLGVCALGR-PMCLLFEYMAPGDLSEFLRACS
..  ...|.|||| |. . . |.  .. ..  ||||||||.|.|. ..|| .|. .. | . |||||..||.|     |.....||...|.|  .|| | 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

P------------YATHQAPTQDRLQ-LNELHLLQMAANIAAGMLYLSE--RKFVHRDLATRNCLINEHMAVKIADFGLSHKIYL-QDYYKGDENDFIPI
|            . .| .| ..|.  ...  |.. |  || || ||..  .|.|||||..||.|..|.  .||.|||.. ..|  ..| . ..   |||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMPLESIL--YNKF-SLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNT-PLSVYALMRRCWNRKPSERPGFAEINHCI
|||..||..  .. . . .||||..|. .||.|..  .|| |.  ..... |..|  .  |..  .  .| ||..||...|.||| |..| | .
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase Nrk.AA Src 425-695 34 6.1e-80 271.28 In-house 1-255 (255) Show / Hide 
Range on Protein: 425-695
Range on HMM: 1-255/255
Sequence Identity: 34% (93 aa)

IVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYA
|  .| |||| || |...   | ..      |||| || .     . .| .|| .. ...|...|.|. ||  . |     |||. | | ..|..     
IKLCRKLGQGQFGEVWMGYWNGNTK------VAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-----

THQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQ-DYYKGDENDFIPIRWMPLESILYNKFSLESD
     ...  .|.  .|. ||| .|.|| ||......||||| || |..|. ..|.|||||   |    | |   .   .||.|.  | |.|..|.  ||
-----DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSD

VWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYA-LMRRCWNRKPSERPGFAEINHCI
|| .|| |.|....   || | | .||.. .. |  . ||.| | ..|  .|..||...| .|| |. ...  
VWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Nrk.AA ALK 425-697 38 1.9e-79 270.22 In-house 1-273 (273) Show / Hide 
Range on Protein: 425-697
Range on HMM: 1-273/273
Sequence Identity: 38% (107 aa)

IVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYA
|  || ||.|||| |. .   ..  |   . ||.| |. |.| | . ||  ||  .. |.|.|.||..|.|    |   . |||. ||.  ||| | |  
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

THQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMA---VKIADFGLSHKI-YLQDYYKGDENDFIPIRWMPLESILYNKFSL
    |.    ||    ||| .  .|.|  || |..|.||| | ||||     .   .|||||| .  | |  |||       .|. ||| |  .   |  
ESLQPS----QLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTS

ESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQH
 .|||..|. .||.||    || | . .||.. . ||. .. | | | .|| .|. ||. .|  || |. |   || 
KTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase Nrk.AA DDR 425-695 37 1.2e-77 264.25 In-house 1-306 (306) Show / Hide 
Range on Protein: 425-695
Range on HMM: 1-306/306
Sequence Identity: 37% (114 aa)

IVYVRSLGQGAFGRVFQARAPGLV-----------PDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFD-HPNIVRLLGVCALGRPMCLLFEYMAP-G
 . |  .|.| || |    . |.               . .|||||||. ||..    || .|.  ..    |||||||.|||    |.|.. |||   |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DLSEFLRACSPY--ATHQAP----TQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFG--LSHKIYLQDYYK--G---D
||  |. .  .   .. ...      ..  .    .. ... ||.|| ||.   ||||||||||||. .   .||.|||  .|   | ||||.  |    
DLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTGR

ENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFA-LQPYFGLTHEEVIK-----YIKEGN--VLGCPDNTPLSVY-ALMRRCWNRKPSERPGFA
     |||||  |||| .||.  ||||| |. .||.|.|.  |||  || | ||      . ..|.  .|  | . | ..|  || |||.| .|.|| |.
QRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSFE

EINHCI
||    
EIHKFL
Kinase Nrk.AA Pkinase 425-695 19 7e-41 145.62 Pfam 1-293 (293) Show / Hide 
Range on Protein: 425-695
Range on HMM: 1-293/293
Sequence Identity: 19% (60 aa)

IVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKML-KDDASDQMQMDFER--EACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPG----DLSEFL
.. .| .|.|.||.|....    . ...  .|||| . |.........   |  |........|||||||....  .. ... .||.  |    ||....
YHIGRKIGSGSFGCVYKCH---HKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RACSPYATHQAPTQDRLQL--NELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAV----KIADFGLSHKIYLQDYYKGDENDFIP--IRWMP
..           ...  .   | ..  ..  |. |. |. .....||||   |.||.... .    ||.||||. ...   | ..  .. .   ...|.
ST-----------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMA

LESIL-YNKFSLESDVWAYGICLWEVFSFALQPYFGL------THEEVIKYIKEGNVLGCPDNT--------------------PLSVYALMRRCWNRKP
 | |. ... . ..|.|..|. |.|...    |. |       .. ..|. |... .    ...                    . .   ....|....|
PEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP

SERPGFAEINHC--I
..||....| .   .
KKRPTAEQILQHPWF
Kinase Nrk.AA S_TKc 425-700 21 9e-41 142.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 425-700
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

IVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAP--GDLSEFLRACSP
   .| .|.||||.|...|  .      . .||.|..|         ...||  .| . .|||||.|..|.     ... .||.    ||| .... . .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

YATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSL-E
  .       | ...| |   ... |. .. |. .....||||   | |..|   .||.||||. ..                 .|. | .   ...  .
HGL-------RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCK

SDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINH----CIQHSIA
.|.|. |..|.| ..    |.   ......| |.           . ..  ..|.|... |..||.  |. .      .|   
CDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF