Gene MAPk-Ak2 (Fruit Fly)

MAPk-Ak2

Species: Fruit Fly
Alias: DmMAPKAPK-2, SFO122, MAPKAP, CG3086, MAP kinase activated protein kin, MAPk-Ak2, MAP kinase activated protein kinase-2
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 5C1--2,

Classification

Group: CAMK
Family: MAPKAPK
Subfamily: MK2

Sequence

Name Sequence Type Origin Length Description Download
MAPk-Ak2.AA Protein Various 359 None Fasta, JSON
MAPk-Ak2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 262 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of MAPk-Ak2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAPk-Ak2.AA MAPKAPK 20-281 68 1.4e-204 685.97 In-house 1-268 (268) Show / Hide 
Range on Protein: 20-281
Range on HMM: 1-268/268
Sequence Identity: 68% (183 aa)

VTSNTVLGYGINGKVVQCTHRRTQQNYALKVLLDSERARREVDLHWRVSGCRYIVNIIDVYENTFKD------RKCLLVVMECMEGGELFQRIQDKADGA
.....|||.||||||.||.|.||||..|||||.||..|||||.|||..||...||.|||||||....      |||||.|||||||||||.|||...| .
QIWKQVLGIGINGKVMQCYHKRTQQKFALKVLRDSPKARREVELHWMCSGHPHIVQIIDVYENMYQFPHEPSPRKCLLIVMECMEGGELFHRIQERGDQH

FTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKETFTSYTLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGVVMYIIM
||||||||||..||.||...||..|||||||||||||..||||..||||||||||||....||.||||||||||||||||||||||||.|||||.|||..
FTEREAAQIMKQICQAVQHCHSMNIAHRDLKPENLLYKDTQPNCVLKLTDFGFAKETTRHNTLMTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYIML

CGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLRIQDVISNKWI
||.||||||||.|||||||.||..|||.||.|||..||..|||||. .|..||..||.|.......||
CGYPPFYSNHGQAISPGMKHRIMNGQYEFPHPEWSCVSEDAKDLIRKLLRTDPTERLTIEEFMNHPWI
Kinase MAPk-Ak2.AA MAPKAPK 20-281 53 1e-198 621.44 In-house 1-292 (292) Show / Hide 
Range on Protein: 20-281
Range on HMM: 1-292/292
Sequence Identity: 53% (156 aa)

VTSNTVLGYGINGKVVQCTHRRTQQNYALKVLLDS-----ERARREVDLHWRVSGCRYIVNIIDVYENTFKDRKCLLVVMECMEGGELFQRIQDKADGAF
 ....|||.||.|||..|.|.||.|.||.|.|.|.     ..|||||.|||...|...||.|||..||.....||...||||||||||||.||......|
KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKHF

TEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKE-------TFT--SYTLQTPCYTPYYVAPEVLGPEK----YDKSCD
|||||.|||..||.|||.|||..||||||||||.|.|.|..|...||.|||||||       | .  ...|.||||||||.||||.|..|    ||||||
TEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFKEAHTYDKSCD

IWSLGVVMYIIMCGFPPFYSNHG-LAISPG-----------MKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLRIQDVISNKWI
.|||||.|||..||.||||||.|  ..|..           |..||..|||.|||.||...|..|||||. .|..||..||.|..|....||
MWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI
Kinase MAPk-Ak2.AA CAMK 25-281 25 4.1e-113 365.97 In-house 1-425 (425) Show / Hide 
Range on Protein: 25-281
Range on HMM: 1-425/425
Sequence Identity: 25% (110 aa)

VLGYGINGKVVQCTHRRTQ------------QNYALKVLL---------------------------------DSERARREVDLHWRVSG------CRYI
.|| |  |||  |.|..|.            | .| |..                                  | .. |||........|       . |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNIIDVYEN-----------TFKD-----RKCLLVVM---ECMEGGEL----FQRIQDKAD-------------GAFTEREAAQIMHEICAAVDYLHSRD
.....|||.           | ..     .|..  ||   | ..||||    |..|... .             | ||||||..... || ||.|.||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IAHRDLKPENLLYTTTQPN--------------ATLKLTDFGFAKETFT------------------------SYTLQTPCYTPYYVA-PEVLGP-----
|.||||||||.|...  ..              ...|..|||||.. .                            ..|.| ||.|.| ||||       
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EKYDKSCDIWSLGVVMYIIMCGFPPFYSNHGLAIS---------PGMKNRIRTGQYDFPDPE------------WTNVSQA--------AK
         . |...||.||.||..||  ||.||||. ..  |          . .. .|..|.||||.|.            | ..|.         .|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLIKGMLNVDPSKRLRIQDVISNKWI
|||..||.|||.||. |... . .|.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MAPk-Ak2.AA CAMK1 32-281 38 5e-105 306.26 In-house 13-276 (276) Show / Hide 
Range on Protein: 32-281
Range on HMM: 13-276/276
Sequence Identity: 38% (105 aa)

GKVVQCTHRRT---QQNYALKVLL-----DS------ERARREVDLHWRVS--GCRYIVNIIDVYENTFKDRKCLLVVMECMEGGELFQRIQDKADGAFT
..|..|||..|   ...||.|..      .       |. ..|.. . .||   .  |......|| . .    .  ||| . ||||| || .|  | .|
SEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNH----FYLVMELVTGGELFDRIVEK--GNYT

EREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLK--LTDFGFAKETFTSY-TLQTPCYTPYYVAPEVLGP---EKYDKSCDIWSLGVVM
|..|. ||..|. || |.||..|.||||||||||| .  .....|  . ||| .| .     ...|.| ||.|||||||     . |||.||.|| ||. 
EKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVIT

YIIMCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQA-AKDLIKGMLNVDPSKRLRIQDVISNKWI
||. ||.||||.. . .    .   |  ..|.|| |.| |.|   |||.||.||.|||.||. .....  .||
YILLCGYPPFYDENVDNE---LFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase MAPk-Ak2.AA S_TKc 20-281 31 1.6e-90 307.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-281
Range on HMM: 1-231/231
Sequence Identity: 31% (88 aa)

VTSNTVLGYGINGKVVQCTHRRTQQNYALKVLLDSERARREVDLHWRVSGCRYIVNIIDVYENTFKDRKCLLVVMECMEG--GELFQRIQDKADGA----
 .   ..| |  ||| .|.|..|.. .|.|..   |..|||.... .  .. .||...||...     ..| .|||...|  |.||..|...  .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKETFTSYTLQTPCYTPYYVAPEVLGPEKYDK-SCDIWSLGVVMYII
|.| .|. .|..|| |..|.||. | ||||||||.| ..     ..|..|||.|..        | | ||.|.|||||   .|.| .||.||.|...|. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

MCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLRIQDVIS-------NKWI
.|| |||.          | ..|.              |. |||.|...|..||.||. . ..           |.
LCGYPPFP------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAPk-Ak2.AA AGC 32-281 25 1e-88 228.76 In-house 13-395 (395) Show / Hide 
Range on Protein: 32-281
Range on HMM: 13-395/395
Sequence Identity: 25% (101 aa)

GKVVQCTHR------RTQQNYALKVLL-----------DSERARRE------------VDLHWRVSG---------CRYIVNIIDVYENTFKDRKC--LL
||| .. ..       |.. ||.|||            . |.. .|             .   ....         . .||.       .|.| .   | 
GKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVK---ILHYSFQDKDHTYLY

VVMECME---------GG-ELFQRIQDK-ADGAFTEREAAQIMHE-------ICAAVDYLHS-RDIAHRD-LKPENLLYTTTQPNATLKLTDFGFAKETF
 ||| |.         || |||...|..   | |.| .|  .. |       |. |..|||| ..| ||| |||||.| .       .||||||..||  
FVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLTDFGLCKEGM

T------------------------------------------------------SYTLQTPCYTPYYVAPEVLGPEKYDKSCDIWS--LGVVMYIIMCG
.                                                       .|.  || || |.|||.|    |.|.||.||  ||..||  ..|
NDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTG

FPPFYS-NHGLAI------SPGMKNRIR------TGQYDFPDP------EWTNVSQAAKDLIKGMLNVDPSKRLR----------IQDVISNKWI
 ||||. | .. .         | ..|.      . .  ||.|      |. ..|. ||||||..|..||.|||           .... . .| 
YPPFYGDNPQE-NRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MAPk-Ak2.AA RSK 23-281 38 6.8e-84 285.03 In-house 1-278 (278) Show / Hide 
Range on Protein: 23-281
Range on HMM: 1-278/278
Sequence Identity: 38% (110 aa)

NTVLGYGINGKVVQC---THRRTQQNYALKVLLDSERARR---------EVDLHWRVSGCRYIVNIIDVYENTFKDRKCLLVVMECMEGGELFQRIQDKA
  ||| | .||| .|   ||. |.| || |||  .....|         |..   |. ..  ||.  ..    |.. . |  .||...||||| ..| . 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYA----FQTEGKLYLIMEYCRGGELFTHLQKEK

D-GAFTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPN-ATLKLTDFGFAKE-TFT-SYTLQTPCYTPYYVAPEVLG---PEK-YDKSCDI
  | |.|.||...| ||  ||..||...| |||||||| ||.  . | ...|||||||.|.     .  ..|.|||  |.|||.|    ... .||.||.
HFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDW

WSLGVVMYIIMCGFPPFYS---NHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLR-----IQDVISNKWI
|||||.||    |.|||..   |.   |.    .||..|..... |.| ..||.|||||..|| .||.|||      .... ...|.
WSLGVLMYEMLTGCPPFQGPNDNNRKEIM----KRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MAPk-Ak2.AA Pkinase 20-281 29 6.5e-82 283.24 Pfam 1-293 (293) Show / Hide 
Range on Protein: 20-281
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

VTSNTVLGYGINGKVVQCTHRRTQQNYALKVLLDSERAR---------REVDLHWRVSGCRYIVNIIDVYENTFKDRKCLLVVMECMEGG----ELFQRI
 .   ..| |  |.| .|.|. |.. .|.|..  ...           .|. .. |. .. .|| ..|..|.    .. . .|||..|||    .|| .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYI

QDKADGAF--TEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYT-TTQPNATLKLTDFGFAKE--TFTSYTLQTPCYTPYYVAPEVLG-PEKYDKSC
. ...|.|  .|.|.  .| .|. ...|.||. | ||||||||.|.  . ...|..|..|||.||   .  .  ..|.| ||.|.||||.   ..|....
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSLGVVMYIIMCGFPPFYSNH----GLAISPGMKNRIRTGQYDFPDPEWTNVS-----------------QAAKDLIKGMLNVDPSKRLRIQDVISNK
|.||.|...|. .|| |||. .|    . .    | .||. ....|. |.| ..|                 ...||.||..|..||.||. ....   .
DMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

WI
|.
WF
Kinase MAPk-Ak2.AA CDPK 75-281 42 2.8e-80 245.97 In-house 62-271 (271) Show / Hide 
Range on Protein: 75-281
Range on HMM: 62-271/271
Sequence Identity: 42% (93 aa)

NIIDVYENTFKDRKCLLVVME--CMEGGELFQRIQDKADGAFTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNA----TLKLTDFGFAK
||| .|| .. |.|   .|||    .|||||..|..|    |||.|||.||  |  || | ||. | ||||||||.|...  ...    ..|. |.| .|
NIIKIYE-FYQDEKNYYIVMETEYCTGGELFDYIIEKGH--FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSK

ETFTS------YTLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGVVMYIIMCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGML
. | .       .. . | ||||.|||||    |...|||||.||..||. || ||||      |     . .. |.|.| .||| ..|. |||||. ||
K-FDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSCGVILYILLCGYPPFYGKNDQEIM----EKVKKGKYSFEGPEWDHISDEAKDLIRKML

NVDPSKRLRIQDVISNKWI
..|| ||.  |..   .|.
CYDPKKRMSAQQALQHPWF
Kinase MAPk-Ak2.AA MSK 20-281 33 2.8e-78 264.22 In-house 1-277 (277) Show / Hide 
Range on Protein: 20-281
Range on HMM: 1-277/277
Sequence Identity: 33% (96 aa)

VTSNTVLGYGINGKVVQCTHRRTQQNYALKVLL---------DSERARREVDLHWRVSGCRYIVNIIDVYENTFKDRKCLLVVMECMEGGELFQRIQDKA
  . . .|||  . .  |.|. | . || |.|            | ...|.    .. .. .|||  ..    |.|   .  |||   ||||| .|  . 
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYA----FQDQCHTYLVMEYCNGGELFTHIRKR-

DGAFTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKETFTS--YTLQTPCYTPYYVAPEVLG----PEK-YDKSCDIW
 . |.| |...|| |.  |||..|.. | ||||||||.|..  ..|...||.|||||... ..  . ...||.|  | |||.|     ..  ||..||.|
-EHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWW

SLGVVMYIIMCGFPPFY--SNHGL---AISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLRIQDVISNKWI
||||..|    |  ||   .  .    . .     ||..|.  ||  .|.|.|..|||||...| .||.|||  .|   . |.
SLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase MAPk-Ak2.AA Ciliate-E2 20-281 24 9.5e-75 254.64 In-house 1-365 (365) Show / Hide 
Range on Protein: 20-281
Range on HMM: 1-365/365
Sequence Identity: 24% (94 aa)

VTSNTVLGYGINGKVVQCTHRRTQQN-----------------------YALKVLLDSERARREVDLHWR-----------------VSGCRYIVNIIDV
   . ..| |  |.| .|.....|..                       ||.|..  ..    .  .|                      . .|......
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YENTFKDRKCLLVVMECMEGGELFQRIQDK----------ADGAFTEREAAQIMHEICA---------------AVDYLHSRD-IAHRDLKPENLLYTTT
...  ||....  |||  .||.||..|...          . . |||.|...|| .|.                |. ||||.  | |||.||||.|.   
FQE--KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

QPNATLKLTDFGFAKE-------------------------TFTSY-------TLQTPCYTPYYVAPEVLGPEK---------YDKSCDIWSLGVVMYII
     .|..|||..|.                         |.. .       . .| |.||.|.|||.|. .|         ||..||||||||..|. 
-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM

MCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPE--------------WTNVSQAAKDLIKG----MLNVDPSKRLR-IQDVISNKWI
..| |||             . |  ...||| ||              | ..|| .|||||     ||..||.||.  ..... ..|.
LFGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MAPk-Ak2.AA RSK 37-281 34 1.7e-68 233.87 In-house 21-271 (271) Show / Hide 
Range on Protein: 37-281
Range on HMM: 21-271/271
Sequence Identity: 34% (90 aa)

CTHRRTQQNYALKVLLDSERARR------EVDLHWRVSGCRYIVNIIDVYENTFKDRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEICAAV
|.|. |.| || |..  . |. .      |..   | .   .||   .|..    | . .  .|. |.||.|| |..  . . |.|||.. .|.||  |.
CQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQ----DEGKVYMIMDFMRGGDLFDRLL--KQKMFSEREVKFYMAEIALAM

DYLHSRDIAHRDLKPENLLYTTT-QPNATLKLTDFGFAKETFTSYT-LQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGVVMYIIMCGFPPFYSNHGLAIS
.|||| .|.|||||||| ||  . .   ..|..||||||.       | |.|||  |.|||||    .|..||.||.||.||.   |..||....     
EYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPM

PGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLRI-----QDVISNKWI
   . ||  |....  . | ..|. ||||. .|| .|| .||       ... . .|.
NIIQ-RIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase MAPk-Ak2.AA TyrKc 20-280 21 4.2e-11 -43.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-280/280
Sequence Identity: 21% (61 aa)

VTSNTVLGYGINGKVVQCTHRRTQQNYALKVLLDSERA--RREVDLHWRV-SGCRYIVNIIDVYENT---FKDRKCLLVVMECMEGGELFQRIQDKADGA
.| . .|| |  |.|...| .   .. | |.| .. |.  .||  .  ..      ||... |       |   . |..||| |..| | ...... .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

FTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKETFTS---------YTLQT--PCY--TPY-YVAPEVLGPEKYDKS
.. ..  .... |..  .||||. . ||||   | |..  .   | | .||| ...             |. ..   .    |.   |||..   |.   
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

CDIWSLGVVMY-IIMCGFPPFYS---NHGLAISPGMKNRIRTGQYDFPDPE-----WTNVSQAAKDLIKGMLNVDPSKRLRIQDVISNKW
 |.|| ||.|. |   | .| .    .        . .....| .  . |.         ...  ...|   . ||..| . ...   ..
SDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase MAPk-Ak2.AA Pkinase_Tyr 90-210 28 1.4e-05 19.53 Pfam 82-205 (270) Show / Hide 
Range on Protein: 90-210
Range on HMM: 82-205/270
Sequence Identity: 28% (37 aa)

LLVVMECMEGGELFQRIQDK--ADGAFTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKET----FTSYTLQTPCYTP
...||| |..| |    ...   ....|  .  |. ..|... .||.|. . ||||   | | |    | . | .||| |.         |. .. .  |
IYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYY-YRKRGGGKLP

Y-YVAPEVLGPEKYDKSCDIWSLGVVMY
    |||..   |.    |.|| ||.|.
IKWMAPECINYGKFTTKSDVWSFGVLMW
Kinase MAPk-Ak2.AA CDPK 20-50 33 0.157666 0.7 In-house 1-33 (271) Show / Hide 
Range on Protein: 20-50
Range on HMM: 1-33/271
Sequence Identity: 33% (11 aa)

VTSNTVLGYGINGKVVQCTHR-RTQQNY-ALKV
 . . ||| |  | |  ..|.  |.|   | |.
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKI