Gene CG6498 (Fruit Fly)

CG6498

Species: Fruit Fly
Alias: MAST 205, SFO188, CG6498
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 71E1,

Classification

Group: AGC
Family: MAST
Subfamily: MAST

Sequence

Name Sequence Type Origin Length Description Download
CG6498.AA Protein Various 2139 None Fasta, JSON
CG6498.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 276 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of CG6498.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF1908 CG6498.AA DUF1908 344-703 56 1.3e-219 740.63 Pfam 1-369 (369) Show / Hide 
Range on Protein: 344-703
Range on HMM: 1-369/369
Sequence Identity: 56% (218 aa)

PVDSPR---LNSPMPFAFAPIKRIASCRGVVADGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGACCAE-------
|.||||   ..|.|.|.|.||.||..||. .||||||||||||||||||.|.|||.|||||||| |||| |..|. ....|........||.|       
PIDSPRNFSTSSMMNFPFVPIRRITNCRD-RADGRRWSVASLPSSGYGTNPPSSNVSSQCSSQERLNQLPHQLPFQPTQDDLHFLSKHFCCTESNPSMEG

----------HLKQHCPKHCALLLAVSQK-----QLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGAANGGSSANSSGSSAMQVGGRMSPY
          ||..|||.|| || | .|.     || .| ..  |.||||   | |..|||..|. | |     . .                 |. || 
RNLHHHHGFHHLHHHCPHHCVLLHAAAQFQPQQPQLHKQ-YQHSQQQPQKLQ-AHCIHCCADHSIKCSGSCQDEDNNFC---------------GCRSPH

FRPRSRSLSSPSRSPIV-DNEIAVMNTLYKERFPKATQQMEERLKLFINENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSEN
.|||||||||||||.|. ||||..||..||||||||||||||||. ||...|...|.|.|...|.|||.||||.||||||||||.||||||.||||..|.
HRPRSRSLSSPSRSCITFDNEIVMMNHVYKERFPKATQQMEERLQHFIHHFKNIPCDSLRLADPVVRFIHHQVVEMARDCLHKSHAKLITSRYFYEMQEK

LERLLVETKEKS-PEAAAELNGVIKKLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYIIHKLGLNRDPIAEL
|||||.|..|.| .|.......||||||.||||||||||||||||.|||.|||||||.||.|..||.|||.||||.||||||||.|.
LERLLHEAHERSESEEVPFITHVIKKLLIIISRPARLLECLEFDPEEFYHLLEAAEGQAKVMQGIKTDIPRYIIHQLGLNRDPIEEM
Kinase CG6498.AA MAST 835-1110 51 4.6e-225 695.49 In-house 1-337 (337) Show / Hide 
Range on Protein: 835-1110
Range on HMM: 1-337/337
Sequence Identity: 51% (175 aa)

FDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFET--KKHLCLVMEYVEGGDCGTLLKNIG-PLP
|...|.||.||||||||||||.|..|||||.||....|..|||.|||.||.||....|||||.|..||.|  ||.||.||||.|||||..||...| ..|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

ADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEG---------------YIDSETRQFS------------
 .||..|.|||||..|||||||||||||||||.||...||||||||||||.|.|...||.|||               .|. ...||.            
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

------------------------DKQVYGTPEYIAPEVILRQG-YGKPVDWWSMGIILYEFLIGCVPFFGETTEE-LFAHTVN--DDIEWPDS----ED
                        .||..|||.||||||||.|| |||||||||||||.||||.||.||.|.| || .|....|  ..||||.     .|
QIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDD

WPVQAEAKDIISQLLQQNPRDRLGTQSGALEMKEHEYF
.....||.|.|..|||.||..|||.. || |.|.|..|
DCMSPEAQDLIKKLLQPNPKKRLGAN-GADEIKQHPFF
Kinase CG6498.AA MAST 835-1110 49 3.9e-207 674.23 In-house 1-334 (334) Show / Hide 
Range on Protein: 835-1110
Range on HMM: 1-334/334
Sequence Identity: 49% (164 aa)

FDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADM
|...|.||.||||.|||||||.|..|||||.|.|...|..|.|.||..||.||....|||||.|..||.||..||.||||.|||||..||...|... .|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEG---------------YIDSETRQFS---------------
|..|.|||||..|||||.|||||||||||.||...||||||||||||.|.|......|||               ... ...||                
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

--------------------DKQVYGTPEYIAPEVILRQG-YGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDD---IEWPDS----EDWPVQ
                    .||..|||.||||||||.|| .||||||||||||.||||.||.||...|.||.|....|..   ||||.     .|.  .
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

AEAKDIISQLLQQNPRDRLGTQSGALEMKEHEYF
 ||.|.|..|||..||.|||...|| |.|.|..|
PEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase CG6498.AA AGC 835-1110 30 7.79999999999e-168 438.08 In-house 1-395 (395) Show / Hide 
Range on Protein: 835-1110
Range on HMM: 1-395/395
Sequence Identity: 30% (121 aa)

FDIVKLISNGAYGAVYLVKHK------TTRQRFAMKKINKNN--------LILRNQVEQ-------VFAERDILSFAD----------NPFVVS-MYCSF
|...|.|. |..| ||||..|      .| . .|||...|           . ....|.       |..||.||. ..          .||.|. ...||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKKH--LCLVMEYVE--------GGDCGTLLKNIG-----PLPADMARFYFAE-------TVLAVEYLHS-YGIVHRD-LKPDNLLITALGHIKLTDFG
..|.|  |..||||..        ||.| ..| . |      .. ..||||.||       .|||.|||||  ||.||| |||.|.|... |||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKMGLMS-----------LATNLYEGYIDS---------------ETRQFS------------DKQVYG--TPEYIAPEVILRQGYGKPVDWWS--MGI
|.|.| ..           . .. ... . .               ... .|             .   |  ||||.|||..    |||..||||  .|.
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-QKSNMDTNKCNPNNWQRNN-MSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGC

ILYEFLIGCVPFFGETTE----------ELFAHTV------NDDIEWPDS------EDWPVQAEAKDIISQLLQQNPRDRLGTQS------GALEMKEHE
..||.|.|. ||.|....          |.|          |.....|.       ||  .  ||||.|..||. .|..|||..       || | |.|.
LMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHP

YF
.|
WF
Kinase CG6498.AA S_TKc 835-1110 34 3e-97 330.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 835-1110
Range on HMM: 1-231/231
Sequence Identity: 34% (99 aa)

FDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEG--GDCGTLLKNIGP---
..|...|  ||.| ||...|| | ...|.|.|.          |..  |..||.  . |..| .| .|.. .||..||||..|  ||  ...|. |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPEVILRQGYG
   .|  .||||......|.||.|| ||.||||||.|.|..   |||..||||..                        . . |||.|.||||.   |||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTPWYMAPEVL---GYG

K-PVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRDRLGTQSGALE----MKEHEYF
| ..|||| |.||||.| |. ||   . ...| . .                ||||.|...|| .|..|..    ||.     | |..|
KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA--EALQDEWDIKCHPWF
Kinase CG6498.AA AktR 835-1110 37 2.1e-95 323.24 In-house 1-268 (268) Show / Hide 
Range on Protein: 835-1110
Range on HMM: 1-268/268
Sequence Identity: 37% (108 aa)

FDIVKLISNGAYGAVYLVKHK-TTRQRFAMKKINKNNLILRNQVEQVFAERDILS-FADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPA
|.. |.. .||.| ||||..| .. . .||| | | ..| ||| ...  ||.|.   ...|| | .. .|.||..| ..|||..||.  . ||... .  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DMARFYFAETVLAVEYLHSY-GIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQ------VYGTPEYIAPEVILR-QG
..||||||. .||.||||.   |. |||||.|.|.   ||.|.|||||||                    || .        ..|||||.|||.|.. .|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK-------------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKG

YGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDD-IEWPDSEDWPVQAEAKDIIS-QLLQQNPRDRLG-TQSGALEMKEHEYF
..|.||||. || .|| ..|| ||. . ....|    . . .. |....  .  ..||.|  .||..||. |||   .|. | |.|  |
HNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSY--FSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase CG6498.AA RSK-Unclassified 835-1110 38 5e-94 295.74 In-house 1-283 (283) Show / Hide 
Range on Protein: 835-1110
Range on HMM: 1-283/283
Sequence Identity: 38% (110 aa)

FDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLK--NIGPLPA
|   .||  |  | ||||. | | | .|||  .|. .| .| .  |  |..|..  . ||.| .| || |.  | |.|||  ||| .  |       .  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

DMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLY----EGYIDSE--TRQFSDKQVYGTPEYIAPEVILRQGYG
| .||| .|...| ||||  ... ||||||| .    ||..||||.||. .  |    .       |.|       |  .   || ||.|||.| | | .
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWP-DSEDWPVQAEAKDIISQLLQQNPRDRLGTQSG-ALEMKEHEYF
| |||| .||..|| |.|| |. |. ..|.|      ..  | ||.   .  ...| |  |||.||  |||  .| | . | | .|
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSY---ISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase CG6498.AA NDR 835-984 50 2e-90 279.07 In-house 1-155 (350) Show / Hide 
Range on Protein: 835-984
Range on HMM: 1-155/350
Sequence Identity: 50% (79 aa)

FDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFAD--NPFVVSMYCSFETKKHLCLVMEYVEGGDCGT---LLKNIGP
|.|.|.|. ||.| |.||..| |.. .|||...|   . .||| .| |||||.. ||  ||.||..|.||  |..|.|||||. ||| .|   ||.. . 
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGL
.. |.|||| ||.|.|.|..|..|..|||.||||.|| . ||||||||||...|.
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGM
Kinase CG6498.AA RSK 838-1110 34 2.8e-83 282.97 In-house 1-278 (278) Show / Hide 
Range on Protein: 838-1110
Range on HMM: 1-278/278
Sequence Identity: 34% (102 aa)

VKLISNGAYGAVYLVKHK---TTRQRFAMKKINKNNLILRNQ-VEQVFAERDILSFAD-NPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGP---
.|.   |.||.|.|.. .    |.| .||| ..|. .. |.  .. ...||.||.     ||.|. . .|.|...| |.|||..||. .| |.. .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITA---LGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPEVIL----R
.  | |.||.|| |||||.||. ||.||||||.| | .     |||||||||..| .            .| . .  .     .| ||.|||..     .
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-----------RCDHNQWTMT---FCYTIEYMAPEMLKRANQQ

QGYGKPVDWWSMGIILYEFLIGCVPFFG---ETTEELFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRDRLG-TQSGALEMKEHEYF
 |..| .|||| |...|| | ||.|| |   .. .|...   . ..  .  ..  . .||||.|...|. .| .|||   ..| | |.|..|
GGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase CG6498.AA Pkinase 835-1110 29 1.8e-81 281.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 835-1110
Range on HMM: 1-293/293
Sequence Identity: 29% (93 aa)

FDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVF-AERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGG----DCGTLLK--NI
. |.. |  |..| ||. .|| |....|.|.|.| .     ... .  .|  |.   . |..| .|..||.|.|...||||.|||    |  ....  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GPL--PADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHI----KLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPEVIL
|..  . . ..||. ... ..||.|| ||.||||||.|.||   |||    |..||||.|                 . ..   . . |||.|.|||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------------Y-NNS-MTTFCGTPWYMAPEVIR

-RQGYGKPVDWWSMGIILYEFLIGCVPFFGE------TTEELFAHTVNDDIEWPDSEDWPVQ-----------------AEAKDIISQLLQQNPRDRLGT
 .|.||..||.||.|.||||.| |  || |.      .  .... .   ..... ... ..                   |.||.|. .|...| .|.. 
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-

QSGALEMKEHEYF
   | . ..|..|
---AEQILQHPWF
Kinase CG6498.AA Akt 835-986 44 7.7e-62 196.43 In-house 1-154 (264) Show / Hide 
Range on Protein: 835-986
Range on HMM: 1-154/264
Sequence Identity: 44% (68 aa)

FDIVKLISNGAYGAVYLVKHKTTRQRF-AMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPAD
||..|..  |..| |.||| | | . . ||| . |. .| .||||....|| ||   ..||.|... || |...|..||.|. ||.  ..|.  .  . |
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

MARFYFAETVLAVEYLHSYGIVHRD-LKPDNLLITALGHIKLTDFGLSKMGLMS
 |||| || .|| |.||| .|. || ||| |.|. . |||.||||||.|.....
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIK
Kinase CG6498.AA SGK 835-983 39 1.1e-58 179.65 In-house 1-175 (283) Show / Hide 
Range on Protein: 835-983
Range on HMM: 1-175/283
Sequence Identity: 39% (69 aa)

FDIVKLISNGAYGAVYLVKHKTT------------------RQRFAMKKINKNNLI-------LRNQVEQVFAER-DILSFADNPFVVSMYCSFETKKHL
||. |.|  | .| ||.|||| .                   . .||| ..|.  |        ....  . ||| .||.    || |.   .| ||. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMG
 .||.||.||. .  |.  . .| | |||| || |.| |||||  |..|||||.|.|  . ||..||||||.| |
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEG
Kinase CG6498.AA PKA 835-981 43 6e-56 192.19 In-house 1-149 (263) Show / Hide 
Range on Protein: 835-981
Range on HMM: 1-149/263
Sequence Identity: 43% (65 aa)

FDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVV-SMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPAD
|.|.... .| .| |.|..||.. . .||| ..|.  . ..||| |  |. ||.  ..||.| .|| .| . ..| .|||||.||.  . | . | .. .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

MARFYFA-ETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSK
.|.|| | . ||| |||||  |..||||| |.||   ||||.|||| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase CG6498.AA SGK 1010-1110 37 1.5e-42 128.96 In-house 187-283 (283) Show / Hide 
Range on Protein: 1010-1110
Range on HMM: 187-283/283
Sequence Identity: 37% (38 aa)

GTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRDRLGTQSGALEMKEHEY
||||| ||||.. |.... ||||..|..|||...|  ||.   .....    | ..  | .    ....|.|.| .||| .|..||||  ...| |.| .
GTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ----MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPF

F
|
F
Kinase CG6498.AA Akt 1010-1110 40 7.9e-40 124.94 In-house 164-264 (264) Show / Hide 
Range on Protein: 1010-1110
Range on HMM: 164-264/264
Sequence Identity: 40% (42 aa)

GTPEYIAPEVILRQGYGKPVDWWS-MGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRDRLG-TQSGALEMKEH
|||||.|||... .|..|.||||.  |...||.. |  ||. .  ...| .  | ... ||  || .. |.||.||.||. .|  ||| . ..| | |.|
GTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDK-DW-ISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRH

EYF
..|
PWF
Kinase CG6498.AA NDR 1010-1110 37 1.8e-36 109.51 In-house 243-350 (350) Show / Hide 
Range on Protein: 1010-1110
Range on HMM: 243-350/350
Sequence Identity: 37% (40 aa)

GTPEYIAPEVILR-QGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEW-----PDSEDWPVQAEAKDIISQLLQQNPRDRLGTQS-GAL
|||.|.||||... .||.. .|||| | |.||.|.|  ||...|..| .    |  . |      . .. ..  ||.| | .|.  .|  ||| .  |. 
GTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVD

EMKEHEYF
|.| | .|
EIKSHPFF
Kinase CG6498.AA PKA 1010-1110 37 2.2e-33 117.2 In-house 160-263 (263) Show / Hide 
Range on Protein: 1010-1110
Range on HMM: 160-263/263
Sequence Identity: 37% (40 aa)

GTPEYIAPEVILRQ-GYGKPVDWWSMGIILYEFLIGCVPFFGE--TTEELFAHTVNDDIEWPDSEDWPVQAEA---KDIISQLLQQNPRDRLGTQS-GAL
|||||.|||.|..  |.||.||||. ||. ||.| |  ||. .  .. ...   .| .|..| .    .   |   || |..||| ..  |.|... |. 
GTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRH----FDSDANYFKDLIKKLLQVDLTKRYGNMKNGVN

EMKEHEYF
  |.|. |
DIKNHKWF
Kinase CG6498.AA TyrKc 835-1104 20 2.6e-13 -7.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 835-1104
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

FDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFA--DNPFVVSMYCSFETK-------KHLCLVMEYVEGGDCGTLLK
    | . .||.| ||. . |   .  | |.....       .|    |  |..    ..| .| .|    ..       . |..||||...||.   |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NIGP-LPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMS-LATNLYEGYIDSETRQFSDKQVYGT-----PE-----
. .| |. .    .        ||||| ...||||   | |... ...| .|||||. .     .                 |..| .            
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--------------ESKDYYRKKEHKGGKTMLPI

-YIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGE------TTEELFAHTVNDDIEWPDSEDWP-----VQAEAKDIISQLLQQNPRDRLGTQSGA
   |||.|    .    | || |. ..| .  . .   .      . .|....  . .   .  .| |       .|  .|..|  . .| ||   .   
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

LEM
 ..
ECF
Kinase CG6498.AA Pkinase_Tyr 947-981 45 6.8e-05 17.19 Pfam 125-159 (270) Show / Hide 
Range on Protein: 947-981
Range on HMM: 125-159/270
Sequence Identity: 45% (16 aa)

EYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSK
|||.| ...||||   | |.|  ...| .||||..
EYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase CG6498.AA S_TK_X 1111-1170 17 8e-05 17.78 SMART 1-79 (79) Show / Hide 
Range on Protein: 1111-1170
Range on HMM: 1-79/79
Sequence Identity: 17% (16 aa)

LGMDWNSLLR----QKAEFVPQLS----HDDDTSYFD---TRMDRYNHDLGGEDTDDTDDTPV---------------------FGSFNSYT
 | ||. |..     .. |.|...    .. |||.||   |...               .||.                     |. |.   
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-------------LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase CG6498.AA Pkinase_Tyr 835-919 24 0.635756 3.75 Pfam 1-93 (270) Show / Hide 
Range on Protein: 835-919
Range on HMM: 1-93/270
Sequence Identity: 24% (23 aa)

FDIVKLISNGAYGAVYLVKHK----TTRQRFAMKKINKNNLILRN-QVEQVFAERDILSFA-DNPFVVSMYCSFE-TKKH--LCLVMEYVEGGD
  . | .  ||.| ||. . |     |..  | |.. |..   ..   |  ..|  |..   ..| .|..|      ...  ...||||...||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGD
PDZ CG6498.AA PDZ 1513-1593 26 4e-13 50.85 SMART 1-80 (80) Show / Hide 
Range on Protein: 1513-1593
Range on HMM: 1-80/80
Sequence Identity: 26% (25 aa)

RGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAG------LRPADLITHVNG-EAVQGLFHTQVLQLLLSGGE-----HVTLRATPLE
 |.||..               ....  | .|.||  ||      ||| | |. ||| . |... | |....| . |.     .|||   . .
GGLGFSIVG-------------GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
PDZ CG6498.AA PDZ 1541-1590 22 9.2e-05 18.87 Pfam 34-86 (86) Show / Hide 
Range on Protein: 1541-1590
Range on HMM: 34-86/86
Sequence Identity: 22% (12 aa)

VDEG-SPAFEAG-LRPADLITHVNGEAVQGLFHTQVLQLLLSGGE-HVTLRAT
| .| ..|  .| ... | |. .||. . .. | .. |.. . ..  |.|   
VMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