Gene hop (Fruit Fly)

hop

Species: Fruit Fly
Alias: msvl, Jak, Hop, Jak-STAT, DmHD-160, l(1)hop, l(1)G18, l(1)10Be, Tumorous, Tum, hop, Tum: Tumorous, 4, Hop1, CG1594, locus 18, L4, JAK, HD-160, l(1)L4, SFO070, Dm JAK
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 10B5--6, Secondary Group: TK, Secondary Family: JakB

Classification

Group: TK
Family: Jak

Sequence

Name Sequence Type Origin Length Description Download
hop.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 254 Kinase domain by global Sugen HMM Fasta, JSON
hop.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
hop.AA Protein Various 1177 None Fasta, JSON

Protein domain

Protein domains of hop.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B41 hop.AA B41 33-259 18 7.6e-41 142.94 SMART 1-232 (232) Show / Hide 
Range on Protein: 33-259
Range on HMM: 1-232/232
Sequence Identity: 18% (46 aa)

RSGTSSQSIHTNDGTIRVFNFTTGEFERFHPNMLCEEICNTMCRQLGIAPIAQLLYGIREHST---SRRP---SPLVRLDLTWCLPGERLNCQLVYCFRM
.. .  ..... |||       | |||   ... ....|...||..|| |... ..|......   .. .    .. . |  |     . .. ....||.
SPKPRFCRVYFMDGT-------TLEFEVD-SSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHEDRHWLDHWKTIMKQDVKW-----HKSEPWTLHFRV

RFRVPEL---DSQLELIDGRSHKFLYRQMRYDMRTEQIPEIRYPEHKDKSTGLAVMDMLIDDQEQSEDQQ------AMRSIEKLYKLYLPPSLWRAHSFF
.| .| .   ..||.. . | . ..| |.|.|. .. .|      |.... .||.... |. ..... ..       .....|.|| .||..... ....
KFYPPDWHGFPNQLQEDPTRYN-YFYLQCRHDILQGRHPCP----HEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWIDSIKQS

----------VGSKIREVFRSLKANSLSVERLKWHYVHQVSHLAPTYMTEQF
          . ..|.|... .   ... | .|..|........|.|..| |
FMHYQMHHKEWRKRIMEWHKNH--CGMTPEEAKLKYLQICQRWPPMYGVEHF
Kinase hop.AA Jak 582-837 22 6.7e-106 358.12 In-house 3-299 (299) Show / Hide 
Range on Protein: 582-837
Range on HMM: 3-299/299
Sequence Identity: 22% (68 aa)

YPDSISLSDDGMMFTMRGDWIQQ-----SPVKD----VSVTMKMLKSDGNFMEFFRLAQTWSLIQSPQFLKLYGLT---LADPYTMVMEYSRYGPLNKFL
...... ...||....|.||||.     .....    |...... ........|.| ....| .......|..|..   ..|.|.|||||..||||...|
WHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDDYL

H-----SMPNVTL--HCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDP-------NSYVLDAKISDPGYPRPYR--ESDSPWIPVKYYRNLQAA
|     ....|..  ............|||||||...||......|..|.....       .....|...||..|.|...  ....||.......|....
HKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCKFY

KTDQFAQLWAFA-TTIYEIFSR-------------CKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNT
.| .....|.|. .|..||...             |... ...||....|..|...|. .....|.|...|.......|..|...|.|...|...|| 
LT-LAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ
Kinase hop.AA TK 597-747 11 4.3e-19 59.96 In-house 19-352 (486) Show / Hide 
Range on Protein: 597-747
Range on HMM: 19-352/486
Sequence Identity: 11% (40 aa)

MRGDWIQQSP-----------------------VKDVSVTMKMLKSDGNFMEFFR--------------LAQTWSLIQ-----SPQFLKLYGLTLAD---
..| |....|                       . .| | |...... . .|||               .|.  .. .      |  ..|||  . .   
YKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPK

----------PYTMVMEYSRYGP----LNKFLHSMPN---------------------------------------------------------------
          |. .||||  .|     | ..|.. ..                                                               
PCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLL

-------------VTLHCLLDLMHGLVRGMHYLEDN------KIIHNYIRCSNLYVTKYDPN-----SYVLDAKISDPGYPR--------------PYRE
             .|.|.||  .. . .|| ||...      ...|  . . |  |.. ...      ... .||.| |  |               |. 
QMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYR

SD------------------------SPWIPVKYY
..                        . ..|....
KSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWM
Kinase hop.AA Ack 598-701 29 5.8e-11 33.22 In-house 17-128 (266) Show / Hide 
Range on Protein: 598-701
Range on HMM: 17-128/266
Sequence Identity: 29% (33 aa)

RGDWIQQSPVKDVSVTMKMLKSD---GN--FMEFFRLAQTWSLIQSPQFLKLYGLTLADPY-TMVMEYSRYGPLNKFLHSMPN--VT-LHCLLDLMHGLV
||.| . .  | ..|  | |.||    .  ...|.| ...   .. |  ..|||. |. |   ||.|    | |   |.  .    . .| |.|    ..
RGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRTAFFLIHTLCDFCMQIA

RGMHYLEDNKIIH
 || |||   .||
MGMRYLEMKRCIH
Kinase hop.AA TKL 605-729 18 1.5e-10 34.17 In-house 23-199 (364) Show / Hide 
Range on Protein: 605-729
Range on HMM: 23-199/364
Sequence Identity: 18% (34 aa)

SPVKDVSVTMKMLKSDGN----------------------------FMEFFRLAQTWSL-IQSPQFLKLYGLTLADP--------------YTMVMEYSR
|  ..  | .|..||. .                            |..|..      . .. |  ....|  .. |              . .||||  
S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCP

YGPLNKFLHSMPNVTLHCLLDLMHGLVRGMHYLEDNK--------IIHNYIRCSNLYVTK-YDPNS-------YVLDAKISDPG
 | |  .||      .| .......  |||.||  ..        |||  .  .|. | . . ..|       .  ..||.| |
GGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFG
Kinase hop.AA TK 762-835 12 3.7e-09 26.06 In-house 378-486 (486) Show / Hide 
Range on Protein: 762-835
Range on HMM: 378-486/486
Sequence Identity: 12% (14 aa)

WAFATTIYEIFSRCKEDLSTLRQ----------EQLLRQKNLD-----------GNILKMLDQDICP--------------APIFETIMDGWSDDETKRF
|.|  ...|||....|                 ......               |. . |   . ||              . ... ... |. |  .| 
WSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRP

SHHDIFSRL
.  .. ..|
TFSQLHEQL
Kinase hop.AA Pkinase_Tyr 642-701 30 1.1e-08 29.99 Pfam 67-134 (270) Show / Hide 
Range on Protein: 642-701
Range on HMM: 67-134/270
Sequence Identity: 30% (21 aa)

LKLYGLTL--ADP--YTMVMEYSRYGPLNKFLHSM----PNVTLHCLLDLMHGLVRGMHYLEDNKIIH
..|||  .   .|  . .||||  .| | ..|..     ...|.. ||.  .   .|| |||....||
VRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH
Kinase hop.AA Fer 762-836 20 4.4e-05 13.39 In-house 202-283 (283) Show / Hide 
Range on Protein: 762-836
Range on HMM: 202-283/283
Sequence Identity: 20% (17 aa)

WAFATTIYEIFSRCKEDLST------LRQE--QLLRQKNLDGNILKMLDQDICPAPIFETIM-DGWSDDETKRFSHHDIFSRLN
|.|  ...|||....|.  .      . .   |. ...  .|. ..| ..  .| .| . .| . |  |  .| .  .|  .|.
WSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNH--MPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase hop.AA TKL 762-835 18 7.9e-05 13.34 In-house 273-364 (364) Show / Hide 
Range on Protein: 762-835
Range on HMM: 273-364/364
Sequence Identity: 18% (17 aa)

WAFATTIYEIFSRCKEDLSTLRQEQLLR-------QKNLDGNILKMLD-----------QDICPAPIFETIMDGWSDDETKRFSHHDIFSRL
..|.  ..||..||.        .....        .. | .    ..            . || .. . ..| |. | .|| |  .| .||
YSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase hop.AA UTK 642-727 25 0.00159 7.93 In-house 73-168 (296) Show / Hide 
Range on Protein: 642-727
Range on HMM: 73-168/296
Sequence Identity: 25% (25 aa)

LKLYGLTLADPYTM-VMEYSRYGPLNKFLHSMPN--------VTLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKY--DPNSYVLDAKISD
|.|.|. ...  .| |.|| . | | ..| . .         .|||..|. .    |||.||.  ...|. . . | .|..   .     ...||.|
LRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWH-CMMVCKIAD
Kinase hop.AA TK-Unique 655-702 18 0.003609 6.92 In-house 82-157 (294) Show / Hide 
Range on Protein: 655-702
Range on HMM: 82-157/294
Sequence Identity: 18% (14 aa)

MVMEYSRYGPLNKFLHSMP-N-------------------------VTLHCLLDLMHGLVRGMHYLED--NKIIHN
..||| ..| | ..|...  .                         .... |.  . .. .|| ||.    ||.|.
IIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHR
Kinase hop.AA Src 648-701 29 0.007042 5.56 In-house 64-120 (255) Show / Hide 
Range on Protein: 648-701
Range on HMM: 64-120/255
Sequence Identity: 29% (17 aa)

TLADPYTMVMEYSRYGPLNKFLH---SMPNVTLHCLLDLMHGLVRGMHYLEDNKIIH
.  .|.  | || . | | ..|.      .. |  |.|.     .|| ||| ...||
SQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIH
Kinase hop.AA Eph 806-835 30 0.009454 4.91 In-house 235-264 (264) Show / Hide 
Range on Protein: 806-835
Range on HMM: 235-264/264
Sequence Identity: 30% (9 aa)

CPAPIFETIMDGWSDDETKRFSHHDIFSRL
||.....  .| |  | ..|   ..| | |
CPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase hop.AA Fer 656-701 29 0.054077 2.71 In-house 87-134 (283) Show / Hide 
Range on Protein: 656-701
Range on HMM: 87-134/283
Sequence Identity: 29% (14 aa)

VMEYSRYGPLNKFLHSMPN--VTLHCLLDLMHGLVRGMHYLEDNKIIH
|||.   | | ..|   .|  |..  ...  ..  .|| ||. ...||
VMEFCNGGSLDSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIH
Kinase hop.AA Pkinase 655-701 25 0.254774 5.75 Pfam 77-131 (293) Show / Hide 
Range on Protein: 655-701
Range on HMM: 77-131/293
Sequence Identity: 25% (14 aa)

MVMEYSRYG----PLNKFLH--SMPNV--TLHCLLDLMHGLVRGMHYLEDNKIIH
||||| . |     |  ...  .  ..  . . . . |  ..||. |. ...|||
MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH
Kinase hop.AA Pkinase_Tyr 762-777 31 2.329273 1.84 Pfam 198-213 (270) Show / Hide 
Range on Protein: 762-777
Range on HMM: 198-213/270
Sequence Identity: 31% (5 aa)

WAFATTIYEIFSRCKE
|.|  ...|||.....
WSFGVLMWEIFTYGEQ
Kinase hop.AA Jak 892-1153 36 5e-131 441.59 In-house 1-299 (299) Show / Hide 
Range on Protein: 892-1153
Range on HMM: 1-299/299
Sequence Identity: 36% (110 aa)

YNMENMIGRGHYGTVYKGHLEFNDK-----DQPRE--QVAIKMLNTM---QVSTDFHREIGIMRTLSHPNIVKFK----YWAEKSHCIIMEYLQSGSFDI
.......|.||.|.||.........     ||..|  ||..|.....   |.|.|||||| ||...||..|||..    .|.....|..|||...|..| 
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

YLR----FTAPNLNN--PRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSD-GYYYAKSKRDIPIRWYSPEAISTCR
||.    ......|.  .....|| .|..||.||.|...||.|..|||||||..|...||||..|.|.....|| .||.....||..|.||.||....|.
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

FSS--YSDVWSYG-VTLFEMF-SRGEEPN------LVPIQTSQED------FLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDIITR
|..  ..|.||.| |||.|.. ....|..      |..|......      .||....|.||..|.||.|.||.|||.|||..|..||||.||....  
FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ
Kinase hop.AA TyrKc 892-1151 36 2.6e-122 413.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 892-1151
Range on HMM: 1-280/280
Sequence Identity: 36% (106 aa)

YNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTDFHREIGIMRTL--SHPNIVKFKYWAE---------KSHCIIMEYLQSGSFDIYLR
  .. ..|.|..|.||||..         .|||.|||.      ||.||. ||. |  .|||||..   .          . ..|.|||   |. . |||
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

FTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSD-------GYYYAKS--KRD--IPIRWYSPEAISTC
 . |.|... |.||...||.|| ||.....|||||||||.||..|.   .||||||||. .  .|        || .|.   ..  .||||..||.| ..
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

RFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQ--TSQEDFLNRLQSGERLNRPAS--------CPDFIYDLMQLCWHATPRSRPSFATIVDII
.|.. |||||.||...|.|..|..|   .||   | .. ......|.|. .|..        ||| .|..|. |||. | .||.|..|....
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase hop.AA Pkinase_Tyr 892-1151 37 2.5e-120 408.15 Pfam 1-270 (270) Show / Hide 
Range on Protein: 892-1151
Range on HMM: 1-270/270
Sequence Identity: 37% (106 aa)

YNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKML--NTMQV---STDFHREIGIMRTL-SHPNIVKFKYWAE---KS--HCIIMEYLQSGSFDIYLR
  .  ..|.|..|.||||..   |.|... .||.|||  ..|.    . || ||. ||..| .|||||..        ..  ..|.||| . |. . |||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

FT---APNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYY-YAKSKRDIPIRWYSPEAISTCRFSSYSD
      ..|. ..|......||.|| ||.....|||||||||.||..   . .|||.|||||    .|.|| ..... ..||.|..||.|....|.. ||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD

VWSYGVTLFEMFSRGEEPNLVPIQT----SQEDFLNRL-QSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDII
|||.||...|.|..||.|      |    | |...... ..|.|. .|  ||| |||||..|||. |  ||.|. |. ..
VWSFGVLMWEIFTYGEQP------TYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase hop.AA TK 892-1151 20 1.1e-94 317.86 In-house 1-486 (486) Show / Hide 
Range on Protein: 892-1151
Range on HMM: 1-486/486
Sequence Identity: 20% (101 aa)

YNMENMIGRGHYG---TVYKGHLEFND--------------------KDQPREQVAIKMLN---TMQVSTDFH----------------REIGIMRT--L
  ... .|.|..|   .|||| ..  .                    |.. ...||.|||    .|.    |                 .|. .|.   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHPNIVKFKYWAEKS--------------HCIIMEYLQSGS----FDIYLRFTAPN--------------------------------------------
 |||||..     ..               .|.||| . |.     . |||   |.                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LNNPRLVSFALDIANGMKYLSDM------GLIHRDLAARNILVDHNGD--------GDCVKISDFG---
                               |. ..|. ....||.|| ||...      ...||||||||.||..|.         | ..||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAQFANSDGYYYAKS------------------------KRDIPIRWYSPEAIS---------TCRFSSYSDVWSYGVTLFEMFSRGEEPNL--V
     ||   .||..||.||                        .. .||||..||..          . .|.. |||||.||...|.|..|.||    .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PI------QTSQEDFLNRLQSG--------------ERLNRPASCP--------------DFIYDLMQLCWHATPRSRPSFATIVDII
.         . ......|..|               |. .|. ||              ...||||| |||. |. ||.|..... .
SNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase hop.AA UTK 898-1151 29 3.9e-80 272.53 In-house 7-296 (296) Show / Hide 
Range on Protein: 898-1151
Range on HMM: 7-296/296
Sequence Identity: 29% (86 aa)

IGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTDFHR----------EIGIMRTLS-HPNIVKFK--YWAEKSHCIIMEYLQSGSFDIYLRFTAP
.|.|..|.|.|..... .   .  .||.| ...  .......          |. .|  .. |||....    ..|.  .|..|| . |. . |||  .|
LGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRP

NLN------NPR-LVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNG----DGDCVKISDFG---LAQFAN---------SDGYYYAKSKRDIPIRWY
...      . . ....|.|||.|| ||. .|..||||||||.||....     .  .||.|||   ..  .|         .. ||.| . . .||||.
TPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWM

SPEAISTC-RFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSG-ERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDII
.|||.    ||.. |||||.||...|....|  |   |  . .. ... .  |  |...|..||. .|.||. |||..|. ||.| ..|. .
APEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLP--YPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase hop.AA TKL 898-1151 24 3.8e-66 226.06 In-house 1-364 (364) Show / Hide 
Range on Protein: 898-1151
Range on HMM: 1-364/364
Sequence Identity: 24% (90 aa)

IGRGHYGTVYKGHLEFNDKDQP----REQVAIKMLNTMQVS-----------------------------TDFHREIGIMRTLSHPNIVKFKY-------
||.|..|.||||..  ..  .      . ||.|........                               . .|| .|. |.|||||.|.        
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

--WAEK------SHCIIMEYLQSGS-FDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMG--------LIHRDLAARNILVDHNGD-----------GD
  . ..       .||.||| . || .....         ......||||| || ||  |.        .|||||  .||||| |.             .
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

CVKISDFGLAQFANSDG----------------YYYAKSKRDI-PIRWYSPEAIS----------------TCRFSSYSDVWSYGVTLFEMFSRGEEPNL
|.||.||||..| . .|                 .  .. . .  .|| .||..                    .|  .||.|.|. |.|...| . |  
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYY

-VPIQTSQ------EDFLNRLQSGERLNRP------------ASCPDFIYDLMQLCWHATPRSRPSFATIVDII
  |  . .      |.|  . . |.|. .|             .||. . .||| ||.. |..|||| .|....
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase hop.AA TK-Unique 892-1151 30 1.9e-65 223.72 In-house 1-294 (294) Show / Hide 
Range on Protein: 892-1151
Range on HMM: 1-294/294
Sequence Identity: 30% (93 aa)

YNMENMIGRGHYGTVYKGHLEFNDKDQPRE-QVAIKMLN---TMQVSTDFHREIGIMRTLS-HPNIVKFKYWAE---KSHCIIMEYLQSGSFDIYLRFTA
 .... ||.| .|.|..| .. ..|.. .  .||.|||.   | .   || .|| .|. |  |||||..         ...|||||.. |. . |||...
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PN-------------------------LNNPRLVSFALDIANGMKYLSD--MGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAK-SKRD
|.                         ..  .|..|| .||.||.||.   .. .||||.|||.|. ...    .||.|||.|   . .| |  . |.  
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKV---CKICDFGMARDVYTNGVYSMMCSQGR

IPIRWYSPEAIS--TCRF-SSYSDVWSYGVTLFEMFSRGEEP--NLVPIQTSQEDFLNRLQSGERLNRPASC-PDFIYDLMQLCWHATPRSRPSFATIVD
||||| .||...  .  . .. |||||.||...|.|. |. |  .. . .     ...... | |...|..| .. .| ||. ||.  | .||||..|..
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-----IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKH

II
..
RL
Kinase hop.AA Src 892-1151 35 4.9e-63 212.98 In-house 1-255 (255) Show / Hide 
Range on Protein: 892-1151
Range on HMM: 1-255/255
Sequence Identity: 35% (94 aa)

YNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVS-TDFHREIGIMRTLSHPNIVKFKYWAEKS--HCIIMEYLQSGSFDIYLR--FTAPNL
  ..  .|.|..| |..|    |       .||.| |   . | ..| .|. || .|.|...|.      .     |. || . ||   ||.   .  .|
IKLCRKLGQGQFGEVWMGYWNGN------TKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

NNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFAN-SDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLF
. |.|...|  .|.||.||. | .|||||||||.||..|    ..|. |||||.     |  | |..   .||.|  ||||.  ||.  |||||.|. | 
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENN---VCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLT

EMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYD-LMQLCWHATPRSRPSFATIVDII
|....|  |   |  | .|  | ... | |. .|. ||| .|. .|. |||..|. || |... .  
EIVTYGRVP--YPGMTNHE-VLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase hop.AA Eph 893-1151 39 9.4e-62 206.17 In-house 2-264 (264) Show / Hide 
Range on Protein: 893-1151
Range on HMM: 2-264/264
Sequence Identity: 39% (106 aa)

NMENMIGRGHYGTVYKGHLEFNDKDQPR--EQVAIKML---NTMQVSTDFHREIGIMRTLSHPNIVKFKYWAEKSHC--IIMEYLQSGSFDIYLRFTAPN
 .|  || | .| |..|.|  .....    . ||||.|    | .   || .|  ||   .||||.. .    ||    |. ||   || | .|| .   
KIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDGQ

LNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDG----YYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYG
.   .||     || ||||||||. .|||||||||||. |    . |.|||||  .  .|.     |  .. . |||||  ||||.  .|.| |||||||
FTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNL---VCKVSDFGLSRVLEDDPSVEATYTTRGGK-IPIRWTAPEAIAYRKFTSASDVWSYG

VTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDII
. . |  | || |       |  | ..  . | ||  |  ||  .. ||. ||.  . .|| |..|| |.
IVMWEVMSYGERPY---WDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase hop.AA Ack 989-1151 42 4.1e-54 180.95 In-house 105-266 (266) Show / Hide 
Range on Protein: 989-1151
Range on HMM: 105-266/266
Sequence Identity: 42% (71 aa)

PRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLA-QFANSDGYYYAKSKR--DIPIRWYSPEAISTCRFSSYSDVWSYGVTLF
..|  |.. ||.|| ||   ..|||||||||||.      . |||.||||       ..||  . .|   .|. |  ||.. . .||. ||||..|||| 
HTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDD--RKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVTLW

EMFSRGEEPNLVPIQTSQEDFLNRLQ-SGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDII
|||| ||||    .  . .. | ..   |||| ||  ||  ||..|  || ..|  ||.|. |.|  
EMFSYGEEPW---AGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase hop.AA Fer 965-1152 31 6.1e-52 175.19 In-house 86-283 (283) Show / Hide 
Range on Protein: 965-1152
Range on HMM: 86-283/283
Sequence Identity: 31% (62 aa)

IIMEYLQSGSFDIYLRFTAP-NLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVK--ISDFGLAQFANSDGYYYAKS--KRDIPIR
|.||.   ||.| ||. .   ..    .. .....|.||.||  .. ||||.||||.|...  |.. .|  |||||..     .|| | .    . .|||
IVMEFCNGGSLDSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHK--DKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIR

WYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLV------PIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQ-LCWHATPRSRPSFATIVDIIT
| .||...|  .|. .||||.||...| |..|.|| .       . ..  ..  .  ..| ..  | ..|..|. .|   ||.. |  ||....|. .. 
WLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase hop.AA Met 991-1145 34 2.1e-47 153.29 In-house 106-271 (271) Show / Hide 
Range on Protein: 991-1145
Range on HMM: 106-271/271
Sequence Identity: 34% (60 aa)

LVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFA-NSDGYYYAKSKRD---IPIRWYSPEAIS--------TCR-FSSYSDV
|..|....| ||.|.     .|||||.|| . |       ||. ||||.        || ......    |..|  ||           | | |.. |||
LIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHF---TVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKSDV

WSYGVTLFEMFSRGEEP--NLVP-IQTSQEDFLNRLQSG--ERLNRPASCPDFIY-DLMQLCWHATPRSRPSFA
|| || . | . ||  |  .  . .     | .  |. |   || .|  ||| .| |.|. ||||.|  ||.| 
WSFGVVMWELMTRGAPPYPHVDNWF-----DITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase hop.AA S_TKc 892-1156 22 8.7e-46 159.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 892-1156
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

YNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTDFHREIGIMRTLSHPNIVKFKYWAE-KSHCIIMEYLQS--GSFDIYLRFTAPN---
| . . ||.| .|.|||..          ..||||...      .. ||| |..   ||||||.... . .. ...|||.    |.   |..   ..   
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSS-YSDVWSYGV
  ..  .  ...  |.....|. ..| |||||   |||.|.     ..||.||||| .          .       . .|| .    ..   .|.|| |.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

TLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVD----IITREVA
.|.||.. |. |        ..  ....            |...  ... |..  |. ||.   .      |   .  
ILYEMLC-GYPPFP-----QMQMMFKKIG----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase hop.AA Pkinase 892-1151 24 2e-35 126.36 Pfam 1-293 (293) Show / Hide 
Range on Protein: 892-1151
Range on HMM: 1-293/293
Sequence Identity: 24% (74 aa)

YNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTDFHR------EIGIMRTLSHPNIVKFKYWAE--KSHCIIMEYLQSG----SFDIYL
|  .  ||.| .|.|||.|   . |     .||.| ..    . ....      || ||. |.|||||....| |  .. ...|||.. |    .   |.
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

R-FTAPNL--NNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDG-DCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAIS-TCRFSSY
.     ..      . .... |. |..|. .|| |||||   |||.|.||.  .||||.||||| ...    .   . .   ... .|| |      .. 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVWSYGVTLFEMFSRGEEPNLVPIQ------TSQEDFLNRLQSGERLNRPASCP-------------------DFIYDLMQLCWHATPRSRPSFATIVD
.|.||.|..|.||...     . | .      . .. . ....   . ..| .|.                   .   |..  |..  | .||... |. 
VDMWSCGCILYEMLCGR---PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

I--I
   .
HPWF
Kinase hop.AA Met 893-952 32 2.8e-17 52.91 In-house 1-63 (271) Show / Hide 
Range on Protein: 893-952
Range on HMM: 1-63/271
Sequence Identity: 32% (21 aa)

NMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLN-----TMQVSTDFHREIGIMRTLSHPNI
 ..  ||.||.| ||.| .   |.|. ....|.| |.     ..|    | ||  .|. ..|||.
HFDDVIGQGHFGCVYHGMYH--DNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNV
Kinase hop.AA Fer 892-955 28 6.3e-11 33.57 In-house 1-74 (283) Show / Hide 
Range on Protein: 892-955
Range on HMM: 1-74/283
Sequence Identity: 28% (21 aa)

YNMENMIGRGHYGTVYKG-HLEFNDKDQPREQ-----VAIKMLNTMQVSTD----FHREIGIMRT-LSHPNIVKF
.......|.|..|.||||   ..  |.. . .     |. |....  ....    | .|  |||. ..|||.|||
VTLGKKLGEGAFGEVYKGRR-TLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKF
Kinase hop.AA Ack 922-954 42 0.000447 9.65 In-house 29-66 (266) Show / Hide 
Range on Protein: 922-954
Range on HMM: 29-66/266
Sequence Identity: 42% (16 aa)

QVAIKMLNTM---QV--STDFHREIGIMRTLSHPNIVK
|||.| |      |   . || ||  ||  | ||..|.
QVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVR