Gene Tak1 (Fruit Fly)

Tak1

Species: Fruit Fly
Alias: CG1388, Tak1, DmTak1, D10, TAK1, Tak 1, CG18492, SFO127, dTAK1, DTak, DTAK1, dTAK, TGF-beta activated-kinase 1, DTak1, TGF-beta activated kinase 1, TAK
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 19D2,

Classification

Group: TKL
Family: MLK
Subfamily: TAK1

Sequence

Name Sequence Type Origin Length Description Download
Tak1.AA Protein Various 678 None Fasta, JSON
Tak1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 245 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Tak1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Tak1.AA TAK1 19-266 52 5.70000000001e-186 624.11 In-house 1-284 (284) Show / Hide 
Range on Protein: 19-266
Range on HMM: 1-284/284
Sequence Identity: 52% (148 aa)

ITLREKVGHGSYGVVCKAVWRDKLVAVKEFF------ASAEQKDIEKEVKQLSRVKHPNIIALHGI-SSYQQATYLIMEFAEGGSLHNFLHG-KVKPAYS
|.....||.|.|||||||.||.| .|||.|.      ...|||.||.|..|.|||.|||||.|.|. ....|...|.||....||||||||| |.|..|.
IQNEHFVGKGTYGVVCKAKWRNKEIAVKRFEFIKYSSEECEQKNIEREIMQWSRVDHPNIIKLYGMYACHRQCQCLVMEYMDCGSLHNFLHGAKPKWEYT

LAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNRGSAAWMAPEV----------------------FEGS
.||||||..|||.|.||||.|.|||.||||.||.|.||.||.|.||||||||..|...|||.|||...||||||                      |...
HAHAMSWMHQCAQGVAYLHSMQPKPQIHRDIKPQNMLLCNKHRTLKICDFGTFCDMHQMMTCNRGTCRWMAPEVRELFDFKSNRIIINQPTGFQKVFRCE

KYTEKCDIFSWAIVLWEVLSRKQPFKGIDN---AYTIQWKIYKGERPPLLTT---CPKRIEDLMTACWKTVPEDRPSMQYIVGV
||..||||.||.|..|||.|||.|...|.|   ||.|.|.|..|.|||..|.   ||||||..|..||...||.|||||..|  
KYNMKCDIYSWGIIMWEVISRKHPYDHIMNPNSAYRIMWAIHNGNRPPMETNRSDCPKRIEQFMKCCWDDNPEKRPSMQECVKY
Kinase Tak1.AA MLK 19-267 40 4.4e-139 468.35 In-house 1-291 (291) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-291/291
Sequence Identity: 40% (117 aa)

ITLREKVGHGSYGVVCKAVWRDKL-----VAVKEFF--------ASAEQKDIEKEVKQLSRVKHPN-----IIALHGISSYQQATYLIMEFAEGGSLHNF
|.. |..|.||.|.|.|..|| |.     ||||...        ...||.|.|.|...|....|||     |. .........  ...||..|||||.|.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHG-KVKPA-----------YSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTN-----KGRNLKICDFGTVADKSTM---MTNNRGSAAWM
||| . |..           |...|||.|| |||.|..|||.| |||.|||| |. |.|...     ....||||||||. |...|   |..|.|..|||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APEVF---EGSKYTEKCDIFSWAIVLWEVLSRKQPFK-GIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVM
||||.   ...||.||||..||..||||.|.|. |.| ..|... . | .|.|.|||.  |||.... ||. ||.. |..|||...||   
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Tak1.AA TKL 25-267 26 1.5e-96 327.04 In-house 1-364 (364) Show / Hide 
Range on Protein: 25-267
Range on HMM: 1-364/364
Sequence Identity: 26% (98 aa)

VGHGSYGVVCKAVWRD----------KLVAVKEFF-----------------------------ASAEQKDIEKEVKQLSRVKHPNIIALHGISSYQQA-
.| |..|.|.|..||           | |||| |                              || ... .|.|....|| .||||. . |.. . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------TYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTP-----KPLIHRDVKPLNLLLTNKGRN-------------
             ...||...||||...||        . . ..||...| |..|||.|.|     .|.|||| |. |.|. ....|             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

LKICDFGTVADKSTM---------------------MTNNRG-SAAWMAPEVFEGS----------------KYTEKCDIFSWAIVLWEVLSRKQPFKGI
.||||||.  ..|..                     .|.... . .||||||..|.                .|.||||..|..|||||.|.|..|....
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

DNAYTI---------QWKIYKGERPPLL------------TTCPKRIEDLMTACWKTVPEDRPSMQYIVGVM
..   |          . ..||.|||.             ..||... .||. ||.. ||.|||.| |.  .
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Tak1.AA TKL-Unique 21-267 33 2.3e-75 256.68 In-house 1-290 (290) Show / Hide 
Range on Protein: 21-267
Range on HMM: 1-290/290
Sequence Identity: 33% (97 aa)

LREKVGHGSYGVVCKAVWRDKLVAVKEFFA---SAEQ--KDIEKEVKQLSRVK-HPNIIALHGISS----YQQATYLIMEFAEGGSLHNFLHG-------
  .|.| |.||.|.|..|| . ||.| |.    |  .  .. |.||. ... . ||||  . |..     |.   ...||. .||||.. ||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-KVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKG----RNLKICDFGTVADKSTM--MTNNR----------GSAAWMAPEVFE
 . .   ...  .. |...| |. |||   |.  |||| |..|.|..|.      | ||||||..  .|..  ||||.          ||. ||||||..
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

G--SKYTEKCDIFSWAIVLWEVLSRKQ------PFKGIDNAYTIQWKIY--KGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVM
.  ..|.||.|..| .||||| ..||.      |..|.|    .. . |  .. |||. . |||.. ||...||.  |..||| . |.   
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase Tak1.AA Pkinase 19-267 27 8e-65 226.46 Pfam 1-293 (293) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

ITLREKVGHGSYGVVCKAVWRDK--LVAVKEFFASAEQKDIEK------EVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGG----SLHNFLHGKVK
... .|.| ||.|.|.|.....   .||||..  . | .. ..      |.. . |..||||. |...  . .  |..||..|||    .|. ..... .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PAY--SLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRN---LKICDFGTV----ADKSTMMTNNRGSAAWMAPEVFE-GSKYTEKCDI
 ..  |  .. ....| ..||.|.|.|     ||||.|| |.|. |.| .   .||||||        ... ||   |.  .|||||   |..|. |.|.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

FSWAIVLWEVLSRKQPFKGI---DNAYTIQWKIYKGERPPLLTTCP-----------------------KRIEDLMTACWKTVPEDRPSMQYIVGV--M
.|  ..|.|.|... ||.|    || .. ...|..  .|||   .|                       .   |... |..  |..||. . |.    .
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Tak1.AA Pkinase_Tyr 19-267 30 1.7e-64 219.07 Pfam 1-270 (270) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-270/270
Sequence Identity: 30% (84 aa)

ITLREKVGHGSYGVVCKAVWR------DKLVAVKEF--FASAEQ---KDIEKEVKQLSRV-KHPNIIALHGISS-YQQA--TYLIMEFAEGGSLHNFLHG
||. .| |.|..|.|.|..|.      .  ||||     |. ||   .|  .|.| ..   .||||. |.|. .  ..    |..||....|.|...|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K--VKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADK-----S-TMMTNNRGSAAWMAPEVFEGSKYTEKCD
.   |.. .. .  ....| |.|..||...    .||||.   | |.|...   ||||||   |        .. .. .    |||||..  .|.|.| |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD

IFSWAIVLWEVLS-RKQP-FKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVM
. |  ...||...  .|| ..|..|.  ...   .|.| |    ||. | |||. ||.  |||||....|.  .
VWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Tak1.AA TyrKc 19-267 27 1.2e-61 212.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-280/280
Sequence Identity: 27% (79 aa)

ITLREKVGHGSYGVVCKAVWRDKLVAVKEFFASAEQKDIEKEVKQLSRV--KHPNIIALHGISSYQ-------QATYLIMEFAEGGSLHNFLHGKVKPAY
||| .| |.| .|.|.|..|.   ||||   ..| ..|. .| . ....  .||||..|.|. . |       .  ...||....|.|...|. . .   
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-L

SLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFG---TVADK-------STMMT----NNR--GSAAWMAPEVFEGSKYTEK
....  |.. | |.| .||| .   ..||||    | |.....   ||.|||    . |.       .. ..    . .      |||||..  .|.|.|
CMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

