Gene p38b (Fruit Fly)

p38b

Species: Fruit Fly
Alias: 186F5S, ESTS:186F5S, D-p38b, CG7393, p38, stress-activated p38b MAP kinase, anon-sts23, BG:DS00797.3, p38b, p38 MAPK, Mpk34C, SFO107, p38B
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 34D1,

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
p38b.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 288 Kinase domain by global Sugen HMM Fasta, JSON
p38b.AA Protein Various 365 None Fasta, JSON

Protein domain

Protein domains of p38b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase p38b.AA p38 24-311 78 8.10000000001e-236 789.71 In-house 1-289 (289) Show / Hide 
Range on Protein: 24-311
Range on HMM: 1-289/289
Sequence Identity: 78% (227 aa)

YQNLQPVGQGAYGQVCKAVVRGTSTK---VAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNII
||||||||.|||||||||..|.|..|   ||||||.|||||..|||||||||||||||.|||||.|||||.|  ||.|...||.||||||.|.||||||.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTP--PAHSMNDFQDVYMVTHFMGADLNNIM

RTQKLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESEMTGYVATRWYRAPEIMLNWMHYNQTADIWSVGCIMAELL
..|.|||||.||||||||||||||||||.|||||||||||||||||||||||||||....|||||||||||||||||||||||.||.||||||||||||.
KCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELI

TGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYIRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYM
||||||||.|||.||. ||.|.|||..||...|.||.|||||.|.| ||||.|...|.||||.||||||||||||.|||||||.|..|||.
TGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase p38b.AA MAPK 24-311 56 1.6e-209 702.34 In-house 1-328 (328) Show / Hide 
Range on Protein: 24-311
Range on HMM: 1-328/328
Sequence Identity: 56% (186 aa)

YQNLQPVGQGAYGQVCKAVVRGTSTK------VAIKKLARPFQSAVHAKRTYRELRLLKHM-DHENVIGLLDVFHPGQ--PADSLDQFQQVYMVTHLMDA
||.|.|.||||||.||.|. . |..|      |||||. ||||...|.||||||..||.|. .|||.|.|||.|.| .  ...||..|...|.|..||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLNNIIRTQK-LSDDHVQFLVYQILRG--LKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESE-----------------MTGYVATRWYRAP
||..||..|. |||||.|...||||||  |||||||.|||||||||||.|||.|.|.|.|||||| ...|                 ||.||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLN--WMHYNQTADIWSVGCIMAELLT-GRTLFPGTDHIHQLNLIMEVLGTPADEFMSRIS-SESARNYIRSL---PVMPRRNFRDIFRG----ANPL
|||||  ||||... |.||||||.||.|| ...||||.|.|.|.|||||||||| .||...|. ||.|||||.||   | .|.......| .    |||.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AIDLLEKMLELDADKRITAEQALAHPYM
|||||||||..| |||||.|.||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase p38b.AA ERK 24-311 51 3.8e-159 534.99 In-house 1-307 (307) Show / Hide 
Range on Protein: 24-311
Range on HMM: 1-307/307
Sequence Identity: 51% (160 aa)

YQNLQPVGQGAYGQVCKAVVRG-----TSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMD-HENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLN
|| ....|.|||| ||.|.  .     |..||||||  ..|  .. .|||.||..||.| . |||.|.|.|.. |    .| .|.  .|.|. ||. || 
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMP----NSPEQYNDIYCVEELMETDLH

NIIRTQ-KLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLAR---PAESE--------MTGYVATRWYRAPEIMLNWMHYNQ
 ||..|  |||||.|...||||.||||||||.||||||||||| ||..| | | ||||||   .  .|        ||.||||||||||||||.|  |..
QIINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTK

TADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTP-ADEFMSRISSESARNYIRSLPV--MPRRNFRDIFRGAN--PLAIDLLEKMLELDADKRI
  ||||.|||.||.| ...|||| |..||.|.| ...|||  .| ...| || |..||..||    | ... .||  ||  |.|||||||||. | ||||
AMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRI

TAEQALAHPYM
|.|..|.||| 
TVEECLEHPYF
Kinase p38b.AA CMGC 24-311 28 2.9e-151 500.9 In-house 1-513 (513) Show / Hide 
Range on Protein: 24-311
Range on HMM: 1-513/513
Sequence Identity: 28% (148 aa)

YQNLQPVGQGAYGQVCKAVV--------------RGTSTKVAIKKLARPFQSAVHAK----------RTYRELRLLKHM-----------------DHEN
|......|.|.||.|.|..               . |  .|||||. .||    .||          |..||...|||.                 .|.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIGLLDVFHPGQPADSLDQ--------FQQVYMVTHLMDADLNNIIRTQK----------LSDDH------------VQFLV------YQILRGLK--YI
...|.|.|.. ... ...         |...|.|. .|| || ..|. ..          ||. |            .....      ||||||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAG--VIHRDLKPSNIAVNEDCEL--------------------RILDFGLARPAESE------------------------MTGYVATRWYRAPEIML
||..  .|||||||.|| .|..|||                    .| ||||||  ...                        .| ||.|||||||||.|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

NW---------MHYNQTADIWSVGCIMAELLTG--------RTLFP-----------GTDHIHQLNLIMEVLGTP----------------ADEFMSRIS
.|         |||... |.||||||.||..||        ..|||           |..||.||..|..|||||                 .|....|.
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------SESARNYIRS---LPVMPRRNFRDIFRG-----------------------------------ANPLAIDLLEKMLELDA
                    ||.|||||.|   .|  |.......| .                                   ..|.|||||.|||..| 
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DKRITAEQALAHPYM
||||||||||.||| 
DKRITAEQALQHPYF
Kinase p38b.AA ERK1 24-311 50 1.9e-118 399.78 In-house 1-289 (289) Show / Hide 
Range on Protein: 24-311
Range on HMM: 1-289/289
Sequence Identity: 50% (149 aa)

YQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRTQ
| ||| .|.|||| || |. . . ..|||||.. ||    . .|| ||...|.   |||.|.. |. .    ||...|.. ||.|  ||. ||  ...||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIR----ADTIEQMRDVYIVQCLMETDLYKLLKTQ

KLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESE------MTGYVATRWYRAPEIMLNWMHYNQTADIWSVGCIMA
.|| ||. . .||||||||||||| |.||||||||. .|  |.|.| |||||| |. |      .| |||||||||||||||   | .  ||||||||.|
HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILA

ELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYIRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYM
|.|  | .|||   . |||.|. ||| |. . .  |  | ||||..|||  |.  .. .| .| . |.|||.|||    .|||| |.||||||.
EMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase p38b.AA JNK 24-277 46 4.90000000001e-114 385.14 In-house 1-260 (309) Show / Hide 
Range on Protein: 24-277
Range on HMM: 1-260/309
Sequence Identity: 46% (122 aa)

YQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARP--FQSAVHAKRTYRELRLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIR
||||...|||| | || |    |  .|||||. ||  ||   |.|| |||. ..|.  |.|.|... .|    |. .|..|| ||.|  .||. | ..| 
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFT---PQETLEEFQDVYIVMEYMDWNLCQVIH

T--QKLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESE--MTGYVATRWYRAPEIMLNWM-HYNQTADIWSVGCIM
    .|  . . .|.||...| |. ||.|.|||||||||| ||.|| | |.|||.|| .     || || ||.|||||. .  |  |    |||||||||
STFMELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIM

AELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYIRSL---PVMPRRNFRDIF
||..... ||||.||| | |.|.|.|||| ..||..   ...|||....   |  . .||  .|
AEMIRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQM-QPHVRNYVENRNMDPYYQPYNFHEHF
Kinase p38b.AA ERK5 24-311 44 1.1e-113 384.0 In-house 1-295 (295) Show / Hide 
Range on Protein: 24-311
Range on HMM: 1-295/295
Sequence Identity: 44% (134 aa)

YQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIR-T
|. .  .|.|||| || |. | .  .|||||.   |     ||||.|||..|.|  |.|.| . |. .| .|   .  ...||.|  ||..||  ||   
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVP---YSEMKDVYVVFDLMESDLHQIIHSN

QKLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLAR------PAESE--MTGYVATRWYRAPEIMLNWMHYNQTADIWSVGC
| .. .|. . .|||||||||.||| ||||||||||. ||| |||.| |||.||      |.. .  || |||||||||||.|.    | |  |.|||||
QPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGC

IMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYIRS-LPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYM
|. |... | .|||   ||||.|||.|||.|.   .  .|..  .||. . .|    ...  .. .| . |.||| .||  .  .|||. .|| ||..
IFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase p38b.AA ERK7 24-311 39 3.8e-107 362.28 In-house 1-292 (292) Show / Hide 
Range on Protein: 24-311
Range on HMM: 1-292/292
Sequence Identity: 39% (119 aa)

YQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMD-HENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIR-
|. .. .|.|||| | ||. . |   ||.||    |. .. | ||.||  .|. .. |.|.| |..|..     |       .|.|   |..||...|| 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRD-------IYLVFEFMETDLHAVIRK

TQKLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESEM---------TGYVATRWYRAPEIMLNWMHYNQTADIWSV
 . | | |.|. .||.|| .||.||. ||||||||||| .. .| ... ||||||   .           | ||||||||||||.|   .| .  | ||.
GNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSI

GCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYIRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYM
|||..|.|.|. .||||  ..|...|.|... |  | .  | |. | | . .... .|. . ...... . ||||| ..| .  .||.||||||.||| 
GCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase p38b.AA nmo 25-311 44 4e-99 305.5 In-house 2-292 (292) Show / Hide 
Range on Protein: 25-311
Range on HMM: 2-292/292
Sequence Identity: 44% (132 aa)

QNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRT-Q
|  .|.| ||.| |          .||.||.   ||. | .|| .|||..|    |.||. .||. .| .    .| || .|.|| || .||  ||   |
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH----KDFFQEIYVVTELMQSDLHKIIVSPQ

KLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESE----MTGYVATRWYRAPEIMLNWMHYNQTADIWSVGCIMAEL
.|| |||.  .|||||||||.|||...|||.|| |. || .| |.| ||||||  | .    ||  | | .||||||..   || .  |||||||| |||
HLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAEL

LTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYI-RSLPVMPRRNFRDIFRG---ANPLAIDLLEKMLELDADKRITAEQALAHPYM
|  | ||     |.||..|...||||. | | .   | |.. . |  .  |  .          |.  |..|| .||  | |||| ...||||||.
LGRRILFQAQSPIQQLQMITDLLGTPSMEDM-KYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase p38b.AA S_TKc 24-311 30 4.1e-94 319.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-311
Range on HMM: 1-231/231
Sequence Identity: 30% (92 aa)

YQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDA---DLNNII
|. |...|.||.|.|.|.. ..|  .||||..          ....||...||. .|.|.. |.|||.           . .|||. ..|    ||  .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD----------DHLYMVMEYCDGDLGDLFDYI

RTQK-------LSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESEMTGYVATRWYRAPEIMLNWMHYNQ-TADIWSV
. ..       ..  |..|..|||...|.|.|| |.|||||||.|| ..|  .. | ||||||      | .. |.||.|||..    .|.   .|.||.
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYIRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALA-----
|||..|.|.|...||      |........|                                      | |.|...|.|. | .||.|| .||.     
GCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

--HPYM
  ||..
KCHPWF
Kinase p38b.AA Pkinase 24-311 30 3.9e-90 310.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-311
Range on HMM: 1-293/293
Sequence Identity: 30% (94 aa)

YQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYR--ELRLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDA-----DL
|. ....|.|..|.|.|.. .||. .||.|.. .. ..    ..  |  |....|...|.|.. |.|.|.           . .|||. ...      ||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---------KDHIYMVMEYCEGGLYVMDL

NNIIR---TQKL--SDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCEL----RILDFGLAR---PAESEMTGYVATRWYRAPEIMLNWMHYN
  .|.     ..  |.....| .|||||||.|.|| |.|||||||.|| .......    .| |||||.      ..||... |.||.|||. .   .| 
FDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYG

QTADIWSVGCIMAELLTGRTLFPGT----DHIHQLNLIMEVLGTPADEFMSRISSESARNYIRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRI
. .|.||.|||..|.|.||..|||     . . |. .| ...|.| ..  .  .|.| .. .|  .    . ..     ... ..|.....|..|  ||.
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRP

TAEQALAHPYM
||||.| ||..
TAEQILQHPWF
Kinase p38b.AA MAPK-Unclassified 24-176 42 4.2e-65 222.6 In-house 1-157 (575) Show / Hide 
Range on Protein: 24-176
Range on HMM: 1-157/575
Sequence Identity: 42% (68 aa)

YQNLQPVGQGAYGQVCKAVVRGT-STKVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDVFHPGQPADSLDQ--FQQVYMVTHLMDA---DLN
|   . .|.|||||||.|.   .   .|||||... |.  . .||. ||.|.| .. |.|.| . |.|     ...|    |. .| |. .|     || 
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFY----NKELHNQEFDDIYIVMDYMQTSLFDLH

NIIRTQK--LSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLAR
 ||.     ... |.| . |||||||||.|||..|||||||||. .|.|| .|| |||..|
QIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase p38b.AA MAPK-Unclassified 181-311 37 7.4e-54 185.24 In-house 404-575 (575) Show / Hide 
Range on Protein: 181-311
Range on HMM: 404-575/575
Sequence Identity: 37% (64 aa)

EMTGYVATRWYRAPEIMLNWMHYNQTADIWSVGCIMAELLTG-----------RTLFPGTD--------------------HIHQLNLIMEVLGTPADEF
.||.||.|||||||||||    |    ||||.||| ||..             | ||||.|                    |. |...| ..||.|  | 
HMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEED

MSRISSESARNYIRSLPVMPRRNFRDIFRGANP----------LAIDLLEKMLELDADKRITAEQALAHPYM
...| . ||| ||.|.   ..  | |..  ..|          ..||.. |||  .. |||||.||| |||.
CNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase p38b.AA TyrKc 24-311 21 9.9e-16 31.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-311
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

YQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHM--DHENVIGLLDVFHPGQPADSLDQF---QQVYMVTHLMDA-DLN
 . ..  | ||.|.|.|.. .   ..||.|.|          .  .||.|....   .|.|.. |. |   ..       |   .....|. .|.  ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-----FMYIEPLMIVMEYMPHGDLK

NIIRTQK--LSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESE--------MT-------GY--VATRWYRAPEIML
. .|  .  |. ..     .|| .|  |.|| ..|||||   |. |.|.   .| ||||.|  ...        .        |   .  ||. ||| . 
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-

NWMHYNQTADIWSVGCIMAELLT-GRTLFPG-------TDHIHQLNLIMEVLGTPAD--EFMSRISSESARNYIRSLPVMPRRNFRDIFRGANPLAIDLL
|   ..   |.|| |  | |..| | .  ||        ......    . .  |..  . ||                         | .. .   .. 
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS-------------------------FVCCPDEMYQIM

EKMLELDADKRITAEQALAHPYM
..  . |...| | ..   | ..
KQCWHEDPEDRPTFSEI--HECF
Kinase p38b.AA Pkinase_Tyr 24-224 27 6e-14 47.87 Pfam 1-213 (270) Show / Hide 
Range on Protein: 24-224
Range on HMM: 1-213/270
Sequence Identity: 27% (61 aa)

YQNLQPVGQGAYGQVCKAVVR----GTSTKVAIKKLARPFQSAVH--AKRTYRELRLLKHM-DHENVIGLLDVFH-PGQPADSLDQFQQVYMVTHLMDA-
 . ..  |.||.|.|.|.. .    .| ..||.|.| ..  .  .   .   ||....|.. .|.|.. |. |    |.|        |.|.|. .|   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-------QIYIVMEYMPHG

DLNNIIRTQ-----KLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPA-------ESEMTGYVATRWYRAPEIMLNWMH
|| .  |..     .|.  .     .|| .|. | .| . |||||   |. |.|.   .| ||||||          .   | .  .|. ||| . .   
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM-APECINYGK-

YNQTADIWSVGCIMAELLT-GRT
..   |.|| |  | |..| |..
FTTKSDVWSFGVLMWEIFTYGEQ
Kinase p38b.AA JNK 286-311 50 7.2e-08 25.42 In-house 284-309 (309) Show / Hide 
Range on Protein: 286-311
Range on HMM: 284-309/309
Sequence Identity: 50% (13 aa)

DLLEKMLELDADKRITAEQALAHPYM
||| .||  . |.||  ..|| ||| 
DLLFRMLVINPDDRISVDDALQHPYI