CDIFSWAIVLWEVLSR-KQPFKG-----IDNAYTIQWKIYKGERPPLLTT--------CPKRIEDLMTACWKTVPEDRPSMQYIVGVM
 |..|. ...||.... .||  |     ..|.  |.. . .|.|.|            ||. . ..|. ||.  |||||... |.  .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEY-VKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Tak1.AA S_TKc 19-271 26 1.9e-56 194.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-271
Range on HMM: 1-231/231
Sequence Identity: 26% (70 aa)

ITLREKVGHGSYGVVCKAVWRD--KLVAVKEFFASAEQKDIEKEVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEG--GSLHNFLHGKVKPA----YS
 .. .|.|.|..|.|.|.....  ..||.|.       ..|..|.. |.. .||||. |...    .  |..||...|  |.|. ... . ..     ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNRGSAAWMAPEVFEGSKYTE-KCDIFSWAIVLWEVLSR
  || ....| ...|.|.| .     ||||.|| |.||..   ..||||||  .      |   |.  .|||||.   .|.  |||. |  ..|.| |..
E-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

KQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVG-----VMHEIV
. ||    . ...  ||            ..   |..  |..  ||.||.   .        .|. .
YPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Tak1.AA TK 19-267 15 2.8e-56 186.82 In-house 1-486 (486) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-486/486
Sequence Identity: 15% (74 aa)

ITLREKVGHGSYG---VVCKAVWRDK---------------------------LVAVKEFF--ASAEQKDIEK-----------------EVKQLS--RV
||| .| |.| .|   .|.|. ||..                            ||||     ....|.. .                  | |...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHPNIIALHGISSYQ------------QATYLIMEFAEGGS----LHNFLHGKVK---------------------------------------------
.||||. |.|... .            .  ...||....|.    |...|. . .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------PAYSLAHAMS-------------------WARQCAEGLAYLHAMTPKPL----IHRDVKPLNLLLTNKGRN----------LKICDFG---
         |. ....  .                   ...| |.|..|||..  . .    .|||.   | |.......           ||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----------------TVADKSTMM-----------------TNNRGSAAWMAPEVFEGSK---------YTEKCDIFSWAIVLWEVLS--RKQPFKGI
                 .. ...|..                 .. .    |||||.... .         .|.| |..|. ...||...  ....  |.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DN---------AYTIQWKI-----------YKGERPPLL--TTCP--------------KRIEDLMTACWKTVPEDRPSMQYIVGVM
.|         .  ..                |.| ..     ||              . ..|||. ||.  |||||... ..  .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Tak1.AA ZAK 19-266 34 1.4e-50 174.36 In-house 1-257 (257) Show / Hide 
Range on Protein: 19-266
Range on HMM: 1-257/257
Sequence Identity: 34% (92 aa)

ITLREKVGHGSYGVVCKAVW--RD---KLVAVKEFFASAEQKDIEKEVKQLSRVKHPNIIALHGISSYQQATYLIM-EFAEGGSLHNFLHGKVKPAYS--
| . . .| |..| | .| |   |   . .|||  |       ||||   || ..| |||   ||       | |  |.|| |||  . |      .   
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKVFK------IEKEAEILSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRSQEMDSS

-----LAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVA--DKSTMMTNNRGSAAWMAPEVF-EGSKYTEKCDIFSWAIV
     . | | || | | |. |||   |   |||| |  |  .   |  .|||||||      ..      | ..|||||.       || ||..|. .|
SGGNSMDHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVIDKNGV-CKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQSEPVTETCDVWSYGVV

LWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGV
|||.|.|  |.|. .        . |..|      ||. . .||  |||  | |||.|. |...
LWEMLTREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase Tak1.AA MLK 19-267 31 6.2e-50 163.1 In-house 1-280 (280) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-280/280
Sequence Identity: 31% (90 aa)

ITLREKVGHGSYGVVCKAVWRDKLVAVK----EFFASAEQK-----DIEKEVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAY
....| .| | .| | .|.|. ..||||    .. . . |      .. .| . .   |||||||| |.   .    |.||...|||| . . ||   . 
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK---RI

SLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGR------------------------NLKICDFGTVADKSTMMTNNRGSA----AWMA
 .     || | |.|. |||   | |.|||| |  | |. .|                           ||| ||| .| . .  |  | ||    ||||
PPHVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFG-LAREWHKTT--RMSAAGTYAWMA

PEVFEGSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKI-YKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVM
|||.  | . .  |. |. ..||| | .  |..||| . .. . .  ..   |   ||| .   ||  ||.. |  ||. . |.  .
PEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGID-PLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL
Kinase Tak1.AA TKL-ciliate1 19-267 29 6.3e-50 169.06 In-house 1-279 (279) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-279/279
Sequence Identity: 29% (83 aa)

ITLREKVGHGSYGVVCKAVWRDKLVAVK--EFFASAE----QKDIEKEVKQLSRVK-HPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVK--PAY
||.  |.| |... | | .   . ||..  . | | |    ||   .|. |....| | | . | |||.|.   |.|||. ..|..   .| | .   . 
ITMGQKIGSGHFCNVYKGRCNSYDVAIMNMNYFNSQESFINQKEFQREIQQHIKIKQHINLQQLQGISFYDNNFYIIMEHCHKGTMFDICHRKHSQIYMI

SLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVAD---------KSTMM---TNNRGSAAWMAPEVFE-----GSKYTE
.  | | | .  | |. |||   . |||||| | .|.|.  .  . |||.|..|            .  |   .   .   |||||..      .  ..|
KWQHRMRWCKDIAQGMQYLHMRQN-PLIHRDLKMQNILY-DEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINE

KCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGE-RPPL-----LTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVM
| ||.. .||...  .|| ||. . ..  |.  .  .  || |        ||  . .||  ||   | .||. . |  ..
KIDIYAYGIVMYILCFRKTPFQQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL
Kinase Tak1.AA Dicty4 19-269 31 8e-49 161.05 In-house 1-277 (277) Show / Hide 
Range on Protein: 19-269
Range on HMM: 1-277/277
Sequence Identity: 31% (88 aa)

ITLREKVGHGSYGVVCKAVWRDKLVAVKEF------FASAEQKDIEKEVKQLSRVKHPNIIALHGISS----YQQATYLIMEFAEGGSLHNFLHG-----
|.  .. | ||.| | |. || | |||| .      | ... ..  |||. ..   ||||. . | .             .|.   |.|.. ||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

--KVKPAYSLAHA-MSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFG--T----VADKST-MMTNNRGSAAWMAPEVFEGSKYTEK
  ..|. ..|  . |  |. .| |...||. .|   |||| |. |||   |  . |.||||  .    . |... .||   |...||||||  .  |.||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLV-DKNWRVKVCDFGLSQYMKKHEDHKDNQMT-ACGTPCWMAPEVMMHQPYNEK

CDIFSWAIVLWEVLSRKQPFK--GIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGV--MHE
 | .| .||||| | |. |.   ...    .     |..|||.   ||... .|.. || . |. |||.. |.    . .
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase Tak1.AA LRRK 59-269 31 2.5e-43 150.25 In-house 106-351 (351) Show / Hide 
Range on Protein: 59-269
Range on HMM: 106-351/351
Sequence Identity: 31% (78 aa)

KEVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAY-----SLAHAMSW--ARQCAEGLAYLHAMTPKPLIHRDVKPLNLLL---
.||  .|. .||||. | |..   .   ..||.|  |.|. ||| | . .      .. . .    | | |.|..|||  .| |.|||| |. | ||   
HEVWIMSHLNHPNIVSLKGFC--IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSS

-TN-------KGRNLKICDFGTVA----DKSTMMTNNRGSAAWMAPEVFEG---SKYTEKCDIFSWAIVLWEVLSRK-QPFKGID-N-----AYTIQWKI
 .|          . ||.|||.      ....      |   |||||.  .   . |||| |..| ...||| |.|. .|| ..|        ..|. ||
PQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKI

YKGERPPLLTT-CPK-----RIEDLMTACWKTVPEDRPSMQYIVGVMHE
 .| ||..  . ||      . .||.. ||.. |..||....|| .. .
IEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase Tak1.AA LRRK 19-51 29 7.2e-05 13.15 In-house 1-34 (351) Show / Hide 
Range on Protein: 19-51
Range on HMM: 1-34/351
Sequence Identity: 29% (10 aa)

ITLREKVGHGSYG-VVCKAVWRDKLVAVKEFFAS
.   |..| |..| .| .| ||.  |.|......
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQK